Amit S. Kalgutkar: search on Z-Library

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101

Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators.

Boehm, Markus, Beaumont, Kevin, Jones, Rhys M, Kalgutkar, Amit S., Zhang, Liying, Atkinson, Karen, Bai, Guoyun, Brown, Janice A., Eng, Heather, Goetz, Gilles H., Holder, Brian R, Khunte, Bhagyashree,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 899 KB

english, 2017

102

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Dealing with Reactive Metabolite-Positive Compounds in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 291 KB

english, 2012

103

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Mitigating Toxicity Risks with Affinity Labeling Drug Candidates

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 253 KB

english, 2012

104

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Role of Reactive Metabolites in Pharmacological Action

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 621 KB

english, 2012

105

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Managing IADRs - a Risk-Benefit Analysis

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 163 KB

english, 2012

106

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Intrinsically Electrophilic Compounds as a Liability in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 242 KB

english, 2012

107

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Case Studies on Eliminating/Reducing Reactive Metabolite Formation in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 570 KB

english, 2012

108

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Experimental Approaches to Reactive Metabolite Detection

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 189 KB

english, 2012

109

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Bioactivation and Natural Products

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 335 KB

english, 2012

110

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Origin and Historical Perspective on Reactive Metabolites

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 113 KB

english, 2012

111

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-activated Protein Kinase (AMPK)

Edmonds, David J., Kung, Daniel W., Kalgutkar, Amit S., Filipski, Kevin J., Ebner, David C, Cabral, Shawn, Smith, Aaron C., Aspnes, Gary E, Bhattacharya, Samit K., Borzilleri, Kris A, Brown, Janice A.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 787 KB

english, 2018

112

Predicting metabolism-mediated toxicities of drug candidates

Kalgutkar, Amit S.S.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 44 KB

english, 2018

113

Discovery of a Novel Small Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

Menhaji-Klotz, Elnaz, Hesp, Kevin D., Londregan, Allyn Timothy, Kalgutkar, Amit S., Piotrowski, David W., Boehm, Markus, Song, Kun, Ryder, Tim, Beaumont, Kevin, Jones, Rhys M, Atkinson, Karen, Brown,

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 487 KB

english, 2018

114

6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577) is a Highly Selective Substrate for Glucuronidation by Uridine Diphosphoglucuronosyl Transferase (UGT) 1A1, Relative to b-Estradiol

Lapham, Kimberly, Lin, Jian, Novak, Jonathan, Orozco, Christine, Niosi, Mark, Di, Li, Goosen, Theunis C, Ryu, Sangwoo, Riccardi, Keith, Eng, Heather, Cameron, Kimberly O., Kalgutkar, Amit S.

Journal:

Drug Metabolism and Disposition

Year:

2018

Language:

english

File:

PDF, 1.18 MB

english, 2018

115

Role of flavin-containing monooxygenases in the species-dependent metabolism of an irreversible thiouracil-based inactivator of human myeloperoxidase

Eng, Heather, Sharma, Raman, Wolford, Angela, Di, Li, Kalgutkar, Amit S.S.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 49 KB

english, 2018

116

Designing Around Structural Alerts in Drug Discovery

Kalgutkar, Amit S.

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 597 KB

english, 2019

117

Structural attributes influencing unbound tissue distribution

Orozco, Christine C., Atkinson, Karen, Ryu, Sangwoo, Chang, George, Keefer, Christopher, Lin, Jian, Riccardi, Keith, Mongillo, Robert K., Tess, David, Filipski, Kevin J., Kalgutkar, Amit S., Litchfiel

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 4.66 MB

english, 2019

118

Is there enough evidence to classify cycloalkyl amine substituents as structural alerts?

Kalgutkar, Amit S., Driscoll, James P.

Journal:

Biochemical Pharmacology

Year:

2020

Language:

english

File:

PDF, 1.30 MB

english, 2020

119

Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7)

Mathialagan, Sumathy, Bi, Yi-an, Costales, Chester, Kalgutkar, Amit S., David Rodrigues, A., Varma, Manthena V.S.

Journal:

Biochemical Pharmacology

Year:

2020

Language:

english

File:

PDF, 1.06 MB

english, 2020

120

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting

Huard, Kim, Smith, Aaron C., Cappon, Gregg D, Dow, Robert L., Edmonds, David J., El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P., Griffith, David A., Kalgutkar, Amit S., Ross, Trenton, Bagley

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 427 KB

2020

121

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs

Tess, David A, Eng, Heather, Kalgutkar, Amit S., Litchfield, John, Edmonds, David J., Griffith, David A., Varma, Manthena V. S.

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.11 MB

2020