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1

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Pen

Journal:

Year:

2016

Language:

english

File:

PDF, 2.96 MB

english, 2016

2

Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Pen

Journal:

Year:

2019

Language:

english

File:

PDF, 1.40 MB

english, 2019

3

Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate

Mark C. Genovese, Stanley Cohen, Larry Moreland, Deborah Lium, Sean Robbins, Richard Newmark, Pirow Bekker, for the 20000223 Study Group

Journal:

Arthritis & Rheumatism

Year:

2004

Language:

english

File:

PDF, 109 KB

english, 2004

4

A pharmaco-scintigraphy study of riboflavin 5′-phosphate sodium capsules (1 vs. 4)

Raymond N Dansereau, Richard J Dansereau, Bruce R Line, Daniel Healy, Pirow Bekker

Journal:

International Journal of Pharmaceutics

Year:

1997

Language:

english

File:

PDF, 413 KB

english, 1997

5

Population PK–PD model for Fc-osteoprotegerin in healthy postmenopausal women

Matthew L. Zierhut, Marc R. Gastonguay, Steven W. Martin, Paolo Vicini, Pirow J. Bekker, Donna Holloway, Philip T. Leese, Mark C. Peterson

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2008

Language:

english

File:

PDF, 848 KB

english, 2008

6

A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Pirow J Bekker, Donna L Holloway, Amy S Rasmussen, Robyn Murphy, Steven W Martin, Philip T Leese, Gregory B Holmes, Colin R Dunstan, Alex M DePaoli

Journal:

Journal of Bone and Mineral Research

Year:

2004

Language:

english

File:

PDF, 99 KB

english, 2004

7

The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women

Pirow J. Bekker, Donna Holloway, Arline Nakanishi, Michael Arrighi, Philip T. Leese, Colin R. Dunstan

Journal:

Journal of Bone and Mineral Research

Year:

2001

Language:

english

File:

PDF, 305 KB

english, 2001

8

A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Pirow J Bekker, Donna L Holloway, Amy S Rasmussen, Robyn Murphy, Steven W Martin, Philip T Leese, Gregory B Holmes, Colin R Dunstan, Alex M DePaoli

Journal:

Journal of Bone and Mineral Research

Year:

2005

Language:

english

File:

PDF, 3.98 MB

english, 2005

9

Risedronate Gastrointestinal Absorption Is Independent of Site and Rate of Administration

David Y. Mitchell, Rachelle A. Eusebio, Lisa E. Dunlap, Karen A. Pallone, John D. Nesbitt, Darrell A. Russell, Marian E. Clay, Pirow J. Bekker

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 395 KB

1998

10

Risedronate in Paget's disease: Preliminary results of a multicenter study

Jacques P. Brown, Jelle W. Kylstra, Pirow J. Bekker, Douglas W. Axelrod, Ethel S. Siris, Roy D. Altman, Frederick R. Singer

Journal:

Seminars in Arthritis and Rheumatism

Year:

1994

Language:

english

File:

PDF, 90 KB

english, 1994

11

The development of novel targeted therapeutics for treatment of multiple myeloma research roundtable

Kenneth C. Anderson, Bart Barlogie, James R. Berenson, William S. Dalton, Julian Adams, Melissa Alsina, Pirow Bekker, Peter L. Bergsagel, Lawrence Boise, Kyle Chan, Asher A. Chanan-Khan, Raymond Comen

Journal:

European Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

12

A randomized, double-blind comparison of risedronate and etidronate in the treatment of paget’s disease of bone

Paul D Miller, Jacques P Brown, Ethel S Siris, Mohammad S Hoseyni, Douglas W Axelrod, Pirow J Bekker

Journal:

The American Journal of Medicine

Year:

1999

Language:

english

File:

PDF, 122 KB

english, 1999

13

392 PROTECT-1 Study Demonstrated Efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Treatment of Patients with Moderate to Severe Crohn's Disease

Satish Keshav, Daniel Johnson, Pirow Bekker, Thomas J. Schall

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 123 KB

english, 2009

14

647 Chemokine Receptor Antagonist CCX282-B (Traficet-En™) Maintained Remission of Crohn's Disease in PROTECT-1 Study

Satish Keshav, Daniel Johnson, Thomas Schall, Pirow Bekker

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 76 KB

english, 2010

15

Tu1652 CCX507, an Orally Bioavailable Antagonist of the Chemokine Receptor CCR9, for the Treatment of IBD

Walters, Matthew, Ebsworth, Karen, Sullivan, Tim, Zhang, Penglie, Powers, Jay, Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Ertl, Linda, Jaen, Juan, Schall, Thomas

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 63 KB

english, 2013

16

T1143 A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Testing CCX282-B in the Treatment of Celiac Disease

Hamilton, Gordon, Mäki, Markku, Lahdeaho, Marja-leena, Bhasin, Madhuri, Bekker, Pirow, Schall, Thomas J.

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 126 KB

english, 2008

17

The development of novel targeted therapeutics for treatment of multiple myeloma research roundtable

Anderson, Kenneth C., Barlogie, Bart, Berenson, James R., Dalton, William S., Adams, Julian, Alsina, Melissa, Bekker, Pirow, Bergsagel, Peter L., Boise, Lawrence, Chan, Kyle, Chanan-Khan, Asher A., Co

Journal:

European Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 87 KB

english, 2003

18

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

de Zeeuw, Dick, Bekker, Pirow, Henkel, Elena, Hasslacher, Christopher, Gouni-Berthold, Ioanna, Mehling, Heidrun, Potarca, Antonia, Tesar, Vladimir, Heerspink, Hiddo J Lambers, Schall, Thomas J

Journal:

The Lancet Diabetes & Endocrinology

Year:

2015

Language:

english

File:

PDF, 509 KB

english, 2015

19

Risedronate, a Highly Effective Oral Agent in the Treatment of Patients with Severe Paget’s Disease 1

Singer, Frederick R., Clemens, Thomas L., Eusebio, Rachelle A., Bekker, Pirow J.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1998

Language:

english

File:

PDF, 114 KB

english, 1998

20

Risedronate Increases Bone Mass in an Early Postmenopausal Population: Two Years of Treatment Plus One Year of Follow-Up 1

Mortensen, Lene, Charles, Peder, Bekker, Pirow J., Digennaro, Joseph, Johnston, C. Conrad

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1998

Language:

english

File:

PDF, 149 KB

english, 1998

21

SP042CREATION OF MOUSE MODELS OF COMPLEMENT MEDIATED RENAL DISEASE USING CRISPR-CAS9 TO INTRODUCE KNOWN HUMAN FACTOR H MUTATIONS IN HUMAN C5A-RECEPTOR KNOCK-IN MICE

Li, Chris, Ertl, Linda, Bekker, Pirow, Charo, Israel, Schall, Thomas

Journal:

Nephrology Dialysis Transplantation

Year:

2016

Language:

english

File:

PDF, 27 KB

english, 2016

22

TO012C5A RECEPTOR INHIBITOR AVACOPAN IN IGA NEPHROPATHY STUDY

Bruchfeld, Annette, Nachman, Patrick, Parikh, Samir, Lafayette, Richard, Potarca, Antonia, Diehl, Janet, Lohr, Lisa, Miao, Shichang, Schall, Thomas, Bekker, Pirow

Journal:

Nephrology Dialysis Transplantation

Year:

2017

Language:

english

File:

PDF, 44 KB

english, 2017

23

SP457CCR2 INHIBITOR CCX140 EFFECTIVE IN PHASE 2 CLINICAL TRIAL IN DIABETIC NEPHROPATHY

de Zeeuw, Dick, Henkel, Elena, Psottova, Jana, Paragh, Gyorgy, Mehling, Heidrun, Hasslacher, Christopher, Potarca, Antonia, Bekker, Pirow, Schall, Thomas J

Journal:

Nephrology Dialysis Transplantation

Year:

2015

Language:

english

File:

PDF, 33 KB

english, 2015

24

CCR9 Antagonists in the Treatment of Ulcerative Colitis

Bekker, Pirow, Ebsworth, Karen, Walters, Matthew J., Berahovich, Robert D., Ertl, Linda S., Charvat, Trevor T., Punna, Sreenivas, Powers, Jay P., Campbell, James J., Sullivan, Timothy J., Jaen, Juan C

Journal:

Mediators of Inflammation

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

25

Effect of disease activity at three and six months on long-term outcomes in ANCA associated vasculitis

Gopaluni, Seerapani, Flossmann, Oliver, Little, Mark A., O'Hara, Paul, Bekker, Pirow, Jayne, David

Journal:

Arthritis & Rheumatology

Year:

2018

Language:

english

File:

PDF, 490 KB

english, 2018

26

326. A RANDOMIZED PHASE 3 TRIAL EVALUATING THE SAFETY AND EFFICACY OF AVACOPAN IN PATIENTS WITH NEW OR RELAPSING ANCA-ASSOCIATED VASCULITIS

Merkel, Peter, Jayne, David, Harigai, Masayoshi, Schall, Thomas, Bekker, Pirow, Potarca, Antonia, Hillson, Jan

Journal:

Year:

2019

Language:

english

File:

PDF, 920 KB

english, 2019

27

Poems

Bekker, Pirow, Pretorius, S.J.

Journal:

Year:

1970

File:

PDF, 120 KB

1970

28

Gedigte

Bekker, Pirow, Bekker, Pirow, Pretorius, S.J., Knobel, Wilhelm, du Plessis, Phil

Journal:

Year:

1967

File:

PDF, 198 KB

1967

29

LB003A RANDOMIZED, DOUBLE-BLIND, ACTIVE CONTROLLED STUDY OF AVACOPAN IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS

Jayne, David, Merkel, Peter, Yue, Huibin, Schall, Thomas J, Kelleher, Catherine, Bekker, Pirow

Journal:

Nephrology Dialysis Transplantation

Year:

2020

File:

PDF, 87 KB

2020

30

Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic AntibodyâAssociated Vasculitis

Merkel, Peter A., Niles, John, Jimenez, Richard, Spiera, Robert F., Rovin, Brad H., Bomback, Andrew, Pagnoux, Christian, Potarca, Antonia, Schall, Thomas J., Bekker, Pirow, Girard, LouisâPhilippe, L

Journal:

ACR Open Rheumatology

Year:

2020

File:

PDF, 357 KB

2020