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51

Intracellular and secreted Aβ42/40 ratios are differently influenced by APP mutations

Heike Sabine Grimm, Stefan Friedrich Lichtenthaler, Beate Katharina Grziwa, Peter Paul Prior

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

52

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment

Bart P.F Rutten, Oliver Wirths, Wilma D.J Van de Berg, Stefan F Lichtenthaler, Jochen Vehoff, Harry W.M Steinbusch, Hubert Korr, Konrad Beyreuther, Gerd Multhaup, Thomas A Bayer, Christoph Schmitz

Journal:

Neurobiology of Disease

Year:

2003

Language:

english

File:

PDF, 608 KB

english, 2003

53

O2-03-01: Novel proteins act as gatekeepers and control access of APP to alpha- and beta-secretase

Stefan F. Lichtenthaler, Susanne Schöbel, Stephanie Neumann, Sylvia Fischer, Christian Haass

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 66 KB

english, 2006

54

P2-043: Developing cell-based assays for detection and quantification of the β-site-cleaved secreted APP ectodomain (sAPPβ)

Jeremy C. Hwang, Hirokazu Okada, Kinnari Pandya, Jimin Wang, Stefan Lichtenthaler, Tae-Wan Kim

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 68 KB

english, 2006

55

O1-04-01: Novel drugs simultaneously modulate both beta- and gamma-secretase cleavage of the amyloid precursor protein

Stefan F. Lichtenthaler, Stefan Mitterreiter, Christian Haass

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

56

Therapeutic potential of BACE1/beta-secretase: Proteome-wide identification of physiological BACE1 substrates in primary neurons and mouse brain

Stefan Lichtenthaler, Bastian Dislich, Sebastian Hogl, Alessio Colombo, Ulrike Zeitschel, Michael Willem, Christian Haass, Christiane Volbracht, Steffen Roßner, Peer-Hendrik Kuhn

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 220 KB

english, 2012

57

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

Regina Augustin, Kristina Endres, Sven Reinhardt, Peer-Hendrik Kuhn, Stefan F Lichtenthaler, Jens Hansen, Wolfgang Wurst, Dietrich Trümbach

Journal:

BMC Medical Genetics

Year:

2012

Language:

english

File:

PDF, 902 KB

english, 2012

58

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

Hogl, Sebastian, van Bebber, Frauke, Dislich, Bastian, Kuhn, Peer-Hendrik, Haass, Christian, Schmid, Bettina, Lichtenthaler, Stefan F.

Journal:

Year:

2013

Language:

english

File:

PDF, 316 KB

english, 2013

59

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

Ohno, Mikiko, Hiraoka, Yoshinori, Lichtenthaler, Stefan F., Nishi, Kiyoto, Saijo, Sayaka, Matsuoka, Tatsuhiko, Tomimoto, Hidekazu, Araki, Wataru, Takahashi, Ryosuke, Kita, Toru, Kimura, Takeshi, Nishi

Journal:

Neurobiology of Aging

Year:

2014

Language:

english

File:

PDF, 2.11 MB

english, 2014

60

4741901 Preparation of polypeptides in vertebrate cell culture

Fischer, Sylvia V., Haass, Christian, Lichtenthaler, Stefan F.

Journal:

Biotechnology Advances

Year:

1988

Language:

english

File:

PDF, 68 KB

english, 1988

61

P4-003

Fischer, Sylvia V., Haass, Christian, Lichtenthaler, Stefan F.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 76 KB

english, 2006

62

P4-070

Neumann, Stephanie, Schöbel, Susanne, Jäger, Sebastian, Haass, Christian, Pietrzik, Claus U., Lichtenthaler, Stefan F.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

63

A plea for more careful consideration of scientific subjects before orthodontic societies

Schöbel, Susanne, Neumann, Stephanie, Haass, Christian, Lichtenthaler, Stefan F.

Journal:

International Journal of Orthodontia

Year:

1916

Language:

english

File:

PDF, 473 KB

english, 1916

64

P4-058

Schöbel, Susanne, Neumann, Stephanie, Haass, Christian, Lichtenthaler, Stefan F.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

65

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Colombo, Alessio, Wang, Huanhuan, Kuhn, Peer-Hendrik, Page, Richard, Kremmer, Elisabeth, Dempsey, Peter J., Crawford, Howard C., Lichtenthaler, Stefan F.

Journal:

Neurobiology of Disease

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

66

P4-190 Translational regulation on BACE expression

Lammich, Sven, Schöbel, Susanne, Zimmer, Ann-Katrin, Lichtenthaler, Stefan F., Haass, Christian

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

67

P4-286

Leuchtenberger, Stefanie, Maler, Juan, Czirr, Eva, Ness, Julia, Lichtenthaler, Stefan, Wiltfang, Jens, Weggen, Sascha

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 77 KB

english, 2006

68

P3-233

Kuhn, Peer-Hendrik, Haass, Christian, Lichtenthaler, Stefan F.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 54 KB

english, 2006

69

Systematic identification of proteases with alpha-secretase activity

Lichtenthaler, Stefan F., Dislich, Bastian, Wang, Huanhuan, Zeitschel, Ulrike, Rossner, Steffen, Haass, Christian, Kuhn, Peer-Hendrik

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 65 KB

english, 2009

70

P4-198 Genome-wide screen identifies proteins stimulating the alpha- and beta-secretase cleavage of AFP

Lichtenthaler, Stefan F., Schöbel, Susanne, Neumann, Stephanie, Seed, Brian, Haass, Christian

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

71

The length of the transmembrane domain of APP in microsomal membranes is shorter than predicted

Beate, Grziwa Katharina, Grimm, Heike Sabine, Regula, Joerg Thomas, Lichtenthaler, Stefan Friedrich

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 160 KB

english, 2000

72

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice

Tesseur, Ina, Pimenova, Anna A., Lo, Adrian C., Ciesielska, Marta, Lichtenthaler, Stefan F., De Maeyer, Joris H., Schuurkes, Jan A.J., D'Hooge, Rudi, De Strooper, Bart

Journal:

Neurobiology of Aging

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

73

Mechanism of the Cleavage Specificity of Alzheimer's Disease γ -secretase Identified by Phenylalanine-Scanning Mutagenesis of the Transmembrane Domain of the Amyloid Precursor Protein

Stefan F. Lichtenthaler, Rong Wang, Heike Grimm, Sacha N. Uljon, Colin L. Masters and Konrad Beyreuther

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.75 MB

english, 1999

74

Mutations in the Transmembrane Domain of APP Altering γ-Secretase Specificity †

Lichtenthaler, Stefan F., Ida, Nobuo, Multhaup, Gerd, Masters, Colin L., Beyreuther, Konrad

Journal:

Year:

1997

Language:

english

File:

PDF, 167 KB

english, 1997

75

Practical Synthesis of .beta.-D-Xyl-(1.fwdarw.2)-.beta.-D-Man-(1.fwdarw.4)-.alpha.-D-Glc-OMe, a Trisaccharide Component of the Hyriopsis schlegelii Glycosphingolipid

Lichtenthaler, Frieder W., Schneider-Adams, Thomas, Immel, Stefan

Journal:

Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 1.27 MB

english, 1994

76

5-HT 4 Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10

Cochet, Maud, Donneger, Romain, Cassier, Elisabeth, Gaven, Florence, Lichtenthaler, Stefan F., Marin, Philippe, Bockaert, Joël, Dumuis, Aline, Claeysen, Sylvie

Journal:

ACS Chemical Neuroscience

Year:

2013

Language:

english

File:

PDF, 3.85 MB

english, 2013

77

Soluble BCMA is shed from B cells by gamma-secretase, functions as APRIL-specific decoy and reflects intrathecal Ig-production in multiple sclerosis

Laurent, Sarah A., Hoffmann, Franziska, Kuhn, Peer-hendrik, Hauck, Stephanie M., Khademi, Mohsen, Olsson, Tomas, Pfister, Hans-walter, Weber, Frank, Hohlfeld, Reinhard, Lichtenthaler, Stefan F., Meinl

Journal:

Journal of Neuroimmunology

Year:

2014

Language:

english

File:

PDF, 48 KB

english, 2014

78

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

Kretner, Benedikt, Fukumori, Akio, Kuhn, Peer-Hendrik, Pérez-Revuelta, Blanca Isabel, Lichtenthaler, Stefan F., Haass, Christian, Steiner, Harald

Journal:

Journal of Neurochemistry

Year:

2013

Language:

english

File:

PDF, 783 KB

english, 2013

79

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Vassar, Robert, Kuhn, Peer-Hendrik, Haass, Christian, Kennedy, Matthew E., Rajendran, Lawrence, Wong, Philip C., Lichtenthaler, Stefan F.

Journal:

Journal of Neurochemistry

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

80

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

Schwenk, Benjamin M., Lang, Christina M., Hogl, Sebastian, Tahirovic, Sabina, Orozco, Denise, Rentzsch, Kristin, Lichtenthaler, Stefan F., Hoogenraad, Casper C., Capell, Anja, Haass, Christian, Edbaue

Journal:

The EMBO Journal

Year:

2013

Language:

english

File:

PDF, 1.83 MB

english, 2013

81

Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein

Neumann, Stephanie, Schöbel, Susanne, Jäger, Sebastian, Trautwein, Anna, Haass, Christian, Pietrzik, Claus U., Lichtenthaler, Stefan F.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.16 MB

english, 2006

82

The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein

Ullrich, Sylvia, Münch, Anna, Neumann, Stephanie, Kremmer, Elisabeth, Tatzelt, Jörg, Lichtenthaler, Stefan F.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 3.85 MB

english, 2010

83

Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways

Kuhn, Peer-Hendrik, Voss, Matthias, Haug-Kröper, Martina, Schröder, Bernd, Schepers, Ute, Bräse, Stefan, Haass, Christian, Lichtenthaler, Stefan F., Fluhrer, Regina

Journal:

Molecular & Cellular Proteomics

Year:

2015

Language:

english

File:

PDF, 6.58 MB

english, 2015

84

Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8

Naus, Silvia, Reipschläger, Simone, Wildeboer, Dirk, Lichtenthaler, Stefan F., Mitterreiter, Stefan, Guan, Ziqiang, Moss, Marcia L., Bartsch, Jörg W.

Journal:

Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 267 KB

english, 2006

85

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking

F. Lichtenthaler, Stefan

Journal:

Current Alzheimer Research

Year:

2012

Language:

english

File:

PDF, 234 KB

english, 2012

86

Label-free quantitative proteomics of mouse cerebrospinal fluid detects BACE1 protease substrates in vivo

Dislich, Bastian, Wohlrab, Felix, Bachhuber, Teresa, Mueller, Stephan, Kuhn, Peer-Hendrik, Hogl, Sebastian, Meyer-Luehmann, Melanie, Lichtenthaler, Stefan F.

Journal:

Molecular & Cellular Proteomics

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

87

iRhoms in the brain – a new frontier?

Lichtenthaler, Stefan F, O'Hara, Bruce F, Blobel, Carl P

Journal:

Year:

2015

Language:

english

File:

PDF, 987 KB

english, 2015

88

Cationic cluster formation versus disproportionation of low-valent indium and gallium complexes of 2,2’-bipyridine

Lichtenthaler, Martin R., Stahl, Florian, Kratzert, Daniel, Heidinger, Lorenz, Schleicher, Erik, Hamann, Julian, Himmel, Daniel, Weber, Stefan, Krossing, Ingo

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 998 KB

english, 2015

89

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

Saftig, Paul, Lichtenthaler, Stefan F.

Journal:

Progress in Neurobiology

Year:

2015

Language:

english

File:

PDF, 1.67 MB

english, 2015

90

Ectodomain Shedding of the Amyloid Precursor Protein: Cellular Control Mechanisms and Novel Modifiers

Lichtenthaler, Stefan F.

Journal:

Neurodegenerative Diseases

Year:

2006

Language:

english

File:

PDF, 154 KB

english, 2006

91

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein

Leuchtenberger, Stefanie, Maler, Juan, Czirr, Eva, Ness, Julia, Lichtenthaler, Stefan F., Esselmann, Hermann, Pietrzik, Claus U., Wiltfang, Jens, Weggen, Sascha

Journal:

Neurodegenerative Diseases

Year:

2009

Language:

english

File:

PDF, 293 KB

english, 2009

92

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

Barão, Soraia, Moechars, Diederik, Lichtenthaler, Stefan F., De Strooper, Bart

Journal:

Trends in Neurosciences

Year:

2016

Language:

english

File:

PDF, 2.04 MB

english, 2016

93

Technology marketing: a firm's core competence?

Tschirky, Hugo, Koruna, Stefan M., Lichtenthaler, Eckhard

Journal:

International Journal of Technology Management

Year:

2004

Language:

english

File:

PDF, 225 KB

english, 2004

94

ALTERED METABOLISM OF BACE1 SUBSTRATES SEIZURE PROTEIN 6 AND SEIZURE 6-LIKE PROTEIN 1 IN NIEMANN-PICK TYPE C DISEASE

Cermak, Stjepko, Causevic, Mirsada, Kuhn, Peer-Hendrik, Gunnersen, Jenny, Hutter-Paier, Birgit, Windisch, Manfred, Lichtenthaler, Stefan, Hecimovic, Silva

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 79 KB

english, 2014

95

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Wichert, Rielana, Prox, Johannes, Altmeppen, Hermann, Kumar, Sathish, Walter, Jochen, Lichtenthaler, Stefan F., Weggen, Sascha, Glatzel, Markus, Bec

Journal:

Molecular Neurodegeneration

Year:

2016

Language:

english

File:

PDF, 1.74 MB

english, 2016

96

ADAM10: potential ‘molecular scissors’ for the treatment of Alzheimer’s disease

Lichtenthaler, Stefan F

Journal:

Future Neurology

Year:

2011

Language:

english

File:

PDF, 342 KB

english, 2011

97

Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System

Munro, Kathryn M., Nash, Amelia, Pigoni, Martina, Lichtenthaler, Stefan F., Gunnersen, Jenny M.

Journal:

Journal of Molecular Neuroscience

Year:

2016

Language:

english

File:

PDF, 430 KB

english, 2016

98

Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33

Dislich, Bastian, Than, Manuel E., Lichtenthaler, Stefan F.

Journal:

Biochemical Journal

Year:

2011

Language:

english

File:

PDF, 935 KB

english, 2011

99

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue

Scilabra, Simone D., Yamamoto, Kazuhiro, Pigoni, Martina, Sakamoto, Kazuma, Müller, Stephan A., Papadopoulou, Alkmini, Lichtenthaler, Stefan F., Troeberg, Linda, Nagase, Hideaki, Kadomatsu, Kenji

Journal:

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

100

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

Biella, Gloria, Fusco, Federica, Nardo, Emanuele, Bernocchi, Ottavia, Colombo, Alessio, Lichtenthaler, Stefan F., Forloni, Gianluigi, Albani, Diego, Gozes, Illana

Journal:

Journal of Alzheimer's Disease

Year:

2016

Language:

english

File:

PDF, 2.55 MB

english, 2016