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51

Phenotypic predictors of increased urinary 11-dehydrothromboxane B2 levels in patients treated with aspirin

Gustavs Latkovskis, Marina Berzina, Milana Zabunova, Dace Juhnevica, Maija Dambrova, Edgars Liepins, Normunds Licis, Andrejs Erglis

Journal:

International Journal of Cardiology

Year:

2007

Language:

english

File:

PDF, 94 KB

english, 2007

52

The anti-inflammatory and antinociceptive effects of NF-κB inhibitory guanidine derivative ME10092

Maija Dambrova, Liga Zvejniece, Elina Skapare, Reinis Vilskersts, Baiba Svalbe, Larisa Baumane, Ruta Muceniece, Edgars Liepinsh

Journal:

International Immunopharmacology

Year:

2010

Language:

english

File:

PDF, 432 KB

english, 2010

53

In vivo measurements of the cerebral perfusion and cardiovascular effects of the novel guanidine ME10092 in the non-human primate, Papio ursinus

D.W. Oliver, I.C. Dormehl, J.E.S. Wikberg, W.K.A Louw, M. Dambrova, A. van Gelder, E. Kilian, E. Jansen van Rensburg

Journal:

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

54

Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart

Edgars Liepinsh, Reinis Vilskersts, Elina Skapare, Baiba Svalbe, Janis Kuka, Helena Cirule, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova

Journal:

Year:

2008

Language:

english

File:

PDF, 443 KB

english, 2008

55

High l-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients

Edgars Liepinsh, Elina Skapare, Edijs Vavers, Ilze Konrade, Ieva Strele, Solveiga Grinberga, Osvalds Pugovics, Maija Dambrova

Journal:

Nutrition Research

Year:

2012

Language:

english

File:

PDF, 302 KB

english, 2012

56

The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model

Ruta Muceniece, Liga Zvejniece, Edgars Liepinsh, Olga Kirjanova, Larisa Baumane, Ramona Petrovska, Felikss Mutulis, Ilze Mutule, Ivars Kalvinsh, Jarl E.S. Wikberg, Maija Dambrova

Journal:

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

57

Effect of inhibiting carnitine biosynthesis on male rat sexual performance

Maija Dambrova, Helena Cirule, Baiba Svalbe, Liga Zvejniece, Osvalds Pugovichs, Tatjana Zorenko, Ivars Kalvinsh, Edgars Liepinsh, Irina Belozertseva

Journal:

Physiology & Behavior

Year:

2008

Language:

english

File:

PDF, 485 KB

english, 2008

58

Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers

Edgars Liepinsh, Ilze Konrade, Elina Skapare, Osvalds Pugovics, Solveiga Grinberga, Janis Kuka, Ivars Kalvinsh, Maija Dambrova

Journal:

Journal of Pharmacy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 276 KB

english, 2011

59

Novel methods for the synthesis of 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]-acetamide ((R)-phenotropil)

M. Vorona, G. Veinberg, S. Vikainis, E. Kuznetsov, A. Lebedev, Yu. Ponomarev, A. Chernobrovijs, L. Zvejniece, M. Dambrova

Journal:

Chemistry of Heterocyclic Compounds

Year:

2012

Language:

english

File:

PDF, 308 KB

english, 2012

60

“Atypical” neuromodulatory profile of glutapyrone, a representative of a novel `class' of amino acid-containing dipeptide-mimicking 1,4-dihydropyridine (DHP) compounds: in vitro and in vivo studies

Ilga Misane, Vija Klusa, Maija Dambrova, Skaidrite Germane, Gunars Duburs, Egils Bisenieks, Roberto Rimondini, Sven Ove Ögren

Journal:

European Neuropsychopharmacology

Year:

1998

Language:

english

File:

PDF, 514 KB

english, 1998

61

520 EFFECT OF CYCLOOXYGENASE-1 POLYMORPHISMS ON URINARY 11-DEHYDROTHROMBOXANE B2 LEVELS IN PATIENTS UNDERGOING STENT IMPLANTATION PRETREATED WITH ASPIRIN

Latkovskis, G., Licis, N., Krivmane, B., Liepins, E., Dambrova, M., Urtane, I., Knipse, A., Zabunova, M., Berzina, M., Erglis, A.

Journal:

Atherosclerosis Supplements

Year:

2011

Language:

english

File:

PDF, 58 KB

english, 2011

62

[3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B- and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine

Staffan Uhlén, Maija Dambrova, Johnny Näsman, Helgi B Schiöth, Yuchen Gu, Anna Wikberg-Matsson, Jarl E.S Wikberg

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 166 KB

english, 1998

63

Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

Liepinsh, Edgars, Skapare, Elina, Kuka, Janis, Makrecka, Marina, Cirule, Helena, Vavers, Edijs, Sevostjanovs, Eduards, Grinberga, Solveiga, Pugovics, Osvalds, Dambrova, Maija

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2013

Language:

english

File:

PDF, 325 KB

english, 2013

64

Synthesis and Quantitative Structure−Activity Relationship of Hydrazones of N -Amino- N ‘-hydroxyguanidine as Electron Acceptors for Xanthine Oxidase

Prusis, Peteris, Dambrova, Maija, Andrianov, Victor, Rozhkov, Eugene, Semenikhina, Valentina, Piskunova, Irena, Ongwae, Enock, Lundstedt, Torbjörn, Kalvinsh, Ivars, Wikberg, Jarl E. S.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 168 KB

english, 2004

65

Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction

Vilskersts, Reinis, Zharkova-Malkova, Olga, Mezhapuke, Rudolfs, Grinberga, Solveiga, Cirule, Helena, Dambrova, Maija

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2013

Language:

english

File:

PDF, 168 KB

english, 2013

66

The heart is better protected against myocardial infarction in the fed state compared to the fasted state

Liepinsh, Edgars, Makrecka, Marina, Kuka, Janis, Makarova, Elina, Vilskersts, Reinis, Cirule, Helena, Sevostjanovs, Eduards, Grinberga, Solveiga, Pugovics, Osvalds, Dambrova, Maija

Journal:

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

67

Mildronate, the inhibitor of l-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation

Makrecka, Marina, Svalbe, Baiba, Volska, Kristine, Sevostjanovs, Eduards, Liepins, Janis, Grinberga, Solveiga, Pugovics, Osvalds, Liepinsh, Edgars, Dambrova, Maija

Journal:

European Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 525 KB

english, 2014

68

Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats

Vilskersts, Reinis, Kuka, Janis, Svalbe, Baiba, Cirule, Helena, Liepinsh, Edgars, Grinberga, Solveiga, Kalvinsh, Ivars, Dambrova, Maija

Journal:

Pharmacological Reports

Year:

2011

Language:

english

File:

PDF, 260 KB

english, 2011

69

Identification of glyoxalase 1 polymorphisms associated with enzyme activity

Peculis, Raitis, Konrade, Ilze, Skapare, Elina, Fridmanis, Davids, Nikitina-Zake, Liene, Lejnieks, Aivars, Pirags, Valdis, Dambrova, Maija, Klovins, Janis

Journal:

Year:

2013

Language:

english

File:

PDF, 309 KB

english, 2013

70

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

Skapare, Elina, Konrade, Ilze, Liepinsh, Edgars, Strele, Ieva, Makrecka, Marina, Bierhaus, Angelika, Lejnieks, Aivars, Pirags, Valdis, Dambrova, Maija

Journal:

Journal of Diabetes and its Complications

Year:

2013

Language:

english

File:

PDF, 227 KB

english, 2013

71

Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria

M. Makrecka, J. Kuka, K. Volska, U. Antone, E. Sevostjanovs, H. Cirule, S. Grinberga, O. Pugovics, M. Dambrova, E. Liepinsh

Journal:

Molecular and Cellular Biochemistry

Year:

2014

Language:

english

File:

PDF, 390 KB

english, 2014

72

A cross-sectional survey of urinary iodine status in Latvia

Konrade, Ilze, Neimane, Lolita, Makrecka, Marina, Strele, Ieva, Liepinsh, Edgars, Lejnieks, Aivars, Vevere, Parsla, Gruntmanis, Ugis, Pīrāgs, Valdis, Dambrova, Maija

Journal:

Year:

2014

Language:

english

File:

PDF, 458 KB

english, 2014

73

The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors

Zvejniece, L, Vavers, E, Svalbe, B, Vilskersts, R, Domracheva, I, Vorona, M, Veinberg, G, Misane, I, Stonans, I, Kalvinsh, I, Dambrova, M

Journal:

British Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

74

Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation

Kuka, Janis, Liepinsh, Edgars, Makrecka-Kuka, Marina, Liepins, Janis, Cirule, Helena, Gustina, Daina, Loza, Einars, Zharkova-Malkova, Olga, Grinberga, Solveiga, Pugovics, Osvalds, Dambrova, Maija

Journal:

Year:

2014

Language:

english

File:

PDF, 614 KB

english, 2014

75

Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

Liepinsh, E, Makrecka-Kuka, M, Kuka, J, Vilskersts, R, Makarova, E, Cirule, H, Loza, E, Lola, D, Grinberga, S, Pugovics, O, Kalvins, I, Dambrova, M

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

76

258 THE SEVERITY OF ISCHEMIA REPERFUSION DAMAGE IS DETERMINED BY THE CHANGES IN METABOLISM PATTERN OF ENERGY SUBSTRATES IN MITOCHONDRIA

Kuka, J., Makrecka, M., Liepinsh, E., Dambrova, M.

Journal:

Heart (British Cardiac Society)

Year:

2013

Language:

english

File:

PDF, 53 KB

english, 2013

77

04 The regulation of mitochondrial energy metabolism by L-carnitine lowering agents in ischaemia-reperfusion injury

Makrecka, M., Kuka, J., Liepinsh, E., Dambrova, M.

Journal:

Heart (BMJ Pub. Group)

Year:

2011

Language:

english

File:

PDF, 70 KB

english, 2011

78

05 The cardioprotective effect of mildronate is associated with decreased CPT I-dependent fatty acid metabolism in mitochondria

Kuka, J., Makrecka, M., Vilskersts, R., Dambrova, M.

Journal:

Heart (BMJ Pub. Group)

Year:

2011

Language:

english

File:

PDF, 54 KB

english, 2011

79

Determination of trimethylamine- N -oxide in combination with l -carnitine and γ -butyrobetaine in human plasma by UPLC/MS/MS

Grinberga, Solveiga, Dambrova, Maija, Latkovskis, Gustavs, Strele, Ieva, Konrade, Ilze, Hartmane, Dace, Sevostjanovs, Eduards, Liepinsh, Edgars, Pugovics, Osvalds

Journal:

Biomedical Chromatography

Year:

2015

Language:

english

File:

PDF, 357 KB

english, 2015

80

Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction

Liepinsh, Edgars, Vilskersts, Reinis, Loca, Dagnija, Kirjanova, Olga, Pugovichs, Osvalds, Kalvinsh, Ivars, Dambrova, Maija

Journal:

Journal of Cardiovascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 120 KB

english, 2006

81

Iodine deficiency during pregnancy: a national cross-sectional survey in Latvia

Konrade, Ilze, Kalere, Ieva, Strele, Ieva, Makrecka-Kuka, Marina, Jekabsone, Anna, Tetere, Elina, Veisa, Vija, Gavars, Didzis, Rezeberga, Dace, Pīrāgs, Valdis, Lejnieks, Aivars, Dambrova, Maija

Journal:

Public Health Nutrition

Year:

2015

Language:

english

File:

PDF, 561 KB

english, 2015

82

Libiguins A and B: Novel Phragmalin Limonoids Isolated from Neobeguea mahafalensis Causing Profound Enhancement of Sexual Activity

Razafimahefa, Solofoniaina, Mutulis, Felikss, Mutule, Ilze, Liepinsh, Edvards, Dambrova, Maija, Cirule, Helena, Svalbe, Baiba, Yahorava, Sviatlana, Yahorau, Aleh, Rasolondratovo, Benoit, Rasoanaivo, P

Journal:

Year:

2014

Language:

english

File:

PDF, 342 KB

english, 2014

83

Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis

Vilskersts, Reinis, Kuka, Janis, Liepinsh, Edgars, Makrecka-Kuka, Marina, Volska, Kristine, Makarova, Elina, Sevostjanovs, Eduards, Cirule, Helena, Grinberga, Solveiga, Dambrova, Maija

Journal:

Vascular Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.00 MB

english, 2015

84

Structure and function of CutC choline lyase from human microbiota bacterium Klebsiella pneumoniae

Kalnins, Gints, Kuka, Janis, Grinberga, Solveiga, Makrecka-Kuka, Marina, Liepinsh, Edgars, Dambrova, Maija, Tars, Kaspars

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.83 MB

english, 2015

85

Taregting acylcarnitine content in vascular tissue to attenuate development of atherosclerosis

Vilskersts, R., Kuka, J., Makrecka-Kuka, M., Volska, K., Dambrova, M., Liepinsh, E.

Journal:

Atherosclerosis

Year:

2015

Language:

english

File:

PDF, 53 KB

english, 2015

86

R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects

Zvejniece, Liga, Vavers, Edijs, Svalbe, Baiba, Veinberg, Grigory, Rizhanova, Kristina, Liepins, Vilnis, Kalvinsh, Ivars, Dambrova, Maija

Journal:

Pharmacology Biochemistry and Behavior

Year:

2015

Language:

english

File:

PDF, 572 KB

english, 2015

87

Potato ( Solanum tuberosum ) Juice Exerts an Anticonvulsant Effect in Mice through Binding to GABA Receptors

Muceniece, Ruta, Saleniece, Kristine, Krigere, Liga, Rumaks, Juris, Dzirkale, Zane, Mezhapuke, Rudolfs, Kviesis, Jorens, Mekss, Peteris, Klusa, Vija, Schiöth, Helgi, Dambrova, Maija

Journal:

Year:

2008

Language:

english

File:

PDF, 288 KB

english, 2008

88

Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance

Liepinsh, Edgars, Makrecka-Kuka, Marina, Makarova, Elina, Volska, Kristine, Svalbe, Baiba, Sevostjanovs, Eduards, Grinberga, Solveiga, Kuka, Janis, Dambrova, Maija

Journal:

Pharmacological Research

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

89

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria

Liepinsh, E., Makrecka-Kuka, M., Volska, K., Kuka, J., Makarova, E., Antone, U., Sevostjanovs, E., Vilskersts, R., Strods, A., Tars, K., Dambrova, M.

Journal:

Biochemical Journal

Year:

2016

Language:

english

File:

PDF, 515 KB

english, 2016

90

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

Dambrova, M., Latkovskis, G., Kuka, J., Strele, I., Konrade, I., Grinberga, S., Hartmane, D., Pugovics, O, Erglis, A., Liepinsh, E.

Journal:

Experimental and Clinical Endocrinology & Diabetes

Year:

2016

Language:

english

File:

PDF, 366 KB

english, 2016

91

Investigations on the Pharmacology of the Cardioprotective Guanidine ME10092

Dambrova, Maija, Liepinsh, Edgars, Kirjanova, Olga, Petrovska, Ramona, Pugovich, Osvalds, Baumane, Larisa, Uhlen, Staffan, Kalvinsh, Ivars, Oliver, Douglas, Wikberg, Jarl E. S.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

92

The unusual pharmacokinetics of meldomium: implications for doping

Liepinsh, Edgars, Dambrova, Maija

Journal:

Pharmacological Research

Year:

2016

Language:

english

File:

PDF, 216 KB

english, 2016

93

ChemInform Abstract: Stereochemistry of Phenylpiracetam and Its Methyl Derivative: Improvement of the Pharmacological Profile

Veinberg, Grigory, Vavers, Edijs, Orlova, Natalja, Kuznecovs, Jevgenijs, Domracheva, Ilona, Vorona, Maxim, Zvejniece, Liga, Dambrova, Maija

Journal:

Year:

2016

File:

PDF, 12 KB

2016

94

Mildronate exerts acute anticonvulsant and antihypnotic effects

Zvejniece, Liga, Svalbe, Baiba, Makrecka, Marina, Liepinsh, Edgars, Kalvinsh, Ivars, Dambrova, Maija

Journal:

Behavioural Pharmacology

Year:

2010

Language:

english

File:

PDF, 238 KB

english, 2010

95

Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport

Liepinsh, Edgars, Makarova, Elina, Sevostjanovs, Eduards, Hartmane, Dace, Cirule, Helena, Zharkova-Malkova, Olga, Grinberga, Solveiga, Dambrova, Maija

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2017

Language:

english

File:

PDF, 887 KB

english, 2017

96

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

Makrecka-Kuka, Marina, Volska, Kristine, Antone, Unigunde, Vilskersts, Reinis, Grinberga, Solveiga, Bandere, Dace, Liepinsh, Edgars, Dambrova, Maija

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 474 KB

english, 2017

97

Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB

Kuka, Janis, Makrecka-Kuka, Marina, Cirule, Helena, Grinberga, Solveiga, Sevostjanovs, Eduards, Dambrova, Maija, Liepinsh, Edgars

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2017

Language:

english

File:

PDF, 311 KB

english, 2017

98

The Differentiation of Skin Mesenchymal Stem Cells Towards a Schwann Cell Phenotype: Impact of Sigma-1 Receptor Activation

Saulite, L., Vavers, E., Zvejniece, L., Dambrova, M., Riekstina, U.

Journal:

Molecular Neurobiology

Year:

2017

Language:

english

File:

PDF, 4.17 MB

english, 2017

99

Novel positive allosteric modulators of sigma-1 receptor

Vavers, Edijs, Zvejniece, Liga, Veinberg, Grigory, Svalbe, Baiba, Domracheva, Ilona, Vilskersts, Reinis, Dambrova, Maija

Journal:

Year:

2015

Language:

english

File:

PDF, 580 KB

english, 2015

100

Denosumab-induced hypophosphataemia in a case of normocalcaemic primary hyperparathyroidism

Konrade, Ilze, Dambrova, Gita, Dambrova, Maija

Journal:

Internal Medicine Journal

Year:

2017

Language:

english

File:

PDF, 492 KB

english, 2017