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51

PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION

Fruman, David A., Snapper, Scott B., Yballe, Claudine M., Mauvais-Jarvis, Franck, Kahn, C. Ronald, Alt, Frederick W., Cantley, Lewis C.

Journal:

Biochemical Society Transactions

Year:

1999

Language:

english

File:

PDF, 140 KB

english, 1999

52

Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling

Walsh, Craig M., Fruman, David A.

Journal:

Journal of Clinical Investigation

Year:

2014

Language:

english

File:

PDF, 224 KB

english, 2014

53

Cancer: A targeted treatment with off-target risks

Fruman, David A., O'Brien, Susan

Journal:

Year:

2017

Language:

english

File:

PDF, 211 KB

english, 2017

54

Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Ueki, Kohjiro, Fruman, David A., Yballe, Claudine M., Fasshauer, Mathias, Klein, Johannes, Asano, Tomoichiro, Cantley, Lewis C., Kahn, C. Ronald

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 46 KB

english, 2017

55

mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL

Vo, Thanh-Trang T, Lee, Jong-Hoon S., Nguyen, Duc, Lui, Brandon, Pandori, William, Khaw, Andrew, Mallya, Sharmila, Lu, Mengrou, Müschen, Markus, Konopleva, Marina, Fruman, David A.

Journal:

Molecular Cancer Therapeutics

Year:

2017

File:

PDF, 1.16 MB

2017

56

The CD11a and Endothelial Protein C Receptor Marker Combination Simplifies and Improves the Purification of Mouse Hematopoietic Stem Cells

Karimzadeh, Alborz, Scarfone, Vanessa M., Varady, Erika, Chao, Connie, Grathwohl, Karin, Fathman, John W., Fruman, David A., Serwold, Thomas, Inlay, Matthew A.

Journal:

Stem Cells Translational Medicine

Year:

2018

Language:

english

File:

PDF, 986 KB

english, 2018

57

Targeting the mevalonate pathway suppresses VHL-deficient CC-RCC through a HIF-dependent mechanism

Thompson, Jordan M., Alvarez, Alejandro, Singha, Monika K., Pavesic, Matthew W., Nguyen, Quy H, Nelson, Luke J., Fruman, David A., Razorenova, Olga V

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 4.85 MB

english, 2018

58

Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1

Mallya, Sharmila, Fitch, Briana A., Lee, J. Scott, So, Lomon, Janes, Matthew R., Fruman, David A., Sobol, Robert W.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.36 MB

english, 2014

59

Effects of Novel Isoform-Selective Phosphoinositide 3-Kinase Inhibitors on Natural Killer Cell Function

Yea, Sung Su, So, Lomon, Mallya, Sharmila, Lee, Jongdae, Rajasekaran, Kamalakannan, Malarkannan, Subramaniam, Fruman, David A., Hirsch, Emilio

Journal:

Year:

2014

Language:

english

File:

PDF, 1.72 MB

english, 2014

60

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

Chiu, Honyin, Mallya, Sharmila, Nguyen, Phuongthao, Mai, Annie, Jackson, Leandra V., Winkler, David G., DiNitto, Jonathan P., Brophy, Erin E., McGovern, Karen, Kutok, Jeffery L., Fruman, David A.

Journal:

Frontiers in Immunology

Year:

2017

Language:

english

File:

PDF, 432 KB

english, 2017

61

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes

Chiu, Honyin, Jackson, Leandra V., Oh, Kwon Ik, Mai, Annie, Ronai, Ze’ev A., Ruggero, Davide, Fruman, David A.

Journal:

The Journal of Immunology

Year:

2018

Language:

english

File:

PDF, 3.31 MB

english, 2018

62

Handbook of Cell Signaling || Phosphoinositide 3-Kinases

Fruman, David A.

Year:

2010

Language:

english

File:

PDF, 643 KB

english, 2010

63

Targeting PI3K-Gamma in Non-Hodgkin Lymphoma

Fruman, David A.

Journal:

Journal of Clinical Oncology

Year:

2019

File:

PDF, 577 KB

2019

64

Targeting PI3K-Gamma in Non-Hodgkin Lymphoma

Fruman, David A.

Journal:

Journal of Clinical Oncology

Year:

2019

Language:

english

File:

PDF, 577 KB

english, 2019

65

Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products

Lu-Kuo, Jennifer M., Fruman, David A., Joyal, David M., Cantley, Lewis C., Katz, Howard R.

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 378 KB

english, 2000

66

MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma

Lee, J. Scott, Tang, Sarah S., Ortiz, Veronica, Vo, Thanh-Trang, Fruman, David A.

Journal:

Year:

2015

Language:

english

File:

PDF, 4.78 MB

english, 2015

67

Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products

Lu-Kuo, Jennifer M., Fruman, David A., Joyal, David M., Cantley, Lewis C., Katz, Howard R.

Journal:

Journal of Biological Chemistry

Year:

2000

File:

PDF, 378 KB

2000

68

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells

Beagle, Brandon R., Nguyen, Duc M., Mallya, Sharmila, Tang, Sarah S., Lu, Mengrou, Zeng, Zhihong, Konopleva, Marina, Vo, Thanh-Trang, Fruman, David A.

Journal:

Year:

2015

Language:

english

File:

PDF, 895 KB

english, 2015

69

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells

Beagle, Brandon R., Nguyen, Duc M., Mallya, Sharmila, Tang, Sarah S., Lu, Mengrou, Zeng, Zhihong, Konopleva, Marina, Vo, Thanh-Trang, Fruman, David A.

Journal:

Year:

2015

File:

PDF, 895 KB

2015

70

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Ishak Gabra, Mari B., Yang, Ying, Li, Haiqing, Senapati, Parijat, Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Zhang, Lishi, Doan, Linda T., Xu, Xiangdong, Schones, Dustin E., Fruman, David A., K

Journal:

Nature Communications

Year:

2020

File:

PDF, 2.09 MB

2020