David E Gloriam: search on Z-Library

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1

Trends in GPCR drug discovery: new agents, targets and indications

Hauser, Alexander S., Attwood, Misty M., Rask-Andersen, Mathias, Schiöth, Helgi B., Gloriam, David E.

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 1.47 MB

english, 2017

2

The Contribution of Atom Accessibility to Site of Metabolism Models for Cytochromes P450

Rydberg, Patrik, Rostkowski, Michal, Gloriam, David E., Olsen, Lars

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

3

Computer-Aided Discovery of Aromatic l -α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

Isberg, Vignir, Andersen, Kirsten B., Bisig, Christoph, Dietz, Gunnar P. H., Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 256 KB

english, 2014

4

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

Xiong, Xiao-Feng, Zhang, Hang, Underwood, Christina R., Harpsøe, Kasper, Gardella, Thomas J., Wöldike, Mie F., Mannstadt, Michael, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian

Journal:

Nature Chemistry

Year:

2016

Language:

english

File:

PDF, 2.68 MB

english, 2016

5

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

Shehata, Mohamed A., Nøhr, Anne C., Lissa, Delphine, Bisig, Christoph, Isberg, Vignir, Andersen, Kirsten B., Harpsøe, Kasper, Björkling, Fredrik, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.16 MB

english, 2016

6

Identification of a novel scaffold for a small molecule GPR139 receptor agonist

Nøhr, Anne Cathrine, Shehata, Mohamed A., Palmer, Daniel, Pokhrel, Rina, Vallianou, Maria, Foster, Simon R., Gentry, Patrick R., Gloriam, David E., Bräuner-Osborne, Hans

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 2.45 MB

english, 2019

7

Bigger is better in virtual drug screens

Gloriam, David E.

Journal:

Year:

2019

Language:

english

File:

PDF, 273 KB

english, 2019

8

The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish

David E.I. Gloriam, Thóra K. Bjarnadóttir, Yi-Lin Yan, John H. Postlethwait, Helgi B. Schiöth, Robert Fredriksson

Journal:

Molecular Phylogenetics and Evolution

Year:

2005

Language:

english

File:

PDF, 1.24 MB

english, 2005

9

Proteomic applications of automated GPCR classification

Matthew N. Davies, David E. Gloriam, Andrew Secker, Alex A. Freitas, Miguel Mendao, Jon Timmis, Darren R. Flower

Journal:

Year:

2007

Language:

english

File:

PDF, 293 KB

english, 2007

10

Minimum information about a protein affinity reagent (MIAPAR)

Bourbeillon, Julie, Orchard, Sandra, Benhar, Itai, Borrebaeck, Carl, de Daruvar, Antoine, Dübel, Stefan, Frank, Ronald, Gibson, Frank, Gloriam, David, Haslam, Niall

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 333 KB

english, 2010

11

G Protein- and Agonist-Bound Serotonin 5-HT2A Receptor Model Activated by Steered Molecular Dynamics Simulations

Ísberg, Vignir, Balle, Thomas, Sander, Tommy, Jørgensen, Flemming Steen, Gloriam, David E.

Journal:

Journal of Chemical Information and Modeling

Year:

2011

Language:

english

File:

PDF, 3.74 MB

english, 2011

12

Structure–Activity Relationships for Negative Allosteric mGluR5 Modulators

Dr. Birgitte H. Kaae, Dr. Kasper Harpsøe, Trine Kvist, Dr. Jesper M. Mathiesen, Christina Mølck, Dr. David Gloriam, Hermogenes N. Jimenez, Michelle A. Uberti, Søren M. Nielsen, Birgitte Nielsen, Prof.

Journal:

Year:

2012

Language:

english

File:

PDF, 866 KB

english, 2012

13

Chemogenomic Discovery of Allosteric Antagonists at the GPRC6A Receptor

David E. Gloriam, Petrine Wellendorph, Lars D. Johansen, Alex Rojas Bie Thomsen, Karina Phonekeo, Daniel Sejer Pedersen, Hans Bräuner-Osborne

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

14

The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents

Tatjana Haitina, Robert Fredriksson, Steven M Foord, Helgi B Schiöth, David E Gloriam

Journal:

Year:

2009

Language:

english

File:

PDF, 376 KB

english, 2009

15

The G protein-coupled receptor subset of the rat genome

David E Gloriam, Robert Fredriksson, Helgi B Schiöth

Journal:

Year:

2007

Language:

english

File:

PDF, 539 KB

english, 2007

16

Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors

Thiele, Stefanie, Malmgaard-Clausen, Mikkel, Engel-Andreasen, Jens, Steen, Anne, Rummel, Pia C., Nielsen, Mads C., Gloriam, David E., Frimurer, Thomas M., Ulven, Trond, Rosenkilde, Mette M.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

17

Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

David E.I. Gloriam, Helgi B. Schiöth, Robert Fredriksson

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2005

Language:

english

File:

PDF, 478 KB

english, 2005

18

Comprehensive comparisons of the current human, mouse, and rat RefSeq, Ensembl, EST, and FANTOM3 datasets: Identification of new human genes with specific tissue expression profile

Karl J.V. Nordström, Majd A.I. Mirza, Thomas P. Larsson, David E.I. Gloriam, Robert Fredriksson, Helgi B. Schiöth

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 620 KB

english, 2006

19

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors

Thóra K. Bjarnadóttir, Robert Fredriksson, Pär J. Höglund, David E. Gloriam, Malin C. Lagerström, Helgi B. Schiöth

Journal:

Year:

2004

Language:

english

File:

PDF, 932 KB

english, 2004

20

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

Thóra K. Bjarnadóttir, David E. Gloriam, Sofia H. Hellstrand, Helena Kristiansson, Robert Fredriksson, Helgi B. Schiöth

Journal:

Year:

2006

Language:

english

File:

PDF, 692 KB

english, 2006

21

Critical evaluation of the FANTOM3 non-coding RNA transcripts

Karl J.V. Nordström, Majd A.I. Mirza, Markus Sällman Almén, David E. Gloriam, Robert Fredriksson, Helgi B. Schiöth

Journal:

Year:

2009

Language:

english

File:

PDF, 323 KB

english, 2009

22

There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini

Robert Fredriksson, David E.I. Gloriam, Pär J. Höglund, Malin C. Lagerström, Helgi B. Schiöth

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 601 KB

english, 2003

23

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

Robert Fredriksson, Pär J Höglund, David E.I Gloriam, Malin C Lagerström, Helgi B Schiöth

Journal:

Year:

2003

Language:

english

File:

PDF, 752 KB

english, 2003

24

Design, Synthesis, and Pharmacological Characterization of N - and O -Substituted 5,6,7,8-Tetrahydro-4 H -isoxazolo[4,5- d ]azepin-3-ol Analogues: Novel 5-HT 2A /5-HT 2C Receptor Agonists with Pro-Cognitive Properties

Jensen, Anders A., Plath, Niels, Pedersen, Martin H. F., Isberg, Vignir, Krall, Jacob, Wellendorph, Petrine, Stensbøl, Tine B., Gloriam, David E., Krogsgaard-Larsen, Povl, Frølund, Bente

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.34 MB

english, 2013

25

SMARTCyp: A 2D Method for Prediction of Cytochrome P450-Mediated Drug Metabolism

Rydberg, Patrik, Gloriam, David E., Zaretzki, Jed, Breneman, Curt, Olsen, Lars

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

26

Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design

Gloriam, David E., Foord, Steven M., Blaney, Frank E., Garland, Stephen L.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 5.77 MB

english, 2009

27

Structure–Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

Chalikiopoulos, Alexander, Thiele, Stefanie, Malmgaard-Clausen, Mikkel, Rydberg, Patrik, Isberg, Vignir, Ulven, Trond, Frimurer, Thomas M., Rosenkilde, Mette M., Gloriam, David E.

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 3.67 MB

english, 2013

28

mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

Mølck, Christina, Harpsøe, Kasper, Gloriam, David E., Mathiesen, Jesper M., Nielsen, Søren M., Bräuner-Osborne, Hans

Journal:

Neurochemical Research

Year:

2014

Language:

english

File:

PDF, 2.09 MB

english, 2014

29

Chemogenomics of allosteric binding sites in GPCRs

Gloriam, David E.

Journal:

Drug Discovery Today: Technologies

Year:

2013

Language:

english

File:

PDF, 986 KB

english, 2013

30

A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors

Fidom, Kimberley, Isberg, Vignir, Hauser, Alexander S., Mordalski, Stefan, Lehto, Thomas, Bojarski, Andrzej J., Gloriam, David E.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.12 MB

english, 2015

31

Generic GPCR residue numbers – aligning topology maps while minding the gaps

Isberg, Vignir, de Graaf, Chris, Bortolato, Andrea, Cherezov, Vadim, Katritch, Vsevolod, Marshall, Fiona H., Mordalski, Stefan, Pin, Jean-Philippe, Stevens, Raymond C., Vriend, Gerrit, Gloriam, David

Journal:

Trends in Pharmacological Sciences

Year:

2015

Language:

english

File:

PDF, 2.88 MB

english, 2015

32

Identification of the first surrogate agonists for the G protein-coupled receptor GPR132

Shehata, Mohamed A., Belcik Christensen, Hanna, Isberg, Vignir, Sejer Pedersen, Daniel, Bender, Andreas, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Year:

2015

Language:

english

File:

PDF, 648 KB

english, 2015

33

The G Protein–Coupled Receptor Subset of the Chicken Genome

Lagerström, Malin C., Hellström, Anders R., Gloriam, David E., Larsson, Thomas P., Schiöth, Helgi B., Fredriksson, Robert

Journal:

PLoS Computational Biology

Year:

2006

Language:

english

File:

PDF, 416 KB

english, 2006

34

A Ligands View of Target Similarity: Chemogenomic Binding Site- Directed Techniques for Drug Discovery

L. Garland, Stephen, E. Gloriam, David

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 687 KB

english, 2011

35

The SMARTCyp cytochrome P450 metabolism prediction server

Rydberg, Patrik, Gloriam, David E., Olsen, Lars

Journal:

Year:

2010

Language:

english

File:

PDF, 104 KB

english, 2010

36

Selective allosteric antagonists for the G protein-coupled receptor GPRC6A based on the 2-phenylindole privileged structure scaffold

Johansson, Henrik, Boesgaard, Michael Worch, Nørskov-Lauritsen, Lenea, Larsen, Inna, Kuhne, Sebastiaan, Gloriam, David E., Bräuner-Osborne, Hans, Sejer Pedersen, Daniel

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 919 KB

english, 2015

37

Present Perspectives on the Automated Classification of the G-Protein Coupled Receptors (GPCRs) at the Protein Sequence Level

N. Davies, Matthew, E. Gloriam, David, Secker, Andrew, A. Freitas, Alex, Timmis, Jon, R. Flower, Darren

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 292 KB

english, 2011

38

Editorial [Hot Topic: Methods for the Successful Application of Chemogenomics to GPCR Drug Design (Guest Editors: Stephen L. Garland & David E. Gloriam)]

L. Garland, Stephen, E. Gloriam, David

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 27 KB

english, 2011

39

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat: Figure 1.

Babbitt, Patricia C., Bagos, Pantelis G., Bairoch, Amos, Bateman, Alex, Chatonnet, Arnaud, Chen, Mark Jinan, Craik, David J., Finn, Robert D., Gloriam, David, Haft, Daniel H., Henrissat, Bernard, Holl

Journal:

Year:

2015

Language:

english

File:

PDF, 624 KB

english, 2015

40

Integrating structural and mutagenesis data to elucidate GPCR ligand binding

Munk, Christian, Harpsøe, Kasper, Hauser, Alexander S, Isberg, Vignir, Gloriam, David E

Journal:

Current Opinion in Pharmacology

Year:

2016

Language:

english

File:

PDF, 2.47 MB

english, 2016

41

Editorial overview: New technologies: GPCR drug design and function—exploiting the current (of) structures

Tautermann, Christofer S, Gloriam, David E

Journal:

Current Opinion in Pharmacology

Year:

2016

Language:

english

File:

PDF, 222 KB

english, 2016

42

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G., Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H., Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.80 MB

english, 2015

43

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

Harpsøe, Kasper, Boesgaard, Michael W., Munk, Christian, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Year:

2016

Language:

english

File:

PDF, 504 KB

english, 2016

44

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

Nøhr, Anne Cathrine, Shehata, Mohamed A., Hauser, Alexander S., Isberg, Vignir, Mokrosinski, Jacek, Andersen, Kirsten B., Farooqi, I. Sadaf, Pedersen, Daniel Sejer, Gloriam, David E., Bräuner-Osborne,

Journal:

Neurochemistry International

Year:

2017

Language:

english

File:

PDF, 2.03 MB

english, 2017

45

Selectivity determinants of GPCR–G-protein binding

Flock, Tilman, Hauser, Alexander S., Lund, Nadia, Gloriam, David E., Balaji, Santhanam, Babu, M. Madan

Journal:

Year:

2017

Language:

english

File:

PDF, 11.82 MB

english, 2017

46

The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site

Nøhr, Anne Cathrine, Jespers, Willem, Shehata, Mohamed A., Floryan, Leonard, Isberg, Vignir, Andersen, Kirsten Bayer, Åqvist, Johan, Gutiérrez-de-Terán, Hugo, Bräuner-Osborne, Hans, Gloriam, David E.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

47

Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils

Christensen, Hanna B., Gloriam, David E., Pedersen, Daniel Sejer, Cowland, Jack B., Borregaard, Niels, Bräuner-Osborne, Hans

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 725 KB

english, 2017

48

Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

Frandsen, Ida Osborn, Boesgaard, Michael W., Fidom, Kimberley, Hauser, Alexander S., Isberg, Vignir, Bräuner-Osborne, Hans, Wellendorph, Petrine, Gloriam, David E.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.50 MB

english, 2017

49

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms

Jespers, Willem, Schiedel, Anke C., Heitman, Laura H., Cooke, Robert M., Kleene, Lisa, van Westen, Gerard J.P., Gloriam, David E., Müller, Christa E., Sotelo, Eddy, Gutiérrez-de-Terán, Hugo

Journal:

Trends in Pharmacological Sciences

Year:

2017

Language:

english

File:

PDF, 4.27 MB

english, 2017

50

Pharmacogenomics of GPCR Drug Targets

Hauser, Alexander S., Chavali, Sreenivas, Masuho, Ikuo, Jahn, Leonie J., Martemyanov, Kirill A., Gloriam, David E., Babu, M. Madan

Journal:

Year:

2017

Language:

english

File:

PDF, 8.56 MB

english, 2017

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