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51

Studies on the mechanism of action of 2-β-d-ribofuranosylthiazole-4-carboxamide (NSC 286193)-II: Relationship between dose level and biochemical effects in P388 leukemia in vivo

Hiremagalur N. Jayaram, Antoinette L. Smith, Robert I. Glazer, David G. Johns, David A. Cooney

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 867 KB

english, 1982

52

Effect of l-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in p388 leukemia and in murine colon adenocarcinomas in vivo

Bach Ardalan, Masato Arakawa, Doris Villacorte, Hiremagalur Jayaram, David A. Cooney

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 590 KB

english, 1982

53

The conversion of 2-β-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties

David A. Cooney, Hiremagalur N. Jayaram, Gulilat Gebeyehu, Charles R. Betts, James A. Kelley, Victor E. Marquez, David G. Johns

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 360 KB

english, 1982

54

Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-β-d-ribofuranosylthiazole-4-carboxamide NSC 286193)

Hiremagalur N. Jayaram, Robert L. Dion, Robert I. Glazer, David G. Johns, Roland K. Robins, Prem C. Srivastava, David A. Cooney

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 1.04 MB

english, 1982

55

Conversion of 2-β-D-ribofuranosylselenazole-4-carboxamide to an analogue of nad with potent imp dehydrogenase-inhibitory properties

Hiremagalur N. Jayaram, Gurpreet S. Ahluwalia, Robert L. Dion, Gulilat Gebeyehu, Victor E. Marquez, James A. Kelley, Roland K. Robins, David A. Cooney, David G. Johns

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 313 KB

english, 1983

56

Studies on the mechanism of action of 2-β-d-ribofuranosylthiazole-4-carboxamide—V: Factors governing the response of murine tumors to tiazofurin

Gurpreet S. Ahluwalia, Hiremagalur N. Jayaram, Jacqueline P. Plowman, David A. Cooney, David G. Johns

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 1.28 MB

english, 1984

57

Mechanism of resistance to tiazofurin in hepatoma 3924A

Hiremagalur N. Jayaram, Konrad Pillwein, May S. Lui, Mary A. Faderan, George Weber

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 978 KB

english, 1986

58

Studies on the mechanism of action of tiazofurin (2-β-d-ribofuranosylthiazole-4-carboxamide) VI: Biochemical and pharmacological studies on the degradation of thiazole-4-carboxamide adenine dinucleotide (TAD)

Gurpreet S. Ahluwalia, David A. Cooney, Victor E. Marquez, Hiremagalur N. Jayaram, David G. Johns

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 655 KB

english, 1986

59

Selective sensitivity to tiazofurin of human leukemic cells

Hiremagalur N. Jayarama, Konrad Pillwein, Craig R. Nichols, Roland Hoffman, George Weber

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 288 KB

english, 1986

60

Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin

Kamran Gharehbaghi, Ajay Sreenath, Zhang Hao, Kenneth D. Paull, Thomas Szekeres, David A. Cooney, Karsten Krohn, Hiremagalur N. Jayaram

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 639 KB

english, 1994

61

Cytotoxic effects of a doxorubicin-transferrin conjugate in multidrug-resistant KB cells

Monika Fritzer, Thomas Szekeres, Viktoria Szüts, Hiremagalur N. Jarayam, Hans Goldenberg

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 587 KB

english, 1996

62

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase

Suthat Liangpunsakul, Sung-Eun Wou, Kevin D. Wineinger, Yan Zeng, Izabela Cyganek, Hiremagalur N. Jayaram, David W. Crabb

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 429 KB

english, 2009

63

S101 – Mometasone Reduces Congestion in Acoustic Rhinometry Study

Anne Marie Frances Salapatek, Piyush Patel, Deepen Patel, Gokul Hiremagalur Gopalan, Santosh Thomas Varghese

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2008

Language:

english

File:

PDF, 36 KB

english, 2008

64

Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells

Weining Zhen, Hiremagalur N. Jayaram, Victor E. Marquez, Barry M. Goldstein, David A. Cooney, George Weber

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 309 KB

english, 1991

65

Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells

Hiremagalur N. Jayaram, Kamran Gharehbaghi, Nagesh H. Jayaram, Jason Rieser, Karsten Krohn, Kenneth D. Paull

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 352 KB

english, 1992

66

Sensitizing human colon carcinoma HT-29 cells to cisplatin by cyclopentenylcytosine, in vitro and in vivo

Kamran Gharehbaghi, Thomas Szekeres, Joel A. Yalowitz, Monika Fritzer-Szekeres, Yves G. Pommier, Hiremagalur N. Jayaram

Journal:

Year:

2000

Language:

english

File:

PDF, 115 KB

english, 2000

67

Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver

Alexandra Salamon, Birgit Hagenauer, Therese Thalhammer, Thomas Szekeres, Karsten Krohn, Hiremagalur N. Jayaram, Walter Jäger

Journal:

Year:

2001

Language:

english

File:

PDF, 237 KB

english, 2001

68

Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo

Kamran Gharehbaghi, Weining Zhen, Monika Fritzer-Szekeres, Thomas Szekeres, Hiremagalur N. Jayaram

Journal:

Year:

1998

Language:

english

File:

PDF, 697 KB

english, 1998

69

Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines

Joel A Yalowitz, Krzysztof Pankiewicz, Steven E Patterson, Hiremagalur N Jayaram

Journal:

Year:

2002

Language:

english

File:

PDF, 128 KB

english, 2002

70

Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin

George Weber, May S. Lui, Hiremagalur N. Jayaram, Konrad Pillwein, Yutaka Natsumeda, Mary A. Faderan, Melissa A. Reardon

Journal:

Advances in Enzyme Regulation

Year:

1985

Language:

english

File:

PDF, 865 KB

english, 1985

71

Metabolites of alanosine, an antitumor antibiotic

Hiremagalur N. Jayaram, Anil K. Tyagi, Spurgeon Anandaraj, John A. Montgomery, James A. Kelley, Janice Kelley, Richard H. Adamson, David A. Cooney

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 1.77 MB

english, 1979

72

Effects of acivicin and pala, singly and in combination, on de novo pyrimidine biosynthesis

Thomas W. Kensler, Hiremagalur N. Jayaram, David A. Cooney

Journal:

Advances in Enzyme Regulation

Year:

1982

Language:

english

File:

PDF, 711 KB

english, 1982

73

Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity

David A. Cooney, Hiremagalur N. Jayaram, Robert I. Glazer, James A. Kelley, Victor E. Marquez, Gulilat Gebeyehu, Anne C. Van Cott, Leonard A. Zwelling, David G. Johns

Journal:

Advances in Enzyme Regulation

Year:

1983

Language:

english

File:

PDF, 1.42 MB

english, 1983

74

Biochemical mechanisms of resistance to tiazofurin

Hiremagalur N. Jayaram

Journal:

Advances in Enzyme Regulation

Year:

1985

Language:

english

File:

PDF, 1020 KB

english, 1985

75

Salvage pathways as targets of chemotherapy

George Weber, Hiremagalur N. Jayaram, Konrad Pillwein, Yutaka Natsumeda, Melissa A. Reardon, Yong-Su Zhen

Journal:

Advances in Enzyme Regulation

Year:

1987

Language:

english

File:

PDF, 857 KB

english, 1987

76

Tiazofurin action in leukemia: Evidence for down-regulation of oncogenes and synergism with retinoic acid

George Weber, Yasufumi Yamaji, Masami Nagai, Yutaka Natsumeda, Hiremagalur N. Jayaram, Weining Zhen, Edith Paulik

Journal:

Advances in Enzyme Regulation

Year:

1990

Language:

english

File:

PDF, 508 KB

english, 1990

77

Clinical and molecular impact of inhibition of IMP dehydrogenase activity by tiazofurin

George Weber, Yasafumi Yamaji, Edith Olah, Yutaka Natsumeda, Hiremagalur N. Jayaram, Elizabeth Lapis, Weining Zhen, Noemi Prajda, Ronald Hoffman, Guido J. Tricot

Journal:

Advances in Enzyme Regulation

Year:

1989

Language:

english

File:

PDF, 1.03 MB

english, 1989

78

Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia

George Weber, Hiremagalur N. Jayaram, Elizabeth Lapis, Yutaka Natsumeda, Yasukazu Yamada, Yasufumi Yamaji, Guido J. Tricot, Ronald Hoffman

Journal:

Advances in Enzyme Regulation

Year:

1988

Language:

english

File:

PDF, 1.58 MB

english, 1988

79

Regulation of de novo and salvage pathways in chemotherapy

George Weber, Masami Nagai, Yutaka Natsumeda, Seiichi Ichikawa, Hiroyuki Nakamura, John N. Eble, Hiremagalur N. Jayaram, Weining Zhen, Edith Paulik, Ronald Hoffman, Guido Tricot

Journal:

Advances in Enzyme Regulation

Year:

1991

Language:

english

File:

PDF, 869 KB

english, 1991

80

Two complementary radiometric methods for the measurement of 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide synthetase (SAICAR synthetase)

Anil.K. Tyagi, David A. Cooney, Marianna Bledsoe, Hiremagalur N. Jayaram

Journal:

Journal of Biochemical and Biophysical Methods

Year:

1980

Language:

english

File:

PDF, 716 KB

english, 1980

81

A facile enzymatic technique for the estimation of nanomolar concentrations of N-phosphonacetyl-l-aspartic acid in plasma

Thomas W. Kensler, Hiremagalur N. Jayaram, David A. Cooney

Journal:

Journal of Biochemical and Biophysical Methods

Year:

1980

Language:

english

File:

PDF, 394 KB

english, 1980

82

Ribose-Modified Purine Nucleosides as Ribonucleotide Reductase Inhibitors. Synthesis, Antitumor Activity, and Molecular Modeling of N 6 -Substituted 3′- C -Methyladenosine Derivatives

Cappellacci, Loredana, Franchetti, Palmarisa, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Jayaram, Hiremagalur N., Saiko, Philipp, Graser, Geraldine, Szekeres, Thomas, Grifantini, Mario

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 2.28 MB

english, 2008

83

Potentiation of poststartle activity by conditioned fear: Effects of anxiolytic and anxiogenic drugs

Uba S. Munonyedi, Hiremagalur J. Hrishikeshavan, Ravindranath S. Shanbhogue, Kshama Devi

Journal:

Biological Psychiatry

Year:

1991

Language:

english

File:

PDF, 337 KB

english, 1991

84

Stress elicits trans-synaptic activation of adrenal neuropeptide Y gene expression

Bhargava Hiremagalur, Richard Kvetnansky, Bistra Nankova, Joseph Fleischer, Robert Geertman, Koki Fukuhara, Emil Viskupic, Esther L. Sabban

Journal:

Molecular Brain Research

Year:

1994

Language:

english

File:

PDF, 1.02 MB

english, 1994

85

348 POSTER Molecular pharmacology of benzamide riboside and sodium meta arsenite in chronic myeloid leukemia: a preclinical evaluation

I. Hariharan, T.R. SantoshKumar, R. Hariharan, J.N. Hiremagalur, M.R. Pillai

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

86

Molecular Biology of Stress-Elicited Induction of Catecholamine Biosynthetic Enzymes

ESTHER L. SABBAN, BHARGAVA HIREMAGALUR, BISTRA NANKOVA, RICHARD KVETŇANSKÝ

Journal:

Annals of the New York Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 684 KB

english, 1995

87

Kirk-Othmer Encyclopedia of Chemical Technology || Enzyme Applications, Therapeutic

Jayaram, Hiremagalur N.

Year:

2000

Language:

english

File:

PDF, 148 KB

english, 2000

88

NAD analogs. 1. Synthesis of isosteric analogs of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide

Pankiewicz, Krzysztof W., Zeidler, Joanna, Ciszewski, Lech A., Bell, J. Ellis, Goldstein, Barry M., Jayaram, Hiremagalur N., Watanabe, Kyoichi A.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 593 KB

english, 1993

89

Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogs. Synthesis, structure, and interactions with IMP dehydrogenase

Gebeyehu, Gulilat, Marquez, Victor E., Van Cott, Anne, Cooney, David A., Kelley, James A., Jayaram, Hiremagalur N., Ahluwalia, Gurpreet S., Dion, Robert L., Wilson, Yvonne A., Johns, David G.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 885 KB

english, 1985

90

Dual Inhibitors of Inosine Monophosphate Dehydrogenase and Histone Deacetylases for Cancer Treatment

Chen, Liqiang, Wilson, Daniel, Jayaram, Hiremagalur N., Pankiewicz, Krzysztof W.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

91

Synthesis, Conformational Analysis, and Biological Activity of C -Thioribonucleosides Related to Tiazofurin

Franchetti, Palmarisa, Marchetti, Stefano, Cappellacci, Loredana, Jayaram, Hiremagalur N., Yalowitz, Joel Aaron, Goldstein, Barry M., Barascut, Jean-Louis, Dukhan, David, Imbach, Jean-Louis, Grifantin

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 248 KB

english, 2000

92

Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats: An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers

Ju, Shenghong, McLennan, Gordon, Bennett, Stacy L., Liang, Yun, Bonnac, Laurent, Pankiewicz, Krzysztof W., Jayaram, Hiremagalur N.

Journal:

Journal of Vascular and Interventional Radiology

Year:

2009

Language:

english

File:

PDF, 554 KB

english, 2009

93

Variability of Apoptosis and Response in N1-S1 Rodent Hepatomas to Benzamide Riboside and Correlation to Early Changes in Water Apparent Diffusion Coefficient and Sodium MR Imaging

Faramarzalian, Ali, McLennan, Gordon, Bennett, Stacy L., Babsky, Andriy, Bansal, Navin, Lieber, Michael, Bonnac, Laurent, Pankiewicz, Krystoff, Jayaram, Hiremagalur N.

Journal:

Journal of Vascular and Interventional Radiology

Year:

2013

Language:

english

File:

PDF, 513 KB

english, 2013

94

Behavioral neurobiology of inverse agonist FG 7142 induced anxiety syndrome in rats

Shanbhogue, Ravindranath, Hrishikeshavan, Hiremagalur J., Devi, Kshama, Munonyedi, Sam

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

1990

Language:

english

File:

PDF, 762 KB

english, 1990

95

Guest Editorial: Environmental Health in Developing Countries: An Overview of the Problems and Capacities

Hiremagalur N. B. Gopalan

Journal:

Environmental Health Perspectives

Year:

2003

Language:

english

File:

PDF, 508 KB

english, 2003

96

Isosteric Analogues of Nicotinamide Adenine Dinucleotide Derived from Furanfurin, Thiophenfurin, and Selenophenfurin as Mammalian Inosine Monophosphate Dehydrogenase (Type I and II) Inhibitors

Franchetti, Palmarisa, Cappellacci, Loredana, Perlini, Paolo, Jayaram, Hiremagalur N., Butler, Adrian, Schneider, Bryan P., Collart, Frank R., Huberman, Eliezer, Grifantini, Mario

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 74 KB

english, 1998

97

Antitumor Activity of C -Methyl-β- d -ribofuranosyladenine Nucleoside Ribonucleotide Reductase Inhibitors

Franchetti, Palmarisa, Cappellacci, Loredana, Pasqualini, Michela, Petrelli, Riccardo, Vita, Patrizia, Jayaram, Hiremagalur N., Horvath, Zsuzsanna, Szekeres, Thomas, Grifantini, Mario

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 169 KB

english, 2005

98

Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia 1

Pankiewicz, Krzysztof W., Lesiak-Watanabe, Krystyna B., Watanabe, Kyoichi A., Patterson, Steven E., Jayaram, Hiremagalur N., Yalowitz, Joel A., Miller, Michael D., Seidman, Michael, Majumdar, Alokes,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

99

Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase

Gebeyehu, Gulilat, Marquez, Victor E., Kelley, James A., Cooney, David A., Jayaram, Hiremagalur N., Johns, David G.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 614 KB

english, 1983

100

Furanfurin and Thiophenfurin: Two Novel Tiazofurin Analogs. Synthesis, Structure, Antitumor Activity, and Interactions with Inosine Monophosphate Dehydrogenase

Franchetti, Palmarisa, Cappellacci, Loredana, Grifantini, Mario, Barzi, Anna, Nocentini, Giuseppe, Yang, Hongyoan, O'Connor, Ayrn, Jayaram, Hiremagalur N., Carrell, Christopher, Goldstein, Barry M.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.79 MB

english, 1995