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1

The Structural Basis for Control of Eukaryotic Protein Kinases

Endicott, Jane A., Noble, Martin E.M., Johnson, Louise N.

Journal:

Annual Review of Biochemistry

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

2

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J., Abbas, Abdullahi Y., Baumli, Sonja, Liu, Xiangrui, Lam, Frankie, Foley, David W., Fischer, Peter M., Noble, Martin, Endicott, Jane A., Pepper

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 651 KB

english, 2013

3

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Sonja Baumli, Alison J. Hole, Lan-Zhen Wang, Martin E.M. Noble, Jane A. Endicott

Journal:

Year:

2012

Language:

english

File:

PDF, 1.83 MB

english, 2012

4

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Griffin, Roger J., Henderson, Andrew, Curtin, Nicola J., Echalier, Aude, Endicott, Jane A., Hardcastle, Ian R., Newell, David R., Noble, Martin E. M., Wang, Lan-Zhen, Golding, Bernard T.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

5

A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

Lu, Min, Zak, Jaroslav, Chen, Shuo, Sanchez-Pulido, Luis, Severson, David T., Endicott, Jane, Ponting, Chris P., Schofield, Christopher J., Lu, Xin

Journal:

Year:

2014

Language:

english

File:

PDF, 4.87 MB

english, 2014

6

Effects of Excited State−Excited State Configurational Mixing on Emission Bandshape Variations in Ruthenium−Bipyridine Complexes

Odongo, Onduru S., Heeg, Mary Jane, Chen, Yuan-Jang, Xie, Puhui, Endicott, John F.

Journal:

Inorganic Chemistry

Year:

2008

Language:

english

File:

PDF, 4.85 MB

english, 2008

7

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Laur

Journal:

Organic & Biomolecular Chemistry

Year:

2018

Language:

english

File:

PDF, 1.68 MB

english, 2018

8

Recent developments in cyclin-dependent kinase biochemical and structural studies

Aude Echalier, Jane A. Endicott, Martin E.M. Noble

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 2.15 MB

english, 2010

9

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

Christian Doerig, Oliver Billker, David Pratt, Jane Endicott

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2005

Language:

english

File:

PDF, 668 KB

english, 2005

10

Exploiting structural principles to design cyclin-dependent kinase inhibitors

Martin Noble, Paul Barrett, Jane Endicott, Louise Johnson, Jim McDonnell, Giles Robertson, Alex Zawaira

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2005

Language:

english

File:

PDF, 643 KB

english, 2005

11

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB

Sonja Baumli, Jane A. Endicott, Louise N. Johnson

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 515 KB

english, 2010

12

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2

Veronique Mesguiche, Rachel J Parsons, Christine E Arris, Johanne Bentley, F.Thomas Boyle, Nicola J Curtin, Thomas G Davies, Jane A Endicott, Ashleigh E Gibson, Bernard T Golding, Roger J Griffin, Phi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

13

Structure-Based design of 2-Arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-Dependent kinases 1 and 2

Kerry L. Sayle, Johanne Bentley, F.Thomas Boyle, A.Hilary Calvert, Yuzhu Cheng, Nicola J. Curtin, Jane A. Endicott, Bernard T. Golding, Ian R. Hardcastle, Philip Jewsbury, Veronique Mesguiche, David R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

14

Understanding Small-Molecule Binding to MDM2: Insights into Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy

Christiane Riedinger, Martin E. Noble, David J. Wright, Florian Mulks, Ian R. Hardcastle, Jane A. Endicott, James M. McDonnell

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 535 KB

english, 2011

15

10.1038/15674

Johnson, Louise N., Brown, Nick R., Noble, Martin E. M., Endicott, Jane A.

Journal:

Nature Cell Biology

Year:

1999

Language:

english

File:

PDF, 1.14 MB

english, 1999

16

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

Gerlach, James H., Endicott, Jane A., Juranka, Peter F., Henderson, Graham, Sarangi, Farida, Deuchars, Kathryn L., Ling, Victor

Journal:

Year:

1986

File:

PDF, 528 KB

1986

17

10.1038/9035

Meijer, Laurent, Hoessel, Ralph, Leclerc, Sophie, Endicott, Jane A., Nobel, Martin E. M., Lawrie, Alison, Tunnah, Paul, Leost, Maryse, Damiens, Eve, Marie, Dominique, Marko, Doris, Niederberger, Ellen

Journal:

Nature Cell Biology

Year:

1999

Language:

english

File:

PDF, 705 KB

english, 1999

18

Structural biology: Pass the protein

Trempe, Jean-François, Endicott, Jane A.

Journal:

Year:

2007

Language:

english

File:

PDF, 284 KB

english, 2007

19

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

Lawrie, Alison M., Noble, Martin E.M., Tunnah, Paul, Brown, Nicholas R., Johnson, Louise N., Endicott, Jane A.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 1013 KB

1997

20

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Davies, Thomas G., Bentley, Johanne, Arris, Christine E., Boyle, F. Thomas, Curtin, Nicola J., Endicott, Jane A., Gibson, Ashleigh E., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R.

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 1.70 MB

english, 2002

21

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

Trempe, Jean-François, Brown, Nicholas R, Lowe, Edward D, Gordon, Colin, Campbell, Iain D, Noble, Martin E M, Endicott, Jane A

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 415 KB

english, 2005

22

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Hardcastle, Ian R., Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U., Blackburn, Timothy J., Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.75 MB

english, 2011

23

N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Hardcastle, Ian R., Arris, Christine E., Bentley, Johanne, Boyle, F. Thomas, Chen, Yuzhu, Curtin, Nicola J., Endicott, Jane A., Gibson, Ashleigh E., Golding, Bernard T., Griffin, Roger J.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 320 KB

english, 2004

24

Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects

Mettey, Yvette, Gompel, Marie, Thomas, Virginie, Garnier, Matthieu, Leost, Maryse, Ceballos-Picot, Irène, Noble, Martin, Endicott, Jane, Vierfond, Jean-michel, Meijer, Laurent

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 658 KB

english, 2003

25

MDM2-p53 protein–protein interaction inhibitors: A-ring substituted isoindolinones

Anna F. Watson, Junfeng Liu, Karim Bennaceur, Catherine J. Drummond, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Karen Haggerty, Xiaohong Lu, James M. McDonnell, David R. Newell, Martin E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 450 KB

english, 2011

26

Development and evaluation of the Daily Assessment of Symptoms – Anxiety (DAS-A) scale to evaluate onset of symptom relief in patients with generalized anxiety disorder

Robert J. Morlock, Valerie S.L. Williams, Joseph C. Cappelleri, Jane Harness, Sheri E. Fehnel, Jean Endicott, Douglas Feltner

Journal:

Journal of Psychiatric Research

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

27

Structures of P. falciparum PfPK5 Test the CDK Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition

Simon Holton, Anais Merckx, Darren Burgess, Christian Doerig, Martin Noble, Jane Endicott

Journal:

Year:

2003

Language:

english

File:

PDF, 456 KB

english, 2003

28

Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design

Anais Merckx, Aude Echalier, Kia Langford, Audrey Sicard, Gordon Langsley, Jos Joore, Christian Doerig, Martin Noble, Jane Endicott

Journal:

Year:

2008

Language:

english

File:

PDF, 1.39 MB

english, 2008

29

Cyclin-dependent kinase homologues of Plasmodium falciparum

Christian Doerig, Jane Endicott, Debopam Chakrabarti

Journal:

International Journal for Parasitology

Year:

2002

Language:

english

File:

PDF, 344 KB

english, 2002

30

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2

Louise N. Johnson, Erika De Moliner, Nick R. Brown, Haiwei Song, David Barford, Jane A. Endicott, Martin E.M. Noble

Journal:

Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 695 KB

english, 2002

31

Structure-based design of cyclin-dependent kinase inhibitors

Thomas G. Davies, David J. Pratt, Jane A. Endicott, Louise N. Johnson, Martin E.M. Noble

Journal:

Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 334 KB

english, 2002

32

Chemical Inhibitors of Cyclin-Dependent Kinases: Insights into Design from X-Ray Crystallographic Studies

Martin E.M Noble, Jane A Endicott

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 1.81 MB

english, 1999

33

Cyclin-dependent kinases: inhibition and substrate recognition

Jane A Endicott, Martin EM Noble, Julie A Tucker

Journal:

Current Opinion in Structural Biology

Year:

1999

Language:

english

File:

PDF, 685 KB

english, 1999

34

The cyclin box fold: protein recognition in cell-cycle and transcription control

Martin E.M. Noble, Jane A. Endicott, Nick R. Brown, Louise N. Johnson

Journal:

Trends in Biochemical Sciences

Year:

1997

Language:

english

File:

PDF, 1.46 MB

english, 1997

35

Inhibitor Binding to Active and Inactive CDK2: The Crystal Structure of CDK2-Cyclin A/Indirubin-5-Sulphonate

Thomas G. Davies, Paul Tunnah, Laurent Meijer, Doris Marko, Gerhard Eisenbrand, Jane A. Endicott, Martin E.M. Noble

Journal:

Year:

2001

Language:

english

File:

PDF, 714 KB

english, 2001

36

Structural principles in cell-cycle control: beyond the CDKs

Jane A Endicott, Martin EM Noble

Journal:

Year:

1998

Language:

english

File:

PDF, 170 KB

english, 1998

37

Xenopus Phospho-CDK7/Cyclin H Expressed in Baculoviral-Infected Insect Cells

Alison M. Lawrie, Paula Tito, Helena Hernandez, Nick R. Brown, Carol V. Robinson, Jane A. Endicott, Martin E.M. Noble, Louise N. Johnson

Journal:

Protein Expression and Purification

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

38

Budding yeast Dsk2 protein forms a homodimer via its C-terminal UBA domain

Toru Sasaki, Minoru Funakoshi, Jane A. Endicott, Hideki Kobayashi

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 198 KB

english, 2005

39

Inhibition of the cell cycle with chemical inhibitors: A targeted approach

Julie P.I. Welburn, Jane A. Endicott

Journal:

Seminars in Cell & Developmental Biology

Year:

2005

Language:

english

File:

PDF, 335 KB

english, 2005

40

Structural biology of cell-cycle proteins

Sarah Major, Jane A Endicott

Journal:

Drug Discovery Today: TARGETS

Year:

2004

Language:

english

File:

PDF, 1008 KB

english, 2004

41

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Arris, Christine E., Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J., Endicott, Jane A., Garman, Elspeth F., Gibson, Ashleigh E., Golding, Bernard T., Grant, Sharon, Griffin, Roger J., Jewsbur

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 542 KB

english, 2000

42

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Hole, Alison J., Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M., Wang, Shudong, Endicott, Jane A., Noble, Martin E.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 950 KB

english, 2013

43

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

Marchetti, Francesco, Sayle, Kerry L., Bentley, Johanne, Clegg, William, Curtin, Nicola J., Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Haggerty, Karen, Harrington, Ross W., Mesguiche,

Journal:

Organic & Biomolecular Chemistry

Year:

2007

Language:

english

File:

PDF, 252 KB

english, 2007

44

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex †

Echalier, Aude, Bettayeb, Karima, Ferandin, Yoan, Lozach, Olivier, Clément, Monique, Valette, Annie, Liger, François, Marquet, Bernard, Morris, Jonathan C., Endicott, Jane A., Joseph, Benoît, Meijer,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.76 MB

english, 2008

45

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP

Lu, Min, Breyssens, Hilde, Salter, Victoria, Zhong, Shan, Hu, Ying, Baer, Caroline, Ratnayaka, Indrika, Sullivan, Alex, Brown, Nicholas R., Endicott, Jane, Knapp, Stefan, Kessler, Benedikt M., Middlet

Journal:

Year:

2013

Language:

english

File:

PDF, 5.24 MB

english, 2013

46

Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6 -Substituted Guanine Derivatives

Gibson, Ashleigh E., Arris, Christine E., Bentley, Johanne, Boyle, F. Thomas, Curtin, Nicola J., Davies, Thomas G., Endicott, Jane A., Golding, Bernard T., Grant, Sharon, Griffin, Roger J., Jewsbury,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 751 KB

english, 2002

47

Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity †

Pratt, David J., Bentley, Jo, Jewsbury, Philip, Boyle, F. Tom, Endicott, Jane A., Noble, Martin E. M.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 452 KB

english, 2006

48

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

Baumli, Sonja, Hole, Alison J., Noble, Martin E. M., Endicott, Jane A.

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 2.89 MB

english, 2012

49

Charge-transfer perturbations of the electronic contributions to bimolecular reactions. Nonadiabatic effects observed in energy-transfer and electron-transfer reactions

Endicott, John F., Ramasami, T., Gaswick, Dennis C., Tamilarasan, R., Heeg, Mary Jane, Brubaker, George R., Pyke, Stephen C.

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 1.20 MB

english, 1983

50

8-Substituted O 6 -Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode

Carbain, Benoit, Paterson, David J., Anscombe, Elizabeth, Campbell, Allyson J., Cano, Celine, Echalier, Aude, Endicott, Jane A., Golding, Bernard T., Haggerty, Karen, Hardcastle, Ian R., Jewsbury, Phi

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.38 MB

english, 2014

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