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1

Lead compounds discovered from libraries

Adam Golebiowski, Sean R Klopfenstein, David E Portlock

Journal:

Current Opinion in Chemical Biology

Year:

2001

Language:

english

File:

PDF, 223 KB

english, 2001

2

Analysis and application of two-current-source circuit as a signal conditioner for resistive sensors

Idzkowski, Adam, Gołębiowski, Jerzy, Walendziuk, Wojciech

Journal:

Journal of Electrical Engineering

Language:

english

File:

PDF, 484 KB

english

3

ChemInform Abstract: High-Throughput Organic Synthesis of Peptide Mimetics.

Adam Golebiowski, Sean R. Klopfenstein, David E. Portlock

Journal:

Year:

2002

File:

PDF, 25 KB

2002

4

X-ray and conformational investigations of a 4:1 mixture of 6-(N-benzyl-N-tert-butoxycarbonylamino)-2,3,6,7-tetradeoxy-α-dl-erythro- and -β-dl-threo-hept-2-enopyranos-4-uloses

Janusz W. Krajewski, Zofia Urbańczyk-Lipkowska, Przemysław Gluziński, Janusz Jurczak, Jerzy Raczko, Adam Gołebiowski

Journal:

Carbohydrate Research

Year:

1990

Language:

english

File:

PDF, 406 KB

english, 1990

5

Enantioselective synthesis of all 2,4-dideoxyhexose stereoisomers

Carl R. Johnson, Adam Golebiowski, Darryl H. Steensma

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 139 KB

english, 1991

6

Synthesis of (+)-1-deoxygalactonojirimycin and a related indolizidine

Carl R. Johnson, Adam Golebiowski, Hari Sundram, Michael W. Miller, Renee L. Dwaihy

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 130 KB

english, 1995

7

Enantioselective synthesis of 7-cycloocten-1,3,5,6-tetraol derivatives by enzymatic asymmetrization

Carl R. Johnson, Lalgudi S. Harikrishnan, Adam Golebiowski

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 218 KB

english, 1994

8

Chemoenzymatic synthesis of (2S,3R)-3-hydroxyproline from cyclopentadiene

Hari Sundram, Adam Golebiowski, Carl R. Johnson

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 211 KB

english, 1994

9

Synthesis of aza-C-disaccharides - a new class of sugar mimics

Carl R. Johnson, Michael W. Miller, Adam Golebiowski, Hari Sundram, Mohamad B. Ksebati

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 335 KB

english, 1994

10

The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones

Matthew J Laufersweiler, Todd A Brugel, Michael P Clark, Adam Golebiowski, Roger G Bookland, Steven K Laughlin, Mark P Sabat, Jennifer A Townes, John C VanRens, Biswanath De, Lily C Hsieh, Sandra A He

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 314 KB

english, 2004

11

The development of new bicyclic pyrazole-based cytokine synthesis inhibitors

Jennifer A. Townes, Adam Golebiowski, Michael P. Clark, Matthew J. Laufersweiler, Todd A. Brugel, Mark Sabat, Roger G. Bookland, Steve K. Laughlin, John C. VanRens, Biswanath De, Lily C. Hsieh, Susan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 313 KB

english, 2004

12

Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1

Todd A. Brugel, Jennifer A. Maier, Michael P. Clark, Mark Sabat, Adam Golebiowski, Roger G. Bookland, Matthew J. Laufersweiler, Steven K. Laughlin, John C. VanRens, Biswanath De, Lily C. Hsieh, Marlen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

13

Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase

Jennifer A. Maier, Todd A. Brugel, Mark Sabat, Adam Golebiowski, Matthew J. Laufersweiler, John C. VanRens, Corey R. Hopkins, Biswanath De, Lily C. Hsieh, Kimberly K. Brown, Vijayasurian Easwaran, Mic

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 138 KB

english, 2006

14

The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production

Mark Sabat, John C. VanRens, Michael P. Clark, Todd A. Brugel, Jennifer Maier, Roger G. Bookland, Matthew J. Laufersweiler, Steven K. Laughlin, Adam Golebiowski, Biswanath De, Lily C. Hsieh, Richard L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

15

Corrigendum to “Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1” [Bioorg. Med. Chem. Lett. 16 (2006) 3510–3513]

Todd A. Brugel, Jennifer A. Maier, Michael P. Clark, Mark Sabat, Adam Golebiowski, Roger G. Bookland, Matthew J. Laufersweiler, Steven K. Laughlin, John C. VanRens, Biswanath De, Lily C. Hsieh, Marlen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

16

The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)

Mark Sabat, John C. VanRens, Matthew J. Laufersweiler, Todd A. Brugel, Jennifer Maier, Adam Golebiowski, Biswanath De, Vijayasurian Easwaran, Lily C. Hsieh, Richard L. Walter, Marlene J. Mekel, Artem

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 260 KB

english, 2006

17

Convergent synthesis of 2,3-bisarylpyrazolones through cyclization of bisacylated pyrazolidines and hydrazines

Todd A. Brugel, Tomas Hudlicky, Michael P. Clark, Adam Golebiowski, Mark Sabat, Mary Ann A. Endoma, Vu Bui, David Adams, Matthew J. Laufersweiler, Jennifer A. Maier, Roger G. Bookland, Biswanath De

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

18

From cycloheptatriene to enantiopure sugars: synthesis of 2-deoxyhexoses

Carl R. Johnson, Adam Golebiowski, Janusz Kozak

Journal:

Carbohydrate Research

Year:

1998

Language:

english

File:

PDF, 154 KB

english, 1998

19

Influence of N-protecting groups on the stereochemical course of [4+2] cycloaddition of activated dienes to α-amino aldehydes

Adam Gołȩbiowski, Jerzy Raczko, Ulla Jacobsson, Janusz Jurczak

Journal:

Year:

1991

Language:

english

File:

PDF, 384 KB

english, 1991

20

High pressure approach to the total synthesis of 6-EPI-d-purpurosamine b

Adam Gołȩbiowski, Janusz Jurczak, Ulla Jacobsson

Journal:

Year:

1987

Language:

english

File:

PDF, 310 KB

english, 1987

21

Enantioselective synthesis through enzymatic asymmetrization

Elke Schoffers, Adam Golebiowski, Carl R. Johnson

Journal:

Year:

1996

Language:

english

File:

PDF, 2.73 MB

english, 1996

22

A practical synthesis of peptide mimetics via the solid-phase Petasis reaction

Sean R Klopfenstein, Jack J Chen, Adam Golebiowski, Min Li, Sean X Peng, Xia Shao

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 152 KB

english, 2000

23

Highly stereoselective synthesis of cis-(2R,3S)-3-hydroxyproline

Janusz Jurczak, Piotr Prokopowicz, Adam Gołȩbiowski

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 198 KB

english, 1993

24

Chemoenzymatic synthesis of 1,3-dideoxynojirimycin

Carl R. Johnson, Adam Golebiowski, Matthew P. Braun, Hari Sundram

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 180 KB

english, 1994

25

Enantioselective synthesis of 6-cycloheptene-1,3,5-triol derivatives by enzymatic asymmetrization

Carl R. Johnson, Adam Golebiowski, Timothy K. McGill, Darryl H. Steensma

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 265 KB

english, 1991

26

High-pressure (4+2)cycloaddition of 1-methoxybuta-1,3-diene to α-amino aldehydes. Influence of n-protecting groups on asymmetric induction

Janusz Jurczak, Adam Gołebiowski, Jerzy Raczko

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 229 KB

english, 1988

27

High-pressure (4+2)cycloaddition of 1-methoxy-3-trialkylsilyloxybuta-1,3-dienes to butyl glyoxylate. Isolation of primary cycloadducts

Janusz Jurczak, Adam Gołebiowski, Alain Rahm

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 192 KB

english, 1986

28

Universal Rink–isonitrile resin: application for the traceless synthesis of 3-acylamino imidazo[1,2-a]pyridines

Jack J Chen, Adam Golebiowski, Joel McClenaghan, Sean R Klopfenstein, Laura West

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 97 KB

english, 2001

29

Total synthesis of (+)-galantinic acid

Adam Gołebiowski, Janusz Kozak, Janusz Jurczak

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 143 KB

english, 1989

30

The universal Rink-isonitrile resin: applications in Ugi reactions

Jack J Chen, Adam Golebiowski, Sean R Klopfenstein, Laura West

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

31

Solid supported synthesis of hydroxamic acids

Adam Golebiowski, Sean Klopfenstein

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 185 KB

english, 1998

32

Lead compounds discovered from libraries: Part 2

Adam Golebiowski, Sean R Klopfenstein, David E Portlock

Journal:

Current Opinion in Chemical Biology

Year:

2003

Language:

english

File:

PDF, 325 KB

english, 2003

33

The synthesis and evaluation of indolylureas as PKCα inhibitors

Jane F. Djung, Richard. J. Mears, Christian A.G.N. Montalbetti, Thomas S. Coulter, Adam Golebiowski, Andrew N. Carr, Oliver Barker, Kenneth D. Greis, Songtao Zhou, Elizabeth Dolan, Gregory F. Davis

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 901 KB

english, 2011

34

The development of monocyclic pyrazolone based cytokine synthesis inhibitors

Adam Golebiowski, Jennifer A. Townes, Matthew J. Laufersweiler, Todd A. Brugel, Michael P. Clark, Cynthia M. Clark, Jane F. Djung, Steven K. Laughlin, Mark P. Sabat, Roger G. Bookland, John C. VanRens

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 191 KB

english, 2005

35

The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production

Steven K. Laughlin, Michael P. Clark, Jane F. Djung, Adam Golebiowski, Todd A. Brugel, Mark Sabat, Roger G. Bookland, Matthew J. Laufersweiler, John C. VanRens, Jennifer A. Townes, Biswanath De, Lily

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

36

The development of novel 1,2-dihydro-pyrimido[4,5-c]pyridazine based inhibitors of lymphocyte specific kinase (Lck)

Mark Sabat, John C. VanRens, Todd A. Brugel, Jennifer Maier, Matthew J. Laufersweiler, Adam Golebiowski, Biswanath De, Vijayasurian Easwaran, Lily C. Hsieh, Jeff Rosegen, Steve Berberich, Eric Suchane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

37

Development of N-2,4-pyrimidine-N-phenyl-N′-alkyl ureas as orally active inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 2

Jennifer A. Maier, Todd A. Brugel, Michael P. Clark, Mark Sabat, Adam Golebiowski, Roger G. Bookland, Matthew J. Laufersweiler, Steven K. Laughlin, John C. VanRens, Biswanath De, Lily C. Hsieh, Kimber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 169 KB

english, 2006

38

Total synthesis of d,l-purpurosamine c

Adam Gołebiowski, Ulla Jacobsson, Marek Chmielewski, Janusz Jurczak

Journal:

Year:

1987

Language:

english

File:

PDF, 448 KB

english, 1987

39

Solid supported high-throughput organic synthesis of peptide β-turn mimetics via tandem Petasis reaction/diketopiperazine formation

Adam Golebiowski, Sean R Klopfenstein, Jack J Chen, Xia Shao

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 128 KB

english, 2000

40

A versatile approach to the regioselective synthesis of diverse (−)-epicatechin-β-d-glucuronides

Eric S. Mull, Michael Van Zandt, Adam Golebiowski, R. Paul Beckett, Pradeep K. Sharma, Hagen Schroeter

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 211 KB

english, 2012

41

Optically active N-protected .alpha.-amino aldehydes in organic synthesis

Jurczak, Janusz, Golebiowski, Adam

Journal:

Chemical Reviews

Year:

1989

Language:

english

File:

PDF, 2.23 MB

english, 1989

42

Solid-Supported Synthesis of a Peptide β-Turn Mimetic

Golebiowski, Adam, Klopfenstein, Sean R., Shao, Xia, Chen, Jack J., Colson, Anny-Odile, Grieb, Arthur L., Russell, Anne F.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 63 KB

english, 2000

43

Solid-Supported Synthesis of Putative Peptide β-Turn Mimetics via Ugi Reaction for Diketopiperazine Formation

Golebiowski, Adam, Jozwik, Julita, Klopfenstein, Sean R., Colson, Anny-Odile, Grieb, Arthur L., Russell, Anne F., Rastogi, Vinit L., Diven, Conrad F., Portlock, David E., Chen, Jack J.

Journal:

Journal of Combinatorial Chemistry

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

44

Discovery of ( R )-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

Van Zandt, Michael C., Whitehouse, Darren L., Golebiowski, Adam, Ji, Min Koo, Zhang, Mingbao, Beckett, R. Paul, Jagdmann, G. Erik, Ryder, Todd R., Sheeler, Ryan, Andreoli, Monica, Conway, Bruce, Mahbo

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 4.68 MB

english, 2013

45

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

Golebiowski, Adam, Paul Beckett, R., Van Zandt, Michael, Ji, Min Koo, Whitehouse, Darren, Ryder, Todd R., Jagdmann, Erik, Andreoli, Monica, Mazur, Adam, Padmanilayam, Manyian, Cousido-Siah, Alexandra,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.43 MB

english, 2013

46

Enantio- and diastereoselective transformations of cycloheptatriene to sugars and related products

Johnson, Carl R., Golebiowski, Adam, Steensma, Darryl H., Scialdone, Mark A.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 1.47 MB

english, 1993

47

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

Golebiowski, Adam, Whitehouse, Darren, Beckett, R. Paul, Van Zandt, Michael, Ji, Min Koo, Ryder, Todd R., Jagdmann, Erik, Andreoli, Monica, Lee, Yung, Sheeler, Ryan, Conway, Bruce, Olczak, Jacek, Mazu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

48

Synthesis of Novel Pyrimido[4,5-c]pyridazines and 1,2-Dihydro-3a,7,9,9b-Tetraaza-cyclopenta[a]naphthalen-3-ones as Potent Inhibitors of Lymphocyte Specific Kinase (LCK)

Sabat, Mark, C. VanRens, John, A. Brugel, Todd, Maier, Jennifer, J. Laufersweiler, Matthew, Golebiowski, Adam, Berberich, Steve, De, Biswanath

Journal:

Year:

2006

Language:

english

File:

PDF, 187 KB

english, 2006

49

Syntheses of destomic acid and anhydro-galantinic acid from L-serinal

Golebiowski, Adam, Kozak, Janusz, Jurczak, Janusz

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 579 KB

english, 1991

50

Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production

Clark, Michael P., Laughlin, Steven K., Laufersweiler, Matthew J., Bookland, Roger G., Brugel, Todd A., Golebiowski, Adam, Sabat, Mark P., Townes, Jennifer A., VanRens, John C., Djung, Jane F., Natchu

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

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