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51

Amyloid β-peptide is produced by cultured cells during normal metabolism

Haass, Christian, Schlossmacher, Michael G., Hung, Albert Y., Vigo-Pelfrey, Carmen, Mellon, Angela, Ostaszewski, Beth L., Lieberburg, Ivan, Koo, Edward H., Schenk, Dale, Teplow, David B.

Journal:

Year:

1992

File:

PDF, 603 KB

1992

52

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, Martin, Oltersdorf, Tilman, Haass, Christian, McConlogue, Lisa, Hung, Albert Y., Seubert, Peter, Vigo-Pelfrey, Carmen, Lieberburg, Ivan, Selkoe, Dennis J.

Journal:

Year:

1992

File:

PDF, 414 KB

1992

53

Reconstitution of γ-secretase activity

Edbauer, Dieter, Winkler, Edith, Regula, Joerg T., Pesold, Brigitte, Steiner, Harald, Haass, Christian

Journal:

Nature Cell Biology

Year:

2003

Language:

english

File:

PDF, 235 KB

english, 2003

54

Initiation and propagation of neurodegeneration

Haass, Christian

Journal:

Nature Medicine

Year:

2010

Language:

english

File:

PDF, 183 KB

english, 2010

55

Regulatory RNA goes awry in Alzheimer's disease

St George-Hyslop, Peter, Haass, Christian

Journal:

Nature Medicine

Year:

2008

Language:

english

File:

PDF, 229 KB

english, 2008

56

New hope for Alzheimer disease vaccine

Haass, Christian

Journal:

Nature Medicine

Year:

2002

Language:

english

File:

PDF, 153 KB

english, 2002

57

The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

Haass, Christian, Lemere, Cynthia A., Capell, Anja, Citron, Martin, Seubert, Peter, Schenk, Dale, Lannfelt, Lars, Selkoe, Dennis J.

Journal:

Nature Medicine

Year:

1995

File:

PDF, 865 KB

1995

58

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

Fuhrmann, Martin, Bittner, Tobias, Jung, Christian K E, Burgold, Steffen, Page, Richard M, Mitteregger, Gerda, Haass, Christian, LaFerla, Frank M, Kretzschmar, Hans, Herms, Jochen

Journal:

Nature Neuroscience

Year:

2010

Language:

english

File:

PDF, 921 KB

english, 2010

59

10.1038/nn0901-859

Haass, Christian, Steiner, Harald

Journal:

Nature Neuroscience

Year:

2001

Language:

english

File:

PDF, 83 KB

english, 2001

60

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, Christian, Selkoe, Dennis J.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2007

Language:

english

File:

PDF, 677 KB

english, 2007

61

Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

Haass, Christian

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 148 KB

english, 2004

62

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

Haffner, Christof, Frauli, Mélanie, Topp, Stephanie, Irmler, Martin, Hofmann, Kay, Regula, Jörg T, Bally-Cuif, Laure, Haass, Christian

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 445 KB

english, 2004

63

The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity

Kaether, Christoph, Capell, Anja, Edbauer, Dieter, Winkler, Edith, Novak, Bozidar, Steiner, Harald, Haass, Christian

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 390 KB

english, 2004

64

How does parkin ligate ubiquitin to Parkinson's disease?

Kahle, Philipp J., Haass, Christian

Journal:

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

65

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

Lammich, Sven, Schöbel, Susanne, Zimmer, Ann-Katrin, Lichtenthaler, Stefan F, Haass, Christian

Journal:

Year:

2004

Language:

english

File:

PDF, 146 KB

english, 2004

66

Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1

Shirotani, Keiro, Valkova, Christina, Novak, Bozidar, Kacmar, Slavomir, Steiner, Harald, Haass, Christian, Kaether, Christoph, Scheuermann, Johanna, Fassler, Matthias, Zilow, Sonja

Journal:

Year:

2007

Language:

english

File:

PDF, 176 KB

english, 2007

67

Nuclear signaling

Harald Steiner, Christian Haass

Journal:

Journal of Molecular Neuroscience

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

68

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer’s APP mutation and sensitizes cells to staurosporine-induced cell death

Steffen Leutz, Barbara Steiner, Celio A. Marques, Christian Haass, Walter E. Müller, Anne Eckert

Journal:

Journal of Molecular Neuroscience

Year:

2002

Language:

english

File:

PDF, 240 KB

english, 2002

69

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

Kuhn, Peer-Hendrik, Koroniak, Katarzyna, Hogl, Sebastian, Colombo, Alessio, Zeitschel, Ulrike, Willem, Michael, Volbracht, Christiane, Schepers, Ute, Imhof, Axel, Hoffmeister, Albrecht, Haass, Christi

Journal:

The EMBO Journal

Year:

2012

File:

PDF, 117 KB

2012

70

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

Hans Wils, Gernot Kleinberger, Sandra Pereson, Jonathan Janssens, Anja Capell, Debby Van Dam, Ivy Cuijt, Geert Joris, Peter P De Deyn, Christian Haass, Christine Van Broeckhoven, Samir Kumar-Singh

Journal:

The Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 8.13 MB

english, 2012

71

Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes

Keiro Shirotani, Masanori Tomioka, Elisabeth Kremmer, Christian Haass, Harald Steiner

Journal:

Neurobiology of Disease

Year:

2007

Language:

english

File:

PDF, 435 KB

english, 2007

72

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

Frauke van Bebber, Dominik Paquet, Alexander Hruscha, Bettina Schmid, Christian Haass

Journal:

Neurobiology of Disease

Year:

2010

Language:

english

File:

PDF, 947 KB

english, 2010

73

Pore-forming scissors? A first structural glimpse of γ-secretase

Harald Steiner, Manuel Than, Wolfram Bode, Christian Haass

Journal:

Trends in Biochemical Sciences

Year:

2006

Language:

english

File:

PDF, 182 KB

english, 2006

74

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

Jochen Walter, Christoph Kaether, Harald Steiner, Christian Haass

Journal:

Current Opinion in Neurobiology

Year:

2001

Language:

english

File:

PDF, 192 KB

english, 2001

75

Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases

Christian Haass, Harald Steiner

Journal:

Trends in Cell Biology

Year:

2002

Language:

english

File:

PDF, 507 KB

english, 2002

76

Proteolysis by presenilins and the renaissance of tau

Christian Haass, Eckhard Mandelkow

Journal:

Trends in Cell Biology

Year:

1999

Language:

english

File:

PDF, 131 KB

english, 1999

77

Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?

Philipp J. Kahle, Uwe Leimer, Christian Haass

Journal:

Trends in Biochemical Sciences

Year:

2000

Language:

english

File:

PDF, 295 KB

english, 2000

78

Molecular characterization of the genomic regions of the Drosophilaα-type submit proteasome genes PROS-Dm28.1 and PROS-Dm35

Stefan FRENTZEL, Megan TROXELL, Christian HAASS, Brigitte PESOLD-HURT, Karl Heinz GLÄTZER, Peter-M. KLOETZEL

Journal:

Year:

1992

Language:

english

File:

PDF, 873 KB

english, 1992

79

Mitochondrial dysfunction in Parkinson’s disease: molecular mechanisms and pathophysiological consequences

Exner, Nicole, Lutz, Anne Kathrin, Haass, Christian, Winklhofer, Konstanze F

Journal:

The EMBO Journal

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

80

Dual Effect of Digitalis Glycosides on Norepinephrine Release from Human Atrial Tissue and Bovine Adrenal Chromaffin Cells: Differential Dependence on [Na+]iand [Ca2+]i

Markus Haass, Christiane Serf, Stefan H. Gerber, Carsten Krüger, Armin Haunstetter, Christian-Friedrich Vahl, Rainer Nobiling, Wolfgang Kübler

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1997

Language:

english

File:

PDF, 424 KB

english, 1997

81

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

Marcia B. Podlisny, Martin Citron, Patricia Amarante, Robin Sherrington, Weiming Xia, Jimin Zhang, Thekla Diehl, George Levesque, Paul Fraser, Christian Haass, Edward H.M. Koo, Peter Seubert, Peter St

Journal:

Neurobiology of Disease

Year:

1997

Language:

english

File:

PDF, 348 KB

english, 1997

82

Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

Harald Steiner, Edith Winkler, Mark S. Shearman, Ron Prywes, Christian Haass

Journal:

Neurobiology of Disease

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

83

The Drosophila proteasome undergoes changes in its subunit pattern during development

Christian Haass, Peter M. Kloetzel

Journal:

Experimental Cell Research

Year:

1989

Language:

english

File:

PDF, 4.46 MB

english, 1989

84

Mitochondrial dysfunction in Parkinson's disease

Konstanze F. Winklhofer, Christian Haass

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2010

Language:

english

File:

PDF, 693 KB

english, 2010

85

Single particle detection and characterization of synuclein co-aggregation

Armin Giese, Benedikt Bader, Jan Bieschke, Gregor Schaffar, Sabine Odoy, Philipp J. Kahle, Christian Haass, Hans Kretzschmar

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 854 KB

english, 2005

86

Fyn-Tau-Amyloid: A Toxic Triad

Christian Haass, Eckhard Mandelkow

Journal:

Year:

2010

Language:

english

File:

PDF, 443 KB

english, 2010

87

Self-care and depression in patients with chronic heart failure

Nicole Holzapfel, Bernd Löwe, Beate Wild, Dieter Schellberg, Christian Zugck, Andrew Remppis, Hugo A. Katus, Markus Haass, Bernhard Rauch, Jana Jünger, Wolfgang Herzog, Thomas Müller-Tasch

Journal:

Heart & Lung: The Journal of Acute and Critical Care

Year:

2009

Language:

english

File:

PDF, 251 KB

english, 2009

88

Statin use and survival in patients with chronic heart failure — results from two observational studies with 5200 patients

Stefan D. Anker, Andrew L. Clark, Ralf Winkler, Christian Zugck, Mariantonietta Cicoira, Piotr Ponikowski, Constantinos H. Davos, Waldemar Banasiak, Piero Zardini, Markus Haass, Jochen Senges, Andrew

Journal:

International Journal of Cardiology

Year:

2006

Language:

english

File:

PDF, 267 KB

english, 2006

89

Panic disorder in patients with chronic heart failure

Thomas Müller-Tasch, Lutz Frankenstein, Nicole Holzapfel, Dieter Schellberg, Bernd Löwe, Manfred Nelles, Christian Zugck, Hugo Katus, Bernhard Rauch, Markus Haass, Jana Jünger, Andrew Remppis, Wolfgan

Journal:

Journal of Psychosomatic Research

Year:

2008

Language:

english

File:

PDF, 108 KB

english, 2008

90

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

Tina Wahle, Kai Prager, Nikolai Raffler, Christian Haass, Michael Famulok, Jochen Walter

Journal:

Molecular and Cellular Neuroscience

Year:

2005

Language:

english

File:

PDF, 2.63 MB

english, 2005

91

Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

Christian Freichel, Manuela Neumann, Theresa Ballard, Veronika Müller, Marie Woolley, Laurence Ozmen, Edilio Borroni, Hans A. Kretzschmar, Christian Haass, Will Spooren, Philipp J. Kahle

Journal:

Neurobiology of Aging

Year:

2007

Language:

english

File:

PDF, 1.71 MB

english, 2007

92

Occurrence and co-localization of amyloid β-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

Dietmar Rudolf Thal, Sergey Larionov, Dorothee Abramowski, Karl-Heinz Wiederhold, Tom Van Dooren, Haruyasu Yamaguchi, Christian Haass, Fred Van Leuven, Matthias Staufenbiel, Estibaliz Capetillo-Zarate

Journal:

Neurobiology of Aging

Year:

2007

Language:

english

File:

PDF, 1.51 MB

english, 2007

93

Function, regulation and therapeutic properties of β-secretase (BACE1)

Michael Willem, Sven Lammich, Christian Haass

Journal:

Seminars in Cell & Developmental Biology

Year:

2009

Language:

english

File:

PDF, 461 KB

english, 2009

94

TDP-43 and FUS: a nuclear affair

Dorothee Dormann, Christian Haass

Journal:

Trends in Neurosciences

Year:

2011

Language:

english

File:

PDF, 649 KB

english, 2011

95

Oxidative Stress in Transgenic Mice with Oligodendroglial α-Synuclein Overexpression Replicates the Characteristic Neuropathology of Multiple System Atrophy

Nadia Stefanova, Markus Reindl, Manuela Neumann, Christian Haass, Werner Poewe, Philipp J. Kahle, Gregor K. Wenning

Journal:

The American Journal of Pathology

Year:

2005

Language:

english

File:

PDF, 764 KB

english, 2005

96

β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice

Michael Willem, Ilse Dewachter, Neil Smyth, Tom Van Dooren, Peter Borghgraef, Christian Haass, Fred Van Leuven

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 1.00 MB

english, 2004

97

Cholesterol-dependent generation of a unique amyloid β-protein from apically missorted amyloid precursor protein in MDCK cells

Tetsuya Mizuno, Christian Haass, Makoto Michikawa, Katsuhiko Yanagisawa

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1998

Language:

english

File:

PDF, 570 KB

english, 1998

98

An in vivo assay for the identification of target proteases which cleave membrane-associated substrates

Harald Steiner, Brigitte Pesold, Christian Haass

Journal:

Year:

1999

Language:

english

File:

PDF, 196 KB

english, 1999

99

Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: Modulation by single components of ischaemia

Carsten Krüger, Armin Haunstetter, Stefan Gerber, Christiane Serf, Alexander Kaufmann, Wolfgang Kübler, Markus Haass

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1995

Language:

english

File:

PDF, 1.47 MB

english, 1995

100

Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch

Christian Haass, Luka Kulic, Anja Capell, Harold Steiner, Gerd Multhaup, David Teplow, Helmut Romig

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 177 KB

english, 2000

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