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51

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers

Y. Ashani, R.D. Gupta, M. Goldsmith, I. Silman, J.L. Sussman, D.S. Tawfik, H. Leader

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 280 KB

english, 2010

52

Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus

Ana Lustig, Ashani T. Weeraratna, William W. Wood III, Diane Teichberg, Dorothy Bertak, Arnell Carter, Suresh Poosala, Jeffrey Firman, Kevin G. Becker, Alan B. Zonderman, Dan L. Longo, Dennis D. Taub

Journal:

Cellular Immunology

Year:

2007

Language:

english

File:

PDF, 6.22 MB

english, 2007

53

Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification

Moshe Goldsmith, Yacov Ashani, Yair Simo, Moshe Ben-David, Haim Leader, Israel Silman, Joel L. Sussman, Dan S. Tawfik

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 593 KB

english, 2012

54

F.113. Wnt5a Regulates Melanoma Antigen Recognized By T-Cells-1 (Mart-1), a Predominant Antigen in Melanoma Cells

Samudra Dissanayake, Devin Rosenthal, Kyle Hewitt, Sherry Yang, Michael Wade, Dennis Taub, Brian Nickoloff, Jeffrey Trent, Michael Bittner, Adam Riker, Ashani Weeraratna

Journal:

Clinical Immunology

Year:

2006

Language:

english

File:

PDF, 41 KB

english, 2006

55

Wnt5a Regulates Melanoma Antigen Recognized by T Cells 1 (MART-1), a Predominant Antigen in Melanoma Cells

Samudra Dissanayake, Devin Rosenthal, Kyle Hewitt, Michael Wade, Sherry Yang, Poloko Leotlela, Dennis Taub, Adam Riker, Brian Nickoloff, Ashani Weeraratna

Journal:

Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 48 KB

english, 2007

56

The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma

Yacov Ashani, Omri Segev, Ayala Balan

Journal:

Toxicology and Applied Pharmacology

Year:

2004

Language:

english

File:

PDF, 285 KB

english, 2004

57

Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues

Ashani T. Weeraratna, Audrey Kalehua, Isoke DeLeon, Dorothy Bertak, Gregory Maher, Michael S. Wade, Ana Lustig, Kevin G. Becker, William Wood III, Douglas G. Walker, Thomas G. Beach, Dennis D. Taub

Journal:

Experimental Cell Research

Year:

2007

Language:

english

File:

PDF, 2.14 MB

english, 2007

58

Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators

Yacov Ashani, Apurba K. Bhattacharjee, Haim Leader, Ashima Saxena, Bhupendra P. Doctor

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 328 KB

english, 2003

59

Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases

Haim Leader, Adam Vincze, Bracha Manisterski, Nathan Rothschild, Carlos Dosoretz, Yacov Ashani

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 446 KB

english, 1999

60

Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime

Chunyuan Luo, Ashima Saxena, Yacov Ashani, Haim Leader, Zoran Radić, Palmer Taylor, Bhupendra P. Doctor

Journal:

Chemico-Biological Interactions

Year:

1999

Language:

english

File:

PDF, 121 KB

english, 1999

61

Acceleration of oxime-induced reactivation of acetylcholinesterase-organophosphate conjugate and 31P NMR detection of phosporyl oxime from the conjugate

C. Luo, Y. Ashani, B.P. Doctor

Journal:

Journal of Physiology-Paris

Year:

1998

Language:

english

File:

PDF, 243 KB

english, 1998

62

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

Ashani T. Weeraratna, Yuan Jiang, Galen Hostetter, Kevin Rosenblatt, Paul Duray, Michael Bittner, Jeffrey M. Trent

Journal:

Year:

2002

Language:

english

File:

PDF, 631 KB

english, 2002

63

Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells

Cheryl A. Sherman-Baust, Ashani T. Weeraratna, Leticia B.A. Rangel, Ellen S. Pizer, Kathleen R. Cho, Donald R. Schwartz, Teresa Shock, Patrice J. Morin

Journal:

Year:

2003

Language:

english

File:

PDF, 595 KB

english, 2003

64

Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes

Harry D Dawson, Gary Collins, Robert Pyle, Michael Key, Ashani Weeraratna, Vishwa Deep-Dixit, Celeste N Nadal, Dennis D Taub

Journal:

Year:

2006

Language:

english

File:

PDF, 435 KB

english, 2006

65

A covalent affinity column for the purification of acetylcholinesterase

Yacov Ashani, Irwin B. Wilson

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1972

Language:

english

File:

PDF, 266 KB

english, 1972

66

The inhibition of cholinesterase by diethyl phosphorochloridate

Yacov Ashani, Pierre Wins, Irwin B. Wilson

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1972

Language:

english

File:

PDF, 402 KB

english, 1972

67

Mechanism of inhibition of cholinesterases by huperzine A

Yacov Ashani, James O. Peggins III, Bhupendra P. Doctor

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 497 KB

english, 1992

68

Seizure-induced changes in the permeability of the blood-brain barrier following administration of anticholinesterase drugs to rats

Yacov Ashani, George N. Catravas

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 760 KB

english, 1981

69

An irreversible anticholinesterase probe for studying increased permeability of the rat blood-brain barrier

Yacov Ashani, George N. Catravas, William A. Alter III

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 711 KB

english, 1981

70

Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase: A new marker in blood-brain barrier research

Drora Levy, Yacov Ashani

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 689 KB

english, 1986

71

Acetylcholinesterase prophylaxis against organophosphate poisoning: Quantitative correlation between protection and blood-enzyme level in mice

Lily Raveh, Yacov Ashani, Drora Levy, Denise De La Hoz, A.David Wolfe, B.P. Doctor

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 835 KB

english, 1989

72

Aged and non-aged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin: Preparation and comparison by 31P-NMR spectroscopy

Jacob Grunwald, Yoffi Segall, Ezra Shirin, Daniel Waysbort, Nitza Steinberg, Israel Silman, Yacov Ashani

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 1.21 MB

english, 1989

73

Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice

Yacov Ashani, Shlomo Shapira, Drora Levy, Alan D. Wolfe, Behupendra P. Doctor, lily raveh

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 553 KB

english, 1991

74

Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters

Lily Raveh, Yoffi Segall, Haim Leader, Nathan Rothschild, Dan Levanon, Yigal Henis, Yacov Ashani

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 431 KB

english, 1992

75

Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity: In vitro and in vivo quantitative characterization

Lily Raveh, Jacob Grunwald, Dino Marcus, Yoel Papier, Ephraim Cohen, Yacov Ashani

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.26 MB

english, 1993

76

Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes

German R. Caranto, Kirk H. Waibel, Jacob M. Asher, Roberta W. Larrison, Karen M. Brecht, Michael B. Schutz, Lily Raveh, Yacov Ashani, Alan D. Wolfe, Donald M. Maxwell, Bhupendra P. Doctor

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.17 MB

english, 1994

77

Refined crystal structures of “aged” and “non-aged” organophosphoryl conjugates of γ-chymotrypsin

M. Harel, C.-T. Su, F. Frolow, Y. Ashani, I. Silman, J.L. Sussman

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 1.14 MB

english, 1991

78

Discovering causes and cures for cancer from gene expression analysis

Ashani T. Weeraratna

Journal:

Ageing Research Reviews

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

79

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases

Yacov Ashani, Moshe Goldsmith, Haim Leader, Israel Silman, Joel L. Sussman, Dan S. Tawfik

Journal:

Toxicology Letters

Year:

2011

Language:

english

File:

PDF, 254 KB

english, 2011

80

Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase

Yvonne Rosenberg, Chunyuan Luo, Yacov Ashani, Bhupendra P Doctor, Randy Fischer, Gary Wolfe, Ashima Saxena

Journal:

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

81

Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug

Jacob Grunwald, Dino Marcus, Yoel Papier, Lily Raveh, Zipora Pittel, Yacov Ashani

Journal:

Journal of Biochemical and Biophysical Methods

Year:

1997

Language:

english

File:

PDF, 373 KB

english, 1997

82

NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation

Kristina Buac, Mai Xu, Julie Cronin, Ashani T. Weeraratna, Stephen M. Hewitt, William J. Pavan

Journal:

Pigment Cell & Melanoma Research

Year:

2009

Language:

english

File:

PDF, 543 KB

english, 2009

83

Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt

Michael P. O’Connell, Ashani T. Weeraratna

Journal:

Pigment Cell & Melanoma Research

Year:

2009

Language:

english

File:

PDF, 312 KB

english, 2009

84

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility

Tura C. Camilli, Mai Xu, Michael P. O’Connell, Bonnie Chien, Brittany P. Frank, Sarah Subaran, Fred E. Indig, Patrice J. Morin, Stephen M. Hewitt, Ashani T. Weeraratna

Journal:

Pigment Cell & Melanoma Research

Year:

2011

Language:

english

File:

PDF, 680 KB

english, 2011

85

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching

Ossia M. Eichhoff, Ashani Weeraratna, Marie C. Zipser, Laurence Denat, Daniel S. Widmer, Mai Xu, Lydia Kriegl, Thomas Kirchner, Lionel Larue, Reinhard Dummer, Keith S. Hoek

Journal:

Pigment Cell & Melanoma Research

Year:

2011

Language:

english

File:

PDF, 861 KB

english, 2011

86

The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy

Silman, Israel, Roth, Esther, Paz, Aviv, Triquigneaux, Mathilde M., Ehrenshaft, Marilyn, Xu, Yechun, Shnyrov, Valery L., Sussman, Joel L., Deterding, Leesa J., Ashani, Yacov, Mason, Ronald P., Weiner,

Journal:

Chemico-Biological Interactions

Year:

2013

Language:

english

File:

PDF, 707 KB

english, 2013

87

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

Khare, Sagar D, Kipnis, Yakov, Greisen, Per Jr, Takeuchi, Ryo, Ashani, Yacov, Goldsmith, Moshe, Song, Yifan, Gallaher, Jasmine L, Silman, Israel, Leader, Haim, Sussman, Joel L, Stoddard, Barry L, Tawf

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

88

A quaternary anti-cholinesterase probe for determining the integrity of the blood - brain barrier

Yacov Ashani, Drora Levy, Eli Heyman, Yona Grunfeld, Tamar Kadar, Michael Spiegelstein

Journal:

Year:

1985

Language:

english

File:

PDF, 273 KB

english, 1985

89

Prophylaxis against organophsphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice

Yacov Ashani, Nathan Rothschild, Yoffi Segall, Dan Levanon, Lily Raveh

Journal:

Year:

1991

Language:

english

File:

PDF, 537 KB

english, 1991

90

Huperzine A as a pretreatment candidate drug against nerve agent toxicity

Jacob Grunwald, Lily Raveh, Bhupendra P. Doctor, Yacov Ashani

Journal:

Year:

1994

Language:

english

File:

PDF, 396 KB

english, 1994

91

Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis

Balduino, Alex, Mello-Coelho, Valeria, Wang, Zhou, Taichman, Russell S., Krebsbach, Paul H., Weeraratna, Ashani T., Becker, Kevin G., de Mello, Wallace, Taub, Dennis D., Borojevic, Radovan

Journal:

Experimental Cell Research

Year:

2012

Language:

english

File:

PDF, 1.34 MB

english, 2012

92

Combined Effect of Organophosphorus Hydrolase and Oxime on the Reactivation Rate of Diethylphosphoryl-Acetylcholinesterase Conjugates

Yacov Ashani, Haim Leader, Nathan Rothschild, Carlos Dosoretz

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 582 KB

english, 1998

93

Uteroglobin: A Potential Novel Tumor Suppressor and Molecular Therapeutic for Prostate Cancer

Patierno, Steven R., Manyak, Michael J., Fernandez, Patricia M., Baker, Angela, Weeraratna, Ashani T., Chou, David S., Szlyk, Greg, Geib, K. Shane, Walsh, Christopher, Patteras, John

Journal:

Clinical Prostate Cancer

Year:

2002

Language:

english

File:

PDF, 325 KB

english, 2002

94

Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy

Steinberg, N., Van der Drift, A. C. M., Grunwald, J., Segall, Y., Shirin, E., Haas, E., Ashani, Y., Silman, I.

Journal:

Year:

1989

Language:

english

File:

PDF, 758 KB

english, 1989

95

Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime †

Sanson, Benoît, Nachon, Florian, Colletier, Jacques-Philippe, Froment, Marie-Thérèse, Toker, Lilly, Greenblatt, Harry M., Sussman, Joel L., Ashani, Yaacov, Masson, Patrick, Silman, Israel, Weik, Ma

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.13 MB

english, 2009

96

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

Worek, Franz, Seeger, Thomas, Goldsmith, Moshe, Ashani, Yacov, Leader, Haim, Sussman, Joel S., Tawfik, Dan, Thiermann, Horst, Wille, Timo

Journal:

Archives of Toxicology

Year:

2014

Language:

english

File:

PDF, 631 KB

english, 2014

97

Change Is in the Air: The Hypoxic Induction of Phenotype Switching in Melanoma

O'Connell, Michael P, Weeraratna, Ashani T

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 316 KB

english, 2013

98

Theoretical, experimental and numerical investigation on the behaviour of tubular shells under internal blast loading

Hadavi, V., Ashani, J. Z., Benvidi, M. H.

Journal:

ARCHIVE Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science 1989-1996 (vols

Year:

2012

Language:

english

File:

PDF, 5.43 MB

english, 2012

99

Aberrant Store-Operated Calcium Entry (SOCE) in Invasive Melanoma

Hooper, Robert, Kedra, Joseph, Weeraratna, Ashani, Soboloff, Jonathan

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

100

New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase

Amitai, G., Ashani, Y., Gafni, A., Silman, I.

Journal:

Neurochemistry International

Year:

1980

Language:

english

File:

PDF, 363 KB

english, 1980

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