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51

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues

Maria Tsoumpra, Bobby Barnett, Aaron Kwaasi, Rick Walters, Frank Ebetino, R. Graham Russell, Udo Oppermann, James Dunford

Journal:

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

52

BISPHOSPHONATES AFFECT HUMAN OSTEOCLAST DEVELOPMENT IN VITRO

Guillaume Mabilleau, Aaron Kwaasi, Afsie Sabokbar, Maria Tsoumpra, Frank Ebetino, Robert Russell

Journal:

Year:

2010

Language:

english

File:

PDF, 70 KB

english, 2010

53

Determination of the relative bone mineral-binding affinities of bisphosphonates by using hydroxyapatite-column chromatography combined with mass spectrometric analysis

Xuchen Duan, Zhidao Xia, Hao Zhang, Mike Quijano, Roy Dobson, Bobby Barnett, James Triffitt, James Dunford, Frank Ebetino, R. Graham Russell

Journal:

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

54

Relative uptake of risedronate in trabecular and cortical bone

Frank Ebetino, Jillian Cornish, Roger Phipps, Bradley Keck, Ian Reid, Karen Callon

Journal:

Year:

2010

Language:

english

File:

PDF, 56 KB

english, 2010

55

The relationship between the chemistry and biological activity of the bisphosphonates

Frank H. Ebetino, Anne-Marie L. Hogan, Shuting Sun, Maria K. Tsoumpra, Xuchen Duan, James T. Triffitt, Aaron A. Kwaasi, James E. Dunford, Bobby L. Barnett, Udo Oppermann, Mark W. Lundy, Alan Boyde, Bo

Journal:

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

56

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

Toshihiro Sugiyama, Lee B. Meakin, Gabriel L. Galea, Brendan F. Jackson, Lance E. Lanyon, Frank H. Ebetino, R. Graham G. Russell, Joanna S. Price

Journal:

Year:

2011

Language:

english

File:

PDF, 925 KB

english, 2011

57

Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach

Tian, Xinrong, Field, Timothy B., Switzer, Adrian G., Mazur, Adam W., Ebetino, Frank H., Wos, John A., Berberich, Steve M., Jayasinghe, Lalith R., Obringer, Cindy M., Dowty, Martin E., Pinney, Beth B.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 303 KB

english, 2006

58

Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2- a ]pyridin-3-yl-2-phosphonopropionic Acid

McKenna, Charles E., Kashemirov, Boris A., Błażewska, Katarzyna M., Mallard-Favier, Isabelle, Stewart, Charlotte A., Rojas, Javier, Lundy, Mark W., Ebetino, Frank H., Baron, Rudi A., Dunford, James E

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.92 MB

english, 2010

59

The aerobic degradation of 1-(5-nitrofurfurylideneamino)-2-imidazolidinone (NF-246) by Escherichia coli

John J. Gavin, Frank F. Ebetino, R. Freedman, W.E. Waterbury

Journal:

Archives of Biochemistry and Biophysics

Year:

1966

Language:

english

File:

PDF, 423 KB

english, 1966

60

Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice

Marcus P. Watkins, Jin Yi Norris, Susan K. Grimston, Xiaowen Zhang, Roger J. Phipps, Frank H. Ebetino, Roberto Civitelli

Journal:

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

61

Synthesis of 2,4,5-Trisubstituted Tetrahydropyrans as Peptidomimetic Scaffolds for Melanocortin Receptor Ligands

Kulesza, Anna, Ebetino, Frank H., Mishra, Rajesh K., Cross-Doersen, Doreen, Mazur, Adam W.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 98 KB

english, 2003

62

Ketopiperazines: Conformationally Constrained Peptidomimetic of Arginine Amides

Chen, Zecheng, Kende, Andrew S., Colson, Anny‐Odile, Mendezandino, Jose L., Ebetino, Frank H., Bush, Rod D., Hu, X. Eric

Journal:

Synthetic Communications

Year:

2006

Language:

english

File:

PDF, 100 KB

english, 2006

63

Synthesis and Biological Evaluation of α-Halogenated Bisphosphonate and Phosphonocarboxylate Analogues of Risedronate

Marma, Mong S., Xia, Zhidao, Stewart, Charlotte, Coxon, Fraser, Dunford, James E., Baron, Rudi, Kashemirov, Boris A., Ebetino, Frank H., Triffitt, James T., Russell, R. Graham G., McKenna, Charles E.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 215 KB

english, 2007

64

The Design and Synthesis of Sulfur Containing Bisphosphonic Acids for the Treatment of Arthritis

Almstead, Neil G., Dansereau, Susan M., Francis, Marion D., Snider, Catherine M., Ebetino, Frank H.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1999

Language:

english

File:

PDF, 203 KB

english, 1999

65

An Extention of the Gomberg—Bachmann Pinacol Synthesis

Ebetino, Frank F., Amstutz, E. D.

Journal:

Journal of Organic Chemistry

Year:

1963

Language:

english

File:

PDF, 267 KB

english, 1963

66

Structure–Activity Relationships Among the Nitrogen Containing Bisphosphonates in Clinical Use and Other Analogues: Time-Dependent Inhibition of Human Farnesyl Pyrophosphate Synthase

Dunford, James E., Kwaasi, Aaron A., Rogers, Michael J., Barnett, Bobby L., Ebetino, Frank H., Russell, R. Graham G., Oppermann, Udo, Kavanagh, Kathryn L.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 577 KB

english, 2008

67

Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents

Tian, Xinrong, Switzer, Adrian G., Derose, Steve A., Mishra, Rajesh K., Solinsky, Mark G., Mumin, Rashid N., Ebetino, Frank H., Jayasinghe, Lalith R., Webster, Mark E., Colson, Anny-Odile, Crossdoerse

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 790 KB

english, 2008

68

How Do Bisphosphonates Inhibit Bone Metastasis In Vivo

Fournier, Pierrick G., Stresing, Verena, Ebetino, Frank H., Clezardin, Philippe

Journal:

Year:

2010

Language:

english

File:

PDF, 643 KB

english, 2010

69

Synthesis and hypotensive properties of new 4-aminoquinolines

Wright, George C., Watson, Edward J., Ebetino, Frank F., Lougheed, Guy, Stevenson, Benjamin F., Winterstein, Alexander, Bickerton, Robert K., Halliday, Robert P., Pals, Donald T.

Journal:

Journal of Medicinal Chemistry

Year:

1971

Language:

english

File:

PDF, 733 KB

english, 1971

70

Reduction of Nitrofurans. I. Aminofurans

Ebetino, Frank F., Carroll, James J., Gever, Gabriel.

Journal:

Journal of Medicinal Chemistry

Year:

1962

Language:

english

File:

PDF, 623 KB

english, 1962

71

Chemotherapeutic Nitrofurans. IX. 1 2-[1-Acyl-2-(5-nitrofurfurylidene)hydrazino]acetamides

Ebetino, Frank F., Carey, Warren F., Stevenson, Benjamin F.

Journal:

Journal of Medicinal Chemistry

Year:

1963

Language:

english

File:

PDF, 503 KB

english, 1963

72

Derivatives of 2-(2-Pyrimidinyl)acetophenone 1

Ebetino, Frank F., Amstutz, E. D.

Journal:

Journal of Medicinal Chemistry

Year:

1964

Language:

english

File:

PDF, 166 KB

english, 1964

73

Chemotherapeutic Nitrofurans. VII. 1 The Formation of 5-Nitrofurfurylidene Derivatives of Some Aminoguanidines, Aminotriazoles, and Related Compounds

EBETINO, FRANK F., GEVER, GABRIEL

Journal:

Journal of Organic Chemistry

Year:

1962

Language:

english

File:

PDF, 524 KB

english, 1962

74

Adsorption-Desorption Properties of Bisphosphonates

Aleksiuk, Oleg, Gabriel, Darlene Z., Kantoci, Darko, Murray, E. David, Wechter, William J., Borchard, Dan, Ebetino, Frank H.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1999

Language:

english

File:

PDF, 78 KB

english, 1999

75

Anticoccidial Activity in a Series of Alkyl 6,7-Dialkoxy-4-hydroxy-3-quinolinecarboxylates

Spencer, Claude F., Engle, Alan, Yu, Chia-Nien, Finch, Raymond C., Watson, Edward J., Ebetino, Frank F., Johnson, Cornell A.

Journal:

Journal of Medicinal Chemistry

Year:

1966

Language:

english

File:

PDF, 408 KB

english, 1966

76

1-Substituted 3-[(5-nitrofurfurylidene)amino]-2-imidazolidinones

Snyder, Harry R., Ebetino, Frank F., Siedler, A. J., Andersen, Jon.

Journal:

Journal of Medicinal Chemistry

Year:

1970

Language:

english

File:

PDF, 519 KB

english, 1970

77

Chemotherapeutic Nitrofurans. I. Some Derivatives of 3-Amino-2-oxazolidone 1

Gever, Gabriel, O'Keefe, Charles, Drake, Gordon, Ebetino, Frank, Michels, Julian, Hayes, Kenyon

Journal:

Journal of the American Chemical Society

Year:

1955

Language:

english

File:

PDF, 709 KB

english, 1955

78

Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acid derivatives

Gruenfeld, Norbert, Stanton, James L., Yuan, Andrew M., Ebetino, Frank H., Browne, Leslie J., Gude, Candido, Huebner, Charles F.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 754 KB

english, 1983

79

The Transformation of 3-Amino-2-iminooxazolidines to Semicarbazone Derivatives 1

Ebetino, Frank F.

Journal:

Journal of Organic Chemistry

Year:

1964

Language:

english

File:

PDF, 515 KB

english, 1964

80

Chemotherapeutic Nitrofurans. II. 1 The Formation and Some Reactions of Derivatives of 3-Amino-2-iminoöxazolidine

Hayes, Kenyon, Ebetino, Frank, Gever, Gabriel

Journal:

Journal of the American Chemical Society

Year:

1955

Language:

english

File:

PDF, 236 KB

english, 1955

81

A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent

Błażewska, Katarzyna M., Haiges, Ralf, Kashemirov, Boris A., Ebetino, Frank H., McKenna, Charles E.

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

82

The Discovery of the Bone-Active Agent Risedronate, and Bisphosphonate Structure-Activity Considerations Including the Aminophenylethane Phosphonate Series

Ebetino, Frank H.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1999

Language:

english

File:

PDF, 204 KB

english, 1999

83

The Design and Synthesis of Bone-Active Phosphinic Acid Analogues: 1. The Pyridylaminomethane Phosphonoalkylphosphinates

Ebetino, Frank H., Jamieson, Laura A.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1990

Language:

english

File:

PDF, 302 KB

english, 1990

84

Bisphosphonates in development for metabolic bone disease

Sietsema, William K, Ebetino, Frank H

Journal:

Expert Opinion on Investigational Drugs

Year:

1994

Language:

english

File:

PDF, 1.99 MB

english, 1994

85

The Rational Design of Drugs with Phos-phonic/phinic Acids as Enzyme Inhibitors Isosteric Receptor Ligands

Ebetino, Frank H., Soper, David L., Dirr, Michelle J., Lundy, Mark W., Mieling, Glen, Wos, John A., deLong, Mitchell A., Liu, Xuewei

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

2002

Language:

english

File:

PDF, 79 KB

english, 2002

86

New Tactics in Heterocycles Synthesis

S. Kende, Andrew, H. Ebetino, Frank, Battista, Robert, J. Boatman, Rodney, P. Lorah, Dennis, Lodge, Eric

Journal:

Year:

1984

Language:

english

File:

PDF, 264 KB

english, 1984

87

Nitrene. Part XIII. Novel conversion of 2-nitrophenyl substituted butyrolactones into indoles with triethyl phosphite

Kametani, Tetsuji, Ebetino, Frank F., Fukumoto, Keiichiro

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1974

Language:

english

File:

PDF, 358 KB

english, 1974

88

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Sun, Shuting, Błażewska, Katarzyna M., Kadina, Anastasia P., Kashemirov, Boris A., Duan, Xuchen, Triffitt, James T., Dunford, James E., Russell, R. Graham G., Ebetino, Frank H., Roelofs, Anke J., Coxo

Journal:

Bioconjugate Chemistry

Year:

2016

Language:

english

File:

PDF, 2.81 MB

english, 2016

89

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Tsoumpra, Maria K., Muniz, Joao R., Barnett, Bobby L., Kwaasi, Aaron A., Pilka, Ewa S., Kavanagh, Kathryn L., Evdokimov, Artem, Walter, Richard L., Von Delft, Frank, Ebetino, Frank H., Oppermann, Udo,

Journal:

Year:

2015

Language:

english

File:

PDF, 993 KB

english, 2015

90

Synthesis of Nitro-, Amino-, and Polycyclic Furans

F. Ebetino, Frank

Journal:

Year:

1974

Language:

english

File:

PDF, 527 KB

english, 1974

91

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)

Lawson, Michelle A, Ebetino, Frank H, Mazur, Adam, Chantry, Andrew D, Paton-Hough, Julia, Evans, Holly R, Lath, Darren, Tsoumpra, Maria K, Lundy, Mark W, Dobson, Roy LM, Quijano, Michael, Kwaasi, Aaro

Journal:

Journal of Bone and Mineral Research

Year:

2017

Language:

english

File:

PDF, 1.33 MB

english, 2017

92

Recent Work on the Synthesis of Phosphonate-containing, Bone-active Heterocycles

H. Ebetino, Frank, R. Degenhardt, Charles, A. Jamieson, Laura, C. Burdsall, Don

Journal:

Year:

1990

Language:

english

File:

PDF, 190 KB

english, 1990

93

ChemInform Abstract: NITRENE PART 13, NOVEL CONVERSION OF 2-NITROPHENYL SUBSTITUTED BUTYROLACTONES INTO INDOLES WITH TRIETHYL PHOSPHITE

KAMETANI, TETSUJI, EBETINO, FRANK F., FUKUMOTO, KEIICHIRO

Journal:

Chemischer Informationsdienst

Year:

1974

File:

PDF, 127 KB

1974

94

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

Wang, Hua, Xiao, Lifeng, Tao, Jianguo, Srinivasan, Venkat, Boyce, Brendan, Ebetino, Frank, Oyajobi, Babatunde, Boeckman, Robert, Xing, Lianping

Journal:

Year:

2018

Language:

english

File:

PDF, 1.59 MB

english, 2018

95

Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice

Hokugo, Akishige, Kanayama, Keiichi, Sun, Shuting, Morinaga, Kenzo, Sun, Yujie, Wu, QingQing, Sasaki, Hodaka, Okawa, Hiroko, Evans, Courtney, Ebetino, Frank H., Lundy, Mark W., Sadrerafi, Keivan, McKe

Journal:

Year:

2019

Language:

english

File:

PDF, 15.97 MB

english, 2019

96

Bisphosphonate use in the horse: what is good and what is not?

Mitchell, Alexis, Watts, Ashlee E., Ebetino, Frank H., Suva, Larry J.

Journal:

BMC Veterinary Research

Year:

2019

Language:

english

File:

PDF, 706 KB

english, 2019

97

History of risedronate

McClung, Michael R., Ebetino, Frank H.

Journal:

Year:

2020

File:

PDF, 953 KB

2020

98

On the pharmacological evaluation of bisphosphonates in humans

Cremers, Serge, Ebetino, Frank (Hal), Phipps, Roger

Journal:

Year:

2020

File:

PDF, 1.26 MB

2020

99

Targeting anti-cancer agents to bone using bisphosphonates

Xing, Lianping, Ebetino, Frank H., Boeckman, Robert K., Srinivasan, Venkat, Tao, Jianguo, Sawyer, Tomi K., Li, Jinbo, Yao, Zhenqiang, Boyce, Brendan F.

Journal:

Year:

2020

File:

PDF, 8.20 MB

2020

100

Bisphosphonates in Veterinary Medicine: The new horizon for use

Suva, Larry J., Cooper, Alexis, Watts, Ashlee E., Ebetino, Frank H., Price, Joanna, Gaddy, Dana

Journal:

Year:

2020

File:

PDF, 1.54 MB

2020