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1

Basic Principles of Drug Discovery and Development || Case Studies in Drug Discovery

Blass, Benjamin E.

Year:

2015

Language:

english

File:

PDF, 824 KB

english, 2015

2

Basic Principles of Drug Discovery and Development || Intellectual Property and Patents in Drug Discovery

Blass, Benjamin E.

Year:

2015

Language:

english

File:

PDF, 331 KB

english, 2015

3

Basic Principles of Drug Discovery and Development || The Drug Discovery Process

Blass, Benjamin E.

Year:

2015

Language:

english

File:

PDF, 3.41 MB

english, 2015

4

Basic Principles of Drug Discovery and Development || Drug Discovery and Development

Blass, Benjamin E.

Year:

2015

Language:

english

File:

PDF, 899 KB

english, 2015

5

PPAR Agonists, Compounds, Pharmaceutical Compositions, and Methods of Use Thereof

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 374 KB

english, 2016

6

Covalent Inhibitors of the TEC Family of Kinases and Their Methods of Use

Blass, Benjamin E.

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 772 KB

english, 2018

7

Modulators of KEAP-1 Activity as Potential Therapies for the Treatment of Neurodegenerative Disorders

Blass, Benjamin E.

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 415 KB

english, 2019

8

ChemInform Abstract: A Facile KF/Al2O3-Mediated Method for the Synthesis of Substituted Oxazolidinones.

Benjamin E. Blass, Matthew Drowns, Cheryl L. Harris, Song Liu, David E. Portlock

Journal:

Year:

1999

File:

PDF, 32 KB

1999

9

ChemInform Abstract: A Facile KF/Al2O3-Mediated, Selective Alkylation of Benzodiazepin-2,5-diones.

Benjamin E. Blass, Thomas M. Burt, Song Liu, David E. Portlock, Erin M. Swing

Journal:

Year:

2000

File:

PDF, 33 KB

2000

10

ChemInform Abstract: Parallel Synthesis and Evaluation of N-(1-Phenylethyl)-5-phenyl-imidazole-2-amines as Na+/K+ ATPase Inhibitors.

Benjamin E. Blass, C. T. Huang, Richard M. Kawamoto, Min Li, Song Liu, David E. Portlock, William M. Rennells, Melanie Simmons

Journal:

Year:

2000

File:

PDF, 34 KB

2000

11

ChemInform Abstract: A Facile, Selective KF/Al2O3 Mediated Method for the Deprotection of Aryl Silyl Ethers and Preparation of Aryl SEM Ethers.

Benjamin E. Blass, Cheryl L. Harris, David E. Portlock

Journal:

Year:

2001

File:

PDF, 35 KB

2001

12

KF/Al2O3-Mediated Organic Synthesis

Benjamin E. Blass

Journal:

Year:

2003

File:

PDF, 70 KB

2003

13

Applications of Solid-Supported Azide Anion: A One-Pot, Two-Step Preparation of Functionalized 1,2,3-Triazoles.

Benjamin E. Blass, Keith R. Coburn, Amy L. Faulkner, William L. Seibel, Anil Srivastava

Journal:

Year:

2003

File:

PDF, 18 KB

2003

14

A Simple Method for the Preparation and Selective Functionalization of 4,5-Diaminopyrazoles.

Benjamin E. Blass, Anil Srivastava, Keith R. Coburn, Amy L. Faulkner, William L. Seibel

Journal:

Year:

2003

File:

PDF, 146 KB

2003

15

Solution Phase Synthesis of Imidazo[1,2-b]pyrazol-2-one, an Interesting 5,5-Fused Heterocyclic Ring System.

Benjamin E. Blass, Anil Srivastava, Keith R. Coburn, Amy L. Faulkner, John J. Janusz, James M. Ridgeway, William L. Seibel

Journal:

Year:

2004

File:

PDF, 112 KB

2004

16

A new paradigm for alkene epoxidation: Activation of hydrogen peroxide by organophosphorus electrophiles

Andrew S. Kende, Philippe Delair, Benjamin E. Blass

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 223 KB

english, 1994

17

Enantioselective total synthesis of didesepoxyrhizoxin

Andrew S Kende, Benjamin E Blass, James R Henry

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 189 KB

english, 1995

18

Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias

Chris M. Jackson, Benjamin Blass, Keith Coburn, Laurent Djandjighian, Gina Fadayel, Andrew J. Fluxe, Steven J. Hodson, John M. Janusz, Michael Murawsky, James M. Ridgeway, Ronald E. White, Shengde Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 134 KB

english, 2007

19

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

Benjamin E. Blass, Keith Coburn, Wenlin Lee, Neil Fairweather, Andrew Fluxe, Shengde Wu, John M. Janusz, Michael Murawsky, Gina M. Fadayel, Bin Fang, Michelle Hare, Jim Ridgeway, Ron White, Chris Jack

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 173 KB

english, 2006

20

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers

Shengde Wu, Andrew Fluxe, John M. Janusz, James B. Sheffer, Greg Browning, Benjamin Blass, Keith Cobum, Richard Hedges, Michael Murawsky, Bin Fang, Gina M. Fadayel, Michelle Hare, Laurent Djandjighian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 160 KB

english, 2006

21

Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers

Shengde Wu, Andrew Fluxe, Jim Sheffer, John M. Janusz, Benjamin E. Blass, Ron White, Chris Jackson, Richard Hedges, Michael Murawsky, Bin Fang, Gina M. Fadayel, Michelle Hare, Laurent Djandjighian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 154 KB

english, 2006

22

Solution phase synthesis of imidazo[1,2-b]pyrazol-2-one, an interesting 5,5-fused heterocyclic ring system

Benjamin E. Blass, Anil Srivastava, Keith R. Coburn, Amy L. Faulkner, John J. Janusz, James M. Ridgeway, William L. Seibel

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 241 KB

english, 2004

23

Solid-phase approach towards the synthesis of functionalized imidazo[1,2-b]pyrazol-2-ones

Benjamin E. Blass, Anil Srivastava, Keith R. Coburn, Amy L. Faulkner, John J. Janusz, James M. Ridgeway, William L. Seibel

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 239 KB

english, 2004

24

A facile, KF/Al2O3 mediated method for the preparation of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones

Benjamin E. Blass, Keith Coburn, Neil Fairweather, Mark Sabat, Laura West

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 99 KB

english, 2006

25

Synthesis of 1-aminoimidazolidin-4-one and 1-aminoimidazolidin-2-one based compounds: an interesting divergence in methodology

Benjamin E. Blass, Keith Coburn, Neil Fairweather, Andrew Fluxe, Steve Hodson, Chris Jackson, John Janusz, Wenlin Lee, Jim Ridgeway, Ron White, Shengde Wu

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 93 KB

english, 2006

26

KF/Al2O3 Mediated organic synthesis

Benjamin E. Blass

Journal:

Year:

2002

Language:

english

File:

PDF, 752 KB

english, 2002

27

A facile, selective KF/Al2O3 mediated method for the deprotection of aryl silyl ethers and preparation of aryl SEM ethers

Benjamin E Blass, Cheryl L Harris, David E Portlock

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

28

A novel dyatropic rearrangement of γ-N,N-dibenzylamino α,β-dehydro N-formylamino acid esters

Andrew S. Kende, K.M.J. Brands, Benjamin Blass

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 283 KB

english, 1993

29

Solid-phase synthesis of functionalized 1,2,3-triazoles

Benjamin E Blass, Keith R Coburn, Amy L Faulkner, Cheryl L Hunn, Michael G Natchus, M.Sharon Parker, David E Portlock, Joshua S Tullis, Richard Wood

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

30

Solid-phase synthesis of functionalized 1,2,4-triazin-6-ones

Benjamin E Blass, Keith R Coburn, Amy L Faulkner, Song Liu, Adam Ogden, David E Portlock, Anil Srivastava

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

31

Applications of solid supported azide anion: a one-pot, two-step preparation of functionalized 1,2,3-triazoles

Benjamin E Blass, Keith R Coburn, Amy L Faulkner, William L Seibel, Anil Srivastava

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 266 KB

english, 2003

32

A simple method for the preparation and selective functionalization of 4,5-diaminopyrazoles

Benjamin E Blass, Anil Srivastava, Keith R Coburn, Amy L Faulkner, William L Seibel

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

33

A facile KF/Al2O3 mediated method for the synthesis of substituted oxazolidinones

Benjamin E. Blass, Matthew Drowns, Cheryl L. Harris, Song Liu, David E. Portlock

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 171 KB

english, 1999

34

Parallel synthesis and evaluation of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines as Na+/K+ ATPase inhibitors

Benjamin E. Blass, C.T. Huang, Richard M. Kawamoto, Min Li, Song Liu, David E. Portlock, William M. Rennells, Melanie Simmons

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 117 KB

english, 2000

35

A facile KF/Al2O3 mediated, selective alkylation of benzodiazepin-2,5-diones

Benjamin E Blass, Thomas M Burt, Song Liu, David E Portlock, Erin M Swing

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 89 KB

english, 2000

36

Derivatives of Heteroarylsulfonamides, Their Preparation, and Their Application in Human Therapy

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 223 KB

english, 2012

37

Fused Heterocyclic Compounds as Ion Channel Modulators

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 218 KB

english, 2012

38

Substituted Benzimidazole and Imidazopyridine Compounds Useful as Cyp17 Modulators

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 228 KB

english, 2012

39

Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling

Mark E. McDonnell, Matthew D. Vera, Benjamin E. Blass, Jeffrey C. Pelletier, Richard C. King, Carmen Fernandez-Metzler, Garry R. Smith, Jay Wrobel, Suzie Chen, Brian A. Wall, Allen B. Reitz

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 692 KB

english, 2012

40

Compounds and Their Use as BACE Inhibitors

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 216 KB

english, 2012

41

Selective Kv1.5 Blockers: Development of ( R )-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia

Blass, Benjamin E., Fensome, Andrew, Trybulski, Eugene, Magolda, Ronald, Gardell, Stephen J., Liu, Kun, Samuel, Manoj, Feingold, Irene, Huselton, Christine, Jackson, Chris M., Djandjighian, Laurent, H

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 822 KB

english, 2009

42

Inhibitors of the Renal Outer Medullary Potassium Channel

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 317 KB

english, 2013

43

5-Amino-oxazepine and 5-Amino-thiazepine Compounds as β-Secretase Antagonists and Methods of Use

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 243 KB

english, 2012

44

Benzoxazine Derivatives As CRAC Modulators

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 235 KB

english, 2013

45

Antiviral Compounds for the Treatment of HCV

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 255 KB

english, 2014

46

Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy

Scimia, Maria Cecilia, Blass, Benjamin E, Koch, Walter J

Journal:

Expert Review of Cardiovascular Therapy

Year:

2014

Language:

english

File:

PDF, 565 KB

english, 2014

47

Substituted Pyridines as Sodium Channel Blockers

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 250 KB

english, 2012

48

HCV Polymerase Inhibitors

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 291 KB

english, 2014

49

Fused Thiazin-3-ones as KCa3.1 Inhibitors

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 231 KB

english, 2014

50

Piperazion[1,2-A]indol-1-ones and [1,4]Diazepino[1,2-A]indol-1-ones

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 236 KB

english, 2014

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