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51

Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat

David Bleakman, Neil L. Harrison, William F. Colmers, Richard J. Miller

Journal:

British Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.48 MB

english, 1992

52

Effects of neuropeptide Y on the electrical properties of neurons

William F. Colmers, David Bleakman

Journal:

Trends in Neurosciences

Year:

1994

Language:

english

File:

PDF, 850 KB

english, 1994

53

A ‘BOLD’ experiment in defining the utility of fMRI in drug development

David Borsook, David Bleakman, Richard Hargreaves, Jaymin Upadhyay, Karl F. Schmidt, Lino Becerra

Journal:

Year:

2008

Language:

english

File:

PDF, 238 KB

english, 2008

54

Improved characterization of BOLD responses for evoked sensory stimuli

Jaymin Upadhyay, Gautam Pendse, Julie Anderson, Adam J. Schwarz, Richard Baumgartner, Alexandre Coimbra, James Bishop, Jamie Knudsen, Ed George, Igor Grachev, Smriti Iyengar, David Bleakman, Richard H

Journal:

Year:

2010

Language:

english

File:

PDF, 2.02 MB

english, 2010

55

S-40-1 - Interactions between cyclothiazide and 2,3-benzodiazepines in vivo and in vitro

D. Lodge, D. Bleakman, A. Palmer, M. Woolley, A. Bond

Journal:

European Neuropsychopharmacology

Year:

1996

Language:

english

File:

PDF, 278 KB

english, 1996

56

Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain

David Borsook, Jaymin Upadhyay, Michael Klimas, Adam J. Schwarz, Alexandre Coimbra, Richard Baumgartner, Edward George, William Z. Potter, Thomas Large, David Bleakman, Jeffrey Evelhoch, Smriti Iyenga

Journal:

Drug Discovery Today

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

57

Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo

Michael J O'Neill, Catherine P Bath, Colin P Dell, Caroline A Hicks, Jeremy Gilmore, Samantha J Ambler, Mark A Ward, David Bleakman

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 448 KB

english, 1997

58

De Novo CNS Activation following Infusion of Fosaprepitant (NK-1 antagonist) in Healthy Human Subjects

J Upadhyay, J Anderson, A.J. Schwarz, R Baumgartner, A Coimbra, E George, J Knudsen, J Bishop, S Keswani, B Robertson, R Schreiber, S Iyengar, D Bleakman, R Hargreaves, L Becerra, D Borsook

Journal:

Year:

2009

Language:

english

File:

PDF, 117 KB

english, 2009

59

fMRI Measures of Drug Modulation of CNS Activation by Noxious Stimuli: Differential effects of a Failed Analgesic (fosaprepitant) vs. an Opioid Analgesic (Buprenorphine)

J Upadhyay, J Anderson, A.J. Schwarz, R Baumgartner, A Coimbra, E George, J Knudsen, J Bishop, L Nutile, B Robertson, R Schreiber, S Iyengar, D Bleakman, R Hargreaves, L Becerra, D Borsook

Journal:

Year:

2009

Language:

english

File:

PDF, 123 KB

english, 2009

60

Calcium Influx and Neurodegeneration

SIMON J. GIBBONS, JAMES R. BRORSON, DAVID BLEAKMAN, PAUL S. CHARD, RICHARD J. MILLER

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.02 MB

english, 1993

61

Synthesis and Pharmacology of Willardiine Derivatives Acting as Antagonists of Kainate Receptors

Dolman, Nigel P., Troop, Helen M., More, Julia C. A., Alt, Andrew, Knauss, Jody L., Nistico, Robert, Jack, Samantha, Morley, Richard M., Bortolotto, Zuner A., Roberts, Peter J., Bleakman, David, Colli

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 229 KB

english, 2005

62

Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors

Shepherd, Timothy A., Aikins, James A., Bleakman, David, Cantrell, Buddy E., Rearick, John P., Simon, Richard L., Smith, Edward C. R., Stephenson, Gregory A., Zimmerman, Dennis M., Mandelzys, Allan, J

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

63

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Martinez-Perez, Jose A., Iyengar, Smriti, Shannon, Harlan E., Bleakman, David, Alt, Andrew, Clawson, David K., Arnold, Brian M., Bell, Michael G., Bleisch, Thomas J., Castaño, Ana M., Del Prado, Miria

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 513 KB

english, 2013

64

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Martinez-Perez, Jose A., Iyengar, Smriti, Shannon, Harlan E., Bleakman, David, Alt, Andrew, Arnold, Brian M., Bell, Michael G., Bleisch, Thomas J., Castaño, Ana M., Del Prado, Miriam, Dominguez, Esteb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 783 KB

english, 2013

65

Processing reactions in the later stages of hormone activation

Bleakman, Alexandra, Bradbury, Alan F., Darby, Nigel J., Maruthainar, Kamala, Smyth, Derek G.

Journal:

Year:

1988

Language:

english

File:

PDF, 745 KB

english, 1988

66

Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: Involvement of calcium-activated proteases

Chard, P.S., Bleakman, D., Savidge, J.R., Miller, R.J.

Journal:

Year:

1995

Language:

english

File:

PDF, 1.16 MB

english, 1995

67

[ 3 H] N -2-(4-( N -Benzamido)phenyl)propyl-2- propanesulfonamide: A Novel AMPA Receptor Potentiator and Radioligand

Zarrinmayeh, Hamideh, Bleakman, David, Gates, Mary R., Yu, Hong, Zimmerman, Dennis M., Ornstein, Paul L., McKennon, Tracey, Arnold, M. Brian, Wheeler, William J., Skolnick, Phil

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 56 KB

english, 2001

68

Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

Ornstein, Paul L., Zimmerman, Dennis M., Arnold, M. Brian, Bleisch, Thomas J., Cantrell, Buddy, Simon, Richard, Zarrinmayeh, Hamideh, Baker, S. Richard, Gates, Mary, Tizzano, Joseph P., Bleakman, Davi

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 64 KB

english, 2000

69

Human Autoantibodies Specific for the α1ACalcium Channel Subunit Reduce Both P-Type and Q-Type Calcium Currents in Cerebellar Neurons

Ashwin Pinto, Samantha Gillard, Fraser Moss, Kathryn Whyte, Paul Brust, Mark Williams, Ken Stauderman, Michael Harpold, Bethan Lang, John Newsom-Davis, David Bleakman, David Lodge and John Boot

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 935 KB

english, 1998

70

The Role of Intracellular Calcium in the Cellular Response to Ionizing Radiation

Dennis E. Hallahan, David Bleakman, Subbulakshmi Virudachalam, Diana Lee, David Grdina, Donald W. Kufe and Ralph R. Weichselbaum

Journal:

Radiation Research

Year:

1994

Language:

english

File:

PDF, 1.68 MB

english, 1994

71

Synthesis of a Series of Aryl Kainic Acid Analogs and Evaluation in Cells Stably Expressing the Kainate Receptor humGluR6

Cantrell, Buddy E., Zimmerman, Dennis M., Monn, James A., Kamboj, Rajender K., Hoo, Ken H., Tizzano, Joseph P., Pullar, Ian A., Farrell, Louise N., Bleakman, David

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 289 KB

english, 1996

72

Synthesis of Willardiine and 6-Azawillardiine Analogs: Pharmacological Characterization on Cloned Homomeric Human AMPA and Kainate Receptor Subtypes

Jane, David E., Hoo, Ken, Kamboj, Raj, Deverill, Michele, Bleakman, David, Mandelzys, Allan

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 122 KB

english, 1997

73

Ethyl (3 S ,4a R ,6 S ,8a R )-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Filla, Sandra A., Winter, Mark A., Johnson, Kirk W., Bleakman, David, Bell, Michael G., Bleisch, Thomas J., Castaño, Ana M., Clemens-Smith, Amy, del Prado, Miriam, Dieckman, Donna K., Dominguez, Esteb

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 86 KB

english, 2002

74

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Dominguez, Esteban, Iyengar, Smriti, Shannon, Harlan E., Bleakman, David, Alt, Andrew, Arnold, Brian M., Bell, Michael G., Bleisch, Thomas J., Buckmaster, Jennifer L., Castano, Ana M., Del Prado, Miri

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

75

Kainate Receptor Agonists, Antagonists and Allosteric Modulators

Bleakman, D., Gates, M., Ogden, A., Mackowiak, M.

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

76

TRP channels as emerging targets for pain therapeutics

Broad, Lisa M, Mogg, Adrian J, Beattie, Ruth E, Ogden, Ann-Marie, Blanco, Maria-Jesus, Bleakman, David

Journal:

Expert Opinion on Therapeutic Targets

Year:

2009

Language:

english

File:

PDF, 355 KB

english, 2009

77

Editorial [Hot Topic: Recent Discoveries in the Search for Novel Antidepressants and Anxiolytics (Executive Editors: D. Bleakman and D. Gehlert)]

Bleakman, David, Gehlert, Donald

Journal:

Current Pharmaceutical Design

Year:

2005

Language:

english

File:

PDF, 19 KB

english, 2005

78

AMPA Receptor Potentiators as Novel Antidepressants

Alt, A., Witkin, J., Bleakman, D.

Journal:

Current Pharmaceutical Design

Year:

2005

Language:

english

File:

PDF, 450 KB

english, 2005

79

Test–retest reliability of evoked heat stimulation BOLD fMRI

Upadhyay, Jaymin, Lemme, Jordan, Anderson, Julie, Bleakman, David, Large, Thomas, Evelhoch, Jeffrey L., Hargreaves, Richard, Borsook, David, Becerra, Lino

Journal:

Journal of Neuroscience Methods

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

80

AMPA Receptors in the Therapeutic Management of Depression

Bleakman, D., Alt, A., Witkin, J.

Journal:

CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders)

Year:

2007

Language:

english

File:

PDF, 265 KB

english, 2007

81

Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and PSD95

Li, Baolin, Rex, Elizabeth, Wang, He, Qian, Yuewei, Ogden, Ann Marie, Bleakman, David, Johnson, Kirk W.

Journal:

Assay and Drug Development Technologies

Year:

2016

Language:

english

File:

PDF, 714 KB

english, 2016

82

Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.

Chard, P S, Bleakman, D, Christakos, S, Fullmer, C S, Miller, R J

Journal:

The Journal of Physiology

Year:

1993

Language:

english

File:

PDF, 2.34 MB

english, 1993

83

METHOHEXITAL AND VOLATILE ANESTHETICS REDUCE DEPOLARIZATION-INDUCED CALCIUM ENTRY INTO CULTURED RAT HIPPOCAMPAL NEURONS

Bleakman, D., Jones, M. V., Roback, J. D., Hornberger, L. A., Radke, H. K., Miller, R. J., Harrison, N. L.

Journal:

Year:

1991

File:

PDF, 115 KB

1991

84

Impact of ixekizumab treatment on skin-related personal relationship difficulties in moderate-to-severe psoriasis patients: 12 week results from two Phase 3 trials

Guenther, L., Warren, R. B., Cather, J. C., Sofen, H., Poulin, Y., Lebwohl, M., Terui, T., Potts Bleakman, A., Zhu, B., Burge, R., Reich, K., van de Kerkhof, P

Journal:

Journal of the European Academy of Dermatology and Venereology

Year:

2017

Language:

english

File:

PDF, 404 KB

english, 2017

85

Impact of ixekizumab on facial psoriasis and related quality of life measures in moderate-to-severe psoriasis patients: 12-week results from 2 phase III trials

Paul, C., Guenther, L., Torii, H., Sofen, H., Burge, R., Lin, C.Y., Potts Bleakman, A., Mallbris, L., Poulin, Y.

Journal:

Journal of the European Academy of Dermatology and Venereology

Year:

2017

Language:

english

File:

PDF, 643 KB

english, 2017

86

The Development of the Genital Psoriasis Sexual Frequency Questionnaire (GenPs-SFQ) to Assess the Impact of Genital Psoriasis on Sexual Health

Gottlieb, Alice B., Kirby, Brian, Ryan, Caitriona, Naegeli, April N., Burge, Russel, Potts Bleakman, Alison, Anatchkova, Milena D., Cather, Jennifer

Journal:

Dermatology and Therapy

Year:

2017

Language:

english

File:

PDF, 468 KB

english, 2017

87

The Development of a Patient-Reported Outcome Measure for Assessment of Genital Psoriasis Symptoms: The Genital Psoriasis Symptoms Scale (GPSS)

Gottlieb, Alice B., Kirby, Brian, Ryan, Caitriona, Naegeli, April N., Burge, Russel, Potts Bleakman, Alison, Anatchkova, Milena D., Yosipovitch, Gil

Journal:

Dermatology and Therapy

Year:

2017

Language:

english

File:

PDF, 459 KB

english, 2017

88

Human autoantibodies specific for the 1A calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons

Pinto, A., Gillard, S., Moss, F., Whyte, K., Brust, P., Williams, M., Stauderman, K., Harpold, M., Lang, B., Newsom-Davis, J., Bleakman, D., Lodge, D., Boot, J.

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 208 KB

english, 1998

89

203 Patients’ Perspectives on the Impact of Moderate-to-Severe Genital Psoriasis

Cather, J.C., Potts Bleakman, A.P., Naegeli, A., Poon, J.L., Wallace, A., Hollister, K., Fretzin, S.

Journal:

The Journal of Sexual Medicine

Year:

2018

Language:

english

File:

PDF, 158 KB

english, 2018

90

Prevalence of genital psoriasis in patients with psoriasis

Meeuwis, Kim A.P., Bleakman, Alison Potts, van de Kerkhof, Peter C.M., Dutronc, Yves, Henneges, Carsten, Kornberg, Lori J., Menter, Alan

Journal:

Journal of Dermatological Treatment

Year:

2018

Language:

english

File:

PDF, 680 KB

english, 2018

91

012 Efficacy and Safety of Ixekizumab in a Randomized, Double-Blinded, Placebo-Controlled, Phase 3b Clinical Trial in Patients with Moderate-to-Severe Genital Psoriasis

Ryan, C., Menter, A., Guenther, L., Blauvelt, A., Bissonnette, R., Yang, F.E., Potts Bleakman, A.

Journal:

The Journal of Sexual Medicine

Year:

2018

Language:

english

File:

PDF, 140 KB

english, 2018

92

039 The Development of a Patient Reported Outcome Measure to Assess Sexual Impacts of Genital Psoriasis: GPSIS

Cather, J., Kirby, B., Ryan, C., Naegeli, A.N., Burge, R., Potts Bleakman, A., Anatchkova, M.D., Gottlieb, A.B.

Journal:

The Journal of Sexual Medicine

Year:

2018

Language:

english

File:

PDF, 86 KB

english, 2018

93

204 The Burden of Moderate-to-Severe Genital Psoriasis: Patients’ Perspective on Symptoms

Ryan, C., Meeuwis, K., Potts Bleakman, A.P., Naegeli, A., Poon, J.L., Hollister, K., Fretzin, S.

Journal:

The Journal of Sexual Medicine

Year:

2018

Language:

english

File:

PDF, 88 KB

english, 2018

94

Association of Touch Avoidance with Disease Severity and Quality of Life in Psoriasis Patients

Armstrong, April W., Cather, Jennifer C., Paul, Carle F., Edson-Heredia, Emily, Zhu, Baojin, Hollister, Kristin, Koo, John, Levin, Ethan, Bleakman, Alison Potts

Journal:

Journal of Psoriasis and Psoriatic Arthritis

Year:

2017

Language:

english

File:

PDF, 282 KB

english, 2017

95

Ixekizumab Improved Patient-Reported Genital Psoriasis Symptoms and Impact of Symptoms on Sexual Activity vs Placebo in a Randomized, Double-Blind Study

Yosipovitch, Gil, Foley, Peter, Ryan, Caitriona, Cather, Jennifer C., Meeuwis, Kim A., Burge, Russel, Bleakman, Alison Potts, Lin, Chen-Yen, Malatestinic, William, Gottlieb, Alice

Journal:

The Journal of Sexual Medicine

Year:

2018

Language:

english

File:

PDF, 404 KB

english, 2018

96

The properties of intracellular calcium stores in cultured rat cerebellar neurons

Brorson, JR, Bleakman, D, Gibbons, SJ, Miller, RJ

Journal:

Journal of Neuroscience

Year:

1991

Language:

english

File:

PDF, 5.81 MB

english, 1991

97

L’ixékizumab permet d’obtenir une amélioration des symptômes du psoriasis génital rapide et plus importante que le placebo

Yosipovitch, G., Foley, P., Burge, R., Potts Bleakman, A., Lin, C.-Y., Malatestinic, W., Gottlieb, A.B., Schneider, P.

Journal:

Annales de Dermatologie et de Vénéréologie

Year:

2018

Language:

french

File:

PDF, 166 KB

french, 2018

98

L’ixékizumab permet d’obtenir une amélioration des symptômes du psoriasis génital rapide et plus importante que le placebo

Yosipovitch, G., Foley, P., Burge, R., Potts Bleakman, A., Lin, C.-Y., Malatestinic, W., Gottlieb, A.B., Schneider, P.

Journal:

Annales de Dermatologie et de Vénéréologie

Year:

2018

File:

PDF, 166 KB

2018

99

Ixekizumab improves secondary lesional signs, pain and sexual health in patients with moderate‐to‐severe genital psoriasis

Merola, J.F., Ghislain, P.‐D., Dauendorffer, J.N., Potts Bleakman, A., Brnabic, A.J.M., Burge, R., Riedl, E.

Journal:

Journal of the European Academy of Dermatology and Venereology

Year:

2020

File:

PDF, 8.71 MB

2020