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101

Protein kinase A as a biological target in cancer therapy

Naviglio, Silvio, Caraglia, Michele, Abbruzzese, Alberto, Chiosi, Emilio, Di Gesto, Davide, Marra, Monica, Romano, Maria, Sorrentino, Annunziata, Sorvillo, Luca, Spina, Annamaria, Illiano, Gennaro

Journal:

Expert Opinion on Therapeutic Targets

Year:

2009

Language:

english

File:

PDF, 335 KB

english, 2009

102

Evaluation of 8-Arylsulfanyl, 8-Arylsulfoxyl, and 8-Arylsulfonyl Adenine Derivatives as Inhibitors of the Heat Shock Protein 90

Llauger, Laura, He, Huazhong, Kim, Joungnam, Aguirre, Julia, Rosen, Neal, Peters, Ulf, Davies, Peter, Chiosis, Gabriela

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 190 KB

english, 2005

103

Monitoring Afatinib Treatment in HER2-Positive Gastric Cancer with 18F-FDG and 89Zr-Trastuzumab PET

Janjigian, Y. Y., Viola-Villegas, N., Holland, J. P., Divilov, V., Carlin, S. D., Gomes-DaGama, E. M., Chiosis, G., Carbonetti, G., de Stanchina, E., Lewis, J. S.

Journal:

Journal of Nuclear Medicine

Year:

2013

Language:

english

File:

PDF, 783 KB

english, 2013

104

Photosensitized oxidation of furans. Part 7. Solvent effects in thermal conversion of the endo-peroxides of arylfurans

Graziano, M. Liliana, Iesce, M. Rosaria, Chiosi, Sergio, Scarpati, Rachele

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1983

Language:

english

File:

PDF, 673 KB

english, 1983

105

Thick disk kinematics from RAVE and the solar motion

Pasetto, S., Grebel, E. K., Zwitter, T., Chiosi, C., Bertelli, G., Bienayme, O., Seabroke, G., Bland-Hawthorn, J., Boeche, C., Gibson, B. K., Gilmore, G., Munari, U., Navarro, J. F., Parker, Q., Reid,

Journal:

Astronomy and Astrophysics

Year:

2012

Language:

english

File:

PDF, 2.52 MB

english, 2012

106

Thin disk kinematics from RAVE and the solar motion

Pasetto, S., Grebel, E. K., Zwitter, T., Chiosi, C., Bertelli, G., Bienayme, O., Seabroke, G., Bland-Hawthorn, J., Boeche, C., Gibson, B. K., Gilmore, G., Munari, U., Navarro, J. F., Parker, Q., Reid,

Journal:

Astronomy and Astrophysics

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

107

Preparation of a Diverse Purine-Scaffold Library via One-Step Palladium Catalyzed Cross-Coupling

Taldone, Tony, Zatorska, Danuta, J. Patel, Hardik, Sun, Weilin, R. Patel, Maulik, Chiosis, Gabriela

Journal:

Year:

2013

Language:

english

File:

PDF, 895 KB

english, 2013

108

Tumor Selectivity of Hsp90 Inhibitors: The Explanation Remains Elusive

Chiosis, Gabriela, Neckers, Len

Journal:

ACS Chemical Biology

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

109

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

Taldone, Tony, Patel, Pallav D., Patel, Maulik, Patel, Hardik J., Evans, Christopher E., Rodina, Anna, Ochiana, Stefan, Shah, Smit K., Uddin, Mohammad, Gewirth, Daniel, Chiosis, Gabriela

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

110

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

Patel, Pallav D, Yan, Pengrong, Seidler, Paul M, Patel, Hardik J, Sun, Weilin, Yang, Chenghua, Que, Nanette S, Taldone, Tony, Finotti, Paola, Stephani, Ralph A, Gewirth, Daniel T, Chiosis, Gabriela

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

111

New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies

De Martino, Gabriella, Edler, Michael C., La Regina, Giuseppe, Coluccia, Antonio, Barbera, Maria Chiara, Barrow, Denise, Nicholson, Robert I., Chiosis, Gabriela, Brancale, Andrea, Hamel, Ernest, Artic

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

112

Facile Synthesis of a Library of 9-Alkyl-8-benzyl-9 H -purin-6-ylamine Derivatives

Lucas, Brian, Rosen, Neal, Chiosis, Gabriela

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 36 KB

english, 2001

113

Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma

Hua, Y., White-Gilbertson, S., Kellner, J., Rachidi, S., Usmani, S. Z., Chiosis, G., DePinho, R., Li, Z., Liu, B.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

114

Racial and Sex Disparities in Life Expectancy Losses among HIV‐Infected Persons in the United States: Impact of Risk Behavior, Late Initiation, and Early Discontinuation of Antiretroviral Therapy

Losina, Elena, Schackman, Bruce R., Sadownik, Sara N., Gebo, Kelly A., Walensky, Rochelle P., Chiosi, John J., Weinstein, Milton C., Hicks, Perrin L., Aaronson, Wendy H., Moore, Richard D., Paltiel, A

Journal:

Clinical Infectious Diseases

Year:

2009

Language:

english

File:

PDF, 460 KB

english, 2009

115

High-Throughput Screening Fluorescence Polarization Assay for Tumor-Specific Hsp90

Yuhong Du,, Moulick, K., Rodina, A., Aguirre, J., Felts, S., Dingledine, R., Haian Fu,, Chiosis, G.

Journal:

Journal of Biomolecular Screening

Year:

2007

Language:

english

File:

PDF, 1.28 MB

english, 2007

116

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

Ambati, Srikanth R., Lopes, Eloisi Caldas, Kosugi, Kohji, Mony, Ullas, Zehir, Ahmet, Shah, Smit K., Taldone, Tony, Moreira, Andre L., Meyers, Paul A., Chiosis, Gabriela, Moore, Malcolm A.S.

Journal:

Molecular Oncology

Year:

2014

Language:

english

File:

PDF, 2.54 MB

english, 2014

117

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE

Lisi, Lucia, McGuire, Susan, Sharp, Anthony, Chiosis, Gabriela, Navarra, Pierluigi, Feinstein, Douglas L., Dello Russo, Cinzia

Journal:

Journal of Neuroimmunology

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

118

Blood-brain-barrier–permeable Hsp90 inhibitor reduces soluble tau burden in a mouse model of Alzheimer's disease

Koren, John, Inda, Maria Carmen, Riolo, Matthew, Uddin, Mohammad, Alonso-Sabadell, Raul, Chiosis, Gabriela

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 49 KB

english, 2013

119

Relationship between the fluidity of the membrane lipids and the activity of the membrane-bound proteins: The effects of lidocaine on the adenylate cyclase activity of rat myocardium

Illiano, Gennaro, Chiosi, Emilio, Draetta, Giulio F., Laurenza, Antonio

Journal:

General Pharmacology: The Vascular System

Year:

1983

Language:

english

File:

PDF, 369 KB

english, 1983

120

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

Jhaveri, Komal, Ochiana, Stefan O, Dunphy, Mark PS, Gerecitano, John F, Corben, Adriana D, Peter, Radu I, Janjigian, Yelena Y, Gomes-DaGama, Erica M, Koren, John, Modi, Shanu, Chiosis, Gabriela

Journal:

Expert Opinion on Investigational Drugs

Year:

2014

Language:

english

File:

PDF, 829 KB

english, 2014

121

Protein chaperones: a composition of matter review (2008 – 2013)

Taldone, Tony, Patel, Hardik J, Bolaender, Alexander, Patel, Maulik R, Chiosis, Gabriela

Journal:

Expert Opinion on Therapeutic Patents

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

122

Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90

Wrona, Iwona E., Gozman, Alexander, Taldone, Tony, Chiosis, Gabriela, Panek, James S.

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 3.80 MB

english, 2010

123

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

Kang, Yanlong, Taldone, Tony, Patel, Hardik J., Patel, Pallav D., Rodina, Anna, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Patel, Maulik R., Brodsky, Jeffrey L., Young, Jason C., Chiosi

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.71 MB

english, 2014

124

General Method for the Synthesis of 8-Arylsulfanyl Adenine Derivatives

He, Huazhong, Llauger, Laura, Rosen, Neal, Chiosis, Gabriela

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 44 KB

english, 2004

125

Improved guanidinium ion-selectivity by novel calix[4]arene and calix[6]arene receptor molecules on CHEMFETs

Kremer, Felix J. B., Chiosis, Gabriela, Engbersen, Johan F. J., Reinhoudt, David N.

Journal:

Journal of the Chemical Society Perkin Transactions 2

Year:

1994

Language:

english

File:

PDF, 764 KB

english, 1994

126

Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects

Chan, C. T., Qi, J., Smith, W., Paranol, R., Mazitschek, R., West, N., Reeves, R., Chiosis, G., Schreiber, S. L., Bradner, J. E., Paulmurugan, R., Gambhir, S. S.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.51 MB

english, 2014

127

Targeting chaperones in transformed systems – a focus on Hsp90 and cancer

Chiosis, Gabriela

Journal:

Expert Opinion on Therapeutic Targets

Year:

2006

Language:

english

File:

PDF, 237 KB

english, 2006

128

Vancomycin resistance: occurrence, mechanisms and strategies to combat it

Boneca, Ivo G, Chiosis, Gabriela

Journal:

Expert Opinion on Therapeutic Targets

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

129

Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching

Kaittanis, Charalambos, Shaffer, Travis M., Ogirala, Anuja, Santra, Santimukul, Perez, J. Manuel, Chiosis, Gabriela, Li, Yueming, Josephson, Lee, Grimm, Jan

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 917 KB

english, 2014

130

[IEEE 2008 5th International Conference on Broadband Communications, Networks and Systems (BROADNETS) - London, United Kingdom (2008.09.8-2008.09.11)] 2008 5th International Conference on Broadband Communications, Networks and Systems - Telecom network services to grid infrastructure access

Berde, Bela, Chiosi, Agostino, Verchere, Dominique

Year:

2008

Language:

english

File:

PDF, 1.53 MB

english, 2008

131

Selective targeting of the stress chaperome as a therapeutic strategy

Taldone, Tony, Ochiana, Stefan O., Patel, Pallav D., Chiosis, Gabriela

Journal:

Trends in Pharmacological Sciences

Year:

2014

Language:

english

File:

PDF, 2.41 MB

english, 2014

132

563 Hsp90 pharmacoproteomics: Harnessing pleiotropy for therapeutic synergy

Goldstein, R., Chiosis, G., Cerchietti, L.C., Melnick, A.M.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 56 KB

english, 2014

133

Adenylate Cyclase/cAMP Pathway Downmodulation Counteracts Apoptosis Induced by IFN- α in Human Epidermoid Cancer Cells

Naviglio, S., Spina, A., Marra, M., Sorrentino, A., Chiosi, E., Romano, M., Improta, S., Budillon, A., Illiano, G., Abbruzzese, A., Caraglia, M.

Journal:

Journal of Interferon & Cytokine Research

Year:

2007

Language:

english

File:

PDF, 3.21 MB

english, 2007

134

Hospital Deliveries

Chiosi, Christine

Journal:

American Journal of Medical Genetics Part A

Year:

2013

Language:

english

File:

PDF, 53 KB

english, 2013

135

Discovery and development of purine-scaffold Hsp90 inhibitors

Chiosis, Gabriela, Kang, Yanlong, Sun, Weilin

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 678 KB

english, 2008

136

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

Rachidi, Saleh, Sun, Shaoli, Wu, Bill X., Jones, Elizabeth, Drake, Richard R., Ogretmen, Besim, Cowart, L. Ashley, Clarke, Christopher J., Hannun, Yusuf A., Chiosis, Gabriela, Liu, Bei, Li, Zihai

Journal:

Journal of Hepatology

Year:

2015

Language:

english

File:

PDF, 9.74 MB

english, 2015

137

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Rampal, Raajit, Ahn, Jihae, Abdel-Wahab, Omar, Nahas, Michelle, Wang, Kai, Lipson, Doron, Otto, Geoff A., Yelensky, Roman, Hricik, Todd, McKenney, Anna Sophia, Chiosis, Gabriela, Chung, Young Rock, Pa

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.81 MB

english, 2014

138

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

Patel, Hardik J, Modi, Shanu, Chiosis, Gabriela, Taldone, Tony

Journal:

Expert Opinion on Drug Discovery

Year:

2011

Language:

english

File:

PDF, 1.03 MB

english, 2011

139

cAMP Elevation Down-Regulates β 3 Integrin and Focal Adhesion Kinase and Inhibits Leptin-Induced Migration of MDA-MB-231 Breast Cancer Cells

Spina, Annamaria, Di Maiolo, Francesca, Esposito, Antonietta, Sapio, Luigi, Chiosi, Emilio, Sorvillo, Luca, Naviglio, Silvio

Journal:

BioResearch Open Access

Year:

2012

Language:

english

File:

PDF, 473 KB

english, 2012

140

HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization

Azoitei, N., Diepold, K., Brunner, C., Rouhi, A., Genze, F., Becher, A., Kestler, H., van Lint, J., Chiosis, G., Koren, J., Frohling, S., Scholl, C., Seufferlein, T.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 3.10 MB

english, 2014

141

Analysis of a Mixture of Polychlorinated Biphenyls, DDT and its Analogues by High-Performance Liquid Chromatography

Chiosi, Sergio, Evidente, Antonio, Randazzo, Giacomino, Scalorbi, Daniela

Journal:

Journal of Liquid Chromatography

Year:

1982

Language:

english

File:

PDF, 272 KB

english, 1982

142

Hereditary macular degeneration: A genetic, clinical and biochemical study

Crecchio, G. De, Sammartino, A., Federico, A., Chiosi, E.

Journal:

Ophthalmic Genetics

Year:

1983

Language:

english

File:

PDF, 1.25 MB

english, 1983

143

La “Sesleria Nitida” Ten. Del Montefeltro E Dell'Alpe Della Luna

Chiosi, Rodolfo

Journal:

Giornale botanico italiano

Year:

1930

Language:

english

File:

PDF, 375 KB

english, 1930

144

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

Basso, A. D., Solit, D. B., Chiosis, G., Giri, B., Tsichlis, P., Rosen, N.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 883 KB

english, 2002

145

The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

Wang, L., Xie, C., Greggio, E., Parisiadou, L., Shim, H., Sun, L., Chandran, J., Lin, X., Lai, C., Yang, W.-J., Moore, D. J., Dawson, T. M., Dawson, V. L., Chiosis, G., Cookson, M. R., Cai, H.

Journal:

Journal of Neuroscience

Year:

2008

Language:

english

File:

PDF, 624 KB

english, 2008

146

Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

Chan, C. T., Reeves, R. E., Geller, R., Yaghoubi, S. S., Hoehne, A., Solow-Cordero, D. E., Chiosis, G., Massoud, T. F., Paulmurugan, R., Gambhir, S. S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 1.64 MB

english, 2012

147

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33

Azoitei, N., Hoffmann, C. M., Ellegast, J. M., Ball, C. R., Obermayer, K., Gossele, U., Koch, B., Faber, K., Genze, F., Schrader, M., Kestler, H. A., Dohner, H., Chiosis, G., Glimm, H., Frohling, S.,

Journal:

Journal of Experimental Medicine

Year:

2012

Language:

english

File:

PDF, 3.69 MB

english, 2012

148

Nuovi avanzi di abete bianco in Italia

Chiosi, Rodolfo

Journal:

Giornale botanico italiano

Year:

1933

File:

PDF, 141 KB

1933

149

Preoperative, postoperative and 1-year follow-up N-terminal pro-B-type natriuretic peptide levels in severe chronic aortic regurgitation: correlations with echocardiographic findings

Della Corte, A., Salerno, G., Chiosi, E., Iarussi, D., Santarpino, G., Miraglia, M., Naviglio, S., De Feo, M.

Journal:

Interactive Cardiovascular and Thoracic Surgery

Year:

2008

Language:

english

File:

PDF, 804 KB

english, 2008

150

Selective Cleavage of D-Ala-D-Lac by Small Molecules: Re-Sensitizing Resistant Bacteria to Vancomycin

Journal:

Year:

2001

Language:

english

File:

PDF, 399 KB

english, 2001