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51

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B

Chen, Guangming, Ren, Hongyu, Zhang, Nanjing, Lennox, William, Turpoff, Anthony, Paget, Steven, Li, Chunshi, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Colacino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 383 KB

english, 2015

52

ChemInform Abstract: Selective Synthesis of 1-Substituted 4-Chloropyrazolo[3,4-d]pyrimidines.

Babu, Suresh, Morrill, Christie, Almstead, Neil G., Moon, Young-Choon

Journal:

Year:

2013

File:

PDF, 33 KB

2013

53

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

Harrison, Bryce A., Almstead, Zheng Y., Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C., Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 986 KB

english, 2015

54

Inhibition of U snRNP assembly by a virus-encoded proteinase

Almstead, L. L., Sarnow, P.

Journal:

Genes & Development

Year:

2007

Language:

english

File:

PDF, 538 KB

english, 2007

55

Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

Gu, Z., Graci, J. D., Lahser, F. C., Breslin, J. J., Jung, S. P., Crona, J. H., McMonagle, P., Xia, E., Liu, S., Karp, G., Zhu, J., Huang, S., Nomeir, A., Weetall, M., Almstead, N. G., Peltz, S. W., T

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 2.18 MB

english, 2013

56

Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil, Moon, Young-Choon

Journal:

Year:

2013

Language:

english

File:

PDF, 383 KB

english, 2013

57

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B

Zhang, Nanjing, Turpoff, Anthony, Zhang, Xiaoyan, Huang, Song, Liu, Yalei, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Pichardo, John, Colacino, Joseph, Lahser,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.77 MB

english, 2015

58

miR-29 and miR-30 regulate B-Myb expression during cellular senescence

Ivan Martinez, Demian Cazalla, Laura L. Almstead, Joan A. Steitz and Daniel DiMaio

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.57 MB

english, 2011

59

Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode

Liu, Chun, Oblak, E. Zachary, Vander Wal, Mark N., Dilger, Andrew K., Almstead, Danielle K., MacMillan, David W. C.

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 659 KB

english, 2016

60

Discovery, Structure-Activity Relationships and Unique Properties of Non- Fluorinated Quinolones (NFQs)

Ledoussal, Benoit, Almstead, Ji-In, Gray, Jeffrey, Hu, Eric, Roychoudhury, Siddhartha

Journal:

Current Medicinal Chemistry - Anti-Infective Agents

Year:

2003

Language:

english

File:

PDF, 86 KB

english, 2003

61

Discovery and optimization of small molecule splicing modifiers of survival motor neuron 2 (SMN2) as a treatment for spinal muscular atrophy

Woll, Matthew G, Qi, Hongyan, Turpoff, Anthony, Zhang, Nanjing, Zhang, Xiaoyan, Chen, Guangming, Li, Chunshi, Huang, Song, Yang, Tianle, Moon, Young-Choon, Lee, Chang-Sun, Choi, Soongyu, Almstead, Nei

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 727 KB

english, 2016

62

ChemInform Abstract: Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines.

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil G., Moon, Young-Choon

Journal:

Year:

2013

File:

PDF, 42 KB

2013

63

ChemInform Abstract: The Origin of Stereoselective Opening of Chiral Dioxane and Dioxolane Acetals: Solution Structure of Their Lewis Acid Complexes.

DENMARK, S. E., WILLSON, T. M., ALMSTEAD, N. G.

Journal:

Year:

1990

File:

PDF, 94 KB

1990

64

ChemInform Abstract: Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines.

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil G., Moon, Young-Choon

Journal:

Year:

2013

File:

PDF, 36 KB

2013

65

ChemInform Abstract: Synthesis of 1,4-Disubstituted Pyrazolo[3,4-d]pyrimidines from 4,6-Dichloropyrimidine-5-carboxaldehyde: Insights into Selectivity and Reactivity.

Morrill, Christie, Babu, Suresh, Almstead, Neil G., Moon, Young-Choon

Journal:

Year:

2013

File:

PDF, 36 KB

2013

66

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation

Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spie

Journal:

Clinical Pharmacology in Drug Development

Year:

2016

Language:

english

File:

PDF, 661 KB

english, 2016

67

4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis

Arnold, Michael A., Gerasyuto, Aleksey I., Wang, Jiashi, Du, Wu, Gorske, Yi Jin Kim, Arasu, Tamil, Baird, John, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Ginzburg, Olya, Lue, Stanley W.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 2.24 MB

english, 2017

68

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multi-Drug Resistant Gram-Negative Bacteria

Gerasyuto, Aleksey I, Arnold, Michael A, Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G., Baird, John, Zhang, Nanjing, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivas

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 933 KB

english, 2018

69

ChemInform Abstract: Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode.

Liu, Chun, Oblak, E. Zachary, Vander Wal, Mark N., Dilger, Andrew K., Almstead, Danielle K., MacMillan, David W. C.

Journal:

Year:

2016

Language:

english

File:

PDF, 34 KB

english, 2016

70

Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria

Gerasyuto, Aleksey I., Arnold, Michael A., Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G., Baird, John, Zhang, Nanjing, Almstead, Neil G., Narasimhan, Jana, Peddi, Sriniv

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 342 KB

english, 2018

71

Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects

Kong, Ronald, Laskin, Oscar L., Kaushik, Diksha, Jin, Fengbin, Ma, Jiyuan, McIntosh, Joseph, Souza, Marcio, Almstead, Neil

Journal:

Clinical Pharmacology in Drug Development

Year:

2019

Language:

english

File:

PDF, 285 KB

english, 2019

72

Metabolism and Disposition of Ataluren following Oral Administration to Mice, Rats, Dogs, and Humans

Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Goodwin, Elizabeth, Northcutt, Valerie, Babiak, John, Almstead, Neil, McIntosh, Joseph

Journal:

Drug Metabolism and Disposition

Year:

2020

File:

PDF, 702 KB

2020

73

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, YoungâChoon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth

Journal:

Pharmacology Research & Perspectives

Year:

2020

Language:

english

File:

PDF, 2.58 MB

english, 2020

74

Interâgroup conflict in a cooperatively breeding bird: New insights into âhome field advantageâ

Almstead, Danielle K., Savagian, Amanda G., Smith, Maria G., Riehl, Christina

Journal:

Year:

2020

File:

PDF, 739 KB

2020