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1

The Growing Impact of Catalysis in the Pharmaceutical Industry

Carl A. Busacca, Daniel R. Fandrick, Jinhua J. Song, Chris H. Senanayake

Journal:

Advanced Synthesis & Catalysis

Year:

2011

Language:

english

File:

PDF, 1.14 MB

english, 2011

2

The Reaction of Grignard Reagents with Bunte Salts: A Thiol-Free Synthesis of Sulfides

Reeves, Jonathan T., Camara, Kaddy, Han, Zhengxu S., Xu, Yibo, Lee, Heewon, Busacca, Carl A., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 606 KB

english, 2014

3

Process Development and Pilot-Plant Synthesis of ( S )- tert -Butyl 1-Oxo-1-(1-(pyridin-2-yl)cyclopropylamino)propan-2-ylcarbamate: Studies on the Scale-Up of Kulinkovich–Szymoniak Cyclopropanation

Li, Wenjie, Gao, Joe J., Lorenz, Jon C., Xu, Jinghua, Johnson, Joe, Ma, Shengli, Lee, Heewon, Grinberg, Nelu, Busacca, Carl A., Lu, Bruce, Senanayake, Chris H.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 231 KB

english, 2012

4

Part 1: A Review and Perspective of the Regulatory Guidance to Support Designation and Justification of API Starting Material

Faul, Margaret M., Kiesman, William F., Smulkowski, Maciej, Pfeiffer, Steven, Busacca, Carl A., Eriksson, Magnus C., Hicks, Fred, Orr, John D.

Journal:

Organic Process Research & Development

Year:

2014

Language:

english

File:

PDF, 204 KB

english, 2014

5

Part 2: Designation and Justification of API Starting Materials: Current Practices across Member Companies of the IQ Consortium

Faul, Margaret M., Busacca, Carl A., Eriksson, Magnus C., Hicks, Fred, Kiesman, William F., Smulkowski, Maciej, Orr, John D., Pfeiffer, Steven

Journal:

Organic Process Research & Development

Year:

2014

Language:

english

File:

PDF, 479 KB

english, 2014

6

Identification of a process impurity formed during synthesis of a nevirapine analogue HIV NNRT inhibitor using LC/MS and forced degradation studies

Fenghe Qiu, Scott Pennino, Carl A. Busacca, Daniel L. Norwood

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2009

Language:

english

File:

PDF, 438 KB

english, 2009

7

One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

Frutos, Rogelio P., Wei, Xudong, Patel, Nitinchandra D., Tampone, Thomas G., Mulder, Jason A., Busacca, Carl A., Senanayake, Chris H.

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 313 KB

english, 2013

8

Development of Multikilogram Continuous Flow Cyclopropanation of N -Benzylmaleimide through Kinetic Analysis

Buono, Frederic G., Eriksson, Magnus C., Yang, Bing-Shiou, Kapadia, Suresh R., Lee, Heewon, Brazzillo, Jason, Lorenz, Jon C., Nummy, Laurence, Busacca, Carl A., Yee, Nathan, Senanayake, Chris

Journal:

Organic Process Research & Development

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

9

Rhodium-Catalyzed Transnitrilation of Aryl Boronic Acids with Dimethylmalononitrile

Malapit, Christian A., Reeves, Jonathan T., Busacca, Carl A., Howell, Amy R., Senanayake, Chris H.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 694 KB

english, 2016

10

Enantioselective Nickel-Catalyzed Mizoroki–Heck Cyclizations To Generate Quaternary Stereocenters

Desrosiers, Jean-Nicolas, Wen, Jialin, Tcyrulnikov, Sergei, Biswas, Soumik, Qu, Bo, Hie, Liana, Kurouski, Dmitry, Wu, Ling, Grinberg, Nelu, Haddad, Nizar, Busacca, Carl A., Yee, Nathan K., Song, Jinhu

Journal:

Organic Letters

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

11

ChemInform Abstract: Cross-Coupling of Vinyl Triflates and Alkyl Grignard Reagents Catalyzed by Nickel(0)-Complexes.

Carl A. Busacca, Magnus C. Eriksson, Rita Fiaschi

Journal:

Year:

1999

File:

PDF, 33 KB

1999

12

ChemInform Abstract: 4-Trifloxy-9-SEM-β-carboline: Preparation and Synthetic Utility.

Carl A. Busacca, Magnus C. Eriksson, Yong Dong, Anthony S. Prokopowicz, Annette M. Salvagno, Matt A. Tschantz

Journal:

Year:

1999

File:

PDF, 40 KB

1999

13

ChemInform Abstract: Synthesis of 4-(p-Methoxyphenyl)-β-carboline, a New Inhibitor of Cellular Calcium Influx.

Carl A. Busacca, Yong Dong

Journal:

Year:

2000

File:

PDF, 32 KB

2000

14

ChemInform Abstract: A Convenient Synthesis of (1S)-tert-Butyl-1,2-ethylenediamine.

Carl A. Busacca, Danja Grossbach, Earl Spinelli

Journal:

Year:

2000

File:

PDF, 26 KB

2000

15

Application of the Palladium-Catalyzed N-Arylation of Hydrazones to Deactivated Heteroaryl Halides in the Synthesis of Pyrazoles.

Nizar Haddad, Annette Salvagno, Carl Busacca

Journal:

Year:

2004

File:

PDF, 18 KB

2004

16

A Superior Method for the Reduction of Secondary Phosphine Oxides.

Carl A. Busacca, et al. et al.

Journal:

Year:

2006

File:

PDF, 29 KB

2006

17

ChemInform Abstract: Palladium-Catalyzed Aminocarbonylation of Heteroaryl Halides Using Di-tert-butylphosphinoferrocene.

Bo Qu, Nizar Haddad, Zhengxu S. Han, Sonia Rodriguez, Jon C. Lorenz, Nelu Grinberg, Heewon Lee, Carl A. Busacca, DhileepKumar Krishnamurthy, Chris H. Senanayake

Journal:

Year:

2010

File:

PDF, 30 KB

2010

18

ChemInform Abstract: Ambient Temperature Hydrophosphination of Internal, Unactivated Alkynes and Allenyl Phosphineoxides with Phosphine Borane Complexes.

Carl A. Busacca, et al. et al.

Journal:

Year:

2010

File:

PDF, 48 KB

2010

19

ChemInform Abstract: The Olefin Metathesis Reaction: Applications in the Pharmaceutical Industry

Vittorio Farina, Chutian Shu, Xingzhong Zeng, Ming-Hong Hao, Xudong Wei, Nathan K. Yee, Carl A. Busacca, Zhengxu Han, Chris Senanayake

Journal:

Year:

2010

File:

PDF, 15 KB

2010

20

ChemInform Abstract: The Growing Impact of Catalysis in the Pharmaceutical Industry

Carl A. Busacca, Daniel R. Fandrick, Jinhua J. Song, Chris H. Senanayake

Journal:

Year:

2012

File:

PDF, 18 KB

2012

21

Synthesis of [14C]- and [13C6]-labeled potent HIV non-nucleoside reverse transcriptase inhibitor

Bachir Latli, Matt Hrapchak, Carl A. Busacca, Dhileepkumar Krishnamurthy, Chris H. Senanayake

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2009

Language:

english

File:

PDF, 184 KB

english, 2009

22

Synthesis of deuterium-, tritium-, and carbon-14-labeled BILN2061, a potent hepatitis C virus protease inhibitor

Bachir Latli, Matt Hrapchak, Vida Gorys, Carl A. Busacca, Chris Senanayake

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2005

Language:

english

File:

PDF, 118 KB

english, 2005

23

Structure elucidation and total synthesis of a unique group of trace impurities in Tipranavir® drug product

Carl A. Busacca, Scot Campbell, Anjan Saha, Jon C. Lorenz, Karl Grozinger, Paul-James Jones, Nelu Grinberg, Sherry Shen, Heewon Lee, Fenghe Qiu, Alice Granger, Zhanna Yuabova, Dan Norwood, Chris H. Se

Journal:

Magnetic Resonance in Chemistry

Year:

2005

Language:

english

File:

PDF, 185 KB

english, 2005

24

31P Solid state NMR study of structure and chemical stability of dichlorotriphenylphosphorane

Nina C. Gonnella, Carl Busacca, Scot Campbell, Magnus Eriksson, Nelu Grinberg, Teresa Bartholomeyzik, Shengli Ma, Daniel L. Norwood

Journal:

Magnetic Resonance in Chemistry

Year:

2009

Language:

english

File:

PDF, 97 KB

english, 2009

25

1H and 13C NMR assignments of all three isomeric o-fluoronaphthaldehydes and three o-fluorophenanthrene aldehydes

Carl A. Busacca, Scot Campbell, Nina C. Gonnella, Chris H. Senanayake

Journal:

Magnetic Resonance in Chemistry

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010

26

Synthesis of novel tetrahydrobenzazepinones

Carl A. Busacca, Robert E. Johnson

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 238 KB

english, 1992

27

A one step synthesis of thiazolines from esters

Carl A. Busacca, Yong Dong, Earl M. Spinelli

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 192 KB

english, 1996

28

A facile synthesis of 4-aryl-2,3-dihydropyrroles

Carl A. Busacca, Yong Dong

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 227 KB

english, 1996

29

Application of the palladium-catalyzed N-arylation of hydrazones to deactivated heteroaryl halides in the synthesis of pyrazoles

Nizar Haddad, Annette Salvagno, Carl Busacca

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 239 KB

english, 2004

30

Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene

Bo Qu, Nizar Haddad, Zhengxu S. Han, Sonia Rodriguez, Jon C. Lorenz, Nelu Grinberg, Heewon Lee, Carl A. Busacca, DhileepKumar Krishnamurthy, Chris H. Senanayake

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 1.26 MB

english, 2009

31

Asymmetric Diels-Alder reactions of chiral α,β-unsaturated lactams

A.I. Meyers, Carl A. Busacca

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 195 KB

english, 1989

32

An asymmetric route to fused carbocyclic systems via Diels-Alder reactions on chiral α,β-unsaturated bicyclic lactams

A.I. Meyers, Carl A. Busacca

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 196 KB

english, 1989

33

Cross coupling of vinyl triflates and alkyl Grignard reagents catalyzed by nickel(0)-complexes

Carl A. Busacca, Magnus C. Eriksson, Rita Fiaschi

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 278 KB

english, 1999

34

A convenient synthesis of (1S)-tert-butyl-1,2-ethylenediamine

Carl A Busacca, Danja Grossbach, Earl Spinelli

Journal:

Tetrahedron: Asymmetry

Year:

2000

Language:

english

File:

PDF, 91 KB

english, 2000

35

Study and characterization of crystalline hydrate/polymorph forms of 5,11-dihydro-11-ethyl-5-methyl-8-(2-(1-oxido-4-quinolinyl)ethyl-6H-dipyrido(3,2-B:2′,3′-E)(1,4)diazepin-6-one by solid-state NMR and solution NMR

N.C. Gonnella, John A. Smoliga, Scot Campbell, Carl A. Busacca, Michael Cerreta, Richard Varsolona, Daniel L. Norwood

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2010

Language:

english

File:

PDF, 751 KB

english, 2010

36

Chelation controlled reductive amination of cyclic ketones to trans-4-methoxycyclohexylamines: 9-BBN reduction mediated with FeCl3

Bo Qu, Nizar Haddad, Sonia Rodriguez, Heewon Lee, Shengli Ma, Xingzhong Zeng, Diana C. Reeves, Kanwar P.S. Sidhu, Jon C. Lorenz, Nelu Grinberg, Carl A. Busacca, Dhileepkumar Krishnamurthy, Chris H. Se

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 1.30 MB

english, 2012

37

Development of a Pilot-Plant Process for a Nevirapine Analogue HIV NNRT Inhibitor

Busacca, Carl A., Cerreta, Mike, Dong, Yong, Eriksson, Magnus C., Farina, Vittorio, Feng, XuWu, Kim, Ji-Young, Lorenz, Jon C., Sarvestani, Max, Simpson, Robert

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 235 KB

english, 2008

38

Practical Large-Scale Synthesis of the Hepatitis C Virus Protease Inhibitor BI 201335

Carl A. Busacca, Xudong Wei, Nizar Haddad, Suresh Kapadia, Jon. C. Lorenz, Anjan K. Saha, Richard J. Varsolona, Thilo Berkenbusch, Scot C. Campbell, Vittorio Farina, XuWu Feng, Nina C. Gonnella, Nelu

Journal:

Asian Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 417 KB

english, 2012

39

Phenethylamines via Heck arylation of a new vinylamine equivalent

Busacca, Carl A., Johnson, Robert E., Swestock, John

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 667 KB

english, 1993

40

Probing the cation binding modes of macrocyclic HCV Protease inhibitor BILN 2061 by multinuclear NMR

Carl A. Busacca, Paul-James Jones, Scot J. Campbell, Anjan K. Saha, Nina C. Gonnella, Chris H. Senanayake

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2012

Language:

english

File:

PDF, 493 KB

english, 2012

41

Synthesis of 4-( p -Methoxyphenyl)-β-Carboline, A New Inhibitor of Cellular Calcium Influx

Busacca, Carl A., Dong, Yong

Journal:

Synthetic Communications

Year:

2000

Language:

english

File:

PDF, 294 KB

english, 2000

42

Hydrophosphination of Propargylic Alcohols and Amines with Phosphine Boranes

Busacca, Carl A., Qu, Bo, Farber, Elisa, Haddad, Nizar, Grět, Nicole, Saha, Anjan K., Eriksson, Magnus C., Wu, Jiang-Ping, Fandrick, Keith R., Han, Steve, Grinberg, Nelu, Ma, Shengli, Lee, Heewon, Li,

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 361 KB

english, 2013

43

A Highly Convergent and Efficient Synthesis of a Macrocyclic Hepatitis C Virus Protease Inhibitor BI 201302

Wei, Xudong, Shu, Chutian, Haddad, Nizar, Zeng, Xingzhong, Patel, Nitinchandra D., Tan, Zhulin, Liu, Jianxiu, Lee, Heewon, Shen, Sherry, Campbell, Scot, Varsolona, Richard J., Busacca, Carl A., Hossai

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 659 KB

english, 2013

44

[2,3]-Sigmatropic Rearrangements of 2-Phosphineborane 2-Propen-1-ols: Rapid Access to Enantioenriched Diphosphine Monoxide Derivatives

Busacca, Carl A., Qu, Bo, Farber, Elisa, Haddad, Nizar, Grět, Nicole, Saha, Anjan K., Eriksson, Magnus C., Wu, Jiang-Ping, Fandrick, Keith R., Han, Steve, Grinberg, Nelu, Ma, Shengli, Lee, Heewon, Li,

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 945 KB

english, 2013

45

Copper-Catalyst-Controlled Site-Selective Allenylation of Ketones and Aldehydes with Propargyl Boronates

Fandrick, Keith R., Ogikubo, Junichi, Fandrick, Daniel R., Patel, Nitinchandra D., Saha, Jaideep, Lee, Heewon, Ma, Shengli, Grinberg, Nelu, Busacca, Carl A., Senanayake, Chris H.

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 987 KB

english, 2013

46

Indoles from o -Haloanilines: Syntheses of Tryptamines and Tryptophols via Regioselective Hydroformylation of Functionalized Anilines

Dong, Yong, Busacca, Carl A.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 56 KB

english, 1997

47

Heart-Cutting Two-Dimensional Ultrahigh-Pressure Liquid Chromatography for Process Development: Asymmetric Reaction Monitoring

Ma, Shengli, Grinberg, Nelu, Haddad, Nizar, Rodriguez, Sonia, Busacca, Carl A., Fandrick, Keith, Lee, Heewon, Song, Jinhua J., Yee, Nathan, Krishnamurthy, Dhileepkumar, Senanayake, Chris H., Wang, Jin

Journal:

Organic Process Research & Development

Year:

2013

Language:

english

File:

PDF, 656 KB

english, 2013

48

RCM Macrocyclization Made Practical: An Efficient Synthesis of HCV Protease Inhibitor BILN 2061

Shu, Chutian, Zeng, Xingzhong, Hao, Ming-Hong, Wei, Xudong, Yee, Nathan K., Busacca, Carl A., Han, Zhengxu, Farina, Vittorio, Senanayake, Chris H.

Journal:

Organic Letters

Year:

2008

Language:

english

File:

PDF, 114 KB

english, 2008

49

Large-Scale Asymmetric Synthesis of a Cathepsin S Inhibitor

Lorenz, Jon C., Busacca, Carl A., Feng, XuWu, Grinberg, Nelu, Haddad, Nizar, Johnson, Joe, Kapadia, Suresh, Lee, Heewon, Saha, Anjan, Sarvestani, Max, Spinelli, Earl M., Varsolona, Rich, Wei, Xudong,

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.05 MB

english, 2010

50

Reduction of Tertiary Phosphine Oxides with DIBAL-H

Busacca, Carl A., Raju, Ravinder, Grinberg, Nelu, Haddad, Nizar, James-Jones, Paul, Lee, Heewon, Lorenz, Jon C., Saha, Anjan, Senanayake, Chris H.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 173 KB

english, 2008