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51

Clinical and virological effects of long-term (over 5 years) lamivudine therapy

Yoshimasa Hashimoto, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Tetuya Hosaka, Norio Akuta, Masahiro Kobayashi, Satoshi Saito, Yoshiyuki Suzuki, Mariko Kobayashi

Journal:

Journal of Medical Virology

Year:

2010

Language:

english

File:

PDF, 100 KB

english, 2010

52

Virus clearance reduces bone fracture in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus

Yasuji Arase, Fumitaka Suzuki, Yoshiyuki Suzuki, Norio Akuta, Masahiro Kobayashi, Hitomi Sezaki, Tetsuya Hosaka, Yusuke Kawamura, Hiromi Yatsuji, Miharu Hirakawa, Kenji Ikeda, Shiun Dong Hsieh, Yuki O

Journal:

Journal of Medical Virology

Year:

2010

Language:

english

File:

PDF, 84 KB

english, 2010

53

Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin

Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Ken

Journal:

Journal of Medical Virology

Year:

2010

Language:

english

File:

PDF, 143 KB

english, 2010

54

Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy

Takahiro Azakami, C. Nelson Hayes, Hitomi Sezaki, Mariko Kobayashi, Norio Akuta, Fumitaka Suzuki, Hiromitsu Kumada, Hiromi Abe, Daiki Miki, Masataka Tsuge, Michio Imamura, Yoshiiku Kawakami, Shoichi T

Journal:

Journal of Medical Virology

Year:

2011

Language:

english

File:

PDF, 521 KB

english, 2011

55

Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy

Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromi

Journal:

Journal of Medical Virology

Year:

2011

Language:

english

File:

PDF, 94 KB

english, 2011

56

A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human α1-acid glycoprotein

Koji Nishi, Megumi Ueno, Yuka Murakami, Naoko Fukunaga, Teruo Akuta, Daisuke Kadowaki, Hiroshi Watanabe, Ayaka Suenaga, Toru Maruyama, Masaki Otagiri

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 205 KB

english, 2009

57

Development of an automatic 3-D shape measuring system using a new auto-focusing method

T Akuta, Y Negishi

Journal:

Year:

1991

Language:

english

File:

PDF, 12.90 MB

english, 1991

58

Regional hyperthermia combined with blockade of the hepatic arterial blood flow by degradable starch microspheres in pigs

Keizo Akuta, Masahiro Hiraoka, Shiken Jo, Fangxiao Ma, Yasumasa Nishimura, Masaji Takahashi, Mitsuyuki Abe, Margareta Malmqvist, Lars-Olof Lindbom, Ragnvald Lindblom

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1987

Language:

english

File:

PDF, 463 KB

english, 1987

59

Histopathological changes of human tumors following thermoradiotherapy

Shiken Jo, Masahiro Hiraoka, Keizo Akuta, Yasumasa Nishimura, Masaji Takahashi, Hisao Nishida, Mutsuhiro Furuta, Mitsuyuki Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1989

Language:

english

File:

PDF, 3.66 MB

english, 1989

60

Evaluation of response of hepatocytes(in-vivo) to radiation and chemotherapeutic agents by micronucleus assay

K. Ono, Y. Nagata, K. Akuta, M. Fushiki, M. Abe, K. Ando

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1989

Language:

english

File:

PDF, 248 KB

english, 1989

61

Hyperthermia combined with radiotherapy for locally advanced and recurrent colorectal cancer

Yasumasa Nishimura, Masahiro Hiraoka, Keizo Akuta, Yasushi Nagata, Shin-ichirou Masunaga, Masaji Takahashi, Mitsuyuki Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1990

Language:

english

File:

PDF, 135 KB

english, 1990

62

Hyperthermia combined with radiotherapy in the treatment of soft tissue tumors

Masahiro Hiraoka, Yasumasa Nishimura, Yasushi Nagata, Shinichiro Masunaga, Yu.P. Li, Mototsugu Koishi, Michihide Mitsumori, Keizou Akuta, Masaji Takahashi, Mitsuyuki Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1992

Language:

english

File:

PDF, 215 KB

english, 1992

63

Regional hyperthermia combined with radiotherapy in the treatment of lung cancers

Masahiro Hiraoka, Shin-Ichiro Masunaga, Yasumasa Nishimura, Yasushi Nagata, Shiken Jo, Keizo Akuta, Yu Ping Li, Masaji Takahashi, Mitsuyuki Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

64

Enhancement of chemo-sensitivity of quiescent cell populations in murine solid tumors using nicotinamide

Shin-ichiro Masunaga, Koji Ono, Keizo Akuta, Mitsuhiko Akaboshi, Mitsuyuki Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1993

Language:

english

File:

PDF, 118 KB

english, 1993

65

Middle dose rate irradiation in combination with carbogen inhalation selectively and more markedly increases the responses of SCCVII tumors

K. Ono, S. Masunaga, K. Akuta, M. Akaboshi

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1994

Language:

english

File:

PDF, 688 KB

english, 1994

66

The radiosensitivity of quiescent cell populations in murine solid tumors in irradiation with fast neutrons

Shin-Ichiro Masunaga, Koji Ono, Keizo Akuta, Mitsuhiko Akaboshi, Mitsuyuki Abe, Koichi Ando, Sachiko Koike

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1994

Language:

english

File:

PDF, 441 KB

english, 1994

67

Radiobiological evidence suggesting heterogeneous microdistribution of boron compounds in tumors: Its relation to quiescent cell population and tumor cure in neutron capture therapy

Koji Ono, Shin-Ichiro Masunaga, Yuko Kinashi, Masao Takagaki, Mitsuhiko Akaboshi, Toru Kobayashi, Keizo Akuta

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1996

Language:

english

File:

PDF, 696 KB

english, 1996

68

Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3 cm or less in diameter

Kenji Ikeda, Masahiro Kobayashi, Satoshi Saitoh, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Yoshiyuki Suzuki, Fumitaka Suzuki, Norio Akuta, Yasuji Arase, Hiromitsu Kumada, Masamichi Matsuda, Masaj

Journal:

Hepatology Research

Year:

2005

Language:

english

File:

PDF, 225 KB

english, 2005

69

Clinical results of radiofrequency hyperthermia for malignant liver tumors

Yasushi Nagata, Masahiro Hiraoka, Yasumasa Nishimura, Shinitirou Masunaga, Michihide Mitumori, Yoshishige Okuno, Masayo Fujishiro, Shuichi Kanamori, Naotoshi Horii, Keizo Akuta, Keisuke Sasai, Mitsuyu

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1997

Language:

english

File:

PDF, 773 KB

english, 1997

70

2051 Radiofrequency hyperthermia for advanced malignant liver tumors

Y. Nagata, Y. Okuno, M. Mitsumori, K. Akuta, Y. Nishimura, S. Masunaga, S. Kanamori, M. Fujishiro, M. Hiraoka, M. Takahashi, M. Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1996

Language:

english

File:

PDF, 138 KB

english, 1996

71

Microangiographic and histologic analysis of the effects of hyperthermia on murine tumor vasculature

Yasumasa Nishimura, Masahiro Hiraoka, Shiken Jo, Keizo Akuta, Yutaka Yukawa, Yuta Shibamoto, Masah Takahashi, Mitsuyuki Abe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1988

Language:

english

File:

PDF, 5.32 MB

english, 1988

72

Randomized controlled clinical trial of lymphoblastoid interferon-α for chronic hepatitis C

Yasuji Arase, Kazuaki Chayama, Kenji Ikeda, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Fumitaka Suzuki, Norio Akuta, Takashi Someya, Mariko Kobayashi, Hiromitsu Kumada

Journal:

Hepatology Research

Year:

2001

Language:

english

File:

PDF, 117 KB

english, 2001

73

Randomized, controlled trial of natural interferon-α therapy for e-antigen-positive chronic hepatitis B patients

Yasuji Arase, Akihito Tsubota, Satoshi Saitoh, Yoshiyuki Suzuki, Masahiro Kobayashi, Fumitaka Suzuki, Takashi Someya, Norio Akuta, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada

Journal:

Hepatology Research

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

74

Serum levels of γ-globulin and total bilirubin influence the prevalence of multiple extrahepatic complication in patients with hepatitis C virus infection

Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Fumitaka Suzuki, Norio Akuta, Takashi Someya, Mariko Kobayashi, Hiromitsu Kumada

Journal:

Hepatology Research

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

75

Randomized trial of prolonged interferon retreatment for chronic hepatitis C patients with HCV-genotype 1b and high virus load

Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Mariko Kobayashi, Fumitaka Suzuki, Hiromitsu Kumada

Journal:

Hepatology Research

Year:

2003

Language:

english

File:

PDF, 126 KB

english, 2003

76

Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus

Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Satoshi Saitoh, Yoshiyuki Suzuki, Masahiro Kobayashi, Fumitaka Suzuki, Takashi Someya, Norio Akuta, Tetsuya Hosaka, Mariko Kobayashi, Hiromitsu Kumada

Journal:

Hepatology Research

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

77

Primary splenic malignant lymphoma associated with hepatitis C virus infection

K. Kishimoto, T. Koyama, Y. Kigami, H. Kobayashi, K. Akuta, K. Ito, N. Matsunaga

Journal:

Abdominal Imaging

Year:

2001

Language:

english

File:

PDF, 3.01 MB

english, 2001

78

The effect of erdosteine and its active metabolite on reactive oxygen species production by inflammatory cells

K. Miyake, T. Kaise, H. Hosoe, K. Akuta, H. Manabe, K. Ohmori

Journal:

Inflammation Research

Year:

1999

Language:

english

File:

PDF, 89 KB

english, 1999

79

Primary splenic malignant lymphoma associated with hepatitis C virus infection

K. Kishimoto, T. Koyama, Y. Kigami, H. Kobayashi, K. Akuta, K. Ito, N. Matsunaga

Journal:

Abdominal Imaging

Year:

2001

Language:

english

File:

PDF, 3.01 MB

english, 2001

80

Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy

Hitomi Sezaki, Yasuji Arase, Akihito Tsubota, Yoshiyuki Suzuki, Masahiro Kobayashi, Satoshi Saitoh, Fumitaka Suzuki, Norio Akuta, Takashi Someya, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

81

Clinical features of hepatitis B virus genotype A in Japanese patients

Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Yoshiyuki Suzuki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Fumitaka Suzuki, Norio Akuta, Takashi Someya, Marie Matsuda, Junko S

Journal:

Journal of Gastroenterology

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

82

Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis

Kenji Ikeda, Yasuji Arase, Masahiro Kobayashi, Satoshi Saitoh, Takashi Someya, Tetsuya Hosaka, Yoshiyuki Suzuki, Fumitaka Suzuki, Akihito Tsubota, Norio Akuta, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2003

Language:

english

File:

PDF, 283 KB

english, 2003

83

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine

Marie Matsuda, Fumitaka Suzuki, Yoshiyuki Suzuki, Akihito Tsubota, Norio Akuta, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Yasuji Arase, Junko Satoh, Kimiko Takagi, Mariko Kob

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 158 KB

english, 2004

84

Successful control of ruptured hepatocellular carcinoma with radiofrequency ablation

Masahiro Kobayashi, Kenji Ikeda, Tetsuya Hosaka, Takashi Someya, Satoshi Saitoh, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Akihito Tsubota, Yasuji Arase, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 225 KB

english, 2004

85

High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load

Akihito Tsubota, Yasuji Arase, Fumitaka Suzuki, Yoshiyuki Suzuki, Norio Akuta, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 174 KB

english, 2004

86

Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy

Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Fumitaka Suzuki, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Mariko Kobayashi, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 142 KB

english, 2004

87

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

Hitomi Sezaki, Masahiro Kobayashi, Tetsuya Hosaka, Takashi Someya, Norio Akuta, Fumitaka Suzuki, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Marie M

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 349 KB

english, 2004

88

Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C

Shintaro Takaki, Akihito Tsubota, Tetsuya Hosaka, Norio Akuta, Takashi Someya, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 209 KB

english, 2004

89

Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis

Yoshiyuki Suzuki, Mariko Kobayashi, Tetsuya Hosaka, Takashi Someya, Norio Akuta, Masahiro Kobayashi, Fumitaka Suzuki, Akihito Tsubota, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Marie Matsuda, Junko S

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 257 KB

english, 2004

90

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment

Satoshi Mamori, Fumitaka Suzuki, Tetsuya Hosaka, Norio Akuta, Takashi Someya, Masahiro Kobayashi, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 159 KB

english, 2004

91

Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis

Hiromi Ooga, Fumitaka Suzuki, Akihito Tsubota, Yasuji Arase, Yoshiyuki Suzuki, Norio Akuta, Hitomi Sezaki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Kenji Ikeda, Mariko Kobay

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 227 KB

english, 2004

92

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001

Mariko Kobayashi, Fumitaka Suzuki, Yasuji Arase, Norio Akuta, Yoshiyuki Suzuki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Akihito Tsubota, Takashi Someya, Kenji Ikeda, Marie Matsuda, Junko S

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

93

Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan

Fumitaka Suzuki, Yasuji Arase, Norio Akuta, Akihito Tsubota, Yoshiyuki Suzuki, Hitomi Sezaki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Kenji Ikeda, Mariko Kobayashi, Marie M

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 146 KB

english, 2004

94

Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C

Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2004

Language:

english

File:

PDF, 171 KB

english, 2004

95

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

Yusuke Kawamura, Norio Akuta, Hitomi Sezaki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2005

Language:

english

File:

PDF, 155 KB

english, 2005

96

Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection

Kiminori Uka, Fumitaka Suzuki, Norio Akuta, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2006

Language:

english

File:

PDF, 171 KB

english, 2006

97

Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis

Takashi Someya, Kenji Ikeda, Satoshi Saitoh, Masahiro Kobayashi, Tetsuya Hosaka, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2006

Language:

english

File:

PDF, 196 KB

english, 2006

98

Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine

Tetsuya Hosaka, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Takashi Someya, Hitomi Sezaki, Norio Akuta, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2007

Language:

english

File:

PDF, 213 KB

english, 2007

99

Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus

Masahiro Kobayashi, Kenji Ikeda, Yasuji Arase, Yoshiyuki Suzuki, Fumitaka Suzuki, Norio Akuta, Tetsuya Hosaka, Naoya Murashima, Satoshi Saitoh, Takashi Someya, Akihito Tsubota, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2008

Language:

english

File:

PDF, 228 KB

english, 2008

100

Clinicopathological features, background liver disease, and survival analysis of HCV-positive patients with hepatocellular carcinoma: differences between young and elderly patients

Hiromi Saneto, Masahiro Kobayashi, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Journal:

Journal of Gastroenterology

Year:

2008

Language:

english

File:

PDF, 190 KB

english, 2008