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51

588 Exome Sequencing of Adenoid Cystic Carcinoma

H. Davies, P.J. Stephens, P. Van Loo, A.K. El-Naggar, P.J. Campbell, M.R. Stratton, P.A. Futreal

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

52

604 Cancer Genomics, Epigenetics and Genomic Instability. Mutational Processes Shaping the Genomes of Twenty-one Breast Cancers

S. Nik-Zainal, L. Alexandrov, D. Wedge, P. Van Loo, K. Raine, D.R. Jones, P.A. Futreal, P.J. Campbell, M.R. Stratton

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 59 KB

english, 2012

53

853 Pharmacogenomic Profiling of Drugs in Cancer Cells Identifies Novel Biomarkers of Sensitivity

M. Garnett, U. McDermott, S. Heidorn, C. Benes, E. Edelman, A. Futreal, S. Ramaswamy, D. Haber, M. Stratton

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

54

Founder BRCA1 and BRCA2 Mutations in French Canadian Breast and Ovarian Cancer Families

Patricia N. Tonin, Anne-Marie Mes-Masson, P. Andrew Futreal, Kenneth Morgan, Michelle Mahon, William D. Foulkes, David E.C. Cole, Diane Provencher, Parviz Ghadirian, Steven A. Narod

Journal:

The American Journal of Human Genetics

Year:

1998

Language:

english

File:

PDF, 439 KB

english, 1998

55

Localization of the Gene for Distal Hereditary Motor Neuronopathy VII (dHMN-VII) to Chromosome 2q14

Meriel McEntagart, Nadine Norton, Hywel Williams, M. Dawn Teare, Melanie Dunstan, Philip Baker, Henry Houlden, Mary Reilly, Nick Wood, Peter S. Harper, P. Andrew Futreal, Nigel Williams, Nazneen Rahma

Journal:

The American Journal of Human Genetics

Year:

2001

Language:

english

File:

PDF, 975 KB

english, 2001

56

Variants in CHEK2 Other than 1100delC Do Not Make a Major Contribution to Breast Cancer Susceptibility

Mieke Schutte, Sheila Seal, Rita Barfoot, Hanne Meijers-Heijboer, Marijke Wasielewski, D. Gareth Evans, Diana Eccles, Carel Meijers, Frans Lohman, Jan Klijn, Ans van den Ouweland, P. Andrew Futreal, K

Journal:

The American Journal of Human Genetics

Year:

2003

Language:

english

File:

PDF, 410 KB

english, 2003

57

203 INVITED Somatic mutations in human cancer: emerging patterns from sequencing the protein kinase gene family and beyond

Journal:

European Journal of Cancer Supplements

Year:

2007

Language:

english

File:

PDF, 46 KB

english, 2007

58

703 POSTER A phase I and pharmacokinetic (PK) study of BIBW 2992, an oral irreversible dual EGFR/HER2 inhibitor

R. Plummer, L. Vidal, R. Perrett, J. Spicer, P. Stopfer, M. Shahidi, G. Temple, A. Futreal, H. Calvert, J. de Bono

Journal:

European Journal of Cancer Supplements

Year:

2007

Language:

english

File:

PDF, 64 KB

english, 2007

59

Breast cancer genome heterogeneity: a challenge to personalised medicine?

Charles Swanton, Rebecca A Burrell, P Andrew Futreal

Journal:

Breast Cancer Research

Year:

2011

Language:

english

File:

PDF, 119 KB

english, 2011

60

Human non-small cell lung cancer (NSCLC) cell lines with inactivated LKB1 and KRAS mutations are sensitive to MEK inhibition

C. Mahoney, B. Choudhury, H. Davies, G. Bignell, M. Stratton, A. Futreal

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 97 KB

english, 2008

61

Screening 101 renal cancers for somatic mutations in 3,726 genes

G.L. Dalgliesh, P.A. Futreal, M.R. Stratton

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

62

FAT tumour suppressor gene is mutated by both homozygous deletion and point mutation in a variety of different cancer types

H. Davies, G. Bignell, M.R. Stratton, P.A. Futreal

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

63

386 POSTER Pharmacokinetic (PK) and pharmacodynamic (PD) phase I study of an oral c-Met inhibitor ARQ197 reaches maximum tolerated dose (MTD) in a twice daily (bid) dosing schedule

T.A. Yap, J. Barriuso, S. Frentzas, R. Riisnaes, J. Clark, J. Dukes, A. Futreal, R.E. Savage, F. Chai, J.S. de Bono

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 62 KB

english, 2008

64

45 Use of somatically acquired genomic rearrangements as biomarkers in solid tumours

D.J. McBride, A. Orpana, C. Sotiriou, H. Joensuu, P.J. Stephens, E. Hamalainen, L.A. Stebbings, P.A. Futreal, M.R. Stratton, P.J. Campbell

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

65

792 The cancer cell line project – systematic resequencing of known cancer genes in over 750 cancer cell lines

H. Davies, G. Bignell, M. Stratton, A. Futreal

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

66

Disease-associated XMRV sequences are consistent with laboratory contamination

Stéphane Hué, Eleanor R Gray, Astrid Gall, Aris Katzourakis, Choon Ping Tan, Charlotte J Houldcroft, Stuart McLaren, Deenan Pillay, Andrew Futreal, Jeremy A Garson, Oliver G Pybus, Paul Kellam, Greg J

Journal:

Year:

2010

Language:

english

File:

PDF, 525 KB

english, 2010

67

The somatic genetic architecture of human cancer: heterogeneity and the challenges for translational medicine

Journal:

Journal of Translational Medicine

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

68

The continuing search for cancer-causing somatic mutations

Gillian L Dalgliesh, P Andrew Futreal

Journal:

Breast Cancer Research

Year:

2007

Language:

english

File:

PDF, 39 KB

english, 2007

69

JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

Scott, Linda M., Tong, Wei, Levine, Ross L., Scott, Mike A., Beer, Philip A., Stratton, Michael R., Futreal, P. Andrew, Erber, Wendy N., McMullin, Mary Frances, Harrison, Claire N., Warren, Alan J., G

Journal:

Boston Medical and Surgical Journal

Year:

2007

Language:

english

File:

PDF, 743 KB

english, 2007

70

Emerging patterns of somatic mutations in cancer

Watson, Ian R., Takahashi, Koichi, Futreal, P. Andrew, Chin, Lynda

Journal:

Nature Reviews Genetics

Year:

2013

Language:

english

File:

PDF, 951 KB

english, 2013

71

c-kit gene mutations in adenoid cystic carcinoma are rare

Moskaluk, Christopher A, Frierson, Henry F, El-Naggar, Adel K, Futreal, P Andrew

Journal:

Modern Pathology

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

72

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer

Kahlert, Christoph, Melo, Sonia A., Protopopov, Alexei, Tang, Jiabin, Seth, Sahil, Koch, Moritz, Zhang, Jianhua, Weitz, Juergen, Chin, Lynda, Futreal, Andrew, Kalluri, Raghu

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 8.10 MB

english, 2014

73

234 Intratumoural Heterogeneity: Roots, Trunks and Branches

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

74

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

Bamford, S, Dawson, E, Forbes, S, Clements, J, Pettett, R, Dogan, A, Flanagan, A, Teague, J, Futreal, P A, Stratton, M R, Wooster, R

Journal:

British Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 107 KB

english, 2004

75

PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data

Greenman, C. D., Bignell, G., Butler, A., Edkins, S., Hinton, J., Beare, D., Swamy, S., Santarius, T., Chen, L., Widaa, S., Futreal, P. A., Stratton, M. R.

Journal:

Year:

2010

Language:

english

File:

PDF, 536 KB

english, 2010

76

BRCA1 mutations in primary breast and ovarian carcinomas

Futreal, P., Liu, Q, Shattuck-Eidens, D, Cochran, C, Harshman, K, Tavtigian, S, Bennett, L., Haugen-Strano, A, Swensen, J, Miki, Y, et, al.

Journal:

Year:

1994

Language:

english

File:

PDF, 996 KB

english, 1994

77

Loss of the Mismatch Repair Protein MSH6 in Human Glioblastomas Is Associated with Tumor Progression during Temozolomide Treatment

Cahill, D. P., Levine, K. K., Betensky, R. A., Codd, P. J., Romany, C. A., Reavie, L. B., Batchelor, T. T., Futreal, P. A., Stratton, M. R., Curry, W. T., Iafrate, A. J., Louis, D. N.

Journal:

Clinical Cancer Research

Year:

2007

Language:

english

File:

PDF, 309 KB

english, 2007

78

Phase I Trial of the Irreversible EGFR and HER2 Kinase Inhibitor BIBW 2992 in Patients With Advanced Solid Tumors

Yap, T. A., Vidal, L., Adam, J., Stephens, P., Spicer, J., Shaw, H., Ang, J., Temple, G., Bell, S., Shahidi, M., Uttenreuther-Fischer, M., Stopfer, P., Futreal, A., Calvert, H., de Bono, J. S., Plumme

Journal:

Journal of Clinical Oncology

Year:

2010

Language:

english

File:

PDF, 345 KB

english, 2010

79

The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene

Schwartz, C. E, Tarpey, P. S, Lubs, H. A, Verloes, A., May, M. M, Risheg, H., Friez, M. J, Futreal, P A., Edkins, S., Teague, J., Briault, S., Skinner, C., Bauer-Carlin, A., Simensen, R. J, Joseph, S.

Journal:

Journal of Medical Genetics

Year:

2007

Language:

english

File:

PDF, 337 KB

english, 2007

80

Estimation of rearrangement phylogeny for cancer genomes

Greenman, C. D., Pleasance, E. D., Newman, S., Yang, F., Fu, B., Nik-Zainal, S., Jones, D., Lau, K. W., Carter, N., Edwards, P. A. W., Futreal, P. A., Stratton, M. R., Campbell, P. J.

Journal:

Genome Research

Year:

2012

Language:

english

File:

PDF, 1.47 MB

english, 2012

81

167 Genomic characterisation of 1003 cancer cell-lines

Bignall, G., Iorio, F., Futreal, P.A., Stratton, M.R., Campbell, P., McDermott, U.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 55 KB

english, 2014

82

Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma

Huang, D., Ding, Y., Zhou, M., Rini, B. I., Petillo, D., Qian, C.-N., Kahnoski, R., Futreal, P. A., Furge, K. A., Teh, B. T.

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 575 KB

english, 2010

83

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

Forbes, S. A., Tang, G., Bindal, N., Bamford, S., Dawson, E., Cole, C., Kok, C. Y., Jia, M., Ewing, R., Menzies, A., Teague, J. W., Stratton, M. R., Futreal, P. A.

Journal:

Nucleic Acids Research

Year:

2010

Language:

english

File:

PDF, 6.31 MB

english, 2010

84

Pre-Counseling Education Materials for BRCA Testing: Does Tailoring Make a Difference?

Skinner, Celette Sugg, Schildkraut, Joellen M., Berry, Donald, Calingaert, Brian, Marcom, P. Kelly, Sugarman, Jeremy, Winer, Eric P., Iglehart, J. Dirk, Futreal, P. Andrew, Rimer, Barbara K.

Journal:

Genetic Testing

Year:

2002

Language:

english

File:

PDF, 197 KB

english, 2002

85

Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers

Norris, J., Fan, D., Aleman, C., Marks, J. R., Futreal, P. A., Wiseman, R. W., Iglehart, J. D., Deininger, P. L., McDonnell, D. P.

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 613 KB

english, 1995

86

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

Khaled, Walid T., Choon Lee, Song, Stingl, John, Chen, Xiongfeng, Raza Ali, H., Rueda, Oscar M., Hadi, Fazal, Wang, Juexuan, Yu, Yong, Chin, Suet-Feung, Stratton, Mike, Futreal, Andy, Jenkins, Nancy A

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.83 MB

english, 2015

87

LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition

Mahoney, C L, Choudhury, B, Davies, H, Edkins, S, Greenman, C, Haaften, G van, Mironenko, T, Santarius, T, Stevens, C, Stratton, M R, Futreal, P A

Journal:

British Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 187 KB

english, 2009

88

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Forbes, S. A., Bindal, N., Bamford, S., Cole, C., Kok, C. Y., Beare, D., Jia, M., Shepherd, R., Leung, K., Menzies, A., Teague, J. W., Campbell, P. J., Stratton, M. R., Futreal, P. A.

Journal:

Nucleic Acids Research

Year:

2011

Language:

english

File:

PDF, 5.41 MB

english, 2011

89

A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

Neuhausen, S.L., Swensen, J., Miki, Y., Llu, Q., Tavtiglan, S., Shattuck-Eidens, D., Kamb, A., Hobbs, M.R., Gingrich, J., Shizuya, H., Kim, U.-J., Cochran, C., Futreal, P.A., Wiseman, R.W., Lynch, H.T

Journal:

Human Molecular Genetics

Year:

1994

Language:

english

File:

PDF, 2.35 MB

english, 1994

90

Novel Chromosomal Rearrangements and Break Points at the t(6;9) in Salivary Adenoid Cystic Carcinoma: Association with MYB-NFIB Chimeric Fusion, MYB Expression, and Clinical Outcome

Mitani, Y., Rao, P. H., Futreal, P. A., Roberts, D. B., Stephens, P. J., Zhao, Y.-J., Zhang, L., Mitani, M., Weber, R. S., Lippman, S. M., Caulin, C., El-Naggar, A. K.

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

91

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

Campbell, P. J., Pleasance, E. D., Stephens, P. J., Dicks, E., Rance, R., Goodhead, I., Follows, G. A., Green, A. R., Futreal, P. A., Stratton, M. R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008

92

Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Zang, Z. J., Ong, C. K., Cutcutache, I., Yu, W., Zhang, S. L., Huang, D., Ler, L. D., Dykema, K., Gan, A., Tao, J., Lim, S., Liu, Y., Futreal, P. A., Grabsch, H., Furge, K. A., Goh, L. K., Rozen, S.,

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.86 MB

english, 2011

93

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

Yang, W., Soares, J., Greninger, P., Edelman, E. J., Lightfoot, H., Forbes, S., Bindal, N., Beare, D., Smith, J. A., Thompson, I. R., Ramaswamy, S., Futreal, P. A., Haber, D. A., Stratton, M. R., Bene

Journal:

Nucleic Acids Research

Year:

2013

Language:

english

File:

PDF, 4.05 MB

english, 2013

94

In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation

Ikediobi, O. N., Reimers, M., Durinck, S., Blower, P. E., Futreal, A. P., Stratton, M. R., Weinstein, J. N.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 355 KB

english, 2008

95

Chromosomal Instability Confers Intrinsic Multidrug Resistance

Lee, A. J. X., Endesfelder, D., Rowan, A. J., Walther, A., Birkbak, N. J., Futreal, P. A., Downward, J., Szallasi, Z., Tomlinson, I. P. M., Howell, M., Kschischo, M., Swanton, C.

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

96

Intratumor Heterogeneity: Seeing the Wood for the Trees

Yap, T. A., Gerlinger, M., Futreal, P. A., Pusztai, L., Swanton, C.

Journal:

Science Translational Medicine

Year:

2012

Language:

english

File:

PDF, 445 KB

english, 2012

97

A survey of homozygous deletions in human cancer genomes

Cox, C., Bignell, G., Greenman, C., Stabenau, A., Warren, W., Stephens, P., Davies, H., Watt, S., Teague, J., Edkins, S., Birney, E., Easton, D. F., Wooster, R., Futreal, P. A., Stratton, M. R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

98

Phase I Trial of a Selective c-MET Inhibitor ARQ 197 Incorporating Proof of Mechanism Pharmacodynamic Studies

Yap, T. A., Olmos, D., Brunetto, A. T., Tunariu, N., Barriuso, J., Riisnaes, R., Pope, L., Clark, J., Futreal, A., Germuska, M., Collins, D., deSouza, N. M., Leach, M. O., Savage, R. E., Waghorne, C.,

Journal:

Journal of Clinical Oncology

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

99

A Multicenter Study of Cancer Incidence in CHEK2 1100delC Mutation Carriers

Thompson, D., Seal, S., Schutte, M., McGuffog, L., Barfoot, R., Renwick, A., Eeles, R., Sodha, N., Houlston, R., Shanley, S., Klijn, J., Wasielewski, M., Chang-Claude, J., Futreal, P. A., Weber, B. L.

Journal:

Cancer Epidemiology Biomarkers & Prevention

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

100

Pharmacogenomics of Non-Small Cell Lung Cancer

Spicer, James, Futreal, Andrew, De Bono, Johann

Journal:

Current Pharmacogenomics

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007