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51

Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B

Mihalyi, Agnes, Jamshidi, Shirin, Slikas, Justinas, Bugg, Timothy D.H.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 880 KB

english, 2014

52

Catalytic Promiscuity in the α/β-Hydrolase Superfamily: Hydroxamic Acid Formation, CC Bond Formation, Ester and Thioester Hydrolysis in the CC Hydrolase Family

Chen Li, Melanie Hassler, Timothy D. H. Bugg

Journal:

Year:

2008

Language:

english

File:

PDF, 358 KB

english, 2008

53

Specificity of E. Coli shikimate dehydrogenase towards analogues of 3-dehydroshikimic acid

Timothy D.H. Bugg, Chris Abell, John R. Coggins

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 241 KB

english, 1988

54

[Methods in Enzymology] Enzyme Kinetics and Mechanism Part F: Detection and Characterization of Enzyme Reaction Intermediates Volume 354 || 2-Hydroxy-6-keto-nona-2,4-diene 1,9-dioic acid 5,6-hydrolase: Evidence from 18O isotope exchange for gem-diol intermediate

Bugg, Timothy D.H.

Year:

2002

Language:

english

File:

PDF, 810 KB

english, 2002

55

M-Mode Echocardiographic Abnormalities in Rocky Mountain Spotted Fever

FELTES, TIMOTHY F., WILCOX, W DEAN, FELDMAN, WILLIAM E., LIPSKIS, DONALD J., CARTER, STEPHEN L., BUGG, GEORGE W.

Journal:

Southern Medical Journal

Year:

1984

File:

PDF, 279 KB

1984

56

Sphingobacterium sp. T2 Manganese Superoxide Dismutase Catalyzes the Oxidative Demethylation of Polymeric Lignin via Generation of Hydroxyl Radical

Rashid, Goran M. M., Zhang, Xiaoyang, Wilkinson, Rachael C., Fülöp, Vilmos, Cottyn, Betty, Baumberger, Stéphanie, Bugg, Timothy D. H.

Journal:

ACS Chemical Biology

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

57

Variation in susceptibility to microbial lignin oxidation in a set of wheat straw cultivars: influence of genetic, seasonal and environmental factors

Konstantopoulou, Marina, Slator, Patrick J., Taylor, Charles R., Bugg, Timothy D.H., Wellington, Elizabeth M., Allison, Gordon, Harper, Andrea L., Bancroft, Ian

Journal:

Issue No 1 Volume 01 1986

Year:

2017

Language:

english

File:

PDF, 734 KB

english, 2017

58

Affinity labelling of E. Coli dehydroquinase

Timothy D.H. Bugg, Chris Abell, John R. Coggins

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 232 KB

english, 1988

59

Identification of a novel β-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A

Lam, Wai-Ho, Rychli, Kathrin, Bugg, Timothy D. H.

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 159 KB

english, 2008

60

Thioester analogues of peptidoglycan fragment MurNAc-L-Ala-γ-D-Glu as substrates for peptidoglycan hydrolase MurNAc-L-Ala amidase

Harding, Ross L., Henshaw, Joanne, Tilling, Joannah, Bugg, Timothy D. H.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 228 KB

english, 2002

61

The dynamics of peptidoglycan structure and function: Conference report on the 3rd Great Wall Symposium

Williams, Allison H., Boneca, Ivo G., Burrows, Lori L., Bugg, Timothy D.H.

Journal:

Research in Microbiology

Year:

2014

Language:

english

File:

PDF, 171 KB

english, 2014

62

Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor

Paradis‑Bleau, Catherine, Lloyd, Adrian, Sanschagrin, François, Maaroufi, Halim, Clarke, Tom, Blewett, Anne, Dowson, Chris, Roper, David I., Bugg, Timothy D. H., Levesque, Roger C.

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 560 KB

english, 2009

63

Crystal Structure and Functional Assignment of YfaU, a Metal Ion Dependent Class II Aldolase from Escherichia coli K12 †‡

Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Timothy D. H., Roper, David I.

Journal:

Year:

2008

Language:

english

File:

PDF, 7.21 MB

english, 2008

64

Stereochemistry of the reaction catalysed by 2-hydroxy-6-keto-6-phenyl-hexa-2,4-dienoic acid 5,6-hydrolase (BphD)

Li, Jian-Jun, Bugg, Timothy D. H.

Journal:

Chemical Communications

Year:

2005

Language:

english

File:

PDF, 211 KB

english, 2005

65

ChemInform Abstract: Pathways for Degradation of Lignin in Bacteria and Fungi

Timothy D. H. Bugg, Mark Ahmad, Elizabeth M. Hardiman, Rahman Rahmanpour

Journal:

Year:

2012

File:

PDF, 18 KB

2012

66

The biosynthesis of peptidoglycan lipid-linked intermediates

Ahmed Bouhss, Amy E. Trunkfield, Timothy D.H. Bugg, Dominique Mengin-Lecreulx

Journal:

FEMS Microbiology Reviews

Year:

2008

Language:

english

File:

PDF, 905 KB

english, 2008

67

Cis − Trans Isomerization of a Cyclopropyl Radical Trap Catalyzed by Extradiol Catechol Dioxygenases: Evidence for a Semiquinone Intermediate

Spence, Emma L., Langley, G. John, Bugg, Timothy D. H.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 512 KB

english, 1996

68

Stereochemistry of the Reaction Catalyzed by 2-Hydroxy-6-keto-6-phenyl-hexa-2,4-dienoic Acid 5,6-Hydrolase (BphD).

Jian-Jun Li, Timothy D. H. Bugg

Journal:

Year:

2005

File:

PDF, 14 KB

2005

69

Does abscisic acid affect strigolactone biosynthesis?

Juan A. López-Ráez, Wouter Kohlen, Tatsiana Charnikhova, Patrick Mulder, Anna K. Undas, Martin J. Sergeant, Francel Verstappen, Timothy D. H. Bugg, Andrew J. Thompson, Carolien Ruyter-Spira and Harro

Journal:

New Phytologist

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

70

ChemInform Abstract: The Development of Mechanistic Enzymology in the 20th Century

Timothy D. H. Bugg

Journal:

Year:

2001

File:

PDF, 25 KB

2001

71

Recent Advances in Antimicrobial Nucleoside Antibiotics Targeting Cell Wall Biosynthesis

Ken-ichi Kimura, Timothy D. H. Bugg

Journal:

Year:

2003

File:

PDF, 4 KB

2003

72

Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors

Elena Cressina, Adrian J. Lloyd, Gianfranco De Pascale, B. James Mok, Stephen Caddick, David I. Roper, Christopher G. Dowson, Timothy D.H. Bugg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 931 KB

english, 2009

73

Identification of DypB from Rhodococcus jostii RHA1 as a Lignin Peroxidase

Ahmad, Mark, Roberts, Joseph N., Hardiman, Elizabeth M., Singh, Rahul, Eltis, Lindsay D., Bugg, Timothy D. H.

Journal:

Year:

2011

Language:

english

File:

PDF, 1002 KB

english, 2011

74

Enzymology of the carotenoid cleavage dioxygenases: Reaction mechanisms, inhibition and biochemical roles

Harrison, Peter J., Bugg, Timothy D.H.

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 1016 KB

english, 2014

75

A fluorescent analogue of UDP-N-acetylglucosamine: application for FRET assay of peptidoglycan translocase II (MurG)

Li, Jian-Jun, Bugg, Timothy D. H.

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

76

Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5

Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., de Pascale, Gianfranco, Dowson, Christopher G., Roper, David I., Bugg, Timothy D. H.

Journal:

Molecular BioSystems

Year:

2006

Language:

english

File:

PDF, 432 KB

english, 2006

77

The Structure and Mechanism of a Unique Rieske-Type Mono-Oxygenase Enzyme from the Human Gut Microbiota Implicated in Cardiovascular Disease

Quareshy, Mussa, Shanmugam, Muralidharan, Cameron, Alexander D., Bugg, Timothy D., Chen, Yin

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 44 KB

2020

78

Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition and inter-subunit electron transfer

Quareshy, Mussa, Shanmugam, Muralidharan, Townsend, Eleanor, Jameson, Eleanor, Bugg, Timothy D.H., Cameron, Alexander D, Chen, Yin

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.69 MB

2020

79

Regulation and Manipulation of the Biosynthesis of Abscisic Acid, Including the Supply of Xanthophyll Precursors

Ian B. Taylor, Tineke Sonneveld, Timothy D. H. Bugg, Andrew J. Thompson

Journal:

Journal of Plant Growth Regulation

Year:

2005

Language:

english

File:

PDF, 367 KB

english, 2005

80

Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein–protein interaction site in translocase MraY

Rodolis, Maria T., Mihalyi, Agnes, Ducho, Christian, Eitel, Kornelia, Gust, Bertolt, Goss, Rebecca J. M., Bugg, Timothy D. H.

Journal:

Chemical Communications

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

81

Pre-Steady-State Kinetic Analysis of 2-Hydroxy-6-keto-nona-2,4-diene-1,9-dioic Acid 5,6-Hydrolase: Kinetic Evidence for Enol/Keto Tautomerization †

Henderson, Ian M. J., Bugg, Timothy D. H.

Journal:

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

82

Reduction of Smoking Behavior: A Multivariable Treatment Package and the Programming of Response Maintenance

Bornstein, Philip H., Carmody, Timothy P., Relinger, Helmut, Zohn, C. Joseph, Devine, David A., Bugge, Irene D.

Journal:

The Psychological Record

Year:

1977

Language:

english

File:

PDF, 1.28 MB

english, 1977

83

Exploring the Lignin Catabolism Potential of Soil-Derived Lignocellulolytic Microbial Consortia by a Gene-Centric Metagenomic Approach

DÃaz-GarcÃa, Laura, Bugg, Timothy D. H., JimÃ©nez, Diego Javier

Journal:

Microbial Ecology

Year:

2020

File:

PDF, 2.09 MB

2020

84

Covalent modification in aqueous solution of poly-γ-D-glutamic acid from bacillus licheniformis

Elizabeth C. King, William J. Watkins, A. John Blacker, Timothy D. H. Bugg

Journal:

Journal of Polymer Science Part A: Polymer Chemistry

Year:

1998

Language:

english

File:

PDF, 119 KB

english, 1998

85

Biomimetic Formation of 2-Tropolones by Dioxygenase-Catalysed Ring Expansion of Substituted 2,4-Cyclohexadienones

Meite Xin, Timothy D. H. Bugg

Journal:

Year:

2010

Language:

english

File:

PDF, 274 KB

english, 2010

86

Biosynthesis: Imaging cell-wall biosynthesis live

Bugg, Timothy D. H.

Journal:

Nature Chemistry

Year:

2012

Language:

english

File:

PDF, 214 KB

english, 2012

87

A biomimetic model reaction for the extradiol catechol dioxygenases

Lin, Gang, Bugg, Timothy D. H., Reid, Gillian

Journal:

Chemical Communications

Year:

2000

Language:

english

File:

PDF, 309 KB

english, 2000

88

Catalytic Role for Arginine 188 in the C−C Hydrolase Catalytic Mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD †

Li, Chen, Li, Jian-Jun, Montgomery, Mark G., Wood, Stephen P., Bugg, Timothy D. H.

Journal:

Year:

2006

Language:

english

File:

PDF, 728 KB

english, 2006

89

Chemical and biochemical properties of 2-hydroxypentadienoic acid, a homologue of enolpyruvic acid

R. Pollard, John, M. J. Henderson, Ian, D. H. Bugg, Timothy

Journal:

Chemical Communications

Year:

1997

Language:

english

File:

PDF, 51 KB

english, 1997

90

Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage

Lam, Winnie W. Y., Bugg, Timothy D. H.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1994

Language:

english

File:

PDF, 262 KB

english, 1994

91

Structure of Thermobifida fusca DyP-type peroxidase and activity towards Kraft lignin and lignin model compounds

Rahmanpour, Rahman, Rea, Dean, Jamshidi, Shirin, Fülöp, Vilmos, Bugg, Timothy D.H.

Journal:

Archives of Biochemistry and Biophysics

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

92

[Topics in Medicinal Chemistry] || Nucleoside Natural Product Antibiotics Targetting Microbial Cell Wall Biosynthesis

Bugg, Timothy D. H.

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

93

Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme

Catherine Paradis-Bleau, Mélanie Beaumont, Lydia Boudreault, Adrian Lloyd, François Sanschagrin, Timothy D.H. Bugg, Roger C. Levesque

Journal:

Year:

2006

Language:

english

File:

PDF, 454 KB

english, 2006

94

ChemInform Abstract: Use of Trityl Thiol for Stereoselective Thioester Synthesis: A New Preparation of (S)-Thiolactic Acid.

Ross L. Harding, Timothy D. H. Bugg

Journal:

Year:

2000

File:

PDF, 27 KB

2000

95

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF

Catherine Paradis-Bleau, Adrian Lloyd, François Sanschagrin, Tom Clarke, Ann Blewett, Timothy DH Bugg, Roger C Levesque

Journal:

BMC Biochemistry

Year:

2008

Language:

english

File:

PDF, 687 KB

english, 2008

96

Investigation of acid–base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry

Brivio, Michela, Schlosrich, Janne, Ahmad, Mark, Tolond, Caroline, Bugg, Timothy D. H.

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 186 KB

english, 2009

97

Hammett analysis of a C???C hydrolase-catalysed reaction using synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates

Speare, Damian M., Olf, Petra, Bugg, Timothy D. H.

Journal:

Chemical Communications

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

98

Phytotoxic effects of selected N-benzyl-benzoylhydroxamic acid metallo-oxygenase inhibitors: investigation into mechanism of action

Sergeant, Martin J., Harrison, Peter J., Jenkins, Robert, Moran, Graham R., Bugg, Timothy D. H., Thompson, Andrew J.

Journal:

New Journal of Chemistry

Year:

2013

Language:

english

File:

PDF, 1.37 MB

english, 2013

99

O 2 -independent demethylation of trimethylamine N -oxide by Tdm of Methylocella silvestris

Zhu, Yijun, Ksibe, Amira Z., Schäfer, Hendrik, Blindauer, Claudia A., Bugg, Timothy D.H., Chen, Yin

Journal:

Year:

2016

Language:

english

File:

PDF, 650 KB

english, 2016

100

LightâActivated Electron Transfer and Catalytic Mechanism of Carnitine Oxidation by Rieskeâtype Oxygenase from Human Microbiota

Shanmugam, Muralidharan, Quareshy, Mussa, Cameron, Alex, Bugg, Timothy D. H., Chen, Yin

Journal:

Angewandte Chemie International Edition

Year:

2020

File:

PDF, 2.53 MB

2020

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