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1

P-type ATPases as drug targets: Tools for medicine and science

Laure Yatime, Morten J. Buch-Pedersen, Maria Musgaard, J. Preben Morth, Anne-Marie Lund Winther, Bjørn P. Pedersen, Claus Olesen, Jens Peter Andersen, Bente Vilsen, Birgit Schiøtt, Michael G. Palmgren

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2009

Language:

english

File:

PDF, 1.92 MB

english, 2009

2

Use of a small TSK GSW high-performance liquid chromatographic column for large-zone chromatographic studies of monomer—oligomer equilibria of membrane protein

Bente Vilsen, Jens P. Andersen

Journal:

Journal of Chromatography A

Year:

1988

Language:

english

File:

PDF, 596 KB

english, 1988

3

Localization of E1–E2conformational transitions of sarcoplasmic reticulum Ca-ATPase by tryptic cleavage and hydrophobic labeling

Jens P. Andersen, Bente Vilsen, John H. Collins, Peter L. Jørgensen

Journal:

Journal of Membrane Biology

Year:

1986

Language:

english

File:

PDF, 1.04 MB

english, 1986

4

Roles of transmembrane segment M1 of Na+,K+-ATPase and Ca2+-ATPase, the gatekeeper and the pivot

Anja Pernille Einholm, Jens Peter Andersen, Bente Vilsen

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2007

Language:

english

File:

PDF, 482 KB

english, 2007

5

Site-Directed Mutagenesis Analysis of the Role of the M5S5 Sector of the Sarcoplasmic Reticulum Ca2+-ATPase

JENS PETER ANDERSEN, THOMAS SØRENSEN, BENTE VILSEN

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 256 KB

english, 1997

6

Functional Consequences of Mutations in the Transmembrane Core Region for Cation Translocation and Energy Transduction in the Na+, K+-ATPase and the SR Ca2+-ATPase

BENTE VILSEN, DORTE RAMLOV, JENS PETER ANDERSEN

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 697 KB

english, 1997

7

Importance of Transmembrane Segment M3 of Na+,K+-ATPase for Control of Conformational Changes and the Cytoplasmic Entry Pathway for Na+

BENTE VILSEN, MADS TOUSTRUP-JENSEN

Journal:

Annals of the New York Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 2.20 MB

english, 2003

8

Mutagenesis of Residues Involved in Control of the Ca2+ Entry Pathway and Conformational Changes Associated with Ca2+ Binding in the SR Ca2+-ATPase

JENS PETER ANDERSEN, JOHANNES D. CLAUSEN, ANJA PERNILLE EINHOLM, BENTE VILSEN

Journal:

Annals of the New York Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 4.79 MB

english, 2003

9

Functional Consequences of Charge Reversals of Acidic Residues in M1 of the SR Ca-ATPase

ANJA PERNILLE EINHOLM, BENTE VILSEN, JENS PETER ANDERSEN

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 648 KB

2003

10

Importance of Thr214 in the Conserved TGES Sequence of the Na+,K+-ATPase for Vanadate Binding and Hydrolysis of E2P

MADS TOUSTRUP-JENSEN, BENTE VILSEN

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 1.18 MB

2003

11

Crystal structure of the sodium–potassium pump

Morth, J. Preben, Pedersen, Bjørn P., Toustrup-Jensen, Mads S., Sørensen, Thomas L.-M., Petersen, Janne, Andersen, Jens Peter, Vilsen, Bente, Nissen, Poul

Journal:

Year:

2007

Language:

english

File:

PDF, 1.65 MB

english, 2007

12

A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps

Morth, J. Preben, Pedersen, Bjørn P., Buch-Pedersen, Morten J., Andersen, Jens Peter, Vilsen, Bente, Palmgren, Michael G., Nissen, Poul

Journal:

Nature Reviews Molecular Cell Biology

Year:

2011

Language:

english

File:

PDF, 938 KB

english, 2011

13

Mutagenesis of Sarcoplasmic Reticulum Ca2+-ATPase

Jens Peter Andersen, Bente Vilsen

Journal:

Trends in Cardiovascular Medicine

Year:

1998

Language:

english

File:

PDF, 957 KB

english, 1998

14

Effect of phospholipid, detergent and protein-protein interaction on stability and phosphoenzyme isomerization of soluble sarcoplasmic reticulum Ca-ATPase

Bente VILSEN, Jens P. ANDERSEN

Journal:

Year:

1987

Language:

english

File:

PDF, 1020 KB

english, 1987

15

Occlusion of Ca2+ in soluble monomeric sarcoplasmic reticulum Ca2+-ATPase

Bente Vilsen, Jens P. Andersen

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1986

Language:

english

File:

PDF, 222 KB

english, 1986

16

Characterization of CrATP-induced calcium occlusion in membrane-bound and soluble monomeric sarcoplasmic reticulum Ca2+-ATPase

Bente Vilsen, Jens P. Andersen

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1987

Language:

english

File:

PDF, 803 KB

english, 1987

17

Reaction of phenylhydrazine with erythrocytes: Cross-linking of spectrin by disulfide exchange with oxidized hemoglobin

Bente Vilsen, Henning Nielsen

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 1.64 MB

english, 1984

18

Equilibrium between monomers and oligomers of soluble Ca2+-ATPase during the functional cycle

Jens P. Andersen, Bente Vilsen

Journal:

Year:

1985

Language:

english

File:

PDF, 543 KB

english, 1985

19

Radiation inactivation analysis of sarcoplasmic reticulum Ca-ATPase in membrane-bound form and in detergent-solubilized monomeric states

Jens P. Andersen, Bente Vilsen

Journal:

Year:

1988

Language:

english

File:

PDF, 634 KB

english, 1988

20

Mutational analysis of the role of Glu309 in the sarcoplasmic reticulum Ca2+-ATPase of frog skeletal muscle

Bente Vilsen, Jens Peter Andersen

Journal:

Year:

1992

Language:

english

File:

PDF, 448 KB

english, 1992

21

Deduced amino acid sequence and E1–E2 equilibrium of the sarcoplasmic reticulum Ca2+-ATPase of frog skeletal muscle Comparison with the Ca2+-ATPase of rabbit fast twitch muscle

Bente Vilsen, Jens Peter Andersen

Journal:

Year:

1992

Language:

english

File:

PDF, 727 KB

english, 1992

22

Functional consequences of alterations to Pro328 and Leu332 located in the 4th transmembrane segment of the α-subunit of the rat kidney Na+,K+-ATPase

Journal:

Year:

1992

Language:

english

File:

PDF, 876 KB

english, 1992

23

A Glu329→ Gln variant of the α-subunit of the rat kidney Na+K+-ATPase can sustain active transport of Na+ and K+ and Na+K+-activated ATP hydrolysis with normal turnover number

Journal:

Year:

1993

Language:

english

File:

PDF, 1.02 MB

english, 1993

24

Chimeric Ca2+-ATPase/Na+,K+-ATPase molecules: Their phosphoenzyme intermediates and sensitivity to Ca2+ and thapsigargin

Anders Nørregaard, Bente Vilsen, Jens Peter Andersen

Journal:

Year:

1993

Language:

english

File:

PDF, 950 KB

english, 1993

25

Structure-function relationships of cation translocation by Ca2+- and Na+,K+-ATPases studied by site-directed mutagenesis

Jens Peter Anderssen, Bente Vilsen

Journal:

Year:

1995

Language:

english

File:

PDF, 600 KB

english, 1995

26

Functional consequences of mutation Asn326→Leu in the 4th transmembrane segment of the a-subunit of the rat kidney Na+,K+-ATPase

Journal:

Year:

1995

Language:

english

File:

PDF, 711 KB

english, 1995

27

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

Kanai, Ryuta, Ogawa, Haruo, Vilsen, Bente, Cornelius, Flemming, Toyoshima, Chikashi

Journal:

Year:

2013

Language:

english

File:

PDF, 4.27 MB

english, 2013

28

Leucine 332 at the Boundary Between the Fourth Transmembrane Segment and the Cytoplasmic Domain of Na + ,K + -ATPase Plays a Pivotal Role in the Ion Translocating Conformational Changes †

Journal:

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

29

Functional consequences of substitution of the seven-residue segment LysIleArgAspGlnMetAla240 located in the stalk helix S3 of the calcium-ATPase of sarcoplasmic reticulum

Andersen, Jens Peter, Vilsen, Bente

Journal:

Year:

1993

Language:

english

File:

PDF, 1.77 MB

english, 1993

30

Mutant Glu781 .fwdarw. Ala of the rat kidney Na+,K+-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions

Journal:

Year:

1995

Language:

english

File:

PDF, 2.00 MB

english, 1995

31

Characterization of detergent-solubilized sarcoplasmic reticulum calcium ATPase by high-performance liquid chromatography

Andersen, Jens P., Vilsen, Bente, Nielsen, Henning, Moeller, Jesper V.

Journal:

Year:

1986

Language:

english

File:

PDF, 1.13 MB

english, 1986

32

Mutational Effects on Conformational Changes of the Dephospho- and Phospho-forms of the Na + ,K + -ATPase †

Toustrup-Jensen, Mads, Hauge, Majbritt, Vilsen, Bente

Journal:

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

33

Glutamate 329 located in the fourth transmembrane segment of the .alpha.-subunit of the rat kidney sodium-potassium-ATPase is not an essential residue for active transport of sodium and potassium ions

Journal:

Year:

1993

Language:

english

File:

PDF, 2.37 MB

english, 1993

34

Mutant Phe788 → Leu of the Na + ,K + -ATPase Is Inhibited by Micromolar Concentrations of Potassium and Exhibits High Na + -ATPase Activity at Low Sodium Concentrations †

Journal:

Year:

1999

Language:

english

File:

PDF, 166 KB

english, 1999

35

Mutation to the Glutamate in the Fourth Membrane Segment of Na + ,K + -ATPase and Ca 2+ -ATPase Affects Cation Binding from Both Sides of the Membrane and Destabilizes the Occluded Enzyme Forms †

Vilsen, Bente, Andersen, Jens Peter

Journal:

Year:

1998

Language:

english

File:

PDF, 154 KB

english, 1998

36

Functional Consequences of Alterations to Ile 279 , Ile 283 , Glu 284 , His 285 , Phe 286 , and His 288 in the NH 2 -terminal Part of Transmembrane Helix M3 of the Na + ,K + -ATPase

Toustrup-Jensen, Mads, Vilsen, Bente

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 1.08 MB

english, 2003

37

Importance of Leu 99 in Transmembrane Segment M1 of the Na + ,K + -ATPase in the Binding and Occlusion of K +

Einholm, Anja Pernille, Andersen, Jens Peter, Vilsen, Bente

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

38

Dissection of the Functional Differences between Sarco(endo)plasmic Reticulum Ca 2+ -ATPase (SERCA) 1 and 2 Isoforms and Characterization of Darier Disease (SERCA2) Mutants by Steady-state and Transient Kinetic Analyses

Dode, Leonard, Andersen, Jens Peter, Leslie, Natalie, Dhitavat, Jittima, Vilsen, Bente, Hovnanian, Alain

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 1.14 MB

english, 2003

39

Rescue of Na + Affinity in Aspartate 928 Mutants of Na + ,K + -ATPase by Secondary Mutation of Glutamate 314

Holm, Rikke, Einholm, Anja P., Andersen, Jens P., Vilsen, Bente

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.61 MB

english, 2015

40

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na⁺ , K⁺ -ATPase α3 sodium pump

Greer S. Kirshenbaum, Steven J. Clapcote, Steven Duffy, Christian R. Burgess, Janne Petersen, Karolina J. Jarowek, Yeni H. Yücel, Miguel A. Cortez, O. Carter Snead III, Bente Vilsen, John H. Peever, M

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.31 MB

english, 2011

41

Importance of a Potential Protein Kinase A Phosphorylation Site of Na + ,K + -ATPase and Its Interaction Network for Na + Binding

Einholm, Anja P., Nielsen, Hang N., Holm, Rikke, Toustrup-Jensen, Mads S., Vilsen, Bente

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 4.35 MB

english, 2016

42

X-Ray Crystallographic Study of Na,K-ATPase in Complex with Cardiotonic Steroids

Ogawa, Haruo, Motoyama, Kanna, Cornelius, Flemming, Vilsen, Bente, Toyoshima, Chikashi

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 44 KB

english, 2015

43

Rescue of Na+ Affinity in Aspartate-928 Mutants of Na+, K+-ATPase by Secondary Mutation of Glutamate-314

Holm, Rikke, Einholm, Anja P., Andersen, Jens P., Artigas, Pablo, Vilsen, Bente

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 42 KB

english, 2016

44

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

Vestergaard, Anna L., Mikkelsen, Stine A., Coleman, Jonathan A., Molday, Robert S., Vilsen, Bente, Andersen, Jens Peter

Journal:

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

45

Glutamate transporter activity promotes enhanced Na + /K + -ATPase-mediated extracellular K + management during neuronal activity

Larsen, Brian Roland, Holm, Rikke, Vilsen, Bente, MacAulay, Nanna

Journal:

The Journal of Physiology

Year:

2016

Language:

english

File:

PDF, 787 KB

english, 2016

46

Membrane Transport in Flux: The Ambiguous Interface between Channels and Pumps || The Structure of the Na⁺,K⁺-ATPase and Mapping of Isoform Differences and Disease-Related Mutations

J. Preben Morth, Hanne Poulsen, Mads S. Toustrup-Jensen, Vivien Rodacker Schack, Jan Egebjerg, Jens Peter Andersen, Bente Vilsen and Poul Nissen

Journal:

Philosophical Transactions Biological Sciences

Year:

2009

Language:

english

File:

PDF, 3.09 MB

english, 2009

47

Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function

Holm, Rikke, Toustrup-Jensen, Mads S., Einholm, Anja P., Schack, Vivien R., Andersen, Jens P., Vilsen, Bente

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2016

Language:

english

File:

PDF, 3.28 MB

english, 2016

48

Arginine substitution of a cysteine in transmembrane helix M8 converts Na + ,K + -ATPase to an electroneutral pump similar to H + ,K + -ATPase

Holm, Rikke, Khandelwal, Jaanki, Einholm, Anja P., Andersen, Jens P., Artigas, Pablo, Vilsen, Bente

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

49

The α2β2 isoform combination dominates the astrocytic Na + /K + -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

Stoica, Anca, Larsen, Brian Roland, Assentoft, Mette, Holm, Rikke, Holt, Leanne Melissa, Vilhardt, Frederik, Vilsen, Bente, Lykke-Hartmann, Karin, Olsen, Michelle Lynne, MacAulay, Nanna

Journal:

Year:

2017

Language:

english

File:

PDF, 2.23 MB

english, 2017

50

Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates

Gantzel, Rasmus H., Mogensen, Louise S., Mikkelsen, Stine A., Vilsen, Bente, Molday, Robert S., Vestergaard, Anna L., Andersen, Jens P.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 4.97 MB

english, 2017

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