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51

Spectrum of p53 mutations in low-grade B-cell malignancies

Bromidge, T, Johnson, S, Howe, D

Journal:

Year:

2007

Language:

english

File:

PDF, 88 KB

english, 2007

52

Expression of ZAP-70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease: response to Smolej et al.

G. Gibbs, T. Bromidge, D. Howe, S. Johnson

Journal:

International Journal of Laboratory Hematology (Blackwell)

Year:

2008

Language:

english

File:

PDF, 34 KB

english, 2008

53

A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Lovell, Peter J., Bromidge, Steven M., Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T., Jennings, Andrew J., King, Frank D., Middlemiss, Derek N., Rahman, Shirley K., Saunders, Damian V.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 145 KB

english, 2000

54

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels

Collins, Ian, Moyes, Christopher, Davey, William B., Rowley, Michael, Bromidge, Frances A., Quirk, Kathleen, Atack, John R., McKernan, Ruth M., Thompson, Sally-Ann, Wafford, Keith

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 169 KB

english, 2002

55

Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045)

Bromidge, Steven M., Arban, Roberto, Bertani, Barbara, Bison, Silvia, Borriello, Manuela, Cavanni, Paolo, Dal Forno, Giovanna, Di-Fabio, Romano, Donati, Daniele, Fontana, Stefano

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

56

Identification of novel NK1/NK3 dual antagonists for the potential treatment of schizophrenia

Maria Pia Catalani, Giuseppe Alvaro, Giovanni Bernasconi, Ezio Bettini, Steven M. Bromidge, Jag Heer, Giovanna Tedesco, Simona Tommasi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 662 KB

english, 2011

57

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue

Claire Scott, Ellen M. Soffin, Matthew Hill, Peter J. Atkinson, Christopher J. Langmead, Paul B. Wren, Stefania Faedo, Laurie J. Gordon, Gary W. Price, Steve Bromidge, Christopher N. Johnson, James J.

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 520 KB

english, 2006

58

SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models

Warren D. Hirst, Tania O. Stean, Derek C. Rogers, David Sunter, Pippa Pugh, Stephen F. Moss, Steven M. Bromidge, Graham Riley, Douglas R. Smith, Sarah Bartlett, Christian A. Heidbreder, Alan R. Atkins

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 402 KB

english, 2006

59

Effects of RO 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety

Guy Kennett, Sean Lightowler, Brenda Trail, Fiona Bright, Steven Bromidge

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 244 KB

english, 2000

60

Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist

Tania O Stean, Warren D Hirst, David R Thomas, Gary W Price, Derek Rogers, Graham Riley, Steven M Bromidge, Halina T Serafinowska, Douglas R Smith, Sarah Bartlett, Nigel Deeks, Mark Duxon, Neil Upton

Journal:

Pharmacology Biochemistry and Behavior

Year:

2002

Language:

english

File:

PDF, 221 KB

english, 2002

61

In vitro chemo-sensitivity of B-chronic lymphocytic leukaemia to ara-G

Teresa Bromidge, Rebecca Frewin, Stephen Johnson

Journal:

Leukemia Research

Year:

2000

Language:

english

File:

PDF, 69 KB

english, 2000

62

Characterization of a new IgGλ myeloma plasma cell line (EJM): a further tool in the investigation of the biology of multiple myeloma

M. S. Hamilton, J. Ball, E. Bromidge, J. Lowe, I. M. Franklin

Journal:

British Journal of Haematology

Year:

1990

Language:

english

File:

PDF, 798 KB

english, 1990

63

Surface antigen expression of human neoplastic plasma cells includes molecules associated with lymphocyte recirculation and adhesion

M. S. Hamilton, J. Ball, E. Bromidge, I. M. Franklin

Journal:

British Journal of Haematology

Year:

1991

Language:

english

File:

PDF, 516 KB

english, 1991

64

Absence of the LiTat 1.3 (CATT antigen) gene in Trypanosoma brucei gambiense stocks from Cameroon

P. Dukes, W.C. Gibson, J.K. Gashumba, K.M. Hudson, T.J. Bromidge, A. Kaukus, T. Asonganyi, E. Magnus

Journal:

Year:

1992

Language:

english

File:

PDF, 987 KB

english, 1992

65

Sensitive detection of trypanosomes in tsetse flies by DNA amplification

Daniel K. Masiga, Audra J. Smyth, Paul Hayes, Teresa J. Bromidge, Wendy C. Gibson

Journal:

International Journal for Parasitology

Year:

1992

Language:

english

File:

PDF, 862 KB

english, 1992

66

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety

M.D. Wood, C. Reavill, B. Trail, A. Wilson, T. Stean, G.A. Kennett, S. Lightowler, T.P. Blackburn, D. Thomas, T.L. Gager, G. Riley, V. Holland, S.M. Bromidge, I.T. Forbes, D.N. Middlemiss

Journal:

Neuropharmacology

Year:

2001

Language:

english

File:

PDF, 957 KB

english, 2001

67

GABAA α1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment

D.S. Reynolds, G.F. O’Meara, R.J. Newman, F.A. Bromidge, J.R. Atack, P.J. Whiting, T.W. Rosahl, G.R. Dawson

Journal:

Neuropharmacology

Year:

2003

Language:

english

File:

PDF, 115 KB

english, 2003

68

SB 242084, a Selective and Brain Penetrant 5-HT2C Receptor Antagonist

G.A. KENNETT, M.D. WOOD, F. BRIGHT, B. TRAIL, G. RILEY, V. HOLLAND, K.Y. AVENELL, T. STEAN, N. UPTON, S. BROMIDGE, I.T. FORBES, A.M. BROWN, D.N. MIDDLEMISS, T.P. BLACKBURN

Journal:

Neuropharmacology

Year:

1997

Language:

english

File:

PDF, 2.63 MB

english, 1997

69

Lupus anticoagulant detection: out of control?

G. W. Moore, K. L. Brown, E. S. Bromidge, A. J. Drew, M. R. Ledford-Kraemer

Journal:

International Journal of Laboratory Hematology (Blackwell)

Year:

2012

Language:

english

File:

PDF, 98 KB

english, 2012

70

Novel and Selective 5-HT 2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Bromidge, Steven M., Dabbs, Steven, Davies, David T., Duckworth, D. Malcolm, Forbes, Ian T., Ham, Peter, Jones, Graham E., King, Frank D., Saunders, Damian V., Starr, Susannah, Thewlis, Kevin M., Wyma

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 260 KB

english, 1998

71

Studies on intramolecular cycloadditions involving 3-oxidopyridinium

Bromidge, Steven M., Archer, David A., Sammes, Peter G.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1990

Language:

english

File:

PDF, 898 KB

english, 1990

72

Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT 1A/B/D Receptor Antagonist

Leslie, Colin P., Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M., Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J., Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarl

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 896 KB

english, 2010

73

A Convenient Synthesis of Masked β-Ketoaldehydes by the Controlled Addition of Nucleophiles to (Trimethylsilyl)ethynyl Ketones

Bromidge, S. M., Entwistle, D. A., Goldstein, J., Orlek, B. S.

Journal:

Synthetic Communications

Year:

1993

Language:

english

File:

PDF, 278 KB

english, 1993

74

Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4- a ]phthalazines as GABA A Receptor Agonists at the α 3 Subunit

Russell, Michael G. N., Carling, Robert W., Atack, John R., Bromidge, Frances A., Cook, Susan M., Hunt, Peter, Isted, Catherine, Lucas, Matt, McKernan, Ruth M., Mitchinson, Andrew, Moore, Kevin W., Na

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 345 KB

english, 2005

75

The isolation and genetic heterogeneity of Trypanosoma brucei gambiense from north-west Uganda

J.C.K. Enyaru, R. Allingham, T. Bromidge, G.D. Kanmogne, J.F. Carasco

Journal:

Year:

1993

Language:

english

File:

PDF, 616 KB

english, 1993

76

Synthesis and properties of [R-(Z)]-(+)-?-(1-azabicyclo[2.2.2]oct-3-yl)-?-(methoxyimino)acetonitrile, a novel functionally selective muscarinic partial agonist

Bromidge, Steven M., Cassdiy, Frederick, Clark, Michael S. G., Eggeleston, Drake S., Oriek, Barry S.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1994

Language:

english

File:

PDF, 374 KB

english, 1994

77

Design of [ R -( Z )]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N -Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere

Bromidge, Steven M., Brown, Frank, Cassidy, Frederick, Clark, Michael S. G., Dabbs, Steven, Hadley, Michael S., Hawkins, Julie, Loudon, Julia M., Naylor, Christopher B., Orlek, Barry S., Riley, Graham

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 461 KB

english, 1997

78

Discovery of Imidazo[1,2- b ][1,2,4]triazines as GABA A α2/3 Subtype Selective Agonists for the Treatment of Anxiety

Russell, Michael G. N., Carling, Robert W., Street, Leslie J., Hallett, David J., Goodacre, Simon, Mezzogori, Elena, Reader, Michael, Cook, Susan M., Bromidge, Frances A., Newman, Robert, Smith, Aliso

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 129 KB

english, 2006

79

Biarylcarbamoylindolines Are Novel and Selective 5-HT 2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

Bromidge, Steven M., Dabbs, Steven, Davies, David T., Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T., Gaster, Laramie M., Ham, Peter, Jones, Graham E., King, Frank D., Mulholland, Keith R., S

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 448 KB

english, 2000

80

Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex

Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham

Journal:

Year:

2014

Language:

english

File:

PDF, 1.09 MB

english, 2014

81

6,7-Dihydro-2-benzothiophen-4(5 H )-ones: A Novel Class of GABA-A α5 Receptor Inverse Agonists

Chambers, Mark S., Atack, John R., Bromidge, Frances A., Broughton, Howard B., Cook, Susan, Dawson, Gerard R., Hobbs, Sarah C., Maubach, Karen A., Reeve, Austin J., Seabrook, Guy R., Wafford, Keith, M

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

82

6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

Bromidge, Steven M., Duckworth, Malcolm, Forbes, Ian T., Ham, Peter, King, Frank D., Thewlis, Kevin M., Blaney, Frank E., Naylor, Christopher B., Blackburn, Thomas P., Kennett, Guy A., Wood, Martyn D.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 131 KB

english, 1997

83

5-Chloro- N -(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT 6 Receptor Antagonist

Bromidge, Steven M., Brown, Anthony M., Clarke, Stephen E., Dodgson, Kathy, Gager, Tracey, Grassam, Helen L., Jeffrey, Phil M., Joiner, Graham F., King, Frank D., Middlemiss, Derek N., Moss, Stephen F

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 82 KB

english, 1999

84

Studies on a new route to (�)-copaene and (�)-ylangene

Archer, David A., Bromidge, Steven M., Sammes, Peter G.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1988

Language:

english

File:

PDF, 761 KB

english, 1988

85

Synthesis of 7-Substituted-(2,3-dihydro-1,4-benzodioxin-5-yl)-piperazine

Rancati, Fabio, Bromidge, Steven M., Del Sordo, Simone, La Rosa, Salvatore, Parini, Carlo, Gagliardi, Stefania

Journal:

Synthetic Communications

Year:

2008

Language:

english

File:

PDF, 398 KB

english, 2008

86

Design, synthesis and structure–activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Trani, Giancarlo, Barker, John J., Bromidge, Steven M., Brookfield, Frederick A., Burch, Jason D., Chen, Yuan, Eigenbrot, Charles, Heifetz, Alexander, Ismaili, M. Hicham A., Johnson, Adam, Krülle, Tho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.68 MB

english, 2014

87

Inside Cover: Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex (ChemMedChem 4/2014)

Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham

Journal:

Year:

2014

File:

PDF, 2.50 MB

2014

88

Preparation of 2-Substituted 3-Hydroxypyridines and Direct Conversion of 2-Furyl Ketone into a Perhydroazulene

Bromidge, Steven M., Archer, David A., Sammes, Peter G.

Journal:

Year:

1992

File:

PDF, 227 KB

1992

89

WITHDRAWN: Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists

Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 16 KB

english, 2005

90

ChemInform Abstract: Studies on a New Route to (.+-.)-Copaene and (.+-.)-Ylangene.

ARCHER, D. A., BROMIDGE, S. M., SAMMES, P. G.

Journal:

Year:

1989

File:

PDF, 205 KB

1989

91

Continuous infusion therapy with very high purity von Willebrand factor concentrate in patients with severe von Willebrand disease

Smith, M. P., Rice, K. M., Bromidge, E. S., Lawn, M., Beresford-Webb, R., Spence, K., Khair, K., Hann, I., Savidge, G. F.

Journal:

Blood Coagulation & Fibrinolysis

Year:

1997

File:

PDF, 534 KB

1997

92

ChemInform Abstract: Studies on Intramolecular Cycloadditions Involving 3-Oxidopyridinium.

BROMIDGE, S. M., ARCHER, D. A., SAMMES, P. G.

Journal:

Year:

1990

File:

PDF, 111 KB

1990

93

The regulation by Ca 2+ of the intramitochondrial Ca 2+ -sensitive dehydrogenases within intact rat kidney mitochondria

McCORMACK, JAMES G., BROMIDGE, ELAINE S.

Journal:

Biochemical Society Transactions

Year:

1987

Language:

english

File:

PDF, 259 KB

english, 1987

94

Platelet-rich plasma for tissue regeneration can be stored at room temperature for at least five days

Moore, Gary W., Maloney, James C., Archer, Robert A., Brown, Kerri L., Mayger, Katarzyna, Bromidge, Elaine S., Najafi, Mitra F.

Journal:

British Journal of Biomedical Science

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

95

The Polymerase Chain Reaction: A New Epidemiological Tool For Investigating Cervical Human Papillomavirus Infection

L. S. Young, I. S. Bevan, M. A. Johnson, P. I. Blomfield, T. Bromidge, N. J. Maitland and C. B. J. Woodman

Journal:

Year:

1989

Language:

english

File:

PDF, 1.73 MB

english, 1989

96

Trisomy 12 is a Rare Event in Cases of CLL with Typical Immunophenotype and Morphology

Howe, Denise J., Bromidge, Teresa J., Stack-Dunne, Michael, Davies, Simon V., Paxton, Annie, Phillips, Malcolm J., Rule, Simon J., Johnson, Stephen A.

Journal:

Hematology (Maney Publishing)

Year:

1997

Language:

english

File:

PDF, 624 KB

english, 1997

97

Screening of the entire coding region of p53 in low grade lymphoproliferative disorders

Journal:

Molecular Pathology

Year:

2000

Language:

english

File:

PDF, 152 KB

english, 2000

98

Heterogeneity of clonal lymphocytes with regard to bcl-2 protein concentration and cell size.

Bromidge, T J, Howe, D J, Johnson, S A, Rule, S A

Journal:

Molecular Pathology

Year:

1997

Language:

english

File:

PDF, 784 KB

english, 1997

99

The polymerase chain reaction: a new epidemiological tool for investigating cervical human papillomavirus infection.

Young, L. S., Bevan, I. S., Johnson, M. A., Blomfield, P. I., Bromidge, T., Maitland, N. J., Woodman, C. B.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.95 MB

english, 1989

100

Elevated bile acids in the plasma of laying hens fed rapeseed meal

Bromidge, E.S., Wells, J.W., Wight, P.A.L.

Journal:

Research in Veterinary Science

Year:

1985

File:

PDF, 1.15 MB

1985