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51

Interaction Model for Anthracycline Activity against DNA Topoisomerase II †

Moro, Stefano, Beretta, Giovanni L., Dal Ben, Diego, Nitiss, John, Palumbo, Manlio, Capranico, Giovanni

Journal:

Year:

2004

Language:

english

File:

PDF, 604 KB

english, 2004

52

Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex

Ricci, Antonio, Marinello, Jessica, Bortolus, Marco, Sánchez, Albert, Grandas, Anna, Pedroso, Enrique, Pommier, Yves, Capranico, Giovanni, Maniero, Anna Lisa, Zagotto, Giuseppe

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.32 MB

english, 2011

53

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

Capranico, Giovanni, Zunino, Franco, Kohn, Kurt W., Pommier, Yves

Journal:

Year:

1990

Language:

english

File:

PDF, 2.68 MB

english, 1990

54

Peptidyl Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA Binding, Redox Cycling, and Biological Activity

Gatto, Barbara, Zagotto, Giuseppe, Sissi, Claudia, Cera, Cinzia, Uriarte, Eugenio, Palù, Giorgio, Capranico, Giovanni, Palumbo, Manlio

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 397 KB

english, 1996

55

Position-Specific Effects of Base Mismatch on Mammalian Topoisomerase II DNA Cleaving Activity †

Bigioni, Mario, Zunino, Franco, Tinelli, Stella, Austin, Caroline A., Willmore, Elaine, Capranico, Giovanni

Journal:

Year:

1996

Language:

english

File:

PDF, 423 KB

english, 1996

56

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide

Pommier, Yves, Capranico, Giovanni, Orr, Ann, Kohn, Kurt W.

Journal:

Nucleic Acids Research

Year:

1991

Language:

english

File:

PDF, 726 KB

english, 1991

57

DNA topoisomerase-trapping antitumour drugs

Capranico, Giovanni, Zunino, Franco

Journal:

European Journal of Cancer

Year:

1992

Language:

english

File:

PDF, 896 KB

english, 1992

58

Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers

Capranico, Giovanni, Tinelli, Stella, Zunino, Franco, Kohn, Kurt W., Pommier, Yves

Journal:

Year:

1993

Language:

english

File:

PDF, 2.20 MB

english, 1993

59

Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent ∞

Tumiatti, Vincenzo, Milelli, Andrea, Minarini, Anna, Micco, Marialuisa, Gasperi Campani, Anna, Roncuzzi, Laura, Baiocchi, Daniela, Marinello, Jessica, Capranico, Giovanni, Zini, Maddalena, Stefanelli,

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.13 MB

english, 2009

60

The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1 Activity by Changing miR Expression Patterns in Human Cancer Cells

Bertozzi, D., Marinello, J., Manzo, S. G., Fornari, F., Gramantieri, L., Capranico, G.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 732 KB

english, 2014

61

Effects of Common Buffer Systems on Drug Activity: The Case of Clerocidin

Richter, Sara, Fabris, Daniele, Binaschi, Monica, Gatto, Barbara, Capranico, Giovanni, Palumbo, Manlio

Journal:

Chemical Research in Toxicology

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

62

Similar sequence specificity of mitoxantrone and VM-26 stimulation of in vitro DNA cleavage by mammalian DNA topoisomerase II

Capranico, Giovanni, De Isabella, Paola, Tinelli, Stella, Bigioni, Mario, Zunino, Franco

Journal:

Year:

1993

Language:

english

File:

PDF, 1.80 MB

english, 1993

63

Intracellular Distribution of β -Catenin in Human Medulloblastoma Cell Lines with Different Degree of Neuronal Differentiation

Salaroli, Roberta, Russo, Alessandra, Ceccarelli, Claudio, Mina, Giorgia D., Arcella, Antonella, Martinelli, Giuseppe N., Giangaspero, Felice, Capranico, Giovanni, Cenacchi, Giovanna

Journal:

Ultrastructural Pathology

Year:

2007

Language:

english

File:

PDF, 4.24 MB

english, 2007

64

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

Zagotto, Giuseppe, Gianoncelli, Alessandra, Sissi, Claudia, Marzano, Cristina, Gandin, Valentina, Pasquale, Riccardo, Capranico, Giovanni, Ribaudo, Giovanni, Palumbo, Manlio

Journal:

Archiv der Pharmazie

Year:

2014

Language:

english

File:

PDF, 485 KB

english, 2014

65

Base sequence determinants of amonafide stimulation of topoisomerase II DNA clevage

De Isabella, Paola, Zunino, Franco, Capranico, Giovanni

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 6.76 MB

english, 1995

66

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

Marinello, J., Chillemi, G., Bueno, S., Manzo, S. G., Capranico, G.

Journal:

Nucleic Acids Research

Year:

2013

Language:

english

File:

PDF, 18.16 MB

english, 2013

67

Intrinsic ellipticity correlations of galaxies: models, likelihoods and interplay with weak lensing

Capranico, F., Merkel, P. M., Schafer, B. M.

Journal:

Monthly Notices of the Royal Astronomical Society

Year:

2013

Language:

english

File:

PDF, 794 KB

english, 2013

68

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1 gene locus

Baranello, L., Bertozzi, D., Fogli, M. V., Pommier, Y., Capranico, G.

Journal:

Nucleic Acids Research

Year:

2010

Language:

english

File:

PDF, 2.22 MB

english, 2010

69

Base mutation analysis of topoisomerase II-idarubicin-DNA ternary complex formation. Evidence for enzyme subunit cooperativity in DNA cleavage

Bigioni, Mario, Zunino, Franco, Capranico, Giovanni

Journal:

Nucleic Acids Research

Year:

1994

Language:

english

File:

PDF, 6.91 MB

english, 1994

70

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide

Pommier, Y., Capranico, G., Orr, A., Kohn, K.W.

Journal:

Nucleic Acids Research

Year:

1991

Language:

english

File:

PDF, 26 KB

english, 1991

71

Novel Symmetric and Asymmetric DNA Scission Determinants for Streptococcus pneumoniae Topoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site

Leo, E., Gould, K. A., Pan, X.-S., Capranico, G., Sanderson, M. R., Palumbo, M., Fisher, L. M.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.11 MB

english, 2005

72

Mapping Drug Interactions at the Covalent Topoisomerase II-DNA Complex by Bisantrene/Amsacrine Congeners

Capranico, G., Guano, F., Moro, S., Zagotto, G., Sissi, C., Gatto, B., Zunino, F., Menta, E., Palumbo, M.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 810 KB

english, 1998

73

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase in reconstituted Simian virus 40 chromatin

Capranico, G., Jaxel, C., Roberge, M., Kohn, K. W., Pommier, Y.

Journal:

Nucleic Acids Research

Year:

1990

Language:

english

File:

PDF, 1.19 MB

english, 1990

74

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin

D'Annessa, Ilda, Tesauro, Cinzia, Fiorani, Paola, Chillemi, Giovanni, Castelli, Silvia, Vassallo, Oscar, Capranico, Giovanni, Desideri, Alessandro

Journal:

Journal of Amino Acids

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

75

Doxorubicin Disaccharide Analogue: Apoptosis-Related Improvement of Efficacy In Vivo

Arcamone, F., Animati, F., Berettoni, M., Bigioni, M., Capranico, G., Casazza, A. M., Caserini, C., Cipollone, A., De Cesare, M., Franciotti, M., Lombardi, P., Madami, A., Manzini, S., Monteagudo, E.,

Journal:

JNCI Journal of the National Cancer Institute

Year:

1997

Language:

english

File:

PDF, 310 KB

english, 1997

76

Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening

Drwal, Malgorzata N., Marinello, Jessica, Manzo, Stefano G., Wakelin, Laurence P. G., Capranico, Giovanni, Griffith, Renate, Sem, Daniel S.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.08 MB

english, 2014

77

Editorial [Hot Topic: Target Specificity of Effective Anticancer Therapeutics (Executive Editor: G. Capranico)]

Capranico, Giovanni

Journal:

Current Pharmaceutical Design

Year:

2007

Language:

english

File:

PDF, 28 KB

english, 2007

78

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

Capranico, Giovanni, Kohn, Kurt W., Pommier, Yves

Journal:

Nucleic Acids Research

Year:

1990

Language:

english

File:

PDF, 1.29 MB

english, 1990

79

DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation

Dal Ben, D., Palumbo, M., Zagotto, G, Capranico, G., Moro, S.

Journal:

Current Pharmaceutical Design

Year:

2007

Language:

english

File:

PDF, 948 KB

english, 2007

80

Characterization of a Topoisomerase II Gene Rearrangement in a Human Small-Cell Lung Cancer Cell Line

Binaschi, M., Giaccone, G., Gazdar, A. F., De Isabella, P., Ricotti, G. C. B. A., Capranico, G., Zunino, F.

Journal:

JNCI Journal of the National Cancer Institute

Year:

1992

File:

PDF, 2.29 MB

1992

81

Anthracyclines: Selected New Developments

Binaschi, M., Bigioni, M., Cipollone, A., Rossi, C., Goso, C., Maggi, C., Capranico, G., Animati, F.

Journal:

Current Medicinal Chemistry - Anti-Cancer Agents

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

82

A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms

Capranico, Giovanni

Journal:

Current Medicinal Chemistry - Anti-Cancer Agents

Year:

2004

Language:

english

File:

PDF, 23 KB

english, 2004

83

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions

Cristini, Agnese, Park, Joon-Hyung, Capranico, Giovanni, Legube, Gaëlle, Favre, Gilles, Sordet, Olivier

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 12.04 MB

english, 2016

84

A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts

Supino, Rosanna, Polizzi, Donatella, Pavesi, Raffaella, Pratesi, Graziella, Guano, Fulvio, Capranico, Giovanni, Palumbo, Manlio, Sissi, Claudia, Richter, Silvia, Beggiolin, Gino, Menta, Ernesto, Pezzo

Journal:

Year:

2001

Language:

english

File:

PDF, 274 KB

english, 2001

85

Toward the development of specific G-quadruplex binders: synthesis, biophysical and biological studies of new hydrazone derivatives

Amato, Jussara, Morigi, Rita, Pagano, Bruno, Pagano, Alessia, Ohnmacht, Stephan A, De Magis, Alessio, Tiang, Yee-Peng, Capranico, Giovanni, Locatelli, Alessandra, Graziadio, Alessandra, Leoni, Alberto

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.69 MB

english, 2016

86

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Amato, Jussara, Pagano, Alessia, Cosconati, Sandro, Amendola, Giorgio, Fotticchia, Iolanda, Iaccarino, Nunzia, Marinello, Jessica, De Magis, Alessio, Capranico, Giovanni, Novellino, Ettore, Pagano, Br

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2016

Language:

english

File:

PDF, 1.23 MB

english, 2016

87

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents

Beretta, Giovanni L., Ribaudo, Giovanni, Menegazzo, Ileana, Supino, Rosanna, Capranico, Giovanni, Zunino, Franco, Zagotto, Giuseppe

Journal:

Archiv der Pharmazie

Year:

2017

Language:

english

File:

PDF, 3.33 MB

english, 2017

88

Influence of structural modifications at the 3' and 4' positions of doxorubicin on the drug ability to trap topoisomerase II and to overcome multidrug resistance

Capranico, G, Supino, R, Binaschi, M, Capolongo, L, Grandi, M, Suarato, a, Zunino, F

Journal:

Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.41 MB

english, 1994

89

Type I DNA Topoisomerases

Capranico, Giovanni, Marinello, Jessica, Chillemi, Giovanni

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 10.85 MB

english, 2017

90

[Advances in DNA Sequence-Specific Agents] Volume 3 || Sequence-specific poisons of type II DNA topoisomerases

Capranico, Giovanni

Year:

1998

Language:

english

File:

PDF, 1.84 MB

english, 1998

91

RNA G-quadruplexes in Kirsten ras ( KRAS ) oncogene as targets for small molecules inhibiting translation

Miglietta, Giulia, Cogoi, Susanna, Marinello, Jessica, Capranico, Giovanni, Tikhomirov, Alexander S., Shchekotikhin, Andrey E., Xodo, Luigi E.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.22 MB

english, 2017

92

DNA Topoisomerase I differentially modulates R-loops across the human genome

Manzo, Stefano G., Hartono, Stella R., Sanz, Lionel A., Marinello, Jessica, De Biasi, Sara, Cossarizza, Andrea, Capranico, Giovanni, Chedin, Frederic

Journal:

Year:

2018

Language:

english

File:

PDF, 2.74 MB

english, 2018

93

Preface

Capranico, Giovanni

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 23 KB

english, 2002

94

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

Marinello, Jessica, Delcuratolo, Maria, Capranico, Giovanni

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 552 KB

english, 2018

95

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

De Magis, Alessio, Manzo, Stefano G., Russo, Marco, Marinello, Jessica, Morigi, Rita, Sordet, Olivier, Capranico, Giovanni

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

96

DNA-Binding Preferences of Bisantrene Analogues: Relevance to the Sequence Specificity of Drug-Mediated Topoisomerase II Poisoning

Sissi, Claudia, Bolgan, Loretta, Moro, Stefano, Zagotto, Giuseppe, Bailly, Christian, Menta, Ernesto, Capranico, Giovanni, Palumbo, Manlio

Journal:

Molecular Pharmacology

Year:

1998

Language:

english

File:

PDF, 355 KB

english, 1998

97

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Cristini, Agnese, Ricci, Giulia, Britton, Sébastien, Salimbeni, Simona, Huang, Shar-yin Naomi, Marinello, Jessica, Calsou, Patrick, Pommier, Yves, Favre, Gilles, Capranico, Giovanni, Gromak, Natalia,

Journal:

Year:

2019

Language:

english

File:

PDF, 5.62 MB

english, 2019

98

Mono-hydrazone based G-quadruplex selective ligands induce DNA damage and genome instability in human cancer cells

Amato, Jussara, Miglietta, Giulia, Morigi, Rita, Iaccarino, Nunzia, Locatelli, Alessandra, Leoni, Alberto, Novellino, Ettore, Pagano, Bruno, Capranico, Giovanni, Randazzo, Antonio

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 4.75 MB

2020

99

G-quadruplexâR-loop interactions and the mechanism of anticancer G-quadruplex binders

Miglietta, Giulia, Russo, Marco, Capranico, Giovanni

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 188 KB

2020

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