Colin W. G. Fishwick: search on Z-Library

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51

Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors

McPhillie, Martin J., Trowbridge, Rachel, Mariner, Katherine R., O’Neill, Alex J., Johnson, A. Peter, Chopra, Ian, Fishwick, Colin W. G.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 4.04 MB

english, 2011

52

ChemInform Abstract: γ-Carboline AC190 Analogues via Palladium Catalyzed Allene Insertion Stereo and Regioselective 3- and 5-Component Cascades.

Dondas, H. Ali, Hempshall, Aiden, Narramore, Sarah, Kilner, Colin, Fishwick, Colin W. G., Grigg, Ronald

Journal:

Year:

2016

File:

PDF, 37 KB

2016

53

Facile intramolecular cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes

Ian T. Barnish, Colin W.G. Fishwick, David R. Hill

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 188 KB

english, 1991

54

Assay Platform for Clinically Relevant Metallo-β-lactamases

van Berkel, Sander S., Brem, Jürgen, Rydzik, Anna M., Salimraj, Ramya, Cain, Ricky, Verma, Anil, Owens, Raymond J., Fishwick, Colin W. G., Spencer, James, Schofield, Christopher J.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1010 KB

english, 2013

55

ChemInform Abstract: Spatial Requirements of the Antagonist Binding Site of the NK2 Receptor.

Mohammed A. Ali, Nirmala Bhogal, Colin W. G. Fishwick, John B. C. Findlay

Journal:

Year:

2001

File:

PDF, 33 KB

2001

56

Macrocyclic Inhibitors of the Bacterial Cell Wall Biosynthesis Enzyme MurD.

James R. Horton, Julieanne M. Bostock, Ian Chopra, Lars Hesse, Simon E. V. Phillips, David J. Adams, A. Peter Johnson, Colin W. G. Fishwick

Journal:

Year:

2003

Language:

english

File:

PDF, 97 KB

english, 2003

57

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century

Lolli, Marco, Narramore, Sarah, Fishwick, Colin W.G., Pors, Klaus

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 988 KB

english, 2015

58

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human

Caseley, Emily A., Muench, Stephen P., Baldwin, Stephen A., Simmons, Katie, Fishwick, Colin W., Jiang, Lin-Hua

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

59

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Calvopiña, Karina, Hinchliffe, Philip, Brem, Jürgen, Heesom, Kate J., Johnson, Samar, Cain, Ricky, Lohans, Christopher T., Fishwick, Colin W. G., Schofield, Christopher J., Spencer, James, Avison, Mat

Journal:

Molecular Microbiology

Year:

2017

Language:

english

File:

PDF, 1.56 MB

english, 2017

60

Ozonolytic Cleavage of 3-Oxidopyrilium Betaine-Derived Cycloadducts: Simple and Efficient Access to Stereodefined Tetrahydrofurans.

Colin W. G. Fishwick, Glynn Mitchell, Peter F. W. Pang

Journal:

Year:

2005

File:

PDF, 17 KB

2005

61

An efficient route to S-N-(9-fluorenylmethoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl)phenylalanine

Colin W.G. Fishwick, John M. Sanderson, John B.C. Findlay

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 333 KB

english, 1994

62

Spatial requirements of the antagonist binding site of the NK2 receptor

Mohammed A. Ali, Nirmala Bhogal, Colin W.G. Fishwick, John B.C. Findlay

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 267 KB

english, 2001

63

ChemInform Abstract: The Synthesis and Reactivity of Optically Pure Amino Acids Bearing Side-Chain Thioamides.

John M. Sanderson, P. Singh, Colin W. G. Fishwick, John B. C. Findlay

Journal:

Year:

2001

File:

PDF, 34 KB

2001

64

ChemInform Abstract: X=Y—ZH Compounds as Potential 1,3-Dipoles. Part 65. Atom Economic Cascade Synthesis of Highly Functionalized Pyrimidinylpyrrolidines.

Elghareeb E. Elboray, Ronald Grigg, Colin W. G. Fishwick, Colin Kilner, Mohammed A. B. Sarker, Moustafa F. Aly, Hussien H. Abbas-Temirek

Journal:

Year:

2011

Language:

english

File:

PDF, 42 KB

english, 2011

65

Cyclic-fused azomethine-, imidate-, and thioimidate methylides: An efficient regiocontrolled entry into spiro-fused pyrrolidines

Colin W.G. Fishwick, Richard J. Foster, Robin E. Carr

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 232 KB

english, 1996

66

Structure-based discovery of antibacterial drugs

Simmons, Katie J., Chopra, Ian, Fishwick, Colin W. G.

Journal:

Nature Reviews Microbiology

Year:

2010

Language:

english

File:

PDF, 622 KB

english, 2010

67

A Simple, One-Pot Synthesis of N-Alkyl and N-Aryl Thieno[2,3-d]pyrimidinones from Thiophene- and Benzothiophene-2-yl-ureas

Yule, Ian A., Fishwick, Colin W. G.

Journal:

Synthetic Communications

Year:

2013

Language:

english

File:

PDF, 366 KB

english, 2013

68

P2-482: De novo design of cellular active beta-secretase inhibitors

Mok, Ngai Y., Chadwick, James, Davey, Katherine A.B., Hooper, Nigel M., Johnson, A. Peter, Fishwick, Colin W.G.

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 76 KB

english, 2008

69

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity

Yule, Ian A., Czaplewski, Lloyd G., Pommier, Stephanie, Davies, David T., Narramore, Sarah K., Fishwick, Colin W.G.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.65 MB

english, 2014

70

A simple route to C-functionalised azaxylylenes and diazaxylylenes

Fishwick, Colin W. G., Storr, Richard C., Manley, Paul W.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1984

Language:

english

File:

PDF, 179 KB

english, 1984

71

Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease

Shaw, Joseph, Fishwick, Colin W.G., Harris, Mark

Journal:

Antiviral Research

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

72

New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase

Narramore, Sarah, Stevenson, Clare E.M., Maxwell, Anthony, Lawson, David M., Fishwick, Colin W.G.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.47 MB

english, 2019

73

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH

Deborah Cowen, Paul Bedingfield, Glenn A. McConkey, Colin W.G. Fishwick, A. Peter Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 472 KB

english, 2010

74

Pd(0) catalyzed three–five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid

Ronald Grigg, M. Ruhul A. Sarkar, Abirami Thayaparan, Visuvanathar Sridharan, Colin W.G. Fishwick

Journal:

Year:

2007

Language:

english

File:

PDF, 1.43 MB

english, 2007

75

Addendum to “Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase” [Tetrahedron 64 (43) (2008) 10049–10054]

Anil K. Agarwal, A. Peter Johnson, Colin W.G. Fishwick

Journal:

Year:

2009

Language:

english

File:

PDF, 60 KB

english, 2009

76

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones and the highly diastereoselective Diels-Alder reactions of 4-vinyl-1,2-isothiazoline-3-one-1-oxides

Andrew S. Bell, Colin W.G. Fishwick, Jessica E. Reed

Journal:

Year:

1999

Language:

english

File:

PDF, 1.02 MB

english, 1999

77

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Timo Heikkilä, Srinath Thirumalairajan, Matthew Davies, Mark R. Parsons, A. Glenn McConkey, Colin W.G. Fishwick, A. Peter Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 283 KB

english, 2006

78

Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

Woon, Esther C. Y., Zervosen, Astrid, Sauvage, Eric, Simmons, Katie J., Živec, Matej, Inglis, Steven R., Fishwick, Colin W. G., Gobec, Stanislav, Charlier, Paulette, Luxen, André, Schofield, Christo

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 874 KB

english, 2011

79

The First de Novo-Designed Antagonists of the Human NK 2 Receptor

Ali, Mohammed A., Bhogal, Nirmala, Findlay, John B. C., Fishwick, Colin W. G.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 246 KB

english, 2005

80

Novel synthesis of calamitic and discotic liquid crystalline derivatives of tetrathiafulvalene (TTF)

Bissell, Richard A., Boden, Neville, Bushby, Richard J., Fishwick, Colin W. G., Holland, Edward, Movaghar, Bijan, Bissell, Richard A., Bushby, Richard J., Ungar, Goran

Journal:

Chemical Communications

Year:

1998

Language:

english

File:

PDF, 44 KB

english, 1998

81

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists

Caseley, Emily A., Muench, Stephen P., Fishwick, Colin W., Jiang, Lin-Hua

Journal:

Biochemical Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

82

Three-Component Bimetallic (Pd/In) Mediated Cascade Allylation of C=X Functionality. Part 1. Scope and Class 1 Examples with Aldehydes and Ketones.

Laura A. T. Cleghorn, Ian R Cooper, Colin W. G. Fishwick, Ronald Grigg, William S. MacLachlan, Marcello Rasparini, Visuvanathar Sridharan

Journal:

Year:

2004

File:

PDF, 217 KB

2004

83

Detection and mechanistic implication of a dynamic equilibrium in some novel spiro-heterocyclic systems

Alex I.D. Alanine, Colin W.G. Fishwick, Csaba Szantay Jr.

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 232 KB

english, 1989

84

An in silico structure-based approach to anti-infective drug discovery

CUNNINGHAM, FRASER, McPHILLIE, MARTIN J., JOHNSON, A. PETER, FISHWICK, COLIN W. G.

Journal:

Year:

2014

Language:

english

File:

PDF, 936 KB

english, 2014

85

Ozonolytic Cleavage of 3-Oxidopyrilium Betaine-Derived Cycloadducts: Simple and Efficient Access to Stereodefined Tetrahydrofurans

Fishwick, Colin W., Mitchell, Glynn, Pang, Peter F.

Journal:

Year:

2005

Language:

english

File:

PDF, 61 KB

english, 2005

86

In Silico Design and Biological Evaluation of a Dual Specificity Kinase Inhibitor Targeting Cell Cycle Progression and Angiogenesis

Latham, Antony M., Kankanala, Jayakanth, Fearnley, Gareth W., Gage, Matthew C., Kearney, Mark T., Homer-Vanniasinkam, Shervanthi, Wheatcroft, Stephen B., Fishwick, Colin W. G., Ponnambalam, Sreenivasa

Journal:

Year:

2014

Language:

english

File:

PDF, 1.85 MB

english, 2014

87

ChemInform Abstract: The Azomethine Ylide Strategy for β-Lactam Synthesis. A Comprehensive Mechanistic Evaluation.

David Brown, Giles A. Brown, Sarah R. Martel, Denis Planchenault, Evelyn Turmes, Kenneth E. Walsh, Richard Wisedale, Neil J. Hales, Colin W. G. Fishwick, Timothy Gallagher

Journal:

Year:

2001

File:

PDF, 33 KB

2001

88

Remarkably high diastereoselective exo diels-alder reactivity of 4-vinyl isothiazoline-3-one-1-oxides: The sulphoxide Syn effect.

Andrew S. Bell, Colin W.G. Fishwick, Jessica E.Reed

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 248 KB

english, 1995

89

Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease

Shaw, Joseph, Harris, Mark, Fishwick, Colin W.G.

Journal:

Antiviral Research

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

90

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

Toshana L. Foster, Mark Verow, Ann L. Wozniak, Matthew J. Bentham, Joseph Thompson, Elizabeth Atkins, Steven A. Weinman, Colin Fishwick, Richard Foster, Mark Harris, Stephen Griffin

Journal:

Year:

2011

Language:

english

File:

PDF, 2.13 MB

english, 2011

91

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C Î²-Lactamase from Escherichia coli

Lang, Pauline, Parkova, Anete, Leissing, Thomas, CalvopiÃ±a, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi, Philippe, Jules, Fishwick, Colin, Trapencieris, Peteris, Page, Malcolm, Schofield

Journal:

Year:

2020

File:

PDF, 1.75 MB

2020

92

Neighbouring group participation in Pummerer-type rearrangements of ortho-substituted arylmethyl sulphoxides

John B.C. Findlay, Colin W.G. Fishwick, Ian D. Kersey, Peter Ward

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 203 KB

english, 1995

93

Generation and cycloadditions of tetrahydrofuryl, pyranyl, and oxepanyl-2-imminium methylides

Alex I.D. Alanine, Colin W.G. Fishwick, Csaba Szantay Jr.

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 223 KB

english, 1989

94

Neighbouring group effects in a Pummerer-type rearrangement: A facile entry into 3,1-benzoxathiins

Ian D. Kersey, Colin W.G. Fishwick, John B.C. Findlay, Peter Ward

Journal:

Year:

1995

Language:

english

File:

PDF, 948 KB

english, 1995

95

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Brem, Jürgen, Cain, Ricky, Cahill, Samuel, McDonough, Michael A., Clifton, Ian J., Jiménez-Castellanos, Juan-Carlos, Avison, Matthew B., Spencer, James, Fishwick, Colin W. G., Schofield, Christopher J

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 883 KB

english, 2016

96

Hyperreactivity of adenines and conformational flexibility of a translational repression site

Simon J. Talbot, Gloria Medina, Colin W.G. Fishwick, I. Haneef, Peter G. Stockley

Journal:

Year:

1991

Language:

english

File:

PDF, 848 KB

english, 1991

97

Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases †

Davies, Matthew, Heikkilä, Timo, McConkey, Glenn A., Fishwick, Colin W. G., Parsons, Mark R., Johnson, A. Peter

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 583 KB

english, 2009

98

Regio- and Chemoselective Alkylation of 2,3-Dialkylindoles. A Convenient Preparation of 2,3,3-Trialkyl-3H-indoles

W. G. Fishwick, Colin, D. Jones, Andrew, B. Mitchell, Michael

Journal:

Year:

1991

Language:

english

File:

PDF, 162 KB

english, 1991

99

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

N. Yi Mok, James Chadwick, Katherine A.B. Kellett, Nigel M. Hooper, A. Peter Johnson, Colin W.G. Fishwick

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 787 KB

english, 2009

100

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1, 3-dienes. Structural investigations using NMR methods. Part I.

Ian T. Barnish, Colin W.G. Fishwick, David R. Hill, Csaba Szantay Jr.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.43 MB

english, 1989

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