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51

Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy

Sindelar, Charles V., Budny, Mary Jane, Rice, Sarah, Naber, Nariman, Fletterick, Robert, Cooke, Roger

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 2.72 MB

english, 2002

52

The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity

Bell, Jessica K, Goetz, David H, Mahrus, Sami, Harris, Jennifer L, Fletterick, Robert J, Craik, Charles S

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 1.00 MB

english, 2003

53

Structure of a kinesin microtubule depolymerization machine

Shipley, Krista, Hekmat-Nejad, Mohammad, Turner, Jennifer, Moores, Carolyn, Anderson, Robert, Milligan, Ronald, Sakowicz, Roman, Fletterick, Robert

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 526 KB

english, 2004

54

The case for a common ancestor: kinesin and myosin motor proteins and G proteins

F. Jon Kull, Ronald D. Vale, Robert J. Fletterick

Journal:

Journal of Muscle Research and Cell Motility

Year:

1998

Language:

english

File:

PDF, 347 KB

english, 1998

55

Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase

William G. Dougherty, T.Dawn Parks, Susan M. Cary, J.Fernando Bazan, Robert J. Fletterick

Journal:

Year:

1989

Language:

english

File:

PDF, 968 KB

english, 1989

56

Detection of a trypsin-like serine protease domain in flaviviruses and pestviruses

J.Fernando Bazan, Robert J. Fletterick

Journal:

Year:

1989

Language:

english

File:

PDF, 336 KB

english, 1989

57

Purification and crystallization of bovine liver phosphorylase

Peter Hwang, Michael Stern, Robert J. Fletterick

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1984

Language:

english

File:

PDF, 696 KB

english, 1984

58

Proteases

Margaret A. Phillips, Robert J. Fletterick

Journal:

Current Biology

Year:

1992

Language:

english

File:

PDF, 102 KB

english, 1992

59

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

Víctor Buzón, Laia R. Carbó, Sara B. Estruch, Robert J. Fletterick, Eva Estébanez-Perpiñá

Journal:

Molecular and Cellular Endocrinology

Year:

2012

Language:

english

File:

PDF, 665 KB

english, 2012

60

The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of an Inhibitor Family

Stephanie X. Wang, Kailash C. Pandey, Julio Scharfstein, James Whisstock, Rick K. Huang, Jordan Jacobelli, Robert J. Fletterick, Philip J. Rosenthal, Magnus Abrahamson, Linda S. Brinen, Andrea Rossi,

Journal:

Year:

2007

Language:

english

File:

PDF, 1.36 MB

english, 2007

61

Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site

Sydney P Craig III, Pamela J Focia, Robert J Fletterick

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1997

Language:

english

File:

PDF, 241 KB

english, 1997

62

Nucleotide switches in molecular motors: structural analysis of kinesins and myosins

Elena P Sablin, Robert J Fletterick

Journal:

Current Opinion in Structural Biology

Year:

2001

Language:

english

File:

PDF, 122 KB

english, 2001

63

Is the tubulin/FtsZ fold related to the G-protein fold?

F.Jon Kull, Robert J Fletterick

Journal:

Trends in Cell Biology

Year:

1998

Language:

english

File:

PDF, 50 KB

english, 1998

64

A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease protease

Linda S Brinen, Elizabeth Hansell, Jianming Cheng, William R Roush, James H McKerrow, Robert J Fletterick

Journal:

Year:

2000

Language:

english

File:

PDF, 978 KB

english, 2000

65

The evolution of an allosteric site in phosphorylase

Virginia L Rath, Kai Lin, Peter K Hwang, Robert J Fletterick

Journal:

Year:

1996

Language:

english

File:

PDF, 934 KB

english, 1996

66

Distinct phosphorylation signals converge at the catalytic center in glycogen phosphorylases

Kai Lin, Peter K Hwang, Robert J Fletterick

Journal:

Year:

1997

Language:

english

File:

PDF, 2.69 MB

english, 1997

67

Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs

Peter K. HWANG, Y. P. SEE, Anna M. VINCENTINI, Maureen A. POWERS, Robert J. FLETTERICK, Michael M. CRERAR

Journal:

Year:

1985

Language:

english

File:

PDF, 1023 KB

english, 1985

68

High-Level Expression and Characterization of a Purified 142-Residue Polypeptide of the Prion Protein†

Mehlhorn, Ingrid, Groth, Darlene, Stöckel, Johannes, Moffat, Barbara, Reilly, Dorothea, Yansura, Daniel, Willett, W. Scott, Baldwin, Michael, Fletterick, Robert, Cohen, Fred E.

Journal:

Year:

1996

Language:

english

File:

PDF, 562 KB

english, 1996

69

Relocating a Negative Charge in the Binding Pocket of Trypsin

John J. Perona, Christopher A. Tsu, Mary E. McGrath, Charles S. Craik, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 941 KB

1993

70

Crystal Structure of Rat Anionic Trypsin Complexed with the Protein Inhibitors APPI and BPTI

John J. Perona, Christopher A. Tsu, Charles S. Craik, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 956 KB

1993

71

The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease

Mary E. McGrath, Ann E. Eakin, Juan C. Engel, James H. McKerrow, Charles S. Craik, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 3.58 MB

english, 1995

72

Preliminary Crystallographic Studies of the Ligand-binding Domain of the Thyroid Hormone Receptor Complexed with Triiodothyronine

Mary E. McGrath, Richard L. Wagner, James W. Apriletti, Brian L. West, V. Ramalingam, John D. Baxter, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 227 KB

1994

73

X-ray Diffraction of Scrapie Prion Rods and PrP Peptides

Jack T. Nguyen, Hideyo Inouye, Michael A. Baldwin, Robert J. Fletterick, Fred E. Cohen, Stanley B. Prusiner, Daniel A. Kirschner

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 2.44 MB

english, 1995

74

Ecotin: a serine protease inhibitor with two distinct and interacting binding sites

Steve Q Yang, Cheng-I Wang, Sarah A Gillmor, Robert J Fletterick, Charles S Craik

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 1.08 MB

english, 1998

75

A comparison of the crystallographic structures of two catalytic antibodies with esterase activity

Jenny L Buchbinder, Robert C Stephenson, Thomas S Scanlan, Robert J Fletterick

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 1.61 MB

english, 1998

76

Antibody binding defines a structure for an epitope that participates in the PrPC → PrPSc conformational change

Zoltan F Kanyo, Keh-Ming Pan, R.Anthony Williamson, Dennis R Burton, Stanley B Prusiner, Robert J Fletterick, Fred E Cohen

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 383 KB

english, 1999

77

Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases

Sarah A Gillmor, Toshihiko Takeuchi, Steven Q Yang, Charles S Craik, Robert J Fletterick

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 604 KB

english, 2000

78

The role of ecotin dimerization in protease inhibition

Christopher T Eggers, Stephanie X Wang, Robert J Fletterick, Charles S Craik

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 661 KB

english, 2001

79

Complete cDNA sequence for rabbit muscle glycogen phosphorylase

Kenichi Nakano, Peter K. Hwang, Robert J. Fletterick

Journal:

Year:

1986

Language:

english

File:

PDF, 477 KB

english, 1986

80

Comparative analysis of viral cysteine protease structural models

J.Fernando Bazan, Robert J. Fletterick

Journal:

Year:

1989

Language:

english

File:

PDF, 334 KB

english, 1989

81

Expression of the protease inhibitor ecotin and its co-crystallization with trypsin

Mary E. McGrath, Thorsten Erpel, Michelle F. Browner, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 1.02 MB

english, 1991

82

Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae

Virginia L. Rath, Peter K. Hwang, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 1.73 MB

english, 1992

83

Conformation Switching of Clathrin Light Chain Regulates Clathrin Lattice Assembly

Jeremy D. Wilbur, Peter K. Hwang, Joel A. Ybe, Michael Lane, Benjamin D. Sellers, Matthew P. Jacobson, Robert J. Fletterick, Frances M. Brodsky

Journal:

Developmental Cell

Year:

2010

Language:

english

File:

PDF, 868 KB

english, 2010

84

An Atomic Model of the Thin Filament in the Relaxed and Ca2+-Activated States

Alnoor Pirani, Maia V. Vinogradova, Paul M.G. Curmi, William A. King, Robert J. Fletterick, Roger Craig, Larry S. Tobacman, Chen Xu, Victoria Hatch, William Lehman

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 654 KB

english, 2006

85

Directed Evolution of an Anti-prion Protein scFv Fragment to an Affinity of 1 pM and its Structural Interpretation

Béatrice Luginbühl, Zoltan Kanyo, R. Mark Jones, Robert J. Fletterick, Stanley B. Prusiner, Fred E. Cohen, R. Anthony Williamson, Dennis R. Burton, Andreas Plückthun

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.58 MB

english, 2006

86

Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein

Maia V. Vinogradova, Galina G. Malanina, Vaka S. Reddy, Anireddy S.N. Reddy, Robert J. Fletterick

Journal:

Journal of Structural Biology

Year:

2008

Language:

english

File:

PDF, 566 KB

english, 2008

87

Conformational adaptation of nuclear receptor ligand binding domains to agonists: Potential for novel approaches to ligand design

Marie Togashi, Sabine Borngraeber, Ben Sandler, Robert J. Fletterick, Paul Webb, John D. Baxter

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 509 KB

english, 2005

88

Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes

David L. Sloane, Michelle F. Browner, Zbigniew Dauter, Keith Wilson, Robert J. Fletterick, Elliott Sigal

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 2.63 MB

english, 1990

89

A Model for the Microtubule-Ncd Motor Protein Complex Obtained by Cryo-Electron Microscopy and Image Analysis

Hernando Sosa, D.Prabha Dias, Andreas Hoenger, Michael Whittaker, Elizabeth Wilson-Kubalek, Elena Sablin, Robert J Fletterick, Ronald D Vale, Ronald A Milligan

Journal:

Year:

1997

Language:

english

File:

PDF, 564 KB

english, 1997

90

Selective modulation of thyroid hormone receptor action

John D Baxter, Wolfgang H Dillmann, Brian L West, Russ Huber, J.David Furlow, Robert J Fletterick, Paul Webb, James W Apriletti, Thomas S Scanlan

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2001

Language:

english

File:

PDF, 482 KB

english, 2001

91

X-ray crystallographic and functional studies of thyroid hormone receptor

Ralff C.J Ribeiro, James W Apriletti, Richard L Wagner, Weijun Feng, Peter J Kushner, Stefan Nilsson, Thomas S Scanlan, Brian L West, Robert J Fletterick, John D Baxter

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1998

Language:

english

File:

PDF, 592 KB

english, 1998

92

Structural Basis for Ligand-Independent Activation of the Orphan Nuclear Receptor LRH-1

Elena P. Sablin, Irina N. Krylova, Robert J. Fletterick, Holly A. Ingraham

Journal:

Year:

2003

Language:

english

File:

PDF, 709 KB

english, 2003

93

THE DESIGN PLAN OF KINESIN MOTORS

Vale, Ronald D., Fletterick, Robert J.

Journal:

Annual Review of Cell and Developmental Biology

Year:

1997

Language:

english

File:

PDF, 707 KB

english, 1997

94

A systematic approach to isomorphous replacement using a series of simple charged mercurials

Stephen G. Withers, Daniel S.C. Yang, Neil B. Madsen, Robert J. Fletterick

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 324 KB

english, 1979

95

Sequence Analysis of the Genes for Yeast and Human Muscle Glycogen Phosphorylases

PETER K. HWANG, JOHN A. BURKE, ROBERT J. FLETTERICK

Journal:

Annals of the New York Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 96 KB

english, 1986

96

Structure of Mammalian Isozymes of Glycogen Phosphorylase : Implications for Function

CHRISTOPHER B. NEWGARD, KENICHI NAKANO, PETER K. HWANG, ROBERT J. FLETTERICK

Journal:

Annals of the New York Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 100 KB

english, 1986

97

Structure of yeast hexokinase: III. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding

Wayne F. Anderson, Robert J. Fletterick, Thomas A. Steitz

Journal:

Journal of Molecular Biology

Year:

1974

Language:

english

File:

PDF, 11.09 MB

english, 1974

98

Structure of yeast hexokinase: II. A 6 Å resolution electron density map showing molecular shape and heterologous interaction of subunits

Thomas A. Steitz, Robert J. Fletterick, Karl J. Hwang

Journal:

Journal of Molecular Biology

Year:

1973

Language:

english

File:

PDF, 5.05 MB

english, 1973

99

The structure of glycogen phosphorylase a at 2.5 Å resolution

Stephen Sprang, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1979

Language:

english

File:

PDF, 2.15 MB

english, 1979

100

Crystal structure of rat trypsin-S195C at −150 °C: Analysis of low activity of recombinant and semisynthetic thiol proteases

Marjorie E. Wilke, Jeffrey N. Higaki, Charles S. Craik, Robert J. Fletterick

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 1.50 MB

english, 1991