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51

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF

Catherine Paradis-Bleau, Adrian Lloyd, François Sanschagrin, Tom Clarke, Ann Blewett, Timothy DH Bugg, Roger C Levesque

Journal:

BMC Biochemistry

Year:

2008

Language:

english

File:

PDF, 687 KB

english, 2008

52

Regulation and Manipulation of the Biosynthesis of Abscisic Acid, Including the Supply of Xanthophyll Precursors

Ian B. Taylor, Tineke Sonneveld, Timothy D. H. Bugg, Andrew J. Thompson

Journal:

Journal of Plant Growth Regulation

Year:

2005

Language:

english

File:

PDF, 367 KB

english, 2005

53

A density functional investigation of the extradiol cleavage mechanism in non-heme iron catechol dioxygenases

Robert J. Deeth, Timothy D. H. Bugg

Journal:

JBIC Journal of Biological Inorganic Chemistry

Year:

2003

Language:

english

File:

PDF, 658 KB

english, 2003

54

Synthesis and activity of 5′-Uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A

Nigel I Howard, Timothy D.H Bugg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 602 KB

english, 2003

55

Does abscisic acid affect strigolactone biosynthesis?

Juan A. López-Ráez, Wouter Kohlen, Tatsiana Charnikhova, Patrick Mulder, Anna K. Undas, Martin J. Sergeant, Francel Verstappen, Timothy D. H. Bugg, Andrew J. Thompson, Carolien Ruyter-Spira, Harro Bou

Journal:

New Phytologist

Year:

2010

Language:

english

File:

PDF, 358 KB

english, 2010

56

From peptidoglycan to glycoproteins: Common features of lipid-linked oligosaccharide biosynthesis

Timothy D.H. Bugg, Philip E. Brandish

Journal:

FEMS Microbiology Letters

Year:

1994

Language:

english

File:

PDF, 558 KB

english, 1994

57

Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria

Jean-Luc Mainardi, Régis Villet, Timothy D. Bugg, Claudine Mayer, Michel Arthur

Journal:

FEMS Microbiology Reviews

Year:

2008

Language:

english

File:

PDF, 855 KB

english, 2008

58

The biosynthesis of peptidoglycan lipid-linked intermediates

Ahmed Bouhss, Amy E. Trunkfield, Timothy D.H. Bugg, Dominique Mengin-Lecreulx

Journal:

FEMS Microbiology Reviews

Year:

2008

Language:

english

File:

PDF, 905 KB

english, 2008

59

Evidence from Mechanistic Probes for Distinct Hydroperoxide Rearrangement Mechanisms in the Intradiol and Extradiol Catechol Dioxygenases

Xin, Meite, Bugg, Timothy D. H.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 221 KB

english, 2008

60

Investigation of acid–base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry

Brivio, Michela, Schlosrich, Janne, Ahmad, Mark, Tolond, Caroline, Bugg, Timothy D. H.

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 186 KB

english, 2009

61

Solving the riddle of the intradiol and extradiol catechol dioxygenases: how do enzymes control hydroperoxide rearrangements?

Bugg, Timothy D. H., Lin, Gang

Journal:

Chemical Communications

Year:

2001

Language:

english

File:

PDF, 864 KB

english, 2001

62

Identification of a novel β-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A

Lam, Wai-Ho, Rychli, Kathrin, Bugg, Timothy D. H.

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 159 KB

english, 2008

63

Thioester analogues of peptidoglycan fragment MurNAc-L-Ala-γ-D-Glu as substrates for peptidoglycan hydrolase MurNAc-L-Ala amidase

Harding, Ross L., Henshaw, Joanne, Tilling, Joannah, Bugg, Timothy D. H.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 228 KB

english, 2002

64

The development of mechanistic enzymology in the 20th century

Bugg, Timothy D. H.

Journal:

Natural Product Reports

Year:

2001

Language:

english

File:

PDF, 1.26 MB

english, 2001

65

Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichiacoli

Timothy D.H. Bugg

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1993

Language:

english

File:

PDF, 623 KB

english, 1993

66

Oxygenases Get to Grips with Polypeptides

Timothy D.H. Bugg

Journal:

Year:

2009

Language:

english

File:

PDF, 84 KB

english, 2009

67

Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli

John R. Pollard, Timothy D. H. Bugg

Journal:

Year:

1998

Language:

english

File:

PDF, 316 KB

english, 1998

68

Purification, Characterization, and Stereochemical Analysis of a C−C Hydrolase: 2-Hydroxy-6-keto-nona-2,4-diene-1,9-dioic Acid 5,6-Hydrolase

Lam, Winnie W. Y., Bugg, Timothy D. H.

Journal:

Year:

1997

Language:

english

File:

PDF, 341 KB

english, 1997

69

Catalytic Mechanism of C–C Hydrolase MhpC from Escherichia coli: Kinetic Analysis of His263 and Ser110 Site-directed Mutants

Chen Li, Mark G. Montgomery, Fiyaz Mohammed, Jian-Jun Li, Stephen P. Wood, Timothy D.H. Bugg

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 279 KB

english, 2005

70

Structure and Mechanism of HpcH: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia coli

Dean Rea, Vilmos Fülöp, Timothy D.H. Bugg, David I. Roper

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.29 MB

english, 2007

71

Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme

Catherine Paradis-Bleau, Mélanie Beaumont, Lydia Boudreault, Adrian Lloyd, François Sanschagrin, Timothy D.H. Bugg, Roger C. Levesque

Journal:

Year:

2006

Language:

english

File:

PDF, 454 KB

english, 2006

72

Biosynthesis: Imaging cell-wall biosynthesis live

Bugg, Timothy D. H.

Journal:

Nature Chemistry

Year:

2012

Language:

english

File:

PDF, 214 KB

english, 2012

73

Acid−Base Catalysis in the Extradiol Catechol Dioxygenase Reaction Mechanism: Site-Directed Mutagenesis of His-115 and His-179 in Escherichia coli 2,3-Dihydroxyphenylpropionate 1,2-Dioxygenase (MhpB) †,‡

Mendel, Sharon, Arndt, Andrew, Bugg, Timothy D. H.

Journal:

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

74

Identification of DypB from Rhodococcus jostii RHA1 as a Lignin Peroxidase

Ahmad, Mark, Roberts, Joseph N., Hardiman, Elizabeth M., Singh, Rahul, Eltis, Lindsay D., Bugg, Timothy D. H.

Journal:

Year:

2011

Language:

english

File:

PDF, 1002 KB

english, 2011

75

Native E.coliinner membrane incorporation in solid-supported lipid bilayer membranes

Charlotte E. Dodd, Benjamin R. G. Johnson, Lars J. C. Jeuken, Timothy D. H. Bugg, Richard J. Bushby, Stephen D. Evans

Journal:

Year:

2008

Language:

english

File:

PDF, 1.45 MB

english, 2008

76

Mechanism of Extradiol Catechol Dioxygenases: Evidence for a Lactone Intermediate in the 2,3-Dihydroxyphenylpropionate 1,2-Dioxygenase Reaction

Sanvoisin, Jonathan, Langley, G. John, Bugg, Timothy D. H.

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 292 KB

english, 1995

77

Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue

Hentall, Philip L., Flowers, Nadine, Bugg, Timothy D. H.

Journal:

Chemical Communications

Year:

2001

Language:

english

File:

PDF, 77 KB

english, 2001

78

A biomimetic model reaction for the extradiol catechol dioxygenases

Lin, Gang, Bugg, Timothy D. H., Reid, Gillian

Journal:

Chemical Communications

Year:

2000

Language:

english

File:

PDF, 309 KB

english, 2000

79

Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis

Kimura, Ken-ichi, Bugg, Timothy D. H.

Journal:

Natural Product Reports

Year:

2003

Language:

english

File:

PDF, 724 KB

english, 2003

80

[Methods in Enzymology] Enzyme Kinetics and Mechanism Part F: Detection and Characterization of Enzyme Reaction Intermediates Volume 354 || 2-Hydroxy-6-keto-nona-2,4-diene 1,9-dioic acid 5,6-hydrolase: Evidence from 18O isotope exchange for gem-diol intermediate

Bugg, Timothy D.H.

Year:

2002

Language:

english

File:

PDF, 810 KB

english, 2002

81

Characterization of Dye-Decolorizing Peroxidases from Rhodococcus jostii RHA1

Roberts, Joseph N., Singh, Rahul, Grigg, Jason C., Murphy, Michael E. P., Bugg, Timothy D. H., Eltis, Lindsay D.

Journal:

Year:

2011

Language:

english

File:

PDF, 4.83 MB

english, 2011

82

The dynamics of peptidoglycan structure and function: Conference report on the 3rd Great Wall Symposium

Williams, Allison H., Boneca, Ivo G., Burrows, Lori L., Bugg, Timothy D.H.

Journal:

Research in Microbiology

Year:

2014

Language:

english

File:

PDF, 171 KB

english, 2014

83

Enzymology of the carotenoid cleavage dioxygenases: Reaction mechanisms, inhibition and biochemical roles

Harrison, Peter J., Bugg, Timothy D.H.

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 1016 KB

english, 2014

84

Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor

Paradis‑Bleau, Catherine, Lloyd, Adrian, Sanschagrin, François, Maaroufi, Halim, Clarke, Tom, Blewett, Anne, Dowson, Chris, Roper, David I., Bugg, Timothy D. H., Levesque, Roger C.

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 560 KB

english, 2009

85

How to Break the Rules of Dioxygen Activation

Bugg, Timothy D.H.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 247 KB

english, 2014

86

Editorial: Antibacterial targets for the 21st century

Bugg, Timothy D.H.

Journal:

Bioorganic Chemistry

Year:

2014

Language:

english

File:

PDF, 161 KB

english, 2014

87

Does abscisic acid affect strigolactone biosynthesis?

Juan A. López-Ráez, Wouter Kohlen, Tatsiana Charnikhova, Patrick Mulder, Anna K. Undas, Martin J. Sergeant, Francel Verstappen, Timothy D. H. Bugg, Andrew J. Thompson, Carolien Ruyter-Spira and Harro

Journal:

New Phytologist

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

88

Bacterial enzymes for lignin degradation: production of aromatic chemicals from lignocellulose

Bugg, Timothy D.H.

Journal:

New Biotechnology

Year:

2014

Language:

english

File:

PDF, 65 KB

english, 2014

89

Catalytic Mechanism of a C−C Hydrolase Enzyme: Evidence for a Gem- Diol Intermediate, Not an Acyl Enzyme †

Fleming, Sarah M., Robertson, Thomas A., Langley, G. John, Bugg, Timothy D. H.

Journal:

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

90

A Solvolytic C−C Cleavage Reaction of 6-Acetoxycyclohexa-2,4-dienones: Mechanistic Implications for the Intradiol Catechol Dioxygenases

Eley, Kirstin L., Crowley, Patrick J., Bugg, Timothy D. H.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

91

Catalytic Role for Arginine 188 in the C−C Hydrolase Catalytic Mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD †

Li, Chen, Li, Jian-Jun, Montgomery, Mark G., Wood, Stephen P., Bugg, Timothy D. H.

Journal:

Year:

2006

Language:

english

File:

PDF, 728 KB

english, 2006

92

Cis − Trans Isomerization of a Cyclopropyl Radical Trap Catalyzed by Extradiol Catechol Dioxygenases: Evidence for a Semiquinone Intermediate

Spence, Emma L., Langley, G. John, Bugg, Timothy D. H.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 512 KB

english, 1996

93

Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B

Mihalyi, Agnes, Jamshidi, Shirin, Slikas, Justinas, Bugg, Timothy D.H.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 880 KB

english, 2014

94

Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes

Zawadzke, Laura E., Bugg, Timothy D. H., Walsh, Christopher T.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.16 MB

english, 1991

95

Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme

Mendel, Sharon, Arndt, Andrew, Bugg, Timothy D. H.

Journal:

Chemical Communications

Year:

2005

Language:

english

File:

PDF, 242 KB

english, 2005

96

Encyclopedia of Life Sciences || Enzymes: General Properties

Bugg, Timothy DH

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

97

Evidence for a gem -Diol Reaction Intermediate in Bacterial C−C Hydrolase Enzymes BphD and MhpC from 13 C NMR Spectroscopy †

Li, Jian-Jun, Li, Chen, Blindauer, Claudia A., Bugg, Timothy D. H.

Journal:

Year:

2006

Language:

english

File:

PDF, 176 KB

english, 2006

98

Multivalent Conjugates of Poly-γ- d -glutamic Acid from Bacillus licheniformis with Antibody F(ab‘) and Glycopeptide Ligands

Prodhomme, Emmanuel J. F., Tutt, Alison L., Glennie, Martin J., Bugg, Timothy D. H.

Journal:

Bioconjugate Chemistry

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

99

Crystal Structure and Functional Assignment of YfaU, a Metal Ion Dependent Class II Aldolase from Escherichia coli K12 †‡

Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Timothy D. H., Roper, David I.

Journal:

Year:

2008

Language:

english

File:

PDF, 7.21 MB

english, 2008

100

Chemical and biochemical properties of 2-hydroxypentadienoic acid, a homologue of enolpyruvic acid

R. Pollard, John, M. J. Henderson, Ian, D. H. Bugg, Timothy

Journal:

Chemical Communications

Year:

1997

Language:

english

File:

PDF, 51 KB

english, 1997

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