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51

Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry †,‡

Wolthers, Kirsten R., Lou, Xiaodong, Toogood, Helen S., Leys, David, Scrutton, Nigel S.

Journal:

Year:

2007

Language:

english

File:

PDF, 906 KB

english, 2007

52

Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction

Pudney, Christopher R, Hay, Sam, Levy, Colin, Pang, Jiayun, Sutcliffe, Michael J, Leys, David, Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 151 KB

english, 2009

53

Isotope Effects Reveal That Para -Substituted Benzylamines Are Poor Reactivity Probes of the Quinoprotein Mechanism for Aromatic Amine Dehydrogenase †,‡

Hothi, Parvinder, Roujeinikova, Anna, Khadra, Khalid Abu, Lee, Michael, Cullis, Paul, Leys, David, Scrutton, Nigel S.

Journal:

Year:

2007

Language:

english

File:

PDF, 424 KB

english, 2007

54

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes

Menon, Binuraj R. K., Fisher, Karl, Rigby, Stephen E. J., Scrutton, Nigel S., Leys, David

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 3.83 MB

english, 2014

55

New Insights into the Reductive Half-reaction Mechanism of Aromatic Amine Dehydrogenase Revealed by Reaction with Carbinolamine Substrates

Roujeinikova, Anna, Hothi, Parvinder, Masgrau, Laura, Sutcliffe, Michael J., Scrutton, Nigel S., Leys, David

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.20 MB

english, 2007

56

A microbial platform for renewable propane synthesis based on a fermentative butanol pathway

Menon, Navya, Pásztor, András, Menon, Binuraj RK, Kallio, Pauli, Fisher, Karl, Akhtar, M Kalim, Leys, David, Jones, Patrik R, Scrutton, Nigel S

Journal:

Biotechnology for Biofuels

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

57

Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli

Toogood, Helen S., Cheallaigh, Aisling Ní, Tait, Shirley, Mansell, David J., Jervis, Adrian, Lygidakis, Antonios, Humphreys, Luke, Takano, Eriko, Gardiner, John M., Scrutton, Nigel S.

Journal:

ACS Synthetic Biology

Year:

2015

Language:

english

File:

PDF, 795 KB

english, 2015

58

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

White, Mark D., Payne, Karl A. P., Fisher, Karl, Marshall, Stephen A., Parker, David, Rattray, Nicholas J. W., Trivedi, Drupad K., Goodacre, Royston, Rigby, Stephen E. J., Scrutton, Nigel S., Hay, Sam

Journal:

Year:

2015

Language:

english

File:

PDF, 2.69 MB

english, 2015

59

Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase

Menon, Binuraj R. K., Menon, Navya, Fisher, Karl, Rigby, Stephen E. J., Leys, David, Scrutton, Nigel S.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

60

Light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers

Peers, Martyn K., Toogood, Helen S., Heyes, Derren J., Mansell, David, Coe, Benjamin J., Scrutton, Nigel S.

Journal:

Catalysis Science & Technology

Year:

2015

Language:

english

File:

PDF, 390 KB

english, 2015

61

Sweating the assets of flavin cofactors: new insight of chemical versatility from knowledge of structure and mechanism

Leys, David, Scrutton, Nigel S

Journal:

Current Opinion in Structural Biology

Year:

2016

Language:

english

File:

PDF, 1.49 MB

english, 2016

62

Management of the Motor Disorders of Children with Cerebral Palsy

Scrutton, David, Lippincott, J. B., Bleck, Eugene E.

Journal:

Journal of Pediatric Orthopaedics

Year:

1985

File:

PDF, 93 KB

1985

63

Improving access to adult vaccination: a tool for healthy ageing

Scrutton, Jonathan, Sinclair, David, Walker, Trinley

Journal:

Working with Older People

Year:

2014

Language:

english

File:

PDF, 185 KB

english, 2014

64

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short-Chain Dehydrogenases/Reductases

Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

65

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short-Chain Dehydrogenases/Reductases

Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 1.31 MB

english, 2016

66

Quantum Catalysis in Enzymes: Beyond the Transition State Theory || Hydrogen Tunnelling in Enzyme-Catalysed H-Transfer Reactions: Flavoprotein and Quinoprotein Systems

Michael J. Sutcliffe, Laura Masgrau, Anna Roujeinikova, Linus O. Johannissen, Parvinder Hothi, Jaswir Basran, Kara E. Ranaghan, Adrian J. Mulholland, David Leys and Nigel S. Scrutton

Journal:

Philosophical Transactions Biological Sciences

Year:

2006

Language:

english

File:

PDF, 2.94 MB

english, 2006

67

Trp 359 regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA

Neeli, Rajasekhar, Sabri, Muna, McLean, Kirsty J., Dunford, Adrian J., Scrutton, Nigel S., Leys, David, Munro, Andrew W.

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 270 KB

english, 2008

68

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg 199 and Arg 200 mutants at the NADP(H) 2′-phosphate binding site

Sabri, Muna, Dunford, Adrian J., McLean, Kirsty J., Neeli, Rajasekhar, Scrutton, Nigel S., Leys, David, Munro, Andrew W.

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 651 KB

english, 2009

69

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation

Hay, Sam, Pudney, Christopher, Hothi, Parvinder, Johannissen, Linus O., Masgrau, Laura, Pang, Jiayun, Leys, David, Sutcliffe, Michael J., Scrutton, Nigel S.

Journal:

Biochemical Society Transactions

Year:

2008

Language:

english

File:

PDF, 321 KB

english, 2008

70

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

Beveridge, Rebecca, Migas, Lukasz G., Payne, Karl A. P., Scrutton, Nigel S., Leys, David, Barran, Perdita E.

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 1.94 MB

english, 2016

71

An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

Ortmayer, Mary, Lafite, Pierre, Menon, Binuraj R. K., Tralau, Tewes, Fisher, Karl, Denkhaus, Lukas, Scrutton, Nigel S., Rigby, Stephen E. J., Munro, Andrew W., Hay, Sam, Leys, David

Journal:

Year:

2016

Language:

english

File:

PDF, 4.72 MB

english, 2016

72

Excited-State Properties of Protochlorophyllide Analogues and Implications for Light-Driven Synthesis of Chlorophyll

Heyes, Derren J., Hardman, Samantha J. O., Mansell, David, Ní Cheallaigh, Aisling, Gardiner, John M., Johannissen, Linus O., Greetham, Gregory M., Towrie, Michael, Scrutton, Nigel S.

Journal:

Journal of Physical Chemistry B

Year:

2017

Language:

english

File:

PDF, 2.70 MB

english, 2017

73

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

Gahloth, Deepankar, Dunstan, Mark S, Quaglia, Daniela, Klumbys, Evaldas, Lockhart-Cairns, Michael P, Hill, Andrew M, Derrington, Sasha R, Scrutton, Nigel S, Turner, Nicholas J, Leys, David

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.74 MB

english, 2017

74

Mechanistic Reappraisal of Early Stage Photochemistry in the Light-Driven Enzyme Protochlorophyllide Oxidoreductase

Heyes, Derren J., Hardman, Samantha J. O., Mansell, David, Gardiner, John M., Scrutton, Nigel S., Subramanyam, Rajagopal

Journal:

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

75

Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway

Cheallaigh, Aisling Ní, Mansell, David J., Toogood, Helen S., Tait, Shirley, Lygidakis, Antonios, Scrutton, Nigel S., Gardiner, John M.

Journal:

Journal of Natural Products

Year:

2018

Language:

english

File:

PDF, 1.32 MB

english, 2018

76

Factors associated with pain in adolescents with bilateral cerebral palsy

Fairhurst, Charlie, Shortland, Adam, Chandler, Susie, Will, Elspeth, Scrutton, David, Simonoff, Emily, Baird, Gillian

Journal:

Developmental Medicine & Child Neurology

Year:

2018

Language:

english

File:

PDF, 134 KB

english, 2018

77

Flavin doesnât put all oxygens in one basket

Leys, David, Scrutton, Nigel S.

Journal:

Nature Chemical Biology

Year:

2020

File:

PDF, 781 KB

2020