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1

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

Janet Hauschild, Bjoern Petersen, Yolanda Santiago, Anna-Lisa Queisser, Joseph W. Carnwath, Andrea Lucas-Hahn, Lei Zhang, Xiangdong Meng, Philip D. Gregory, Reinhard Schwinzer, Gregory J. Cost and Hei

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 963 KB

english, 2011

2

Telomere length is reset during early mammalian embryogenesis

Schaetzlein, S., Lucas-Hahn, A., Lemme, E., Kues, W. A., Dorsch, M., Manns, M. P., Niemann, H., Rudolph, K. L.

Journal:

Proceedings of the National Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 403 KB

english, 2004

3

Nuclear and Nucleolar Reprogramming during the First Cell Cycle in Bovine Nuclear Transfer Embryos

Østrup, Olga, Petrovicova, Ida, Strejcek, Frantisek, Morovic, Martin, Lucas-Hahn, Andrea, Lemme, Erika, Petersen, Bjorn, Niemann, Heiner, Laurincik, Jozef, Maddox-Hyttel, Poul

Journal:

Cloning & Stem Cells

Year:

2009

Language:

english

File:

PDF, 62.09 MB

english, 2009

4

Maternally inherited rRNA triggers de novo nucleolus formation in porcine embryos

Morovic, Martin, Østrup, Olga, Strejcek, Frantisek, Benc, Michal, Murin, Matej, Jedlickova, Katarina, Bartkova, Alexandra, Lucas-Hahn, Andrea, Pendovski, Lazo, Laurincik, Jozef

Journal:

Year:

2018

Language:

english

File:

PDF, 523 KB

english, 2018

5

Intranuclear characteristics of pig oocytes stained with brilliant cresyl blue and nucleologenesis of resulting embryos

Murin, Matej, Strejcek, Frantisek, Bartkova, Alexandra, Morovic, Martin, Benc, Michal, Prochazka, Radek, Lucas-Hahn, Andrea, Pendovski, Lazo, Laurincik, Jozef

Journal:

Year:

2019

Language:

english

File:

PDF, 3.20 MB

english, 2019

6

CRISPR/Cas12a mediated knock-in of the Polled Celtic variant to produce a polled genotype in dairy cattle

Schuster, Felix, Aldag, Patrick, Frenzel, Antje, Hadeler, Klaus-Gerd, Lucas-Hahn, Andrea, Niemann, Heiner, Petersen, BjÃ¶rn

Journal:

Scientific Reports

Year:

2020

File:

PDF, 1.48 MB

2020

7

Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologies

Christine Wrenzycki, Doris Herrmann, Andrea Lucas-Hahn, Claudia Gebert, Karin Korsawe, Erika Lemme, Joseph W. Carnwath, Heiner Niemann

Journal:

Birth Defects Research Part C: Embryo Today: Reviews

Year:

2005

Language:

english

File:

PDF, 212 KB

english, 2005

8

Production and characterization of pigs transgenic for human thrombomodulin

Björn Petersen, Andrea Lucas-Hahn, Erika Lemme, Doris Herrmann, Brigitte Barg-Kues, Joseph W. Carnwath, Wolf Ramackers, Wolfgang Schuettler, Andreas Tiede, Lars Friedrich, Reinhard Schwinzer, Michael

Journal:

Xenotransplantation

Year:

2007

Language:

english

File:

PDF, 77 KB

english, 2007

9

Production and characterization of pigs transgenic for human hemeoxygenase-I by somatic nuclear transfer

B. Petersen, W. Ramackers, A. Lucas-Hahn, D. Herrmann, W. Kues, L. Friedrich, S. Bergmann, W. Schuettler, W. Baars, J. Carnwath, R. Schwinzer, M. Winkler, H. Niemann

Journal:

Xenotransplantation

Year:

2008

Language:

english

File:

PDF, 51 KB

english, 2008

10

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

Björn Petersen, Wolf Ramackers, Andreas Tiede, Andrea Lucas-Hahn, Doris Herrmann, Brigitte Barg-Kues, Wolfgang Schuettler, Lars Friedrich, Reinhard Schwinzer, Michael Winkler, Heiner Niemann

Journal:

Xenotransplantation

Year:

2009

Language:

english

File:

PDF, 480 KB

english, 2009

11

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

Marianne Oropeza, Björn Petersen, Joseph W. Carnwath, Andrea Lucas-Hahn, Erika Lemme, Petra Hassel, Doris Herrmann, Brigitte Barg-Kues, Stephanie Holler, Anna-Lisa Queisser, Reinhard Schwinzer, Rabea

Journal:

Xenotransplantation

Year:

2009

Language:

english

File:

PDF, 704 KB

english, 2009

12

Generation and characterization of pigs transgenic for human hemeoxygenase-1 (hHO-1)

B. Petersen, A. Lucas-Hahn, E. Lemme, A.-L. Queisser, M. Oropeza, D. Herrmann, W. Kues, B. Barg-Kues, H. Niemann

Journal:

Xenotransplantation

Year:

2010

Language:

english

File:

PDF, 79 KB

english, 2010

13

New transgenic pigs for xenotransplantation, part 1

H. Niemann, B. Petersen, A. Lucas-Hahn, E. Lemme, M. Oropeza, D. Herrmann, W. Kues, B. Barg-Kues, J. W. Carnwath

Journal:

Xenotransplantation

Year:

2011

Language:

english

File:

PDF, 65 KB

english, 2011

14

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

Björn Petersen, Wolf Ramackers, Andrea Lucas-Hahn, Erika Lemme, Petra Hassel, Anna-Lisa Queißer, Doris Herrmann, Brigitte Barg-Kues, Joseph W. Carnwath, Johannes Klose, Andreas Tiede, Lars Friedrich,

Journal:

Xenotransplantation

Year:

2011

Language:

english

File:

PDF, 579 KB

english, 2011

15

A detailed analysis of pronucleus development in bovine zygotes in vitro: Cell-cycle chronology and ultrastructure

J. Laurinčík, P. Hyttel, V. Baran, J. Eckert, A. Lucas-Hahn, J. Pivko, H. Niemann, G. Brem, K. Schellander

Journal:

Molecular Reproduction and Development

Year:

1998

Language:

english

File:

PDF, 670 KB

english, 1998

16

Fertilization and developmental competence of bovine oocytes derived from different categories of antral follicles

Dr. A. Pavlok, A. Lucas-Hahn, Dr. H. Niemann

Journal:

Molecular Reproduction and Development

Year:

1992

Language:

english

File:

PDF, 593 KB

english, 1992

17

Transcriptional activity and nuclear ultrastructure of 8-cell bovine embryos developed by in vitro maturation and fertilization of oocytes from different growth categories of antral follicles

Dr. A. Pavlok, V. Kopečný, A. Lucas-Hahn, H. Niemann

Journal:

Molecular Reproduction and Development

Year:

1993

Language:

english

File:

PDF, 1.42 MB

english, 1993

18

Cryopreservation of bovine oocytes and embryos following microsurgical operations

H. Niemann, A. Lucas-Hahn, C. Stoffregen

Journal:

Molecular Reproduction and Development

Year:

1993

Language:

english

File:

PDF, 359 KB

english, 1993

19

Altered mRNA expression patterns in bovine blastocysts after fertilisation in vitro using flow-cytometrically sex-sorted sperm

K.M. Morton, D. Herrmann, B. Sieg, C. Struckmann, W.M.C. Maxwell, D. Rath, G. Evans, A. Lucas-Hahn, H. Niemann, C. Wrenzycki

Journal:

Molecular Reproduction and Development

Year:

2007

Language:

english

File:

PDF, 260 KB

english, 2007

20

Messenger RNA expression patterns of histone-associated genes in bovine preimplantation embryos derived from different origins

Monika Nowak-Imialek, Christine Wrenzycki, Doris Herrmann, Andrea Lucas-Hahn, Irina Lagutina, Erika Lemme, Giovanna Lazzari, Cesare Galli, Heiner Niemann

Journal:

Molecular Reproduction and Development

Year:

2008

Language:

english

File:

PDF, 433 KB

english, 2008

21

The role of RNA polymerase I transcription and embryonic genome activation in nucleolar development in bovine preimplantation embryos

O. Svarcova, F. Strejcek, I. Petrovicova, B. Avery, H.G. Pedersen, A. Lucas-Hahn, H. Niemann, J. Laurincik, P. Maddox-Hyttel

Journal:

Molecular Reproduction and Development

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008

22

Freezing experiments with normal and bisected mouse embryos

A. Lucas-Hahn, H. Niemann

Journal:

Year:

1988

Language:

english

File:

PDF, 229 KB

english, 1988

23

Gene expression patterns in in vitro-produced and somatic nuclear transfer-derived preimplantation bovine embryos: relationship to the large offspring syndrome?

C Wrenzycki, D Herrmann, A Lucas-Hahn, E Lemme, K Korsawe, H Niemann

Journal:

Animal Reproduction Science

Year:

2004

Language:

english

File:

PDF, 113 KB

english, 2004

24

Cloning in pigs

B. Petersen, A. Lucas-Hahn, E. Lemme, P. Hassel, H. Niemann

Journal:

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

25

The bovine IGF2 gene is differentially methylated in oocyte and sperm DNA

Claudia Gebert, Christine Wrenzycki, Doris Herrmann, Daniela Gröger, Richard Reinhardt, Petra Hajkova, Andrea Lucas-Hahn, Joseph Carnwath, Hans Lehrach, Heiner Niemann

Journal:

Year:

2006

Language:

english

File:

PDF, 589 KB

english, 2006

26

DNA methylation in the IGF2 intragenic DMR is re-established in a sex-specific manner in bovine blastocysts after somatic cloning

Claudia Gebert, Christine Wrenzycki, Doris Herrmann, Daniela Gröger, Janina Thiel, Richard Reinhardt, Hans Lehrach, Petra Hajkova, Andrea Lucas-Hahn, Joseph W. Carnwath, Heiner Niemann

Journal:

Year:

2009

Language:

english

File:

PDF, 1.24 MB

english, 2009

27

Somatic Cell Nuclear Transfer Cloning: Practical Applications and Current Legislation

H Niemann, A Lucas-Hahn

Journal:

Reproduction in Domestic Animals

Year:

2012

Language:

english

File:

PDF, 502 KB

english, 2012

28

Cryopreservation of isolated bovine blastomeres

A. Lucas-Hahn, H. Niemann

Journal:

Year:

1991

Language:

english

File:

PDF, 68 KB

english, 1991

29

In vitro survival of fresh and frozen/thawed bovine demi-embryos

A. Lucas-Hahn, H. Niemann

Journal:

Year:

1991

Language:

english

File:

PDF, 594 KB

english, 1991

30

Effects of insulin-like growth factor-I on in-vitro production of bovine embryos

A. Herrler, A. Lucas-Hahn, H. Niemann

Journal:

Year:

1992

Language:

english

File:

PDF, 749 KB

english, 1992

31

Fertilization and cleavage of bovine oocytes following cooling to 0°C or −7°C

C. Stoffregen, A. Lucas-Hahn, H. Niemann

Journal:

Year:

1992

Language:

english

File:

PDF, 86 KB

english, 1992

32

Collection of oocytes from cattle via follicular aspiration aided by ultrasound with or without gonadotropin pretreatment and in different reproductive stages

L. Bungartz, A. Lucas-Hahn, D. Rath, H. Niemann

Journal:

Year:

1995

Language:

english

File:

PDF, 678 KB

english, 1995

33

Direct rehydration of IVM, IVF and IVC bovine embryos frozen in ethylene-glycol

S. Cseh, U. Kreysing, A. Lucas-Hahn, H. Niemann

Journal:

Year:

1995

Language:

english

File:

PDF, 70 KB

english, 1995

34

Use of fresh or aged bovine oocytes for intracytoplasmic sperm injection (ICSI)

A. Lucas-Hahn, J. Eckert, H. Niemann

Journal:

Year:

1996

Language:

english

File:

PDF, 79 KB

english, 1996

35

Long-term ultrasound guided ovum pick-up in heifers from 6 to 15 months of age

G. Rick, K.G. Hadeler, E. Lemme, A. Lucas-Hahn, D. Rath, L. Schindler, H. Niemann

Journal:

Year:

1996

Language:

english

File:

PDF, 90 KB

english, 1996

36

Gender non-specific efficacy of ZFN mediated gene targeting in pigs

Janet Hauschild-Quintern, Bjoern Petersen, Anna-Lisa Queisser, Andrea Lucas-Hahn, Reinhard Schwinzer, Heiner Niemann

Journal:

Transgenic Research

Year:

2013

Language:

english

File:

PDF, 230 KB

english, 2013

37

Survival of isolated blastomeres derived from different stage bovine embryos upon freezing and thawing

A. Lucas-Hahn, H. Niemann

Journal:

Year:

1994

Language:

english

File:

PDF, 78 KB

english, 1994

38

Pronucleus development and organization of intranuclear bodies during the first bovine embryonic cell cycle in vitro

J. Laurinčík, P. Hyttel, V. Baran, A. Lucas-Hahn, J. Eckert, J. Pivko, F. Schmoll, K. Schellander

Journal:

Year:

1997

Language:

english

File:

PDF, 88 KB

english, 1997

39

Intracytoplasmic sperm injection (ICSI) with flow cytometrically sorted Y-chromosome bearing bovine sperm

S. Medvedev, N. Bossak, J. Eckert, A. Lucas-Hahn, H. Niemann, L.A. Johnson

Journal:

Year:

1997

Language:

english

File:

PDF, 88 KB

english, 1997

40

Histone modifications and mRNA expression in the inner cell mass and trophectoderm of bovine blastocysts

Herrmann, Doris, Dahl, John Arne, Lucas-Hahn, Andrea, Collas, Philippe, Niemann, Heiner

Journal:

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

41

Gene Expression Patterns in Bovine In vitro -Produced and Nuclear Transfer-Derived Embryos and Their Implications for Early Development

Niemann, H., Wrenzycki, C., Lucas-Hahn, A., Brambrink, T., Kues, W.A., Carnwath, J.W.

Journal:

Cloning & Stem Cells

Year:

2002

Language:

english

File:

PDF, 159 KB

english, 2002

42

Development and Validation of a Highly Efficient Protocol of Porcine Somatic Cloning Using Preovulatory Embryo Transfer in Peripubertal Gilts

Petersen, Björn, Lucas-Hahn, Andrea, Oropeza, Marianne, Hornen, Nadine, Lemme, Erika, Hassel, Petra, Queisser, Anna-Lisa, Niemann, Heiner

Journal:

Cloning & Stem Cells

Year:

2008

Language:

english

File:

PDF, 153 KB

english, 2008

43

Oct4-Enhanced Green Fluorescent Protein Transgenic Pigs: A New Large Animal Model for Reprogramming Studies

Nowak-Imialek, Monika, Kues, Wilfried A., Petersen, Bjoern, Lucas-Hahn, Andrea, Herrmann, Doris, Haridoss, Srividyameena, Oropeza, Marianne, Lemme, Erika, Schöler, Hans R., Carnwath, Joseph W., Nieman

Journal:

Stem Cells and Development

Year:

2011

Language:

english

File:

PDF, 485 KB

english, 2011

44

Combined multiphoton imaging and automated functional enucleation of porcine oocytes using femtosecond laser pulses

Kuetemeyer, Kai, Lucas-Hahn, Andrea, Petersen, Bjoern, Lemme, Erika, Hassel, Petra, Niemann, Heiner, Heisterkamp, Alexander

Journal:

Journal of Biomedical Optics

Year:

2010

Language:

english

File:

PDF, 525 KB

english, 2010

45

Production of multi-transgenic pigs tailored for xenotransplantation by using zinc-finger nucleases and sleeping beauty transposons

Petersen, Björn, Petkov, Stoyan, Hauschild, Janet, Ahrens, Hellen, Lucas-Hahn, Andrea, Hassel, Petra, Ziegler, Maren, Hadeler, Klaus-Gerd, Schwinzer, Reinhard, Niemann, Heiner

Journal:

Xenotransplantation

Year:

2014

Language:

english

File:

PDF, 116 KB

english, 2014

46

Role of Ooplasm in Nuclear and Nucleolar Remodeling of Intergeneric Somatic Cell Nuclear Transfer Embryos during the First Cell Cycle

Østrup, Olga, Strejcek, Frantisek, Petrovicova, Ida, Lucas-Hahn, Andrea, Morovic, Martin, Lemme, Erika, Petersen, Bjorn, Laurincikova, Nada, Niemann, Heiner, Laurincik, Jozef, Hyttel, Poul

Journal:

Cellular Reprogramming (Formerly "Cloning and Stem Cells")

Year:

2011

Language:

english

File:

PDF, 672 KB

english, 2011

47

DNA Methylation Patterns Reflect Epigenetic Reprogramming in Bovine Embryos

Niemann, Heiner, Carnwath, Joseph W., Herrmann, Doris, Wieczorek, Georg, Lemme, Erika, Lucas-Hahn, Andrea, Olek, Sven

Journal:

Cellular Reprogramming (Formerly "Cloning and Stem Cells")

Year:

2010

Language:

english

File:

PDF, 6.72 MB

english, 2010

48

Generation of transgenic pigs carrying siRNA vector directed against human tissue factor expression

Ahrens, Hellen, Petersen, Björn, Herrmann, Doris, Lucas-Hahn, Andrea, Hassel, Petra, Ziegler, Maren, Kues, Wilfried, Niemann, Heiner

Journal:

Xenotransplantation

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014

49

Isolation of Bovine Cardiomyocytes for Reprogramming Studies Based on Nuclear Transfer

Schwarzer, M., Carnwath, J.W., Lucas-Hahn, A., Lemme, E., Kues, W.A., Wachsmann, B., Haverich, A., Martin, U., Niemann, H.

Journal:

Cloning & Stem Cells

Year:

2006

Language:

english

File:

PDF, 2.09 MB

english, 2006

50

Production of Viable Pigs from Fetal Somatic Stem Cells

Hornen, Nadine, Kues, Wilfried A., Carnwath, Joseph W., Lucas-Hahn, Andrea, Petersen, Björn, Hassel, Petra, Niemann, Heiner

Journal:

Cloning & Stem Cells

Year:

2007

Language:

english

File:

PDF, 220 KB

english, 2007

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