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51

Double Mutation at the Subunit Interface of Glutathione Transferase rGSTM1-1 Results in a Stable, Folded Monomer †

Thompson, Lawrence C., Walters, John, Burke, Jonathan, Parsons, James F., Armstrong, Richard N., Dirr, Heini W.

Journal:

Year:

2006

Language:

english

File:

PDF, 443 KB

english, 2006

52

Class Sigma Glutathione Transferase Unfolds via a Dimeric and a Monomeric Intermediate: Impact of Subunit Interface on Conformational Stability in the Superfamily †

Stevens, Julie M., Hornby, Judith A. T., Armstrong, Richard N., Dirr, Heini W.

Journal:

Year:

1998

Language:

english

File:

PDF, 115 KB

english, 1998

53

Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance

Naicker, Previn, Achilonu, Ikechukwu, Fanucchi, Sylvia, Fernandes, Manuel, Ibrahim, Mahmoud A.A., Dirr, Heini W., Soliman, Mahmoud E.S., Sayed, Yasien

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2013

Language:

english

File:

PDF, 511 KB

english, 2013

54

A Conserved Interdomain Interaction Is a Determinant of Folding Cooperativity in the GST Fold

Parbhoo, Nishal, Stoychev, Stoyan H., Fanucchi, Sylvia, Achilonu, Ikechukwu, Adamson, Roslin J., Fernandes, Manuel, Gildenhuys, Samantha, Dirr, Heini W.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

55

Class Pi Glutathione Transferase Unfolds via a Dimeric and Not Monomeric Intermediate: Functional Implications for an Unstable Monomer

Gildenhuys, Samantha, Wallace, Louise A., Burke, Jonathan P., Balchin, David, Sayed, Yasien, Dirr, Heini W.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.48 MB

english, 2010

56

Structural Dynamics of Soluble Chloride Intracellular Channel Protein CLIC1 Examined by Amide Hydrogen−Deuterium Exchange Mass Spectrometry

Stoychev, Stoyan H., Nathaniel, Christos, Fanucchi, Sylvia, Brock, Melissa, Li, Sheng, Asmus, Kyle, Woods, Virgil L., Dirr, Heini W.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.51 MB

english, 2009

57

Equilibrium Folding of Dimeric Class μ Glutathione Transferases Involves a Stable Monomeric Intermediate †

Hornby, Judith A. T., Luo, Jiann-Kae, Stevens, Julie M., Wallace, Louise A., Kaplan, Warren, Armstrong, Richard N., Dirr, Heini W.

Journal:

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

58

Role of the C-Terminal Helix 9 in the Stability and Ligandin Function of Class α Glutathione Transferase A1-1 †

Dirr, Heini W., Wallace, Louise A.

Journal:

Year:

1999

Language:

english

File:

PDF, 156 KB

english, 1999

59

Folding and Assembly of Dimeric Human Glutathione Transferase A1-1 †

Wallace, Louise A., Dirr, Heini W.

Journal:

Year:

1999

Language:

english

File:

PDF, 157 KB

english, 1999

60

A Single Amino Acid in the Hinge Loop Region of the FOXP Forkhead Domain is Significant for Dimerisation

Perumal, Kershia, Dirr, Heini W., Fanucchi, Sylvia

Journal:

The Protein Journal

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

61

The kinetics of the substitution of coordinated H2O on Co(III) by cyanide in aquacobalamin (vitamin B12a) and in a corrole analogue

Zipp, Caitlin F., Michael, Joseph P., Fernandes, Manuel A., Nowakowska, Monika, Dirr, Heini W., Marques, Helder M.

Journal:

Inorganic Chemistry Communications

Year:

2015

Language:

english

File:

PDF, 472 KB

english, 2015

62

Amide hydrogen exchange in HIV-1 subtype B and C proteases - insights into reduced drug susceptibility and dimer stability

Naicker, Previn, Stoychev, Stoyan, Dirr, Heini W., Sayed, Yasien

Journal:

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

63

Plasmodium falciparumHsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion

Zininga, Tawanda, Achilonu, Ikechukwu, Hoppe, Heinrich, Prinsloo, Earl, Dirr, Heini W., Shonhai, Addmore

Journal:

Cell Stress and Chaperones

Year:

2016

Language:

english

File:

PDF, 923 KB

english, 2016

64

Electrostatic interactions affecting the active site of class Sigma glutathione S-transferase

STEVENS, Julie M., ARMSTRONG, Richard N., DIRR, Heini W.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 150 KB

english, 2000

65

Heat shock cognate protein 70 chaperone-binding site in the co-chaperone murine stress-inducible protein 1 maps to within three consecutive tetratricopeptide repeat motifs

VAN DER SPUY, Jacqueline, KANA, Bavesh D., DIRR, Heini W., BLATCH, Gregory L.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 221 KB

english, 2000

66

Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding

SAYED, Yasien, HORNBY, Judith A. T., LOPEZ, Marimar, DIRR, Heini

Journal:

Biochemical Journal

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

67

The role of an evolutionarily conserved cis-proline in the thioredoxin-like domain of human class Alpha glutathione transferase A1-1

NATHANIEL, Chris, WALLACE, Louise A., BURKE, Jonathan, DIRR, Heini W.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

68

The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met 51 and Phe 52 in function and dimer stability

Alves, Carla S., Kuhnert, Diane C., Sayed, Yasien, Dirr, Heini W.

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

69

A topologically conserved aliphatic residue in α-helix 6 stabilizes the hydrophobic core in domain II of glutathione transferases and is a structural determinant for the unfolding pathway

WALLACE, Louise A., BLATCH, Gregory L., DIRR, Heini W.

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 164 KB

english, 1998

70

Heat shock cognate protein 70 chaperone-binding site in the co-chaperone murine stress-inducible protein 1 maps to within three consecutive tetratricopeptide repeat motifs

VAN DER SPUY, Jacqueline, KANA, Bavesh D., DIRR, Heini W., BLATCH, Gregory L.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 221 KB

english, 2000

71

Electrostatic interactions affecting the active site of class Sigma glutathione S-transferase

STEVENS, Julie M., ARMSTRONG, Richard N., DIRR, Heini W.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 150 KB

english, 2000

72

Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding

SAYED, Yasien, HORNBY, Judith A.T., LOPEZ, Marimar, DIRR, Heini

Journal:

Biochemical Journal

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

73

The Lyssavirus glycoprotein: A key to cross-immunity

Buthelezi, Sindisiwe G., Dirr, Heini W., Chakauya, Ereck, Chikwamba, Rachel, Martens, Lennart, Tsekoa, Tsepo L., Stoychev, Stoyan H., Vandermarliere, Elien

Journal:

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

74

Analysis of the Levels of Conservation of the J Domain among the Various Types of DnaJ-like Proteins

Fritha Hennessy, Michael E. Cheetham, Heini W. Dirr and Gregory L. Blatch

Journal:

Cell Stress and Chaperones

Year:

2000

Language:

english

File:

PDF, 1.20 MB

english, 2000

75

The effects of mutating Tyr9 and Arg15 on the structure, stability, conformational dynamics and mechanism of GSTA3-3

Robertson, Gary J., Stoychev, Stoyan H., Sayed, Yasien, Achilonu, Ikechukwu, Dirr, Heini W.

Journal:

Biophysical Chemistry

Year:

2017

Language:

english

File:

PDF, 1.67 MB

english, 2017

76

The FOXP2 forkhead domain binds to a variety of DNA sequences with different rates and affinities

Webb, Helen, Steeb, Olga, Blane, Ashleigh, Rotherham, Lia, Aron, Shaun, Machanick, Phillip, Dirr, Heini, Fanucchi, Sylvia

Journal:

Journal of Biochemistry

Year:

2017

Language:

english

File:

PDF, 546 KB

english, 2017

77

Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease

Zondagh, Jake, Balakrishnan, Vijayakumar, Achilonu, Ikechukwu, Dirr, Heini W., Sayed, Yasien

Journal:

Journal of Molecular Graphics and Modelling

Year:

2018

Language:

english

File:

PDF, 6.49 MB

english, 2018

78

An update on the biophysical character of the human eukaryotic elongation factor 1 beta: Perspectives from interaction with elongation factor 1 gamma

Achilonu, Ikechukwu, Elebo, Nnenna, Hlabano, Babongiwe, Owen, Gavin R., Papathanasopoulos, Maria, Dirr, Heini W.

Journal:

Journal of Molecular Recognition

Year:

2018

Language:

english

File:

PDF, 1.05 MB

english, 2018

79

Analysis of the levels of conservation of the J domain among the various types of DnaJ-like proteins

Hennessy, Fritha, Cheetham, Michael E., Dirr, Heini W., Blatch, Gregory L.

Journal:

Cell Stress and Chaperones

Year:

2000

Language:

english

File:

PDF, 750 KB

english, 2000

80

A Phosphomimetic Study Implicates Ser557 in Regulation of FOXP2 DNA Binding

Blane, Ashleigh, Dirr, Heini W., Fanucchi, Sylvia

Journal:

The Protein Journal

Year:

2018

Language:

english

File:

PDF, 1.79 MB

english, 2018

81

Overexpression, Purification and Functional Characterisation of Wild-Type HIV-1 Subtype C Protease and Two Variants Using a Thioredoxin and His-Tag Protein Fusion System

Zondagh, Jake, Williams, Alison, Achilonu, Ikechukwu, Dirr, Heini W., Sayed, Yasien

Journal:

The Protein Journal

Year:

2018

Language:

english

File:

PDF, 2.60 MB

english, 2018

82

The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2

Morris, Gavin, Stoychev, Stoyan, Naicker, Previn, Dirr, Heini W., Fanucchi, Sylvia

Journal:

Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.50 MB

english, 2018

83

(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

Zininga, Tawanda, Ramatsui, Lebogang, Makhado, Pertunia, Makumire, Stanley, Achilinou, Ikechukwu, Hoppe, Heinrich, Dirr, Heini, Shonhai, Addmore

Journal:

Year:

2017

Language:

english

File:

PDF, 1.43 MB

english, 2017

84

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif

Mabate, Blessing, Zininga, Tawanda, Ramatsui, Lebogang, Makumire, Stanley, Achilonu, Ikechukwu, Dirr, Heini W., Shonhai, Addmore

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2018

Language:

english

File:

PDF, 2.23 MB

english, 2018

85

A conserved cation binding site in the DNA binding domain of forkhead box transcription factors regulates DNA binding by FOXP2

Morris, Gavin, Pahad, Naadira, Dirr, Heini W., Fanucchi, Sylvia

Journal:

Archives of Biochemistry and Biophysics

Year:

2018

Language:

english

File:

PDF, 3.86 MB

english, 2018

86

The study of degradation mechanisms of glyco-engineered plant produced anti-rabies monoclonal antibodies E559 and 62-71-3

Buthelezi, Sindisiwe G., Dirr, Heini W., Chakauya, Ereck, Chikwamba, Rachel, Martens, Lennart, Tsekoa, Tsepo L., Vandermarliere, Elien, Stoychev, Stoyan H., Kaur, Balveen

Journal:

Year:

2018

Language:

english

File:

PDF, 3.72 MB

english, 2018

87

Double trouble? Gag in conjunction with double insert in HIV protease contribute to reduced DRV susceptibility

Williams, Alison, Basson, Adriaan, Achilonu, Ikechukwu, Dirr, Heini W., Morris, Lynn, Sayed, Yasien

Journal:

Biochemical Journal

Year:

2018

Language:

english

File:

PDF, 493 KB

english, 2018

88

An empirical and theoretical description of Schistosoma japonicum glutathione transferase inhibition by bromosulfophthalein and indanyloxyacetic acid 94

Pooe, Kagiso, Worth, Roland, Iwuchukwu, Emmanuel Amarachi, Dirr, Heini W., Achilonu, Ikechukwu

Journal:

Journal of Molecular Structure

Year:

2021

File:

PDF, 4.37 MB

2021

89

Molecular basis of inhibition of Schistosoma japonicum glutathione transferase by ellagic acid: Insights into biophysical and structural studies

Akumadu, Blessing O., Pandian, Ramesh, Olfsen, Jessica, Worth, Roland, Thulo, Monare, Mentor, Tshireletso, Fanucchi, Sylvia, Sayed, Yasien, Dirr, Heini W., Achilonu, Ikechukwu

Journal:

Molecular and Biochemical Parasitology

Year:

2020

File:

PDF, 5.64 MB

2020