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51

A new class of anti-HIV agents: Synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor

Tooru Kimura, Hikaru Matsumoto, Takashi Matsuda, Tomonori Hamawaki, Kenichi Akaji, Yoshiaki Kiso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 195 KB

english, 1999

52

Evaluation of lipid-binding properties of the N-terminal helical segments in human apolipoprotein A-I using fragment peptides

Masafumi Tanaka, Toshitaka Tanaka, Shinya Ohta, Toru Kawakami, Hiroyuki Konno, Kenichi Akaji, Saburo Aimoto, Hiroyuki Saito

Journal:

Journal of Peptide Science

Year:

2009

Language:

english

File:

PDF, 171 KB

english, 2009

53

Polypeptide synthesis using an expressed peptide as a building block for condensation with a peptide thioester: Application to the synthesis of phosphorylated p21Max protein(1–101)

Toru Kawakami, Koki Hasegawa, Kenta Teruya, Kenichi Akaji, Masataka Horiuchi, Fuyuhiko Inagaki, Yasuyuki Kurihara, Seiichi Uesugi, Saburo Aimoto

Journal:

Journal of Peptide Science

Year:

2001

Language:

english

File:

PDF, 585 KB

english, 2001

54

Synthesis of a membrane protein with two transmembrane regions

Takeshi Sato, Toru Kawakami, Kenichi Akaji, Hiroki Konishi, Koji Mochizuki, Toshimichi Fujiwara, Hideo Akutsu, Saburo Aimoto

Journal:

Journal of Peptide Science

Year:

2002

Language:

english

File:

PDF, 135 KB

english, 2002

55

Preparation of phosphopeptide thioesters by Fmoc-and Fmoc(2-F)-solid phase synthesis

Koki Hasegawa, Yin Lin Sha, Jeong Kyu Bang, Toru Kawakami, Kenichi Akaji, Saburo Aimoto

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2001

Language:

english

File:

PDF, 505 KB

english, 2001

56

Indirect portography enhanced by nicardipine versus prostaglandin E1

Yutaka Inoue, Hironobu Nakamura, Hideyo Akaji, Kolchi Yamasaki

Journal:

CardioVascular and Interventional Radiology

Year:

1995

Language:

english

File:

PDF, 744 KB

english, 1995

57

Intracellular dynamics of topoisomerase I inhibitor, CPT-11, by slit-scanning confocal Raman microscopy

Yoshinori Harada, Ping Dai, Yoshihisa Yamaoka, Mitsugu Ogawa, Hideo Tanaka, Kazuto Nosaka, Kenichi Akaji, Tetsuro Takamatsu

Journal:

Histochemistry and Cell Biology

Year:

2009

Language:

english

File:

PDF, 435 KB

english, 2009

58

Studies on Substrate Specificity at PR/p3 Cleavage Site of HTLV-1 Protease

Jeong Kyu Bang, Kenta Teruya, Saburo Aimoto, Hiroyuki Konno, Kazuto Nosaka, Tadashi Tatsumi, Kenichi Akaji

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2007

Language:

english

File:

PDF, 275 KB

english, 2007

59

Surgical excision of intra-oral dermoid cyst under local anaesthesia: a review of nine cases

F. N. Chukwuneke, C. Akaji, T. C. Onyeka, P. Udeagha

Journal:

Journal of Maxillofacial and Oral Surgery

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

60

Synthesis of [19, 35, 36-13C3]-labeled TAK779 as a molecular probe

Hiroyuki Konno, Saburo Aimoto, Steven O. Smith, Kazuto Nosaka, Kenichi Akaji

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 306 KB

english, 2009

61

Secoiridoid glucosides from Fraxinus malacophylla

He Zheng-Dan, Shinichi Ueda, Kenichiro Inoue, Masako Akaji, Tetsuro Fujita, Yang Chong-Ren

Journal:

Year:

1993

Language:

english

File:

PDF, 389 KB

english, 1993

62

Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae

Kazuto Nosaka, Mari Onozuka, Hiroyuki Konno, Yuko Kawasaki, Hiroshi Nishimura, Mamoru Sano, Kenichi Akaji

Journal:

Molecular Microbiology

Year:

2005

Language:

english

File:

PDF, 293 KB

english, 2005

63

Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells

Michibata, Hideo, Mukoyama, Masashi, Tanaka, Issei, Suga, Shin-ichi, Nakagawa, Masayo, Ishibashi, Rieko, Goto, Masahisa, Akaji, Kenichi, Fujiwara, Yoichi, Kiso, Yoshiaki, Nakao, Kazuwa

Journal:

Kidney International

Year:

1998

Language:

english

File:

PDF, 343 KB

english, 1998

64

Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae

Mari Onozuka, Hiroyuki Konno, Yuko Kawasaki, Kenichi Akaji, Kazuto Nosaka

Journal:

FEMS Yeast Research

Year:

2008

Language:

english

File:

PDF, 279 KB

english, 2008

65

Preparation of phosphopeptide thioesters by Fmoc- and Fmoc(2-F)-solid phase synthesis

Koki Hasegawa, YinLin Sha, JeongKyu Bang, Toru Kawakami, Kenichi Akaji, Saburo Aimoto

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

66

Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors

Hattori, Yasunao, Ozaki, Takeshi, Kusunoki, Masami, Sanjoh, Akira, Akaji, Kenichi, Konno, Hiroyuki, Mitsui, Hironori, Teruya, Kenta, Shimamoto, Yasuhiro

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.73 MB

english, 2011

67

ChemInform Abstract: An Unusual Thermodynamic Preference of Chiral N-Arylsulfonyl cis-3- Alkyl-2-vinylaziridines over Their trans-Isomers: Palladium(0)- Catalyzed Equilibration Reactions.

N. MIMURA, T. IBUKA, M. AKAJI, Y. MIWA, T. TAGA, K. NAKAI, H. TAMAMURA, N. FUJII, Y. YAMAMOTO

Journal:

Year:

1996

File:

PDF, 31 KB

1996

68

ChemInform Abstract: A Thermodynamic Preference of Chiral cis-γ,δ-Epimino-(E)-. alpha.,β-Unsaturated Esters over Other Stereoisomers: Synthetically Useful Pd(0)-Catalyzed Equilibrated Reactions of Aziridines Bearing an α,β-Unsaturated Ester Group.

T. IBUKA, M. AKAJI, N. MIMURA, H. HABASHITA, K. NAKAI, H. TAMAMURA, N. FUJII, Y. YAMAMOTO

Journal:

Year:

1996

File:

PDF, 35 KB

1996

69

ChemInform Abstract: Simple One-Pot Transformations of Toluene-p-sulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols.

N. FUJII, H. HABASHITA, M. AKAJI, K. NAKAI, T. IBUKA, M. FUJIWARA, H. TAMAMURA, Y. YAMAMOTO

Journal:

Year:

1996

File:

PDF, 28 KB

1996

70

ChemInform Abstract: Studies on Development of Disulfide Bond Forming Reaction and the Application to Regioselective Disulfide Formation

Journal:

Year:

1996

File:

PDF, 23 KB

1996

71

Urotensin II-immunoreactive neurons in the caudal neurosecretory system of freshwater and seawater fish

Kyoko Owada, Mitsuhiro Kawata, Kenichi Akaji, Atsushi Takagi, Motoyuki Moriga, Hideshi Kobayashi

Journal:

Cell and Tissue Research

Year:

1985

Language:

english

File:

PDF, 2.44 MB

english, 1985

72

The Optimal Dose of Nicardipine for Enhancement of Indirect Portography

Inoue, Yutaka, Nakamura, Hironobu, Akaji, Hideyo

Journal:

CardioVascular and Interventional Radiology

Year:

1998

Language:

english

File:

PDF, 137 KB

english, 1998

73

Intact-cell-based surface plasmon resonance measurements for ligand affinity evaluation of a membrane receptor

Takaaki Mizuguchi, Hiromasa Uchimura, Hiroshi Kataoka, Kenichi Akaji, Yoshiaki Kiso, Kazuki Saito

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 309 KB

english, 2012

74

Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B

Mari Kikuchi, Yoshihisa Watanabe, Masaki Tanaka, Kenichi Akaji, Hiroyuki Konno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 485 KB

english, 2011

75

Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae

Kazuto Nosaka, Mari Onozuka, Hiroyuki Konno, Kenichi Akaji

Journal:

Year:

2008

Language:

english

File:

PDF, 246 KB

english, 2008

76

Development of UV-responsive catch-and-release system of a cysteine protease model peptide

Akira Shigenaga, Ko Morishita, Keiko Yamaguchi, Hao Ding, Koji Ebisuno, Kohei Sato, Jun Yamamoto, Kenichi Akaji, Akira Otaka

Journal:

Year:

2011

Language:

english

File:

PDF, 757 KB

english, 2011

77

Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella aff. mirabilis

Hiroyuki Konno, Kazuto Nosaka, Kenichi Akaji

Journal:

Year:

2011

Language:

english

File:

PDF, 518 KB

english, 2011

78

Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide

Youhei Sohma, Hitomi Kitamura, Hiroyuki Kawashima, Hironobu Hojo, Masayuki Yamashita, Kenichi Akaji, Yoshiaki Kiso

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 280 KB

english, 2011

79

Effect of intra-ischemic hypothermia on the expression of c-Fos and c-Jun, and DNA binding activity of AP-1 after focal cerebral ischemia in rat brain

Kazunori Akaji, Sadao Suga, Tadahiro Fujino, Keita Mayanagi, Joji Inamasu, Takashi Horiguchi, Shuzo Sato, Takeshi Kawase

Journal:

Year:

2003

Language:

english

File:

PDF, 621 KB

english, 2003

80

Post-ischemic hypothermia delayed neutrophil accumulation and microglial activation following transient focal ischemia in rats

Joji Inamasu, Sadao Suga, Shuzo Sato, Takashi Horiguchi, Kazunori Akaji, Keita Mayanagi, Takeshi Kawase

Journal:

Journal of Neuroimmunology

Year:

2000

Language:

english

File:

PDF, 1.69 MB

english, 2000

81

Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation

Kazuto Nosaka, Hiroyoshi Esaki, Mari Onozuka, Hiroyuki Konno, Yasunao Hattori, Kenichi Akaji

Journal:

FEMS Microbiology Letters

Year:

2012

Language:

english

File:

PDF, 366 KB

english, 2012

82

STUDIES ON PEPTIDES LXXXI. Application of a New Arginine Derivative, NG-Mesitylene-2-Sulfonylarginine, to the Synthesis of Substance P and Neurotensin

HARUAKI YAJIMA, KENICHI AKAJI, KAZUYA MITANI, NOBUTAKA FUJII, SUSUMU FUNAKOSHI, HIDEKI ADACHI, MARIKO OISHI, YOSHIHARU AKAZAWA

Journal:

Chemical Biology & Drug Design

Year:

1979

Language:

english

File:

PDF, 617 KB

english, 1979

83

STUDIES ON PEPTIDES : CII. Synthesis of a Heptacosapeptide Amide Corresponding to the Entire Amino Acid Sequence of Gástrin-Releasing Peptide

KENICHI AKAJI, NOBUTAKA FUJII, HARUAKI YAJIMA, MOTOYUKI MORIGA, MITSURU AONO, ATSUSHI TAKAGI

Journal:

Chemical Biology & Drug Design

Year:

1981

Language:

english

File:

PDF, 1.06 MB

english, 1981

84

Studies on peptides : CXI. Synthesis of chicken gastrin-releasing peptide

Kenichi Akaji, Nobutaka Fujii, Dr. Haruaki Yajim, Motoyuki Morig, Atsushi Takagi, Kazuhiko Mizuta, Masato Noguchi, T.J. Mcdonald

Journal:

Chemical Biology & Drug Design

Year:

1982

Language:

english

File:

PDF, 907 KB

english, 1982

85

Current contributions of peptide synthesis to studies on brain-gut-skin triangle peptides

HARUAKI YAJIMA, SUSUMU FUNAKOSHI, KENICHI AKAJI

Journal:

Chemical Biology & Drug Design

Year:

1985

Language:

english

File:

PDF, 1.52 MB

english, 1985

86

Studies on peptides : CXXVIII. Application of new heterobifunctional crosslinking reagents for the preparation of neurokinin (A and B)-BSA (bovine serum albumin) conjugates

NOBUTAKA FUJII, YOSHIO HAYASHI, SHINICHI KATAKURA, KENICHI AKAJI, HARUAKI YAJIMA, ATSUKO INOUYE, TOMIRO SEGAWA

Journal:

Chemical Biology & Drug Design

Year:

1985

Language:

english

File:

PDF, 627 KB

english, 1985

87

Efficient solid phase peptide synthesis : Use of methanesulfonic acid α-amino deprotecting procedure and new coupling reagent, 2-(benzotriazol-1-yl)oxy-1,3-dimethylimidazolidinium hexafluorophosphate (BOI)

YOSHIAKI KISO, YOICHI FUJIWARA, TOORU KIMURA, AKIKO NISHITANI, KENICHI AKAJI

Journal:

Chemical Biology & Drug Design

Year:

1992

Language:

english

File:

PDF, 588 KB

english, 1992

88

Epimerization in peptide thioester condensation

Kenta Teruya, Takeyuki Tanaka, Toru Kawakami, Kenichi Akaji, Saburo Aimoto

Journal:

Journal of Peptide Science

Year:

2012

Language:

english

File:

PDF, 807 KB

english, 2012

89

Solution Structure of Intracellular Signal-Transducing Peptide Derived from Human β2-Adrenergic Receptor

Ayumu Okuda, Osamu Matsumoto, Masako Akaji, Tooru Taga, Tadayasu Ohkubo, Yuji Kobayashi

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 229 KB

english, 2002

90

Predicting the overall management outcome in patients with a subarachnoid hemorrhage accompanied by a massive intracerebral or full-packed intraventricular hemorrhage: a 15-year retrospective study

Toru Nakagawa, Sadao Suga, Keita Mayanagi, Kazunori Akaji, Joji Inamasu, Takeshi Kawase

Journal:

Surgical Neurology

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

91

Late hemorrhage from persistent pseudoaneurysm in vertebral artery dissection presenting with ischemia: case report

Masachika Sagoh, Yuichi Hirose, Hideki Murakami, Kazunori Akaji, Masateru Katayama, Takuro Hayashi

Journal:

Surgical Neurology

Year:

1999

Language:

english

File:

PDF, 251 KB

english, 1999

92

Dual Role of an N-terminal Amyloidogenic Mutation in Apolipoprotein A-I: DESTABILIZATION OF HELIX BUNDLE AND ENHANCEMENT OF FIBRIL FORMATION

Adachi, E., Nakajima, H., Mizuguchi, C., Dhanasekaran, P., Kawashima, H., Nagao, K., Akaji, K., Lund-Katz, S., Phillips, M. C., Saito, H.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 2.93 MB

english, 2013

93

Evaluation of dimerization–inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor

Takaaki Mizuguchi, Naho Ohara, Mika Iida, Ryunosuke Ninomiya, Shinji Wada, Yoshiaki Kiso, Kazuki Saito, Kenichi Akaji

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 841 KB

english, 2012

94

A new class of amino protecting group removable by reductive acidolysis: the 4-methylsulphinylbenzyloxycarbonyl (Msz) group

Kiso, Yoshiaki, Kimura, Tooru, Yoshida, Makoto, Shimokura, Masanori, Akaji, Kenichi, Mimoto, Tsutomu

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1989

Language:

english

File:

PDF, 243 KB

english, 1989

95

Trimethylsilyl trifluoromethanesulphonate as a useful deprotecting reagent in both solution and solid phase peptide syntheses

Fujii, Nobutaka, Otaka, Akira, Ikemura, Osamu, Akaji, Kenichi, Funakosho, Susumu, Hayashi, Yoshio, Kuroda, Yoshihiro, Yajima, Haruaki

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1987

Language:

english

File:

PDF, 276 KB

english, 1987

96

Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an α,β-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2 E )-4,5- cis -4,5-Epimino- N -(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers

Ibuka, Toshiro, Mimura, Norio, Ohno, Hiroaki, Nakai, Kazuo, Akaji, Masako, Habashita, Hiromu, Tamamura, Hirokazu, Miwa, Yoshihisa, Taga, Tooru, Fujii, Nobutaka, Yamamoto, Yoshinori

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 504 KB

english, 1997

97

Disulfide bond formation using the silyl chloride-sulfoxide system for the synthesis of a cystine peptide

Akaji, Kenichi, Tatsumi, Tadashi, Yoshida, Makoto, Kimura, Tooru, Fujiwara, Yoichi, Kiso, Yoshiaki

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 867 KB

english, 1992

98

Practical synthesis of peptide C-terminal aldehyde on a solid support

Konno, Hiroyuki, Sema, Yoshihiro, Ishii, Manabu, Hattori, Yasunao, Nosaka, Kazuto, Akaji, Kenichi

Journal:

Tetrahedron Letters

Year:

2013

Language:

english

File:

PDF, 554 KB

english, 2013

99

Convergent Synthesis of Dolastatin 15 by Solid Phase Coupling of an N -Methylamino Acid

Akaji, Kenichi, Hayashi, Yuzo, Kiso, Yoshiaki, Kuriyama, Naohiro

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 140 KB

english, 1999

100

Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method

Akaji, Kenichi, Fujino, Kenji, Tatsumi, Tadashi, Kiso, Yoshiaki

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 1.10 MB

english, 1993