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51

Mechanisms of NSAID-Induced Hepatotoxicity

Dr Urs A. Boelsterli

Journal:

Year:

2002

Language:

english

File:

PDF, 218 KB

english, 2002

52

Nimesulide-Induced Electrophile Stress Activates Nrf2 in Human Hepatocytes and Mice but Is Not Sufficient to Induce Hepatotoxicity in Nrf2-Deficient Mice

Kale, Vijay M., Hsiao, Chin-ju J., Boelsterli, Urs A.

Journal:

Chemical Research in Toxicology

Year:

2010

Language:

english

File:

PDF, 352 KB

english, 2010

53

Drug-induced Liver Disease || Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Antiinflammatory Drugs

Boelsterli, Urs A.

Year:

2013

Language:

english

File:

PDF, 2.41 MB

english, 2013

54

Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone

Lee, Yie Hou, Goh, Wilson Wen Bin, Ng, Choon Keow, Raida, Manfred, Wong, Limsoon, Lin, Qingsong, Boelsterli, Urs A., Chung, Maxey C. M.

Journal:

Journal of Proteome Research

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

55

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

Saitta, Kyle S., Zhang, Carmen, Lee, Kang Kwang, Fujimoto, Kazunori, Redinbo, Matthew R., Boelsterli, Urs A.

Journal:

Year:

2014

Language:

english

File:

PDF, 366 KB

english, 2014

56

Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Lee, Kang Kwang, Boelsterli, Urs A.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.09 MB

english, 2014

57

Mo2014 A Small Molecule Inhibitor of Intestinal Bacterial β-Glucuronidase Prevents Ketoprofen-Induced Small Intestinal Ulceration in Mice

Saitta, Kyle S., Zhang, Carmen, Redinbo, Matthew R., Boelsterli, Urs A.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 58 KB

english, 2013

58

Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes

Lee, Kang Kwang, Fujimoto, Kazunori, Zhang, Carmen, Schwall, Christine T., Alder, Nathan N., Pinkert, Carl A., Krueger, Winfried, Rasmussen, Theodore, Boelsterli, Urs A.

Journal:

Free Radical Biology and Medicine

Year:

2013

Language:

english

File:

PDF, 1.40 MB

english, 2013

59

Effects of endotoxin tolerance on hepatic excretory function: In vivo study

Boelsterli, Urs A., Abernathy, Charles O., Balazs, Tibor, Zimmerman, Hyman J.

Journal:

Toxicology Letters

Year:

1982

Language:

english

File:

PDF, 386 KB

english, 1982

60

Synthesis and Biodistribution of a Short Nonionic Oligonucleotide Analogue in Mouse with a Potential to Mimic Peptides

Eschgfäller, Bernd, König, Marcel, Boess, Franziska, Boelsterli, Urs A., Benner, Steven A.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 100 KB

english, 1998

61

Selective Protein Adduct Formation of Diclofenac Glucuronide Is Critically Dependent on the Rat Canalicular Conjugate Export Pump (Mrp2) †

Seitz, Sven, Kretz-Rommel, Anke, Oude Elferink, Ronald P. J., Boelsterli, Urs A.

Journal:

Chemical Research in Toxicology

Year:

1998

Language:

english

File:

PDF, 111 KB

english, 1998

62

Idiosyncratic Drug Hepatotoxicity Revisited: New Insights from Mechanistic Toxicology

Boelsterli, Urs A.

Journal:

Toxicology Mechanisms and Methods

Year:

2003

Language:

english

File:

PDF, 306 KB

english, 2003

63

NSAID Acyl Glucuronides and Enteropathy

A. Boelsterli, Urs, Ramirez-Alcantara, Veronica

Journal:

Current Drug Metabolism

Year:

2011

Language:

english

File:

PDF, 150 KB

english, 2011

64

Mechanisms of isoniazid-induced idiosyncratic liver injury: Emerging role of mitochondrial stress

Boelsterli, Urs A, Lee, Kang Kwang

Journal:

Journal of Gastroenterology and Hepatology

Year:

2014

Language:

english

File:

PDF, 416 KB

english, 2014

65

Lipid Peroxidation-Independent Mechanisms of Vitamin E-Mediated Protection Against Cyclosporine A-Induced Hepatocellular Toxicity and Apoptosis

Grub, Sibylle, Boelsterli, Urs A., Trendelenburg, Christian, Trommer, Wolfgang E., Wolf, Armin

Journal:

Toxicology Mechanisms and Methods

Year:

2003

Language:

english

File:

PDF, 579 KB

english, 2003

66

Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Imaizumi, Naoki, Kwang Lee, Kang, Zhang, Carmen, Boelsterli, Urs A.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

67

How close are we to developing enteric-protective drugs against non-steroidal anti-inflammatory drug-induced small intestinal injury? New mechanistic insight from preclinical models

Boelsterli, Urs A

Journal:

Journal of Gastroenterology and Hepatology

Year:

2013

Language:

english

File:

PDF, 146 KB

english, 2013

68

REACTIVE ACYL GLUCURONIDES: POSSIBLE ROLE IN SMALL INTESTINAL TOXICITY INDUCED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

Boelsterli, Urs A.

Journal:

Toxic Substance Mechanisms

Year:

1999

Language:

english

File:

PDF, 297 KB

english, 1999

69

Bioactivation and Hepatotoxicity of Nitroaromatic Drugs

Boelsterli, Urs, Ho, Han, Zhou, Shufeng, Yeow Leow, Koon

Journal:

Current Drug Metabolism

Year:

2006

Language:

english

File:

PDF, 149 KB

english, 2006

70

Pharmacokinetic Mechanisms for Reduced Toxicity of Irinotecan by Coadministered Thalidomide

Yang, Xiao-Xia, Hu, Ze-Ping, Chan, Sui, Duan, Wei, Ho, Paul, Boelsterli, Urs, Ng, Ka-Yun, Chan, Eli, Bian, Jin-Song, Chen, Yu-Zong, Huang, Min, Zhou, >

Journal:

Current Drug Metabolism

Year:

2006

Language:

english

File:

PDF, 703 KB

english, 2006

71

Therapeutic Drugs that Behave as Mechanism-Based Inhibitors of Cytochrome P450 3A4

Zhou, Shufeng, Chan, Eli, Lim, Lee, Boelsterli, Urs, Li, Shu, Wang, Jiancheng, Zhang, Qiang, Huang, Min, Xu, Anlong

Journal:

Current Drug Metabolism

Year:

2004

Language:

english

File:

PDF, 235 KB

english, 2004

72

Specific Targets of Covalent Drug-Protein Interactions in Hepatocytes and Their Toxicological Significance in Drug-Induced Liver Injury

Boelsterli, Urs A.

Journal:

Drug Metabolism Reviews

Year:

1993

Language:

english

File:

PDF, 2.78 MB

english, 1993

73

Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury

Lee, Kang Kwang, Imaizumi, Naoki, Chamberland, Sally R., Alder, Nathan N., Boelsterli, Urs A.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

74

Editorial [Hot Topic:Acyl Glucuronides: Mechanistic Role in Drug Toxicity? (Guest Editor: Urs A. Boelsterli)]

A. Boelsterli, Urs

Journal:

Current Drug Metabolism

Year:

2011

Language:

english

File:

PDF, 37 KB

english, 2011

75

Drug Acyl Glucuronides: Reactivity and Analytical Implication

Yang, Xiao-Xia, Hu, Ze-Ping, Alex Boelsterli, Urs, Zhou, Shu-Feng

Journal:

Current Pharmaceutical Analysis

Year:

2006

Language:

english

File:

PDF, 295 KB

english, 2006

76

Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-α gene knockout in mice

Boess, Franziska, Bopst, Martin, Althaus, Roland, Polsky, Stacey, Cohen, Steven D., Eugster, Hans-Pietro, Boelsterli, Urs A.

Journal:

European Journal of Gastroenterology & Hepatology

Year:

1998

File:

PDF, 100 KB

1998

77

ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENT

Boelsterli, Urs A.

Journal:

The Journal of Toxicological Sciences

Year:

2003

Language:

english

File:

PDF, 101 KB

english, 2003