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51

Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum

Prakash Rao Pendyala, Lawrence Ayong, Jennifer Eatrides, Melissa Schreiber, Connie Pham, Ratna Chakrabarti, David A. Fidock, Charles M. Allen, Debopam Chakrabarti

Journal:

Molecular and Biochemical Parasitology

Year:

2008

Language:

english

File:

PDF, 1010 KB

english, 2008

52

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

Louis J. Nkrumah, Paul M. Riegelhaupt, Pedro Moura, David J. Johnson, Jigar Patel, Karen Hayton, Michael T. Ferdig, Thomas E. Wellems, Myles H. Akabas, David A. Fidock

Journal:

Molecular and Biochemical Parasitology

Year:

2009

Language:

english

File:

PDF, 803 KB

english, 2009

53

Recent highlights in antimalarial drug resistance and chemotherapy research

David A. Fidock, Richard T. Eastman, Stephen A. Ward, Steven R. Meshnick

Journal:

Trends in Parasitology

Year:

2008

Language:

english

File:

PDF, 506 KB

english, 2008

54

Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum

David A Fidock, Takashi Nomura, Roland A Cooper, Xin-zhuan Su, Angela K Talley, Thomas E Wellems

Journal:

Molecular and Biochemical Parasitology

Year:

2000

Language:

english

File:

PDF, 166 KB

english, 2000

55

Disruption of the C-terminal region of EBA-175 in the Dd2/Nm clone of Plasmodium falciparum does not affect erythrocyte invasion

Osamu Kaneko, David A Fidock, Owen M Schwartz, Louis H Miller

Journal:

Molecular and Biochemical Parasitology

Year:

2000

Language:

english

File:

PDF, 469 KB

english, 2000

56

The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome

Tania F. de Koning-Ward, David A. Fidock, Vandana Thathy, Robert Menard, Rosalina M.L. van Spaendonk, Andrew P. Waters, Chris J. Janse

Journal:

Molecular and Biochemical Parasitology

Year:

2000

Language:

english

File:

PDF, 344 KB

english, 2000

57

Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants

Mark Fidock, Michele Miller, Jerry Lanfear

Journal:

Cellular Signalling

Year:

2002

Language:

english

File:

PDF, 374 KB

english, 2002

58

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

Straimer, Judith, Lee, Marcus C S, Lee, Andrew H, Zeitler, Bryan, Williams, April E, Pearl, Jocelynn R, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Llinás, Manuel, Urnov, Fyodor D, Fidock, David A

Journal:

Year:

2012

Language:

english

File:

PDF, 805 KB

english, 2012

59

Cloning and Characterization of the Human and Mouse PDE7B, a Novel cAMP-Specific Cyclic Nucleotide Phosphodiesterase

Clare Gardner, Nicola Robas, Darren Cawkill, Mark Fidock

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 261 KB

english, 2000

60

Discovery of novel inhibitors targeting enoyl–acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening

George Nicola, Colin A. Smith, Edinson Lucumi, Mack R. Kuo, Luchezar Karagyozov, David A. Fidock, James C. Sacchettini, Ruben Abagyan

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 612 KB

english, 2007

61

Taking Charge: Feeding Malaria via Anion Channels

Eric H. Ekland, Myles H. Akabas, David A. Fidock

Journal:

Year:

2011

Language:

english

File:

PDF, 294 KB

english, 2011

62

Advances in understanding the genetic basis of antimalarial drug resistance

Eric H Ekland, David A Fidock

Journal:

Current Opinion in Microbiology

Year:

2007

Language:

english

File:

PDF, 1.01 MB

english, 2007

63

Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

David J. Johnson, David A. Fidock, Mathirut Mungthin, Viswanathan Lakshmanan, Amar Bir Singh Sidhu, Patrick G. Bray, Stephen A. Ward

Journal:

Year:

2004

Language:

english

File:

PDF, 376 KB

english, 2004

64

Anti-inflammatory modulation of chronic airway inflammation in the murine house dust mite model

Kristina Ulrich, Jennifer S. Hincks, Roddy Walsh, E.M. Caroline Wetterstrand, Mark D. Fidock, Sasha Sreckovic, David J. Lamb, Garry J. Douglas, Michael Yeadon, Christelle Perros-Huguet, Steven M. Evan

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 341 KB

english, 2008

65

P. falciparum CG2, Linked to Chloroquine Resistance, Does Not Resemble Na+/H+ Exchangers

Thomas E. Wellems, John C. Wootton, Hisashi Fujioka, Xin-zhuan Su, Roland Cooper, Dror Baruch, David A. Fidock

Journal:

Year:

1998

Language:

english

File:

PDF, 76 KB

english, 1998

66

Loss of malarial susceptibility to artemisinin in Thailand

Anne-Catrin Uhlemann, David A Fidock

Journal:

Year:

2012

Language:

english

File:

PDF, 288 KB

english, 2012

67

868 EVALUATION OF THE IMMUNOSTIMULATORY ACTIONS OF THE TLR7 AGONIST SM-360320 IN EX VIVO ASSAYS IN THE BLOOD OF HCV PATIENTS AND HEALTHY DONORS

S. Barker, H. Perkins, R. Bannister, K. Gore, C. Laxton, D. Hamilton, T. Corey, M. Fidock, M. Westby, T. Parkinson, A. Semper, W. Rosenberg

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

68

Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

David A. Fidock, Takashi Nomura, Angela K. Talley, Roland A. Cooper, Sergey M. Dzekunov, Michael T. Ferdig, Lyann M.B. Ursos, Amar bir Singh Sidhu, Bronwen Naudé, Kirk W. Deitsch, Xin-zhuan Su, John C

Journal:

Year:

2000

Language:

english

File:

PDF, 438 KB

english, 2000

69

Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum

Jane M.R Carlton, David A Fidock, Abdoulaye Djimdé, Christopher V Plowe, Thomas E Wellems

Journal:

Current Opinion in Microbiology

Year:

2001

Language:

english

File:

PDF, 102 KB

english, 2001

70

Genome projects, genetic analysis, and the changing landscape of malaria research

Thomas E Wellems, Xin-zhuan Su, Michael Ferdig, David A Fidock

Journal:

Current Opinion in Microbiology

Year:

1999

Language:

english

File:

PDF, 638 KB

english, 1999

71

Maximizing serendipity: strategies for identifying ligands for orphan G-protein-coupled receptors

Nicola Robas, Mark O’Reilly, Sidath Katugampola, Mark Fidock

Journal:

Current Opinion in Pharmacology

Year:

2003

Language:

english

File:

PDF, 211 KB

english, 2003

72

In Vitro and In Vivo Activity of Solithromycin (CEM-101) against Plasmodium Species

Wittlin, S., Ekland, E., Craft, J. C., Lotharius, J., Bathurst, I., Fidock, D. A., Fernandes, P.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 255 KB

english, 2012

73

Tricks in Plasmodium’s molecular repertoire – Escaping 3′UTR excision-based conditional silencing of the chloroquine resistance transporter gene

Andrea Ecker, Rebecca E. Lewis, Eric H. Ekland, Bamini Jayabalasingham, David A. Fidock

Journal:

International Journal for Parasitology

Year:

2012

Language:

english

File:

PDF, 631 KB

english, 2012

74

Degrees of chloroquine resistance in Plasmodium – Is the redox system involved?

Adele M. Lehane, Christopher A. McDevitt, Kiaran Kirk, David A. Fidock

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Year:

2012

Language:

english

File:

PDF, 383 KB

english, 2012

75

PfCRT and its role in antimalarial drug resistance

Andrea Ecker, Adele M. Lehane, Jérôme Clain, David A. Fidock

Journal:

Trends in Parasitology

Year:

2012

Language:

english

File:

PDF, 791 KB

english, 2012

76

Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria

M Aidoo, A Lalvani, C.E.M Allsopp, M Plebanski, P Krausa, M Browning, F Gotch, K.J.H Robson, A.V.S Hill, S.J Meisner, S Morris Jones, B.M Greenwood, H.C Whittle, D.A Fidock, P Druilhe, M Takiguchi

Journal:

Year:

1995

Language:

english

File:

PDF, 709 KB

english, 1995

77

A candidate molecule for chloroquine resistance in Plasmodium falciparum malaria

T Wellems, X Su, D Fidock, T Nomura, R Cooper, D Baruch, H Fujioka

Journal:

Parasitology International

Year:

1998

Language:

english

File:

PDF, 60 KB

english, 1998

78

How can we identify parasite genes that underlie antimalarial drug resistance?

Anderson, Tim, Nkhoma, Standwell, Ecker, Andrea, Fidock, David

Journal:

Pharmacogenomics

Year:

2011

Language:

english

File:

PDF, 8.99 MB

english, 2011

79

Perspectives: The missing pieces

Crabb, Brendan S., Beeson, James G., Amino, Rogerio, Ménard, Robert, Waters, Andy, Winzeler, Elizabeth A., Wahlgren, Mats, Fidock, David A., Nwaka, Solomon

Journal:

Year:

2012

Language:

english

File:

PDF, 349 KB

english, 2012

80

Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum

McMillan, Paul J., Millet, Coralie, Batinovic, Steven, Maiorca, Mauro, Hanssen, Eric, Kenny, Shannon, Muhle, Rebecca A., Melcher, Martin, Fidock, David A., Smith, Joseph D., Dixon, Matthew W. A., Till

Journal:

Cellular Microbiology

Year:

2013

Language:

english

File:

PDF, 1.67 MB

english, 2013

81

Using Genetic Methods To Define the Targets of Compounds with Antimalarial Activity

Flannery, Erika L., Fidock, David A., Winzeler, Elizabeth A.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 878 KB

english, 2013

82

In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei

Fitzgerald, Jay T, Henrich, Philipp P, O'Brien, Connor, Krause, Michael, Ekland, Eric H, Mattheis, Corinna, Sá, Juliana M, Fidock, David, Khosla, Chaitan

Journal:

The Journal of Antibiotics

Year:

2011

Language:

english

File:

PDF, 200 KB

english, 2011

83

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

Yuan, J., Cheng, K. C.-C., Johnson, R. L., Huang, R., Pattaradilokrat, S., Liu, A., Guha, R., Fidock, D. A., Inglese, J., Wellems, T. E., Austin, C. P., Su, X.-z.

Journal:

Year:

2011

Language:

english

File:

PDF, 553 KB

english, 2011

84

Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay

Lucantoni, L., Duffy, S., Adjalley, S. H., Fidock, D. A., Avery, V. M.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 4.45 MB

english, 2013

85

Expression of recombinant human plasminogen activator inhibitor type-2

Bunn, C.L., Joseph, J.L., Lehrbach, P.R., Bertram, K.C., Byatt, J.A., Fidock, D.A., Golding, J.C., Goss, N.H., Lindner, J.H., Richardson, M., Riley, E.H., Tomkins, S.M., Woodrow, G.C.

Journal:

Fibrinolysis and Proteolysis

Year:

1989

Language:

english

File:

PDF, 164 KB

english, 1989

86

ATP regulates MMP expression and macrophage invasion through a three-dimensional matrix

Yates, Matthew, Fidock, Mark, Bevan, Damon, Gavrilovic, Jelena

Journal:

Atherosclerosis

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

87

Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice

Prestia, Kevin, Bandyopadhyay, Sheila, Slate, Andrea, Francis, Richard O., Francis, Kevin P., Spitalnik, Steven L., Fidock, David A., Brittenham, Gary M., Hod, Eldad A.

Journal:

Transfusion (Elsevier)

Year:

2014

Language:

english

File:

PDF, 694 KB

english, 2014

88

Transformation with Human Dihydrofolate Reductase Renders Malaria Parasites Insensitive to WR99210 but does not Affect the Intrinsic Activity of Proguanil

David A. Fidock and Thomas E. Wellems

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.37 MB

english, 1997

89

Origin of Robustness in Generating Drug-Resistant Malaria Parasites

Kumpornsin, K., Modchang, C., Heinberg, A., Ekland, E. H., Jirawatcharadech, P., Chobson, P., Suwanakitti, N., Chaotheing, S., Wilairat, P., Deitsch, K. W., Kamchonwongpaisan, S., Fidock, D. A., Kirkm

Journal:

Molecular Biology and Evolution

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

90

Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

Moura, P. A., Dame, J. B., Fidock, D. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 1.19 MB

english, 2009

91

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

Hrycyna, Christine A., Summers, Robert L., Lehane, Adele M., Pires, Marcos M., Namanja, Hilda, Bohn, Kelsey, Kuriakose, Jerrin, Ferdig, Michael, Henrich, Philipp P., Fidock, David A., Kirk, Kiaran, Ch

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 950 KB

english, 2014

92

DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparum

Lee, A. H., Symington, L. S., Fidock, D. A.

Journal:

Microbiology and Molecular Biology Reviews

Year:

2014

Language:

english

File:

PDF, 2.83 MB

english, 2014

93

Why Do Users Employ the Same System in So Many Different Ways?

J. Fidock, J. Carroll

Journal:

IEEE Intelligent Systems

Year:

2011

Language:

english

File:

PDF, 2.01 MB

english, 2011

94

Multicolor Bioluminescence Boosts Malaria Research: Quantitative Dual-Color Assay and Single-Cell Imaging in Plasmodium falciparum Parasites

Cevenini, Luca, Camarda, Grazia, Michelini, Elisa, Siciliano, Giulia, Calabretta, Maria Maddalena, Bona, Roberta, Kumar, T. R. Santha, Cara, Andrea, Branchini, Bruce R., Fidock, David A., Roda, Aldo,

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 2.91 MB

english, 2014

95

Evidence for a pfcrt -Associated Chloroquine Efflux System in the Human Malarial Parasite Plasmodium falciparum †

Sanchez, Cecilia P., McLean, Jeremy E., Rohrbach, Petra, Fidock, David A., Stein, Wilfred D., Lanzer, Michael

Journal:

Year:

2005

Language:

english

File:

PDF, 392 KB

english, 2005

96

Chemical genomics identifies compounds affecting Xenopus laevis pigment cell development

Tomlinson, Matthew L., Rejzek, Martin, Fidock, Mark, Field, Robert A., Wheeler, Grant N.

Journal:

Molecular BioSystems

Year:

2009

Language:

english

File:

PDF, 1.94 MB

english, 2009

97

Editing the Plasmodium vivax Genome, Using Zinc-Finger Nucleases

Moraes Barros, R. R., Straimer, J., Sa, J. M., Salzman, R. E., Melendez-Muniz, V. A., Mu, J., Fidock, D. A., Wellems, T. E.

Journal:

The Journal of Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 331 KB

english, 2015

98

CRISPR-mediated genome editing ofPlasmodium falciparummalaria parasites

Marcus CS Lee,David A Fidock

Journal:

Genome Medicine

Year:

2014

Language:

english

File:

PDF, 309 KB

english, 2014

99

Evidence for Different Mechanisms of Chloroquine Resistance in 2 Plasmodium Species That Cause Human Malaria

Nomura, Takashi, Carlton, Jane M‐R., Baird, J. Kevin, del Portillo, Hernando A., Fryauff, David J., Rathore, Dharmendar, Fidock, David A., Su, Xin‐zhuan, Collins, William E., McCutchan, Thomas F., Woo

Journal:

The Journal of Infectious Diseases

Year:

2001

Language:

english

File:

PDF, 536 KB

english, 2001

100

In Vitro Efficacy, Resistance Selection, and Structural Modeling Studies Implicate the Malarial Parasite Apicoplast as the Target of Azithromycin

Sidhu, A. B. S., Sun, Q., Nkrumah, L. J., Dunne, M. W., Sacchettini, J. C., Fidock, D. A.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.02 MB

english, 2007