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51

Clinical benefit in Phase-I trials of novel molecularly targeted agents: does dose matter?

Postel-Vinay, S, Arkenau, H-T, Olmos, D, Ang, J, Barriuso, J, Ashley, S, Banerji, U, De-Bono, J, Judson, I, Abbruzzese, J L

Journal:

British Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 172 KB

english, 2009

52

Is There a Place for Thyroidectomy in Older Patients with Thyrotoxic Storm and Cardiorespiratory Failure?

Scholz, Gerhard H., Hagemann, Eva, Arkenau, Cord, Engelmann, Lothar, Lamesch, Peter, Schreiter, Dierk, Schoenfelder, Manfred, Olthoff, Derk, Paschke, Ralf

Journal:

Year:

2003

Language:

english

File:

PDF, 181 KB

english, 2003

53

Lenalidomide in combination with gemcitabine as first-line treatment for patients with metastatic carcinoma of the pancreas: A Sarah Cannon Research Institute phase II trial

Infante, Jeffrey, Arkenau, Hendrik-Tobias, Bendell, Johanna, Rubin, Mark, Waterhouse, David, Jones, George, Spigel, David, Lane, Cassie, Hainsworth, John, Burris, III, Howard

Journal:

Cancer Biology & Therapy

Year:

2013

Language:

english

File:

PDF, 840 KB

english, 2013

54

Efficacy of Oxaliplatin Plus Capecitabine or Infusional Fluorouracil/Leucovorin in Patients With Metastatic Colorectal Cancer: A Pooled Analysis of Randomized Trials

Arkenau, H.-T., Arnold, D., Cassidy, J., Diaz-Rubio, E., Douillard, J.-Y., Hochster, H., Martoni, A., Grothey, A., Hinke, A., Schmiegel, W., Schmoll, H.-J., Porschen, R.

Journal:

Journal of Clinical Oncology

Year:

2008

Language:

english

File:

PDF, 199 KB

english, 2008

55

In Reply

Porschen, R., Arkenau, H.-T., Kubicka, S., Greil, R., Seufferlein, T., Freier, W., Kretzschmar, A., Graeven, U., Grothey, A., Hinke, A., Schmiegel, W., Schmoll, H.-J.

Journal:

Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 76 KB

english, 2007

56

Improving Patient Selection for Phase I Oncology Trials

Voskoboynik, M., Arkenau, H.-T.

Journal:

Journal of Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 35 KB

english, 2014

57

First-in-Human Phase I Trial of Two Schedules of OSI-930, a Novel Multikinase Inhibitor, Incorporating Translational Proof-of-Mechanism Studies

Yap, T. A., Arkenau, H.-T., Camidge, D. R., George, S., Serkova, N. J., Gwyther, S. J., Spratlin, J. L., Lal, R., Spicer, J., Desouza, N. M., Leach, M. O., Chick, J., Poondru, S., Boinpally, R., Gedri

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 695 KB

english, 2013

58

Resistance surveillance in a BRAF mutant melanoma patient on long-term BRAF-inhibitor treatment

Mak, Gabriel, Arkenau, Hendrik-Tobias, Chin, Melvin

Journal:

Melanoma Research

Year:

2014

Language:

english

File:

PDF, 350 KB

english, 2014

59

In Reply

Porschen, R., Arkenau, H.-T., Kubicka, S., Greil, R., Seufferlein, T., Freier, W., Kretzschmar, A., Graeven, U., Grothey, A., Hinke, A., Schmiegel, W., Schmoll, H.-J.

Journal:

Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 63 KB

english, 2007

60

The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: rationale and latest evidence

Lemech, C., Infante, J., Arkenau, H.-T.

Journal:

Therapeutic Advances in Medical Oncology

Year:

2012

Language:

english

File:

PDF, 402 KB

english, 2012

61

Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)

Nathanson, K. L., Martin, A.-M., Wubbenhorst, B., Greshock, J., Letrero, R., D'Andrea, K., O'Day, S., Infante, J. R., Falchook, G. S., Arkenau, H.-T., Millward, M., Brown, M. P., Pavlick, A., Davies,

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 538 KB

english, 2013

62

The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation

Lolkema, M. P., Bohets, H. H., Arkenau, H.-T., Lampo, A., Barale, E., de Jonge, M. J. A., van Doorn, L., Hellemans, P., de Bono, J. S., Eskens, F. A. L. M.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

63

The role of intrathecal chemotherapy prophylaxis in patients with diffuse large B-cell lymphoma

Arkenau, H-T, Chong, G, Cunningham, D, Watkins, D, Agarwal, R, Sirohi, B, Trumper, M, Norman, A, Wotherspoon, A, Horwich, A

Journal:

Annals of Oncology

Year:

2006

Language:

english

File:

PDF, 87 KB

english, 2006

64

Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience

Olmos, D., Arkenau, H.-T., Ang, J. E., Ledaki, I., Attard, G., Carden, C. P., Reid, A. H. M., A'Hern, R., Fong, P. C., Oomen, N. B., Molife, R., Dearnaley, D., Parker, C., Terstappen, L. W. M. M., de

Journal:

Annals of Oncology

Year:

2008

Language:

english

File:

PDF, 342 KB

english, 2008

65

A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies

Arkenau, H.- T., Plummer, R., Molife, L. R., Olmos, D., Yap, T. A., Squires, M., Lewis, S., Lock, V., Yule, M., Lyons, J., Calvert, H., Judson, I.

Journal:

Annals of Oncology

Year:

2012

Language:

english

File:

PDF, 492 KB

english, 2012

66

Effects of blackcurrant-based juice on atherosclerosis-related biomarkers in cultured macrophages and in human subjects after consumption of a high-energy meal

Huebbe, Patricia, Giller, Katrin, de Pascual-Teresa, Sonia, Arkenau, Anne, Adolphi, Berit, Portius, Sebastian, Arkenau, Cord N., Rimbach, Gerald

Journal:

British Journal Of Nutrition

Year:

2012

Language:

english

File:

PDF, 234 KB

english, 2012

67

Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil and Leucovorin Plus Oxaliplatin in Metastatic Colorectal Cancer: A Final Report of the AIO Colorectal Study Group

Porschen, R., Arkenau, H.-T., Kubicka, S., Greil, R., Seufferlein, T., Freier, W., Kretzschmar, A., Graeven, U., Grothey, A., Hinke, A., Schmiegel, W., Schmoll, H.-J.

Journal:

Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 175 KB

english, 2007

68

RGS 2 expression is regulated by TSH and inhibits TSH receptor signaling

Eszlinger, M, Holzapfel, H., Voigt, C, Arkenau, C, Paschke, R

Journal:

European Journal of Endocrinology

Year:

2004

Language:

english

File:

PDF, 148 KB

english, 2004

69

Combination Therapies for the Treatment of Advanced Melanoma: A Review of Current Evidence

Voskoboynik, Mark, Arkenau, Hendrik-Tobias

Journal:

Biochemistry Research International

Year:

2014

Language:

english

File:

PDF, 570 KB

english, 2014

70

A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors

Pacey, S., Wilson, R. H., Walton, M., Eatock, M. M., Hardcastle, A., Zetterlund, A., Arkenau, H.-T., Moreno-Farre, J., Banerji, U., Roels, B., Peachey, H., Aherne, W., de Bono, J. S., Raynaud, F., Wor

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 831 KB

english, 2011

71

Novel Treatments for Metastatic Cutaneous Melanoma and the Management of Emergent Toxicities

Arkenau,, Lemech,, Charlotte Lemech,, Arkenau,

Journal:

Clinical Medicine Insights Oncology

Year:

2012

Language:

english

File:

PDF, 594 KB

english, 2012

72

Why German Medical Students Abandon Dissertations

Diez, Cord Arkenau, Friederike Meye, Claudius

Journal:

Education for Health

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

73

Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice

Lemech, Charlotte, Arkenau, Hendrik-Tobias

Journal:

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

74

Second primary colorectal cancers (SPCRCs): experiences from a large Australian Cancer Registry

Ringland, C. L., Arkenau, H.-T., O'Connell, D. L., Ward, R. L.

Journal:

Annals of Oncology

Year:

2010

Language:

english

File:

PDF, 166 KB

english, 2010

75

Capecitabine combined with oxaliplatin (CAPOX) in clinical practice: how significant is peripheral neuropathy?

Arkenau, H.- K.

Journal:

Annals of Oncology

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

76

Long-term outcome of autologous stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma

Sirohi, B., Cunningham, D., Powles, R., Murphy, F., Arkenau, T., Norman, A., Oates, J., Wotherspoon, A., Horwich, A.

Journal:

Annals of Oncology

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

77

Paraneoplastic syndrome: Subacute cerebellar degeneration in Hodgkin's disease

Arkenau, Hendrik-Tobias, Gordon, Claire, Murphy, Felicity, Cunningham, David

Journal:

Leukemia and Lymphoma

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

78

Zur Pharmakokinetik von Clindamycin bei gestörter Leber- und Nierenfunktion

Brandl, R., Arkenau, C., Simon, C., Malerczyk, V., Eidelloth, G.

Journal:

DMW - Deutsche Medizinische Wochenschrift

Year:

1972

Language:

german

File:

PDF, 50 KB

german, 1972

79

Elevated Nitric Oxide Levels in Patients with Chronic Liver Disease and Cirrhosis Correlate with Disease Stage and Parameters of Hyperdynamic Circulation

Arkenau, H.-T, Stichtenoth, D O, Frölich, J C, Manns, M P, Böker, K.-H W

Journal:

Zeitschrift für Gastroenterologie

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

80

Bearbeitung und Betreuungsqualität medizinischer Dissertationen an der Medizinischen Fakultät Würzburg aus der Sicht von Promovenden des 5. und 6. Studienjahres

C. Diez, C. Arkenau, F. Meyer-wentrup

Year:

2002

File:

PDF, 407 KB

2002

81

Microangiopathic Hemolytic Anemia (MAHA) as Paraneoplastic Syndrome in Metastasized Signet Ring Cell Carcinomas: Case Reports and Review of the Literature

Arkenau, H.-T, Müssig, O, Buhr, T, Jend, H H, Porschen, R

Journal:

Zeitschrift für Gastroenterologie

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

82

Clinical Benefit of New Targeted Agents in Phase I Trials in Patients with Advanced Colorectal Cancer

Arkenau, Hendrik-Tobias, Brunetto, Andre T., Barriuso, Jorge, Olmos, David, Eaton, David, de Bono, Johann, Judson, Ian, Kaye, Stan

Journal:

Year:

2009

Language:

english

File:

PDF, 113 KB

english, 2009

83

Reporting Incidental Germline Variants in the context of day-to-day somatic genomic profiling

Mak, Gabriel, Moschetta, Michele, Arkenau, Hendrik-Tobias

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 195 KB

english, 2016

84

The German Medical Dissertation—Time to Change?

Diez, Claudius, Arkenau, Cord, Meyer-Wentrup, Frierike

Journal:

Academic Medicine

Year:

2000

Language:

english

File:

PDF, 101 KB

english, 2000

85

8PD * Phase I JAVELIN solid tumor trial of avelumab (MSB0010718C), an anti-PD-L1 antibody: Safety and pharmacokinetics

Arkenau, H.- T., Kelly, K., Patel, M. R., Neuteboom, B., Speit, I., Chin, K., Heery, C. R., Gulley, J. L.

Journal:

Annals of Oncology

Year:

2015

Language:

english

File:

PDF, 38 KB

english, 2015

86

Systematic evaluation of pembrolizumab dosing in patients with advanced non-small cell lung cancer

Chatterjee, M., Turner, D. C., Felip, E., Lena, H., Cappuzzo, F., Horn, L., Garon, E. B., Hui, R., Arkenau, H.-T., Gubens, M. A., Hellmann, M. D., Dong, D., Li, C., Mayawala, K., Freshwater, T., Ahama

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 481 KB

english, 2016

87

Phase 1 study of cardiac safety of TAS-102 in patients with advanced solid tumors

Bendell, Johanna C., Patel, Manish R., Yoshida, Kenichiro, Seraj, Jabed, Weaver, Racquel, Lemech, Charlotte, Todaro, Thomas G., Pant, Shubham, Arkenau, Hendrik-Tobias

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2016

Language:

english

File:

PDF, 548 KB

english, 2016

88

Heilung einer schweren Jakschschen Anämie mit Purpura (Werlhof-Gruppe) nach Bluttransfusion

Arkenau, Wilhelm

Journal:

DMW - Deutsche Medizinische Wochenschrift

Year:

1921

Language:

german

File:

PDF, 63 KB

german, 1921

89

Development and Evaluation of a New Technological Way of Engaging Patients and Enhancing Understanding of Drug Tolerability in Early Clinical Development: PROACT

Hughes, Andrew, Landers, Donal, Arkenau, Hendrik-Tobias, Shah, Saj, Stephens, Richard, Mahal, Amrik, Simmons, Matthew, Lemech, Charlotte, Royle, Jennifer

Journal:

Advances in Therapy

Year:

2016

Language:

english

File:

PDF, 735 KB

english, 2016

90

2364 Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with advanced gastric or gastroesophageal junction cancer: A phase Ib trial

Chung, H.C., Arkenau, H.T., Wyrwicz, L., Oh, D.Y., Lee, K.W., Infante, J.R., Chin, K., Von Heydebreck, A., Kang, Y.K., Safran, H.

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 58 KB

english, 2015

91

27LBA Evidence of activity of a new mechanism of action (MoA): A first-in-human study of the first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640, as monotherapy or in combination

Arkenau, H.T., Voskoboynik, M., Infante, J., Brenner, A., Patel, M., Borazanci, E., Falchook, G., Molife, L.R., Pant, S., Dean, E., Pelosof, L., Jones, S., Rubino, C., McCulloch, W., Zhukova-Harrill,

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 61 KB

english, 2015

92

817 PROACT: A new way of engaging and empowering patients that fundamentally changes our understanding of tolerability impacts in early clinical development

Hughes, A., Landers, D., Arkenau, T., O'Connor, B., Royle, J.

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 57 KB

english, 2015

93

1571 Ideal Body Mass Index (BMI) is significantly different between curatively resected and metastatic colorectal cancer (CRC) patients on chemotherapy

Formica, V., Pellicori, S., Arkenau, H.T., Morelli, C., Lucchetti, J., Nardecchia, A., Riondino, S., Ferroni, P., Cereda, V., Tesauro, M., Guadagni, F., Roselli, M.

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 64 KB

english, 2015

94

Complexity of FGFR signalling in metastatic urothelial cancer

Rodriguez-Vida, Alejo, Saggese, Matilde, Hughes, Simon, Rudman, Sarah, Chowdhury, Simon, Smith, Neil R., Lawrence, Peter, Rooney, Claire, Dougherty, Brian, Landers, Donal, Kilgour, Elaine, Arkenau, He

Journal:

Journal of Hematology & Oncology

Year:

2015

Language:

english

File:

PDF, 2.32 MB

english, 2015

95

ATNT-06EVALUATION OF THE SAFETY OF GSK2256098 AND PHARMACOKINETICS OF 11 C-GSK2256098 IN PATIENTS WITH RECURRENT GLIOBLASTOMA BY POSITRON EMISSION TOMOGRAPHY (PET) IMAGING

Mulholland, Paul, Williams, Matthew, Arkenau, Hendrik-Tobias, Fleming, Ronald, Tolson, Jerry, Yan, Li, Zhang, Jianping, Swartz, Lisa, Singh, Rajendra, Auger, Kurt, Lenox, Laurie, Cox, David, Plisson,

Journal:

Year:

2015

Language:

english

File:

PDF, 28 KB

english, 2015

96

Enumeration and Molecular Characterisation of Circulating Tumour Cells in Endometrial Cancer

Lemech, Charlotte R., Ensell, Leah, Paterson, Jennifer C., Eminowicz, Gemma, Lowe, Helen, Arora, Rupali, Arkenau, Hendrik-Tobias, Widschwendter, Martin, MacDonald, Nicola, Olaitan, Adeola, Mould, Tim,

Journal:

Year:

2016

Language:

english

File:

PDF, 116 KB

english, 2016

97

Evaluation of CYP3A-mediated drug-drug interactions with romidepsin in patients with advanced cancer

Laille, Eric, Patel, Manish, Jones, Suzanne F., Burris, Howard A., Infante, Jeffrey, Lemech, Charlotte, Liu, Liangang, Arkenau, Hendrik-Tobias

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 358 KB

english, 2015

98

Immunotherapy for bladder cancer: rediscovering an old friend

Voskoboynik, Mark, Rudman, Sarah, Arkenau, Hendrik-Tobias, Hughes, Simon, Chowdhury, Simon

Journal:

BJU International

Year:

2016

Language:

english

File:

PDF, 175 KB

english, 2016

99

Phase I Cancer Trials and Palliative Care: Antagonism, Irrelevance, or Synergy?

Cassel, J. Brian, Del Fabbro, Egidio, Arkenau, Tobias, Higginson, Irene J., Hurst, Samia, Jansen, Lynn A., Poklepovic, Andrew, Rid, Annette, Rodón, Jordi, Strasser, Florian, Miller, Franklin G.

Journal:

Journal of Pain and Symptom Management

Year:

2016

Language:

english

File:

PDF, 893 KB

english, 2016

100

A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

Soria, J. C., Gan, H. K., Blagden, S. P., Plummer, R., Arkenau, H. T., Ranson, M., Evans, T. R. J., Zalcman, G., Bahleda, R., Hollebecque, A., Lemech, C., Dean, E., Brown, J., Gibson, D., Peddareddiga

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 316 KB

english, 2016