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51

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Quashie, P. K., Mesplede, T., Han, Y.-S., Veres, T., Osman, N., Hassounah, S., Sloan, R. D., Xu, H.-T., Wainberg, M. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

File:

PDF, 60 KB

2014

52

The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir

Cutillas, Vincent, Mesplede, Thibault, Anstett, Kaitlin, Hassounah, Said, Wainberg, Mark A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

53

Repression by Homeoprotein Pitx1 of Virus-Induced Interferon A Promoters Is Mediated by Physical Interaction and trans Repression of IRF3 and IRF7

Island, M.-L., Mesplede, T., Darracq, N., Bandu, M.-T., Christeff, N., Djian, P., Drouin, J., Navarro, S.

Journal:

Molecular and Cellular Biology

Year:

2002

Language:

english

File:

PDF, 445 KB

english, 2002

54

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Quashie, P. K., Mesplede, T., Han, Y.-S., Veres, T., Osman, N., Hassounah, S., Sloan, R. D., Xu, H.-T., Wainberg, M. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

File:

PDF, 62 KB

2014

55

Dolutegravir inhibits HIV-1 Env evolution in primary human cells

Mesplède, Thibault, Moïsi, Daniela, Oliveira, Maureen, Ibanescu, Ilinca, Ohnona, Frédéric, Brenner, Bluma, Wainberg, Mark A.

Journal:

Year:

2015

Language:

english

File:

PDF, 300 KB

english, 2015

56

Resistance to HIV integrase inhibitors

Mesplède, Thibault, Quashie, Peter K., Wainberg, Mark A.

Journal:

Current Opinion in HIV and AIDS

Year:

2012

Language:

english

File:

PDF, 391 KB

english, 2012

57

Simian-Tropic HIV as a Model To Study Drug Resistance against Integrase Inhibitors

Wares, Melissa, Hassounah, Said, Mesplède, Thibault, Sandstrom, Paul A., Wainberg, Mark A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 936 KB

english, 2015

58

Evolution of HIV integrase resistance mutations

Quashie, Peter K., Mesplède, Thibault, Wainberg, Mark A.

Journal:

Current Opinion in Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 275 KB

english, 2012

59

p53 Degradation Activity, Expression, and Subcellular Localization of E6 Proteins from 29 Human Papillomavirus Genotypes

Mesplede, T., Gagnon, D., Bergeron-Labrecque, F., Azar, I., Senechal, H., Coutlee, F., Archambault, J.

Journal:

Journal of Virology

Year:

2012

Language:

english

File:

PDF, 4.89 MB

english, 2012

60

The POU Transcription Factor Oct-1 Represses Virus-Induced Interferon A Gene Expression

Mesplede, T., Island, M.-L., Christeff, N., Petek, F., Doly, J., Navarro, S.

Journal:

Molecular and Cellular Biology

Year:

2005

Language:

english

File:

PDF, 619 KB

english, 2005

61

Vesicular Stomatitis Virus Oncolysis of T Lymphocytes Requires Cell Cycle Entry and Translation Initiation

Oliere, S., Arguello, M., Mesplede, T., Tumilasci, V., Nakhaei, P., Stojdl, D., Sonenberg, N., Bell, J., Hiscott, J.

Journal:

Journal of Virology

Year:

2008

Language:

english

File:

PDF, 1.74 MB

english, 2008

62

Productive Entry of HIV-1 during Cell-to-Cell Transmission via Dynamin-Dependent Endocytosis

Sloan, R. D., Kuhl, B. D., Mesplede, T., Munch, J., Donahue, D. A., Wainberg, M. A.

Journal:

Journal of Virology

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

63

Exposure to Entry Inhibitors Alters HIV Infectiousness and Sensitivity to Broadly Neutralizing Monoclonal Antibodies

Kramer, Victor G., Varsaneux, Olivia, Oliviera, Maureen, Colby-Germinario, Susan P., Mesplède, Thibault, Wainberg, Mark A.

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2014

Language:

english

File:

PDF, 572 KB

english, 2014

64

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Quashie, P. K., Mesplede, T., Han, Y.-S., Veres, T., Osman, N., Hassounah, S., Sloan, R. D., Xu, H.-T., Wainberg, M. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 2.15 MB

english, 2013

65

HIV gp120 H375 Is Unique to HIV-1 Subtype CRF01_AE and Confers Strong Resistance to the Entry Inhibitor BMS-599793, a Candidate Microbicide Drug

Schader, S. M., Colby-Germinario, S. P., Quashie, P. K., Oliveira, M., Ibanescu, R.-I., Moisi, D., Mesplede, T., Wainberg, M. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 2.53 MB

english, 2012

66

I B Kinase -Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis

Nakhaei, P., Sun, Q., Solis, M., Mesplede, T., Bonneil, E., Paz, S., Lin, R., Hiscott, J.

Journal:

Journal of Virology

Year:

2012

Language:

english

File:

PDF, 1.91 MB

english, 2012

67

Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor

Han, Y.-S., Xiao, W.-L., Xu, H., Kramer, V. G., Quan, Y., Mesplede, T., Oliveira, M., Colby-Germinario, S. P., Sun, H.-D., Wainberg, M. A.

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2015

Language:

english

File:

PDF, 262 KB

english, 2015

68

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

Nakhaei, Peyman, Mesplede, Thibault, Solis, Mayra, Sun, Qiang, Zhao, Tiejun, Yang, Long, Chuang, Tsung-Hsien, Ware, Carl F., Lin, Rongtuan, Hiscott, John, Gale, Michael

Journal:

Year:

2009

Language:

english

File:

PDF, 799 KB

english, 2009

69

Positive and Negative Control of Virus-induced Interferon-A Gene Expression

Mesplède, Thibault, Navarro, Sébastien, Génin, Pierre, Morin, Pierre, Island, Marie-Laure, Bonnefoy, Eliette, Civas, Ahmet

Journal:

Year:

2003

Language:

english

File:

PDF, 143 KB

english, 2003

70

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

Osman, Nathan, Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Zanichelli, Veronica, Wainberg, Mark A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2015

Language:

english

File:

PDF, 318 KB

english, 2015

71

The combination of the R263K and T66I resistance substitutions in HIV-1 integrase is incompatible with high level viral replication and the development of high-level drug resistance

Liang, Jiaming, Mesplède, Thibault, Oliveira, Maureen, Anstett, Kaitlin, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 1.83 MB

english, 2015

72

Dolutegravir-selected HIV-1 containing the N155H/R263K resistance substitutions does not acquire additional compensatory mutations under drug pressure that lead to higher level resistance and increased replicative capacity

Anstett, Kaitlin, Fusco, Robert, Cutillas, Vincent, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 621 KB

english, 2015

73

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in SIVmac239

Hassounah, Said A., Liu, Yannan, Quashie, Peter K., Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma G., Sandstrom, Paul A, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

74

Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity

Anstett, Kaitlin, Cutillas, Vincent, Fusco, Robert, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 278 KB

english, 2016

75

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

Brenner, Bluma G., Thomas, Réjean, Blanco, José Luis, Ibanescu, Ruxandra-Ilinca, Oliveira, Maureen, Mesplède, Thibault, Golubkov, Olga, Roger, Michel, Garcia, Federico, Martinez, Esteban, Wainberg, Ma

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 213 KB

english, 2016

76

Might dolutegravir be part of a functional cure for HIV? 1

Wainberg, Mark A., Han, Ying-Shan, Mesplède, Thibault

Journal:

Canadian Journal of Microbiology

Year:

2016

Language:

english

File:

PDF, 747 KB

english, 2016

77

Will LEDGIN molecules be able to play a role in a cure for HIV infection?

Mesplède, Thibault, Wainberg, Mark A.

Journal:

Year:

2016

Language:

english

File:

PDF, 611 KB

english, 2016

78

Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

Pham, Hanh T., Mesplède, Thibault, Wainberg, Mark A.

Journal:

Year:

2016

Language:

english

File:

PDF, 951 KB

english, 2016

79

HIV-1 Group O Resistance Against Integrase Inhibitors

Depatureaux, Agnès, Mesplède, Thibault, Quashie, Peter, Oliveira, Maureen, Moisi, Daniela, Plantier, Jean-Christophe, Brenner, Bluma, Wainberg, Mark A.

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2015

Language:

english

File:

PDF, 413 KB

english, 2015

80

Differences among HIV-1 subtypes indrug resistance against integrase inhibitors

Han, Ying-Shan, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Infection, Genetics and Evolution

Year:

2016

Language:

english

File:

PDF, 340 KB

english, 2016

81

A resveratrol analog termed 3,3′,4,4′,5,5′-hexahydroxy- trans -stilbene is a potent HIV-1 inhibitor

Han, Ying-Shan, Quashie, Peter K., Mesplède, Thibault, Xu, Hongtao, Quan, Yudong, Jaeger, Walter, Szekeres, Thomas, Wainberg, Mark A.

Journal:

Journal of Medical Virology

Year:

2015

Language:

english

File:

PDF, 144 KB

english, 2015

82

Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors

Oliveira, Maureen, Mesplède, Thibault, Quashie, Peter K., Moïsi, Daniela, Wainberg, Mark A.

Journal:

Year:

2014

Language:

english

File:

PDF, 398 KB

english, 2014

83

The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B

Mesplède, Thibault, Quashie, Peter K., Hassounah, Said, Osman, Nathan, Han, Yingshan, Liang, Jiaming, Singhroy, Diane N., Wainberg, Mark A.

Journal:

Year:

2015

Language:

english

File:

PDF, 248 KB

english, 2015

84

The dolutegravir R263K resistance mutation in HIV-1 integrase is incompatible with the emergence of resistance against raltegravir

Oliveira, Maureen, Mesplède, Thibault, Moïsi, Daniela, Ibanescu, Ruxandra-Ilinca, Brenner, Bluma, Wainberg, Mark A.

Journal:

Year:

2015

Language:

english

File:

PDF, 243 KB

english, 2015

85

Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

Palanisamy, Navaneethan, Osman, Nathan, Ohnona, Frédéric, Xu, Hong-Tao, Brenner, Bluma, Mesplède, Thibault, Wainberg, Mark A.

Journal:

AIDS Research and Therapy

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

86

JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1

Quan, Yudong, Xu, Hongtao, Han, Yingshan, Mesplède, Thibault, Wainberg, Mark A., Silvestri, Guido

Journal:

Journal of Virology

Year:

2017

Language:

english

File:

PDF, 719 KB

english, 2017

87

The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration

Mesplède, Thibault, Leng, Jing, Pham, Hanh Thi, Liang, Jiaming, Quan, Yudong, Han, Yingshan, Wainberg, Mark A., Karim, Salim Abdool

Journal:

Year:

2017

Language:

english

File:

PDF, 457 KB

english, 2017

88

A Mathematical Model to Predict HIV Virological Failure and Elucidate the Role of Lymph Node Drug Penetration

Sanche, S, Sheehan, N, Mesplède, T, Wainberg, MA, Li, J, Nekka, F

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2017

Language:

english

File:

PDF, 575 KB

english, 2017

89

HIV drug resistance against strand transfer integrase inhibitors

Anstett, Kaitlin, Brenner, Bluma, Mesplede, Thibault, Wainberg, Mark A.

Journal:

Year:

2017

Language:

english

File:

PDF, 958 KB

english, 2017

90

The M184I/V and K65R nucleoside resistance mutations in HIV-1 prevent the emergence of resistance mutations against dolutegravir

Oliveira, Maureen, Ibanescu, Ruxandra I., Pham, Hanh Thi, Brenner, Bluma, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Year:

2016

Language:

english

File:

PDF, 383 KB

english, 2016

91

M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA

Oliveira, Maureen, Brenner, Bluma G., Xu, Hongtao, Ibanescu, Ruxandra-Ilinca, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2017

Language:

english

File:

PDF, 102 KB

english, 2017

92

HIV-1 resistance to dolutegravir is affected by cellular histone acetyltransferase activity

Anstett, Kaitlin, Brenner, Bluma, Mesplède, Thibault, Wainberg, Mark A.

Journal:

Journal of Virology

Year:

2017

Language:

english

File:

PDF, 2.80 MB

english, 2017

93

Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs

Gantner, Pierre, Lee, Guinevere Q, Rey, David, Mesplede, Thibault, Partisani, Marialuisa, Cheneau, Christine, Beck-Wirth, Geneviève, Faller, Jean-Pierre, Mohseni-Zadeh, Mahsa, Martinot, Martin, Wainbe

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2017

Language:

english

File:

PDF, 372 KB

english, 2017

94

The antimalarial drug amodiaquine possesses anti-ZIKA virus activities

Han, Yingshan, Mesplède, Thibault, Xu, Hongtao, Quan, Yudong, Wainberg, Mark A.

Journal:

Journal of Medical Virology

Year:

2018

Language:

english

File:

PDF, 912 KB

english, 2018

95

ChemInform Abstract: SOLVENTEXTRAKTION VON AM, CM UND CF AUS DEM GESCHMOLZENEN EUTEKTIKUM LINO3-KNO3 DURCH ALPHA,OMEGA-BIS-(DIPHENYLPHOSPHINYL)-ALKANE UND TRI-N-OCTYLPHOSPHINOXID

FOOS, JACQUES, MESPLEDE, JACQUES

Journal:

Chemischer Informationsdienst

Year:

1972

File:

PDF, 99 KB

1972

96

ChemInform Abstract: UNTERSUCHUNG DES SYNERGETISCHEN EFFEKTS WAEHREND DER EXTRAKTION VON LANTHANIDEN AUS ALKALIMETALLNITRATSCHMELZEN

FOOS, J., MESPLEDE, J., ROUCHOUSE, A.

Journal:

Chemischer Informationsdienst

Year:

1975

File:

PDF, 115 KB

1975

97

ChemInform Abstract: FLUESSIG-FLUESSIG-EXTRAKTION VON HALOGENIDIONEN AUS ALKALIMETALLNITRATSCHMELZEN MIT HILFE EINER ORGANOPHOSPHORVERBINDUNG, TETRA-N-OCTYLPHOSPHONIUMNITRAT (TOPN)

ROUCHOUSE, ALAIN, MESPLEDE, JACQUES, PORTHAULT, MAURICE

Journal:

Chemischer Informationsdienst

Year:

1975

File:

PDF, 122 KB

1975

98

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

Osman, Nathan, Mesplède, Thibault, Oliveira, Maureen, Hassounah, Said, Wainberg, Mark A., Brenner, Bluma G.

Journal:

Year:

2018

Language:

english

File:

PDF, 313 KB

english, 2018

99

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

Quashie, Peter K., Han, Ying-Shan, Hassounah, Said, Mesplède, Thibault, Wainberg, Mark A., Harrich, David

Journal:

Year:

2015

Language:

english

File:

PDF, 5.21 MB

english, 2015

100

Exploring an alternative explanation for the second phase of viral decay: Infection of short-lived cells in a drug-limited compartment during HAART

Sanche, Steven, Mesplède, Thibault, Sheehan, Nancy L., Li, Jun, Nekka, Fahima, Apetrei, Cristian

Journal:

Year:

2018

Language:

english

File:

PDF, 2.17 MB

english, 2018

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