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51

A method for measuring 1H-1H coupling constants in 13C-labeled molecules

Gerd Gemmecker, Stephen W Fesik

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 369 KB

english, 1969

52

Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506

Gary T. Wang, Ben Lane, Stephen W. Fesik, Andrew Petros, Jay Luly, Grant A. Krafft

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 433 KB

english, 1994

53

10.1038/31972

Fesik, Stephen W., Eberstadt, Matthias, Huang, Baohua, Chen, Zehan, Meadows, Robert P., Ng, Shi-Chung, Zheng, Lixin, Lenardo, Michael J.

Journal:

Year:

1998

Language:

english

File:

PDF, 879 KB

english, 1998

54

Isotope-edited NMR spectroscopy

Journal:

Year:

1988

File:

PDF, 265 KB

1988

55

10.1038/35050006

Fesik, Stephen W., Liu, Zhihong, Sun, Chaohong, Olejniczak, Edward T., Meadows, Robert P., Betz, Stephen F., Oost, Thorsten, Herrmann, Julia, Wu, Joe C.

Journal:

Year:

2000

Language:

english

File:

PDF, 375 KB

english, 2000

56

Solution structure of the cyclosporin A/cyclophilin complex by NMR

Thériault, Yves, Logan, Timothy M., Meadows, Robert, Yu, Liping, Olejniczak, Edward T., Holzman, Thomas F., Simmer, Robert L., Fesik, Stephen W.

Journal:

Year:

1993

File:

PDF, 549 KB

1993

57

Solution structure of a pleckstrin-homology domain

Yoon, Ho Sup, Hajduk, Philip J., Petros, Andrew M., Olejniczak, Edward T., Meadows, Robert P., Fesik, Stephen W.

Journal:

Year:

1994

File:

PDF, 445 KB

1994

58

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

Harlan, John E., Hajduk, Philip J., Yoon, Ho Sup, Fesik, Stephen W.

Journal:

Year:

1994

File:

PDF, 749 KB

1994

59

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Zhou, Ming-Ming, Ravichandran, Kodimangalam S., Olejniczak, Edward T., Petros, Andrew M., Meadows, Robert P., Sattler, Michael, Harlan, John E., Wade, Warren S., Burakoff, Steven J., Fesik, Stephen W.

Journal:

Year:

1995

File:

PDF, 2.85 MB

1995

60

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

Huang, Baohua, Eberstadt, Matthias, Olejniczak, Edward T., Meadows, Robert P., Fesik, Stephen W.

Journal:

Year:

1996

File:

PDF, 1.03 MB

1996

61

Bcl-xL forms an ion channel in synthetic lipid membranes

Minn, Andy J., Vélez, Patricio, Schendel, Sharon L., Liang, Heng, Muchmore, Steven W., Fesik, Stephen W., Fill, Michael, Thompson, Craig B.

Journal:

Year:

1997

File:

PDF, 1.09 MB

1997

62

Promoting apoptosis as a strategy for cancer drug discovery

Fesik, Stephen W.

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 138 KB

english, 2005

63

Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain

Zhou, Ming-Ming, Huang, Baohua, Olejniczak, Edward T., Meadows, Robert P., Shuker, Suzanne B., Miyazaki, Masaya, Trüb, Thomas, Shoelson, Steven E., Fesik, Stephen W.

Journal:

Natural Structural Biology

Year:

1996

File:

PDF, 958 KB

1996

64

Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance

Yu, Liping, Petros, Andrew M., Schnuchel, Arndt, Zhong, Ping, Severin, Jean M., Walter, Karl, Holzman, Thomas F., Fesik, Stephen W.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 970 KB

1997

65

Solution structure of the ets domain of Fli-1 when bound to DNA

Liang, Heng, Mao, Xiaohong, Olejniczak, Edward T., Nettesheim, David G., Yu, Liping, Meadows, Robert P., Thompson, Craig B., Fesik, Stephen W.

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 675 KB

1994

66

The lymphoproliferation mutation in Fas locally unfolds the Fas death domain

Eberstadt, Matthias, Huang, Baohua, Olejniczak, Edward T., Fesik, Stephen W.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 324 KB

1997

67

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors

Morgan-Lappe, S, Woods, K W, Li, Q, Anderson, M G, Schurdak, M E, Luo, Y, Giranda, V L, Fesik, S W, Leverson, J D

Journal:

Year:

2005

Language:

english

File:

PDF, 199 KB

english, 2005

68

‘Seed’ analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737

Lin, X, Morgan-Lappe, S, Huang, X, Li, L, Zakula, D M, Vernetti, L A, Fesik, S W, Shen, Y

Journal:

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

69

Reaction of [Pt(NH3)4]Cl2·H2O and NH4ReO4in alkaline aqueous solution at 190°C (under pressure)

V. I. Zarazhevskii, V. V. Grebnev, E. F. Fesik, G. D. Mal’chikov

Journal:

Russian Journal of General Chemistry

Year:

2008

Language:

english

File:

PDF, 113 KB

english, 2008

70

Reaction of [Pd(NH3)4]Cl2with NH4ReO4in alkaline water solution at 190°C (autoclave process)

V. I. Zarazhevskii, V. V. Grebnev, E. V. Fesik, G. D. Mal’chikov

Journal:

Russian Journal of General Chemistry

Year:

2011

Language:

english

File:

PDF, 150 KB

english, 2011

71

A liquid crystalline medium for measuring residual dipolar couplings over a wide range of temperatures

Hong Wang, Matthias Eberstadt, Edward T. Olejniczak, Robert P. Meadows, Stephen W. Fesik

Journal:

Journal of Biomolecular NMR

Year:

1998

Language:

english

File:

PDF, 52 KB

english, 1998

72

Structure of the N-terminal region of Haemophilus Influenzae HI0017: Implications for function

Liping Yu, Jamey Mack, Phil Hajduk, Stephen W. Fesik

Journal:

Journal of Biomolecular NMR

Year:

2001

Language:

english

File:

PDF, 205 KB

english, 2001

73

One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules

Hajduk, Philip J., Olejniczak, Edward T., Fesik, Stephen W.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 140 KB

english, 1997

74

Rational Design of Diflunisal Analogues with Reduced Affinity for Human Serum Albumin

Mao, Hongyuan, Hajduk, Philip J., Craig, Richard, Bell, Randy, Borre, Tony, Fesik, Stephen W.

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 12 KB

english, 2001

75

Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery

Li, L, Wang, R, Wilcox, D, Zhao, X, Song, J, Lin, X, Kohlbrenner, W M, Fesik, S W, Shen, Y

Journal:

Year:

2012

Language:

english

File:

PDF, 602 KB

english, 2012

76

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Qi Sun, Dr. Jason P. Burke, Prof. Jason Phan, Michael C. Burns, Prof. Edward T. Olejniczak, Prof. Alex G. Waterson, Prof. Taekyu Lee, Prof. Olivia W. Rossanese, Prof. Stephen W. Fesik

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

77

pH Titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands

Liping Yu, Stephen W. Fesik

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

78

A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A

Elaine M. Souza-Fagundes, Andreas O. Frank, Michael D. Feldkamp, Daniel C. Dorset, Walter J. Chazin, Olivia W. Rossanese, Edward T. Olejniczak, Stephen W. Fesik

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 915 KB

english, 2012

79

Structural biology of the Bcl-2 family of proteins

Andrew M. Petros, Edward T. Olejniczak, Stephen W. Fesik

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2004

Language:

english

File:

PDF, 1.63 MB

english, 2004

80

Structure and function of the phosphotyrosine binding (PTB) domain

Ming-Ming Zhou, Stephen W. Fesik

Journal:

Progress in Biophysics and Molecular Biology

Year:

1995

Language:

english

File:

PDF, 932 KB

english, 1995

81

Use of deuterium labeling in NMR: overcoming a sizeable problem

Michael Sattler, Stephen W Fesik

Journal:

Year:

1996

Language:

english

File:

PDF, 720 KB

english, 1996

82

Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

Hajduk, Philip J., Huth, Jeffrey R., Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 322 KB

english, 2005

83

Structural Characterization of the FK506 Binding Protein Unfolded in Urea and Guanidine Hydrochloride

Timothy M. Logan, Yves Thériault, Stephen W. Fesik

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 623 KB

1994

84

Three-dimensional structures of proteins involved in programmed cell death

Heng Liang, Stephen W Fesik

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 1.10 MB

english, 1997

85

Expression, Refolding, and Isotopic Labeling of Human Serum Albumin Domains for NMR Spectroscopy

Hongyuan Mao, Angelo H. Gunasekera, Stephen W. Fesik

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 234 KB

english, 2000

86

Two-dimensional 1H NMR studies of rat atrial natriuretic factor(1–23)

Stephen W. Fesik, William H. Holleman, Thomas J. Perun

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 373 KB

english, 1985

87

Heteronuclear three-dimensional NMR spectroscopy applied to CMP-KDO synthetase (27.5 kD)

Stephen W. Fesik, Robert T. Gampe Jr., Erik R.P. Zuiderweg, William E. Kohlbrenner, Debra Weigl

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 548 KB

english, 1989

88

Efficiency of phosphorylation of the Cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their anti-herpesvirus activity

William E. Kohlbrenner, Carole D. Carter, Stephen W. Fesik, Daniel W. Norbeck, John Erickson

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 494 KB

english, 1990

89

NMR methods for determining the structures of enzyme/inhibitor complexes as an aid in drug design

Stephen W. Fesik, Erik R.P. Zuiderweg, Edward T. Olejniczak, Robert T. Gampe Jr.

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 621 KB

english, 1990

90

NMR studies of [U-13C]cyclosporin A bound to human cyclophilin B

Placido Neri, Gerd Gemmecker, Lynne D. Zydowsky, Christopher T. Walsh, Stephen W. Fesik

Journal:

Year:

1991

Language:

english

File:

PDF, 599 KB

english, 1991

91

1H,13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site

Placido Neri, Robert Meadows, Gerd Gemmecker, Edward Olejniczak, David Nettesheim, Timothy Logan, Robert Simmer, Rosalind Helfrich, Thomas Holzman, Jean Severin, Stephen Fesik

Journal:

Year:

1991

Language:

english

File:

PDF, 695 KB

english, 1991

92

Stereospecific assignments and χ1 rotamers for FKBP when bound to ascomycin from 3JHα,Hβ and 3JN,Hβ coupling constants

Robert X. Xu, Edward T. Olejniczak, Stephen W. Fesik

Journal:

Year:

1992

Language:

english

File:

PDF, 481 KB

english, 1992

93

Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR

Andrew M. Petros, Megumi Kawai, Jay R. Luly, Stephen W. Fesik

Journal:

Year:

1992

Language:

english

File:

PDF, 397 KB

english, 1992

94

Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments

Timothy M. Logan, Edward T. Olejniczak, Robert X. Xu, Stephen W. Fesik

Journal:

Year:

1992

Language:

english

File:

PDF, 563 KB

english, 1992

95

Development of a tightly regulated U6 promoter for shRNA expression

Xiaoyu Lin, Jianguo Yang, Jun Chen, Angelo Gunasekera, Stephen W. Fesik, Yu Shen

Journal:

Year:

2004

Language:

english

File:

PDF, 542 KB

english, 2004

96

Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2

Qiulong Huang, Andrew M. Petros, Herbert W. Virgin, Stephen W. Fesik, Edward T. Olejniczak

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.02 MB

english, 2003

97

Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide

Zhihong Liu, Edward T. Olejniczak, Stephen W. Fesik

Journal:

Protein Expression and Purification

Year:

2004

Language:

english

File:

PDF, 1.74 MB

english, 2004

98

Amide proton exchange rates of a bound pepsin inhibitor determined by isotope-edited proton NMR experiments

Stephen W. Fesik, Jay R. Luly, Herman H. Stein, Nwe BaMaung

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 353 KB

english, 1987

99

Defining the p53 DNA-binding domain/Bcl-xL-binding interface using NMR

Andrew M Petros, Angelo Gunasekera, Nan Xu, Edward T Olejniczak, Stephen W Fesik

Journal:

Year:

2004

Language:

english

File:

PDF, 246 KB

english, 2004

100

Insights into Programmed Cell Death through Structural Biology

Stephen W. Fesik

Journal:

Year:

2000

Language:

english

File:

PDF, 1.14 MB

english, 2000