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51

Molecular docking study and development of an empirical binding free energy model for phosphodiesterase 4 inhibitors

Fernanda G. Oliveira, Carlos M.R. Sant’Anna, Ernesto R. Caffarena, Laurent E. Dardenne, Eliezer J. Barreiro

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 315 KB

english, 2006

52

Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators

Carolina Martins Avila, Nelilma Correia Romeiro, Gilberto M. Sperandio da Silva, Carlos M.R. Sant’Anna, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 540 KB

english, 2006

53

Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties

Heleno J.C. Bezerra-Netto, Daniel I. Lacerda, Ana Luisa P. Miranda, Hélio M. Alves, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 477 KB

english, 2006

54

Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes

Renata B. Lacerda, Cleverton K.F. de Lima, Leandro L. da Silva, Nelilma C. Romeiro, Ana Luisa P. Miranda, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 917 KB

english, 2009

55

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates

Nelilma C. Romeiro, Gabriela Aguirre, Paola Hernández, Mercedes González, Hugo Cerecetto, Ignacio Aldana, Silvia Pérez-Silanes, Antonio Monge, Eliezer J. Barreiro, Lídia M. Lima

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 608 KB

english, 2009

56

Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates

Jorge L.M. Tributino, Carolina D. Duarte, Rodrigo S. Corrêa, Antonio C. Doriguetto, Javier Ellena, Nelilma C. Romeiro, Newton G. Castro, Ana Luisa P. Miranda, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 529 KB

english, 2009

57

Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: Discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole

Rodolfo C. Maia, Leandro L. Silva, Eduardo F. Mazzeu, Milla M. Fumian, Claudia M. de Rezende, Antonio C. Doriguetto, Rodrigo S. Corrêa, Ana Luisa P. Miranda, Eliezer J. Barreiro, Carlos Alberto Mansso

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 574 KB

english, 2009

58

Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide

Alexandre Légora Machado, Lı́dia Moreira Lima, João Xavier Araújo-Jr, Carlos Alberto M. Fraga, Vera Lúcia Gonçalves Koatz, Eliezer J. Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 156 KB

english, 2005

59

Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)

Arthur E. Kümmerle, Marina M. Vieira, Martine Schmitt, Ana L.P. Miranda, Carlos A.M. Fraga, Jean-Jacques Bourguignon, Eliezer J. Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 444 KB

english, 2009

60

Structural insights into IKKβ inhibition by natural products staurosporine and quercetin

Carolina M. Avila, Nelilma C. Romeiro, Carlos M.R. Sant’Anna, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 699 KB

english, 2009

61

Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives

Nailton M. Nascimento-Júnior, Thaiana C.F. Mendes, Daniella M. Leal, Claudia Maria N. Corrêa, Roberto T. Sudo, Gisele Zapata-Sudo, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 373 KB

english, 2010

62

Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294

Emmanuel O. Carneiro, Carolina H. Andrade, Rodolpho C. Braga, Andréa C.B. Tôrres, Rosângela O. Alves, Luciano M. Lião, Carlos A.M. Fraga, Eliezer J. Barreiro, Valéria de Oliveira

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 323 KB

english, 2010

63

New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies

Gabriela Aguirre, Mariana Boiani, Eliana Cabrera, Hugo Cerecetto, Rossanna Di Maio, Mercedes González, Ana Denicola, Carlos Mauricio R. Sant’Anna, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 449 KB

english, 2006

64

Synthesis and anti-platelet activity of novel arylsulfonate–acylhydrazone derivatives, designed as antithrombotic candidates

Lídia M. Lima, Flávia S. Frattani, Jean L. dos Santos, Helena C. Castro, Carlos Alberto M. Fraga, Russolina B. Zingali, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 420 KB

english, 2008

65

NSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARγ)

Nelilma C. Romeiro, Carlos M.R. Sant'Anna, Lidia M. Lima, Carlos A.M. Fraga, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.04 MB

english, 2008

66

Synthesis, pharmacological evaluation and docking studies of new sulindac analogues

Nelilma C. Romeiro, Ramon D.F. Leite, Lidia M. Lima, Suzana V.S. Cardozo, Ana L.P. de Miranda, Carlos A.M. Fraga, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

67

CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes

Aline Guerra M. Fraga, Leandro Louback da Silva, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 652 KB

english, 2011

68

Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β

Carolina M. Avila, Alexandra B. Lopes, Arlan S. Gonçalves, Leandro L. da Silva, Nelilma C. Romeiro, Ana Luisa P. Miranda, Carlos M.R. Sant’Anna, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

69

Characterization of the conformational ensemble from bioactive N-acylhydrazone derivatives

Laercio Pol-Fachin, Carlos Alberto Massour Fraga, Eliezer J. Barreiro, Hugo Verli

Journal:

Journal of Molecular Graphics and Modelling

Year:

2010

Language:

english

File:

PDF, 668 KB

english, 2010

70

Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC–MS/MS: Application for a pharmacokinetic study

Rodolpho C. Braga, Andréa C.B. Tôrres, Camille B. Persiano, Rosângela O. Alves, Carlos A.M. Fraga, Eliezer J. Barreiro, Valéria de Oliveira

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 586 KB

english, 2011

71

Binuclear zinc(II) complexes with the anti-inflammatory compounds salicylaldehyde semicarbazone and salicylaldehyde-4-chlorobenzoyl hydrazone (H2LASSBio-1064)

Gabrieli L. Parrilha, Rafael P. Vieira, Anayive P. Rebolledo, Isolda C. Mendes, Lidia M. Lima, Eliezer J. Barreiro, Oscar E. Piro, Eduardo E. Castellano, Heloisa Beraldo

Journal:

Year:

2011

Language:

english

File:

PDF, 615 KB

english, 2011

72

Synthesis of Functionalized γ-Spirolactone and 2-Oxabicyclo[3.3.0]octane Derivatives from Nucleophilic Oxirane Ring Opening

Margareth Rôse de L. Santos, Eliezer J. Barreiro, Raimundo Braz-Filho, Carlos Alberto M. Fraga

Journal:

Year:

2000

Language:

english

File:

PDF, 155 KB

english, 2000

73

Synthesis of new allenic prostanoids

Paul Baret, Eliezer Barreiro, Andrew E. Greene, Jean-Louis Luché, Marco-Antonio Teixeira, Pierre Crabbe

Journal:

Year:

1979

Language:

english

File:

PDF, 876 KB

english, 1979

74

Highly diastereoselective mercury-mediated synthesis of functionalized 2-azabicyclo[3.3.0]octane derivatives

Emerson P Peçanha, Hugo Verli, Carlos R Rodrigues, Eliezer J Barreiro, Carlos A.M Fraga

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 353 KB

english, 2002

75

Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole.

Patrícia C. Lima, Lídia M. Lima, Kelli Cristine M. da Silva, Paulo Henrique O. Léda, Ana Luisa P. de Miranda, Carlos A.M. Fraga, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 241 KB

english, 2000

76

Local intersection volume: a new 3D descriptor applied to develop a 3D-QSAR pharmacophore model for benzodiazepine receptor ligands

Hugo Verli, Magaly Girão Albuquerque, Ricardo Bicca de Alencastro, Eliezer J Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 310 KB

english, 2002

77

Synthesis and antinociceptive properties of new structurally planned imidazo[1,2-a]pyridine 3-acylarylhydrazone derivatives

Izabella G. Ribeiro, Kelly Christine M. da Silva, Sergio C. Parrini, Ana Luisa P. de Miranda, Carlos A.M. Fraga, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 793 KB

english, 1998

78

Synthesis and evaluation of analgesic, antiinflammatory and antiplatelet properties of new 2-pyridylarylhydrazone derivatives

Adriane R. Todeschini, Ana Luisa P. de Miranda, Kelly Christine M. da Silva, Sergio C. Parrini, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 883 KB

english, 1998

79

Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents

Carla R Cardoso, Fernanda C.F de Brito, Kelli C.M da Silva, Ana L.P de Miranda, Carlos A.M Fraga, Eliezer J Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 136 KB

english, 2002

80

Novel phthalimide derivatives, designed as leukotriene D4 receptor antagonists

Lı́dia M. Lima, Fernanda C.F. de Brito, Simone D. de Souza, Ana L.P. Miranda, Carlos R. Rodrigues, Carlos A.M. Fraga, Eliezer J. Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 145 KB

english, 2002

81

Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole

Adriana S. Lages, Kelli C.M. Silva, Ana L.P. Miranda, Carlos A.M. Fraga, Eliezer J. Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 465 KB

english, 1998

82

Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylhydrazone Derivatives

Juliana M Figueiredo, Celso de A Câmara, Emanuel G Amarante, Ana Luisa P Miranda, Fúlvia M Santos, Carlos R Rodrigues, Carlos Alberto M Fraga, Eliezer J Barreiro

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 176 KB

english, 2000

83

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

Ricardo Menegatti, Anna C Cunha, Vı́tor F Ferreira, Edna F.R Perreira, Ahmed El-Nabawi, Amira T Eldefrawi, Edson X Albuquerque, Gilda Neves, Stela M.K Rates, Carlos A.M Fraga, Eliezer J Barreiro

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 297 KB

english, 2003

84

Design of new potential 5-lipoxygenase inhibitors, dual thromboxane synthase inhibitors, and thromboxane a2 receptor antagonists by AM1

Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Ricardo Bicca De Alencastro, Eliezer J. Barreiro

Journal:

International Journal of Quantum Chemistry

Year:

1995

Language:

english

File:

PDF, 758 KB

english, 1995

85

Crystal structure of pyrazole derivatives. IV. 5-chloro-4-chlorosulfonyl-3-methyl-1-phenylpyrazole

J. Zukerman-Schpector, I. Caracelli, Eliezer J. Barreiro, Antonio C. C. Freitas

Journal:

Journal of Chemical Crystallography

Year:

1996

Language:

english

File:

PDF, 296 KB

english, 1996

86

Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors

Gilda Neves, Ricardo Menegatti, Camila B. Antonio, Luiza R. Grazziottin, Renan O. Vieira, Stela M.K. Rates, François Noël, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 483 KB

english, 2010

87

The molecular basis for coxib inhibition of p38α MAP kinase

Gilberto M. Sperandio da Silva, Lidia M. Lima, Carlos A.M. Fraga, Carlos M.R. Sant’Anna, Eliezer J. Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 360 KB

english, 2005

88

2-Acetylpyridine thiosemicarbazones: Cytotoxic activity in nanomolar doses against malignant gliomas

Josane A. Lessa, Isolda C. Mendes, Paulo R.O. da Silva, Marcella A. Soares, Raquel G. dos Santos, Nivaldo L. Speziali, Nelilma C. Romeiro, Eliezer J. Barreiro, Heloisa Beraldo

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 602 KB

english, 2010

89

Studies on diastereoselective reduction of cyclic β-ketoesters with boron hydrides. Part 4: The reductive profile of functionalized cyclohexanone derivatives

Carlos A.M Fraga, Lis Helena P Teixeira, Carla Maria de S Menezes, Carlos Mauricio R Sant'Anna, Maria da Conceição K.V Ramos, Francisco R.de Aquino Neto, Eliezer J Barreiro

Journal:

Year:

2004

Language:

english

File:

PDF, 613 KB

english, 2004

90

Chiral separation of γ-butyrolactone derivatives by gas chromatography on 2,3-di-O-methyl-6-O-tert.-butyldimethylsilyl-β-cyclodextrin

Maria da Conceição K.V. Ramos, Lis H.P Teixeira, Francisco R de Aquino Neto, Eliezer J Barreiro, Carlos R Rodrigues, Carlos A.M Fraga

Journal:

Journal of Chromatography A

Year:

2003

Language:

english

File:

PDF, 654 KB

english, 2003

91

Tetracyclic triterpenes of Barbacenia bicolor

Paul M. Baker, Eliezer J.L. Barreiro, Benjamin Gilbert

Journal:

Year:

1976

Language:

english

File:

PDF, 305 KB

english, 1976

92

Hydrolysis of new phthalimide-derived esters catalyzed by immobilized lipase

Juliana Vaz Bevilaqua, Lidia M. Lima, Aline Gomes Cunha, Eliezer J. Barreiro, Tito L. M. Alves, Lucia Moreira Campos Paiva, Denise M.Guimarães Freire

Journal:

Applied Biochemistry and Biotechnology

Year:

2005

Language:

english

File:

PDF, 278 KB

english, 2005

93

Anti-inflammatory Profile of N-Phenylpyrazole Arylhydrazone Derivatives in Rats

CHRISTINA BARJA-FIDALGO, IOLANDDA MARGHERITA FIERRO, ALINE C. BRANDO LIMA, EMERSON TEIXEIRA DA SILVA, CELSO DE AMORIM CÂMARA, ELIEZER J. BARREIRO

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 80 KB

english, 1999

94

Synthesis and Antinociceptive Profile of Novel Acidic Sulphonylhydrazone Derivatives From Natural Safrole

LÍDIA M. LIMA, EMANUEL G. AMARANTE, ANA L. P. MIRANDA, CARLOS A. M. FRAGA, ELIEZER J. BARREIRO

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 1.19 MB

english, 1999

95

Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype

Daniela J. Conrado, Hugo Verli, Gilda Neves, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro, Stela Maris Kuze Rates, Teresa Dalla Costa

Journal:

Journal of Pharmacy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 452 KB

english, 2008

96

The Methylation Effect in Medicinal Chemistry

Barreiro, Eliezer J., Kümmerle, Arthur E., Fraga, Carlos A. M.

Journal:

Chemical Reviews

Year:

2011

Language:

english

File:

PDF, 2.31 MB

english, 2011

97

Further Bioactive Piperidine Alkaloids from the Flowers and Green Fruits of Cassia spectabilis

Viegas,, Claudio, da S. Bolzani, Vanderlan, Furlan, Maysa, Barreiro, Eliezer J., Young, Maria Claudia M., Tomazela, Daniela, Eberlin, Marcos N.

Journal:

Journal of Natural Products

Year:

2004

Language:

english

File:

PDF, 43 KB

english, 2004

98

Synthesis and characterization of the atropisomeric relationships of a substituted N-phenyl-bipyrazole derivative with anti-inflammatory properties

Marcia P. Veloso, Nelilma C. Romeiro, Gilberto M. S. Silva, Hélio De M. Alves, Antonio C. Doriguetto, Javier Ellena, Ana L. P. Miranda, Eliezer J. Barreiro, Carlos A. M. Fraga

Journal:

Year:

2012

Language:

english

File:

PDF, 351 KB

english, 2012

99

The synthesis of a new 8-azaprostanoid

Francisco C. Biaggio, Eliezer J. Barreiro

Journal:

Journal of Heterocyclic Chemistry

Year:

1989

File:

PDF, 298 KB

1989

100

Synthesis of pyrazole derivatives as potential bioisosteres of thromboxane-synthetase inhibitors

Eliezer J. Barreiro, Antonio C. C. Freitas

Journal:

Journal of Heterocyclic Chemistry

Year:

1992

File:

PDF, 345 KB

1992