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51

4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action

Claudia Vergelli, Maria Paola Giovannoni, Stefano Pieretti, Amalia Di Giannuario, Vittorio Dal Piaz, Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, Nicoletta Cesari

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 339 KB

english, 2007

52

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity

Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, Nicoletta Cesari, Maria Paola Giovannoni, Agostino Cilibrizzi, Vittorio Dal Piaz, Claudia Vergelli, Letizia Crocetti, Maurizio Delcanale, E

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 520 KB

english, 2010

53

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Letizia Crocetti, Maria Paola Giovannoni, Igor A. Schepetkin, Mark T. Quinn, Andrei I. Khlebnikov, Agostino Cilibrizzi, Vittorio Dal Piaz, Alessia Graziano, Claudia Vergelli

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 737 KB

english, 2011

54

New pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors

Joan Feixas, Maria Paola Giovannoni, Claudia Vergelli, Amadeu Gavaldà, Nicoletta Cesari, Alessia Graziano, Vittorio Dal Piaz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 118 KB

english, 2005

55

β-Glycosyl Azides as Substrates for α-Glycosynthases: Preparation of Efficient α-L-Fucosynthases

Beatrice Cobucci-Ponzano, Fiorella Conte, Emiliano Bedini, Maria Michela Corsaro, Michelangelo Parrilli, Gerlind Sulzenbacher, Alexandra Lipski, Fabrizio Dal Piaz, Laura Lepore, Mosè Rossi, Marco Mora

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 646 KB

english, 2009

56

Fragmentation Pathways of Polycyclic Polyisoprenylated Benzophenones and Degradation Profile of Nemorosone by Multiple-Stage Tandem Mass Spectrometry

Anna Lisa Piccinelli, Luca Campone, Fabrizio Dal Piaz, Osmany Cuesta-Rubio, Luca Rastrelli

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2009

Language:

english

File:

PDF, 1.26 MB

english, 2009

57

Secondary metabolites from the aerial parts of Salvia palaestina Bentham

Giuseppina Cioffi, Ammar Bader, Anna Malafronte, Fabrizio Dal Piaz, Nunziatina De Tommasi

Journal:

Year:

2008

Language:

english

File:

PDF, 162 KB

english, 2008

58

Diels-alder reactions on 5-acetyl-2-methyl-4-nitro-6-phenylpyridazin-3(2H)-one: A new facet of the pyridazine system

Vittorio Dal Piaz, Maria P. Giovannoni, Giovanna Ciciani, Donatella Giomi, Rodolfo Nesi

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 147 KB

english, 1993

59

A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-chloropyridazines.

Vittorio Dal Piaz, Maria Paola Giovannoni, Giovanna Ciciani

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 288 KB

english, 1993

60

Isoxazolo [3,4-d]pyridazin-7(6h)-ones. synthesis of 3-unsubstituted derivatives: A reinvestigation

V. Dal Piaz, G. Ciciani, M.P. Giovannoni

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 149 KB

english, 1991

61

Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies

Vittorio Dal Piaz, Maria Paola Giovannoni

Journal:

European Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 285 KB

english, 2000

62

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-ones and their Corresponding 4,5-Disubstituted-3-(2H)-pyridazinone Analogues as New Substrates for α1-Adrenoceptor Selective Antagonists: Synthesis, Modeling, and Binding Studies

Federica Montesano, Daniela Barlocco, Vittorio Dal Piaz, Amedeo Leonardi, Elena Poggesi, Francesca Fanelli, Piero G. De Benedetti

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 524 KB

english, 1998

63

296 A NEW ARYLPIPERAZINYLALKYL DERIVATIVE WITH POTENT ANTINOCICEPTIVE ACTIVITY IN MICE

M. Mastriota, A. Di Giannuario, M. Colucci, M.P. Giovannoni, C. Biancalani, V. Dal Piaz, S. Pieretti

Journal:

European Journal of Pain

Year:

2009

Language:

english

File:

PDF, 46 KB

english, 2009

64

Expression and purification of the recombinant subunits of toluene/o-xylene monooxygenase and reconstitution of the active complex

Valeria Cafaro, Roberta Scognamiglio, Ambra Viggiani, Viviana Izzo, Irene Passaro, Eugenio Notomista, Fabrizio Dal Piaz, Angela Amoresano, Annarita Casbarra, Piero Pucci, Alberto Di Donato

Journal:

Year:

2002

Language:

english

File:

PDF, 411 KB

english, 2002

65

Selective and asymmetric action of trypsin on the dimeric forms of seminal RNase

Claudia De Lorenzo, Renata Piccoli, Antimo Di Maro, Piero Pucci, Giuseppe D'alessio, Fabrizio Dal Piaz

Journal:

Protein Science

Year:

1998

Language:

english

File:

PDF, 1.58 MB

english, 1998

66

Structure of Lipid A from Pseudomonas corrugata by electrospray ionization quadrupole time-of-flight tandem mass spectrometry

M. M. Corsaro, F. Dal Piaz, R. Lanzetta, T. Naldi, M. Parrilli

Journal:

Rapid Communications in Mass Spectrometry

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

67

Electrospray ionization mass spectrometry for identification and structural characterization of pregnane glycosides

Fabrizio Dal Piaz, Marinella De Leo, Alessandra Braca, Francesco De Simone, Ivano Morelli, Nunziatina De Tommasi

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 405 KB

english, 2005

68

Intramolecular interchain reactions in bidesmosidic glycosides, a new insight into carbohydrate rearrangements induced by electrospray ionisation

Fabrizio Dal Piaz, Marinella De Leo, Alessandra Braca, Francesco De Simone, Nunziatina De Tommasi

Journal:

Rapid Communications in Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

69

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

Chiara Giommarelli, Valentina Zuco, Enrica Favini, Claudio Pisano, Fabrizio Dal Piaz, Nunziatina De Tommasi, Franco Zunino

Journal:

Cellular and Molecular Life Sciences

Year:

2010

Language:

english

File:

PDF, 432 KB

english, 2010

70

Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site

Christian Martin, Rolf Göggel, Vittorio Dal Piaz, Claudia Vergelli, Maria Giovannoni, Martin Ernst, Stefan Uhlig

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2002

Language:

english

File:

PDF, 100 KB

english, 2002

71

Coupling of oceanic and continental crust during Eocene eclogite-facies metamorphism: evidence from the Monte Rosa nappe, western Alps

Thomas J. Lapen, Clark M. Johnson, Lukas P. Baumgartner, Giorgio V. Dal Piaz, Susanne Skora, Brian L. Beard

Journal:

Contributions to Mineralogy and Petrology

Year:

2007

Language:

english

File:

PDF, 1013 KB

english, 2007

72

Tertiary age and paleostructural inferences of the eclogitic imprint in the Austroalpine outliers and Zermatt–Saas ophiolite, western Alps

G. Dal Piaz, G. Cortiana, A. Del Moro, S. Martin, G. Pennacchioni, P. Tartarotti

Journal:

International Journal of Earth Sciences

Year:

2001

Language:

english

File:

PDF, 476 KB

english, 2001

73

The Aosta–Ranzola extensional fault system and Oligocene–Present evolution of the Austroalpine–Penninic wedge in the northwestern Alps

A. Bistacchi, G. Dal Piaz, M. Massironi, M. Zattin, M. Balestrieri

Journal:

International Journal of Earth Sciences

Year:

2001

Language:

english

File:

PDF, 629 KB

english, 2001

74

Foreword

Francesco Sassi, Giorgio V. Dal Piaz, Carlo Doglioni

Journal:

Rendiconti Lincei

Year:

2010

Language:

english

File:

PDF, 115 KB

english, 2010

75

Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands

Maria Paola Giovannoni, Claudia Vergelli, Agostino Cilibrizzi, Letizia Crocetti, Claudio Biancalani, Alessia Graziano, Vittorio Dal Piaz, Maria Isabel Loza, Maria Isabel Cadavid, José Luis Díaz, Amade

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 444 KB

english, 2010

76

A fast and efficient LC–MS/MS method for detection, identification and quantitative analysis of bioactive sesterterpenes in Salvia dominica crude extracts

Fabrizio Dal Piaz, Salvatore Imparato, Laura Lepore, Ammar Bader, Nunziatina De Tommasi

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2010

Language:

english

File:

PDF, 1021 KB

english, 2010

77

Heterocyclic-fused 3(2H)-pyridazinones as potent and selective PDE IV inhibitors: Further structure-activity relationships and molecular modelling studies

Vittorio Dal Piaz, Maria Paola Giovannoni, Carla Castellana, José Maria Palacios, Jorge Beleta, Teresa Doménech, Victor Segarra

Journal:

European Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 739 KB

english, 1998

78

4,5-Functionalized 6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity

V Dal Piaz, MP Giovannoni, G Ciciani, D Barlocco, G Giardina, G Petrone, GD Clarke

Journal:

European Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 360 KB

english, 1996

79

Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation

Venturi, Annamaria, Piaz, Fabrizio Dal, Giovannini, Catia, Gramantieri, Laura, Chieco, Pasquale, Bolondi, Luigi

Journal:

Laboratory Investigation

Year:

2008

Language:

english

File:

PDF, 532 KB

english, 2008

80

Conformational analysis of putative regulatory subunit D of the toluene/o-xylene-monooxygenase complex from Pseudomonas stutzeri OX1

Roberta Scognamiglio, Eugenio Notomista, Paola Barbieri, Piero Pucci, Fabrizio Dal Piaz, Anna Tramontano, Alberto Di Donato

Journal:

Protein Science

Year:

2001

Language:

english

File:

PDF, 459 KB

english, 2001

81

Conformational changes in the NS3 protease from hepatitis C virus strain Bk monitored by limited proteolysis and mass spectrometry

Stefania Orrù, Fabrizio Dal Piaz, Annarita Casbarra, Gabriella Biasiol, Raffaele De Francesco, Christian Steinkühler, Piero Pucci

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 725 KB

english, 1999

82

Removal of the N-terminal hexapeptide from human β2-microglobulin facilitates protein aggregation and fibril formation

G. Esposito, R. Michelutti, G. Verdone, P. Viglino, H. Hern ÁNdez, C. V. Robinson, A. Amoresano, F. Dal Piaz, M. Monti, P. Pucci, P. Mangione, M. Stoppini, G. Merlini, G. Ferri, V. Bellotti

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 2.50 MB

english, 2000

83

Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors

Giovannoni, Maria P., Cesari, Nicoletta, Graziano, Alessia, Vergelli, Claudia, Biancalani, Claudio, Biagini, Pierfrancesco, Piaz, Vittorio Dal

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 250 KB

english, 2007

84

ChemInform Abstract: 4,5-Functionalized 6-Phenyl-3(2H)-pyridazinones: Synthesis and Evaluation of Antinociceptive Activity.

V. DAL PIAZ, M. P. GIOVANNONI, G. CICIANI, D. BARLOCCO, G. GIARDINA, G. PETRONE, G. D. CLARKE

Journal:

Year:

1996

File:

PDF, 30 KB

1996

85

Condensation of some 3-methylisoxazolo[3,4-d]pyridazin-7(6H)ones with aromatic aldehydes

V. Dal Piaz, S. Pinzauti, P. Lacrimini

Journal:

Journal of Heterocyclic Chemistry

Year:

1976

File:

PDF, 115 KB

1976

86

The use of 3,5-dimethyl-4-nitroisoxazole for the preparation of α,β-unsaturated aromatic acids

P. Sarti-Fantoni, D. Donati, M. Fiorenza, E. Moschi, V. Dal Piaz

Journal:

Journal of Heterocyclic Chemistry

Year:

1980

File:

PDF, 113 KB

1980

87

Cystatin B and its EPM1 mutants are polymeric and aggregate prone in vivo

Elena Cipollini, Massimo Riccio, Rossella Di Giaimo, Fabrizio Dal Piaz, Giuseppe Pulice, Sandra Catania, Ilaria Caldarelli, Maja Dembic, Spartaco Santi, Marialuisa Melli

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2008

Language:

english

File:

PDF, 1.61 MB

english, 2008

88

Isolation and structural characterization of glycosides from an anti-angiogenic extract of Monnina obtusifolia H.B.K.

Laura Lepore, Nicola Malafronte, Fausto Bedoya Condero, Maria J. Gualtieri, Susana Abdo, Fabrizio Dal Piaz, Nunziatina De Tommasi

Journal:

Year:

2011

Language:

english

File:

PDF, 274 KB

english, 2011

89

13-Hydroxy-15-oxo-zoapatlin, an ent-kaurane diterpene, induces apoptosis in human leukemia cells, affecting thiol-mediated redox regulation

Fabrizio Dal Piaz, Patrizia Nigro, Alessandra Braca, Nunziatina De Tommasi, Maria Antonietta Belisario

Journal:

Free Radical Biology and Medicine

Year:

2007

Language:

english

File:

PDF, 1.09 MB

english, 2007

90

Inhibition of the thioredoxin system is a basis for the antileukemic potential of 13-hydroxy-15-oxo-zoapatlin

Patrizia Nigro, Fabrizio Dal Piaz, Dario Gallotta, Nunziatina De Tommasi, Maria Antonietta Belisario

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 830 KB

english, 2008

91

Isoxazolo[3,4-d]pyridazinones and analogues as Leishmania mexicana PDE inhibitors

Vittorio Dal Piaz, A Rascón, M.E Dubra, M.P Giovannoni, C Vergelli, M.C Castellana

Journal:

Year:

2002

Language:

english

File:

PDF, 153 KB

english, 2002

92

4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity

Vittorio Dal Piaz, Claudia Vergelli, Maria Paola Giovannoni, Mark A Scheideler, Giuseppe Petrone, Paola Zaratin

Journal:

Year:

2003

Language:

english

File:

PDF, 277 KB

english, 2003

93

Antiinflammatory and antiplatelet activity of new 5-acyl-6-aryl-pyridazine derivatives

M. Miceli, L. Raimondi, R. Pirisino, V. Dal Piaz, G. Ciciani, G. Turco

Journal:

Pharmacological Research Communications

Year:

1988

Language:

english

File:

PDF, 62 KB

english, 1988

94

Ophiolite eclogites from Verres, Val d'Aosta, Western Alps, Italy

C. Baldelli, G.V. Dal Piaz, B. Lombardo

Journal:

Chemical Geology

Year:

1985

Language:

english

File:

PDF, 908 KB

english, 1985

95

Tectonic significance of Alpine eclogites

Maria Iole Spalla, Jean Marc Lardeaux, Giorgio vittorio Dal Piaz, Guido Gosso, Bruno Messiga

Journal:

Journal of Geodynamics

Year:

1996

Language:

english

File:

PDF, 2.26 MB

english, 1996

96

Stabilization of the Escherichia coli DNA polymerase III ε subunit by the θ subunit favors in vivo assembly of the Pol III catalytic core

Emanuele Conte, Gabriele Vincelli, Roel M. Schaaper, Daniela Bressanin, Alessandra Stefan, Fabrizio Dal Piaz, Alejandro Hochkoeppler

Journal:

Archives of Biochemistry and Biophysics

Year:

2012

Language:

english

File:

PDF, 819 KB

english, 2012

97

Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells

N. Calonghi, E. Pagnotta, C. Parolin, C. Molinari, C. Boga, F. Dal Piaz, G.L. Brusa, M.A. Santucci, L. Masotti

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2007

Language:

english

File:

PDF, 955 KB

english, 2007

98

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

Agostino Cilibrizzi, Igor A. Schepetkin, Gianluca Bartolucci, Letizia Crocetti, Vittorio Dal Piaz, Maria Paola Giovannoni, Alessia Graziano, Liliya N. Kirpotina, Mark T. Quinn, Claudia Vergelli

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 956 KB

english, 2012

99

Characterization of the Structure and the Amyloidogenic Properties of the Josephin Domain of the Polyglutamine-containing Protein Ataxin-3

Laura Masino, Giuseppe Nicastro, Rajesh P. Menon, Fabrizio Dal Piaz, Lesley Calder, Annalisa Pastore

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 704 KB

english, 2004

100

Polyglutamine is Not All: The Functional Role of the AXH Domain in the Ataxin-1 Protein

Cesira de Chiara, Rajesh P. Menon, Fabrizio Dal Piaz, Lesley Calder, Annalisa Pastore

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 526 KB

english, 2005