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51

Anticonvulsant Activity of Pyrid-3-yl-Sulfonyl Ureas and Thioureas

B. Masereel, D. M. Lambert, J. M. Dogné, J. H. Poupaert, J. Delarge

Journal:

Year:

1997

Language:

english

File:

PDF, 327 KB

english, 1997

52

Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide–L-lysine–cyclodextrin complexes

G. Piel, B. Pirotte, I. Delneuville, P. Neven, G. Llabres, J. Delarge, L. Delattre

Journal:

Journal of Pharmaceutical Sciences

Year:

1997

Language:

english

File:

PDF, 172 KB

english, 1997

53

Thromboxane A2 Receptor Antagonism in Man and Rat by a Sulphonylcyanoguanidine (BM-144) and a Sulphonylurea (BM-500)

B. MASEREEL, J. DAMAS, J. FONTAINE, M. LEMBEGE, F. LACAN, A. NUHRICH, J. DELARGE, L. POCHET, J. M. DOGNE

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 101 KB

english, 1999

54

Pharmacomodulation Studies of Torasemide Leading to Original Non-carboxylic Thromboxane A2 Receptor Antagonists

J. M. DOGNÉ, X. DE LEVAL, P. NEVEN, S. ROLIN, J. WOUTERS, J. DELARGE, B. MASEREEL

Journal:

Journal of Pharmacy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

55

Comparison of the Effects of Nimesulide and Nimesulide-L-lysine on PGE2 Production by COX-1 and COX-2 and on Chondrocyte Metabolism In-vitro

X. DE LEVAL, Y. HENROTIN, A. LABASSE, J.-Y. REGINSTER, P. NEVEN, J. DELARGE, F. SOMERS, B. MASEREEL, B. PIROTTE, J.-M. DOGNE

Journal:

Journal of Pharmacy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 71 KB

english, 2000

56

3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as Potent KATP-Channel Activators: Structural Study and Influence of Stereochemistry

P. DE TULLIO, S. KHELILI, R. OUEDRAOGO, F. SOMERS, S. BOVERIE, L. DUPONT, J. FONTAINE, M. -H. ANTOINE, J. DELARGE, P. LEBRUN, B. PIROTTE

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 81 KB

english, 1999

57

Synthesis and Pharmacological Evaluation of KATP-channel Openers Related to Cromakalim: Introduction of Arylsulphonylurea Moieties

S. KHELILI, Q. -A. NGUYEN, P. LEBRUN, J. DELARGE, B. PIROTTE

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

58

4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure−Activity Relationships

Pirotte, Bernard, Podona, Tchao, Diouf, Ousmane, de Tullio, Pascal, Lebrun, Philippe, Dupont, Léon, Somers, Fabian, Delarge, Jacques, Morain, Philippe, Lestage, Pierre

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 436 KB

english, 1998

59

ChemInform Abstract: 3-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido(2,3-b)(1,4) benzodiazepine.

L. DUPONT, J.-F. LIEGEOIS, F. ROGISTER, J. DELARGE

Journal:

Year:

1996

File:

PDF, 24 KB

1996

60

ChemInform Abstract: 3- and 4-Substituted 4H-Pyrido(4,3-e)-1,2,4-thiadiazine 1,1-Dioxides as Potassium Channel Openers (PCO): Synthesis, Pharmacological Evaluation, and Structure-Activity Relationships.

P. DE TULLIO, B. PIROTTE, P. LEBRUN, J. FONTAINE, L. DUPONT, M.-H. ANTOINE, R. OUEDRAOGO, S. KHELILI, C. MAGGETTO, B. MASEREEL, O. DIOUF, T. PODONA, J. DELARGE

Journal:

Year:

1996

Language:

english

File:

PDF, 30 KB

english, 1996

61

ChemInform Abstract: Esters and Amides of 6-(Chloromethyl)-2-oxo-2H-1-benzopyran-3- carboxylic Acid as Inhibitors of α-Chymotrypsin: Significance of the “Aromatic” Nature of the Novel Ester-Type Coumarin for Strong Inhibitory Activity.

L. POCHET, C. DOUCET, M. SCHYNTS, N. THIERRY, N. BOGGETTO, B. PIROTTE, K. Y. JIANG, B. MASEREEL, P. DE TULLIO, J. DELARGE, M. REBOUD-RAVAUX

Journal:

Year:

1996

File:

PDF, 35 KB

1996

62

Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test

J. Bruhwyler, E. Chleide, J-F. Liégeois, J. Delarge, M. Mercier

Journal:

Pharmacology Biochemistry and Behavior

Year:

1990

Language:

english

File:

PDF, 556 KB

english, 1990

63

Effects of specific dopaminergic agonists and antagonists in the open-field test

J. Bruhwyler, E. Chleide, J-F. Liégeois, J. Delarge, M. Mercier

Journal:

Pharmacology Biochemistry and Behavior

Year:

1991

Language:

english

File:

PDF, 461 KB

english, 1991

64

Effects of JL 3, a putative antidepressant, on rat noradrenergic and serotonergic systems

Jean-François Liégeois, Vincent Seutin, Jacqueline Scuvée-Moreau, Albert Dresse, Jacques Bruhwyler, Joseph Géczy, Jacques Delarge, Jacques Damas

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 264 KB

english, 1999

65

Pyridothiadiazinedioxides structurally related to quinazolinones cholecystokinin/gastrin receptor ligands: synthesis and biological evaluation

Bernard Pirotte, Pascal de Tullio, Tchao Podona, Ousmane Diouf, Daniel Dewalque, Philippe Neven, Bernard Masereel, Daniel-Henri Caignard P, Pierre Renard, Jacques Delarge

Journal:

European Journal of Pharmaceutical Sciences

Year:

1998

Language:

english

File:

PDF, 238 KB

english, 1998

66

Un poumon s'organise aux portes de Paris

Alexandre Delarge

Journal:

Museum International (Edition Francaise)

Year:

1991

Language:

french

File:

PDF, 1.26 MB

french, 1991

67

A lung‘ just outside Paris

Alexandre Delarge

Journal:

Museum International

Year:

1991

Language:

english

File:

PDF, 1.35 MB

english, 1991

68

Oxidation Sensitivity May Be a Useful Tool for the Detection of the Hematotoxic Potential of Newly Developed Molecules: Application to Antipsychotic Drugs

Jean-François Liégeois, Jacques Bruhwyler, Christine Petit, Jacques Damas, Jacques Delarge, Joseph Géczy, Jean-Michel Kauffmann, Maurice Lamy, Herbert Meltzer, Ange Mouithys-Mickalad

Journal:

Archives of Biochemistry and Biophysics

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

69

JL 13, a Potential Successor to Clozapine, Is Less Sensitive to Oxidative Phenomena

Jean-François Liégeois, Ange Mouithys-Mickalad, Jacques Bruhwyler, Jacques Delarge, Christine Petit, Jean-Michel Kauffmann, Maurice Lamy

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 116 KB

english, 1997

70

A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+ channels

B. Pirotte, M.-H. Antoine, P. De Tullio, M. Hermann, A. Herchuelz, J. Delarge, P. Lebrun

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 656 KB

english, 1994

71

Na+,2Cl−,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives

Bernard Masereel, Patrizia Ferrari, Marra Ferrandi, Bernard Pirotte, Marc Schynts, Paolo Parenti, Jacques Delarge

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 753 KB

english, 1992

72

Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor

Jean-François Liégeois, Jacques Bruhwyler, Jacques Damas, Françoise Rogister, Bernard Masereel, Joseph Geczy, Jacques Delarge

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 225 KB

english, 1995

73

Minimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats

Jean-François Liégeois, Jacques Bruhwyler, Jean-Claude Hendrick, Jacques Delarge, Jean-Jacques Legros, Jacques Damas

Journal:

Neuroscience Letters

Year:

2002

Language:

english

File:

PDF, 76 KB

english, 2002

74

Pharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation

X de Leval, V Benoit, J Delarge, F Julémont, B Masereel, B Pirotte, M.-P Merville, J.-L David, J.-M Dogné

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

75

Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function

J.M. Dogné, X. de Leval, P. Neven, S. Rolin, J. Wauters, J.-L. David, J. Delarge, B. Massereel

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2000

Language:

english

File:

PDF, 240 KB

english, 2000

76

Activity of a novel dual thromboxane A2receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles

S. Rolin, J.M. Dogné, C. Michaux, J. Delarge, B. Masereel

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2001

Language:

english

File:

PDF, 315 KB

english, 2001

77

Evaluation of classical NSAIDs and COX-2 selective inhibitors on purified ovine enzymes and human whole blood

X. de Leval, J. Delarge, P. Devel, P. Neven, C. Michaux, B. Masereel, B. Pirotte, J.-L. David, Y. Henrotin, J.-M. Dogné

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2001

Language:

english

File:

PDF, 235 KB

english, 2001

78

Synthesis and Biological Evaluation of New 3-Aralkylamino-2-aryl-2H-1,2,4-pyridothiadiazine 1,1-dioxides as Potential CCK-Receptor Ligands

PASCAL DE TULLIO, BERNARD PIROTTE, PHILIPPE NEVEN, BERNARD MASEREEL, DANIEL DEWALQUE, OUSMANE DIOUF, TCHAO PODONA, DANIEL CAIGNARD, PIERRE RENARD, JACQUES DELARGE

Journal:

Journal of Pharmacy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 954 KB

english, 1997

79

14-126 - JL 13, a promising atypical antipsychotic: A review of its preclinical profile

J.-F. Liégeois, J. Bruhwyler, J. Damas, J. Delarge, J. Géczy

Journal:

Biological Psychiatry

Year:

1997

Language:

english

File:

PDF, 237 KB

english, 1997

80

JL13, A PYRIDOBENZOXAZEPINE COMPOUND WITH POTENTIAL ATYPICAL ANTIPSYCHOTIC ACTIVITY: A REVIEW OF ITS BEHAVIOURAL PROPERTIES

J. Bruhwyler, J.-F. Liégeois, J. Bergman, G. Carey, A. Goudie, A. Taylor, H. Meltzer, J. Delarge, J. Géczy

Journal:

Pharmacological Research

Year:

1997

Language:

english

File:

PDF, 115 KB

english, 1997

81

P.3.031 - The preclinical profile of an original pyridobenzoxazepine, JL 13

J.-F. Lié, J. Bruhwyler, A.J. Goudie, A. Taylor, J. Damas, J. Delarge, J. Géczy

Journal:

European Neuropsychopharmacology

Year:

1996

Language:

english

File:

PDF, 164 KB

english, 1996

82

The Mycologist binder

Journal:

Year:

1988

Language:

english

File:

PDF, 103 KB

english, 1988

83

3-(Alkylamino)-4H-pyrido[4,3-e]1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

Pirotte, Bernard, de Tullio, Pascal, Lebrun, Philippe, Antoine, Marie Helene, Fontaine, Jeanine, Masereel, Bernard, Schynts, Marc, Dupont, Leon, Herchuelz, Andre, Delarge, Jacques

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 391 KB

english, 1993

84

New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study

Liegeois, Jean Francois F., Bruhwyler, Jacques, Damas, Jacques, Nguyen, Thuy Phuong, Chleide, Eric M. G., Mercier, Michel G. A., Rogister, Francoise A., Delarge, Jacques E.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.07 MB

english, 1993

85

Esters and Amides of 6-(Chloromethyl)-2-oxo-2 H -1-benzopyran-3-carboxylic Acid as Inhibitors of α-Chymotrypsin: Significance of the “Aromatic” Nature of the Novel Ester-Type Coumarin for Strong Inhibitory Activity

Pochet, Lionel, Doucet, Caroline, Schynts, Marc, Thierry, Nicole, Boggetto, Nicole, Pirotte, Bernard, Jiang, Kai Y., Masereel, Bernard, de Tullio, Pascal, Delarge, Jacques, Reboud-Ravaux, Michèle

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 193 KB

english, 1996

86

Electrooxidation Potential as a Tool in the Early Screening for New Safer Clozapine-like Analogues

Mouithys-Mickalad, Ange, Kauffmann, Jean-Michel, Petit, Christine, Bruhwyler, Jacques, Liao, Yi, Wikström, Håkan, Damas, Jacques, Delarge, Jacques, Deby-Dupont, Ginette, Géczy, Joseph, Liégeois, Jean-

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

87

Synthesis and Anticonvulsant Activity of 2(3 H )-Benzoxazolone and 2(3 H )-Benzothiazolone Derivatives

Ucar, Huseyin, Van derpoorten, Kim, Cacciaguerra, Silvia, Spampinato, Santi, Stables, James P., Depovere, Paul, Isa, Majed, Masereel, Bernard, Delarge, Jacques, Poupaert, Jacques H.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 112 KB

english, 1998

88

Original 2-Alkylamino-6-halogenoquinazolin-4(3 H )-ones and K ATP Channel Activity

Somers, Fabian, Ouedraogo, Raogo, Antoine, Marie-Hélène, de Tullio, Pascal, Becker, Bénédicte, Fontaine, Jeanine, Damas, Jacques, Dupont, Léon, Rigo, Benoit, Delarge, Jacques, Lebrun, Philippe, Pirott

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 134 KB

english, 2001

89

6-Substituted 2-Oxo-2 H -1-benzopyran-3-carboxylic Acid as a Core Structure for Specific Inhibitors of Human Leukocyte Elastase †

Doucet, Caroline, Pochet, Lionel, Thierry, Nicole, Pirotte, Bernard, Delarge, Jacques, Reboud-Ravaux, Michèle

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 228 KB

english, 1999

90

New Pyridobenzodiazepine Derivatives: Modifications of the Basic Side Chain Differentially Modulate Binding to Dopamine (D 4.2 , D 2L ) and Serotonin (5-HT 2A ) Receptors

Liégeois, Jean-François, Eyrolles, Laurence, Ellenbroek, Bart A., Lejeune, Christel, Carato, Pascal, Bruhwyler, Jacques, Géczy, Joseph, Damas, Jacques, Delarge, Jacques

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 236 KB

english, 2002

91

Advances in the field of COX-2 inhibition

Delarge, Jacques, Dogné, Jean-Michel, Julémont, Fabien, Leval, Xavier de, Pirotte, Bernard, Sanna, Vanna

Journal:

Expert Opinion on Therapeutic Patents

Year:

2002

Language:

english

File:

PDF, 276 KB

english, 2002

92

Synthesis and Anticonvulsant Activity of 2(3 H )-Benzoxazolone and 2(3 H )-Benzothiazolone Derivatives

Ucar, Huseyin, Van derpoorten, Kim, Cacciaguerra, Silvia, Spampinato, Santi, Stables, James P., Depovere, Paul, Isa, Majed, Masereel, Bernard, Delarge, Jacques, Poupaert, Jacques H.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 12 KB

english, 1998

93

4-Acylamino-4 H -1,2,4-triazoles and related structures: new investigations of their chemical and physicochemical properties associated with their particular exocyclic amide function

Pirotte, Bernard, Tullio, Pascal De, Masereel, Bernard, Schynts, Marc, Delarge, Jacques, Dupont, Léon, Thunus, Léopold

Journal:

Canadian Journal of Chemistry

Year:

1993

Language:

english

File:

PDF, 650 KB

english, 1993

94

Evaluation of the Inhibitory Activity on Serine and Aspartic Proteases of 4-Amino-4H-1,2,4-triazole and 5-Aminothiazole Derivatives Structurally Related to β-Lactam Antibiotics

A. Vilain, B. Pirotte, I. Vergely, N. Boggetto, B. Masereel, M. Schynts, J. Delarge, M. Reboud-ravaux

Year:

1993

Language:

english

File:

PDF, 581 KB

english, 1993

95

Recent developments of thromboxane modulators

Masereel, Bernard, Dogné, Jean-Michel, Delarge, Jacques, Leval, Xavier de

Journal:

Expert Opinion on Therapeutic Patents

Year:

2001

Language:

english

File:

PDF, 186 KB

english, 2001

96

Application of epifluorescence scanning for monitoring the efficacy of protein removal by RF gas–plasma decontamination

H. C. Baxter, P. R. Richardson, G. A. Campbell, V. I. Kovalev, R. Maier, J. S. Barton, A. C. Jones, G. Delarge, M. Casey, R. L. Baxter

Year:

2009

Language:

english

File:

PDF, 1.32 MB

english, 2009

97

New Trends in Thromboxane and Prostacyclin Modulators

Dogne, Jean, Leval, Xavier, Delarge, Jacques, David, Jean, Masereel, Bernard

Journal:

Current Medicinal Chemistry

Year:

2000

File:

PDF, 117 KB

2000

98

Recent Advances in Inducible Cyclooxygenase (COX-2) Inhibition.

X. De Leval, J. Delarge, F. Somers, P. De Tullio, Y. Henrotin, B. Pirotte, J. Dogne

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

99

New Trends in Thromboxane and Prostacyclin Modulators

Dogne, Jean, Leval, Xavier, Delarge, Jacques, David, Jean, Masereel, Bernard

Journal:

Current Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 117 KB

english, 2000

100

Recent Advances in Antiplatelet Agents

Dogne, Jean-Michel, Leval, Xavier, Benoit, Patricia, Delarge, Jacques, Masereel, Bernard, David, Jean-Louis

Journal:

Current Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 80 KB

english, 2002

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