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1

Multiparametric characterization by flow cytometry of flow-sorted subpopulations of a human hepatoma cell line useful for drug research

José-Enrique O'Connor, Alicia Martínez, José V. Castell, María-José Gómez-Lechón

Journal:

Cytometry Part A

Year:

2005

Language:

english

File:

PDF, 469 KB

english, 2005

2

Inhibition of human P450 enzymes by natural extracts used in traditional medicine

Idania Rodeiro, María T. Donato, Nuria Jimenez, Gabino Garrido, Jorge Molina-Torres, Roberto Menendez, José V. Castell, María J. Gómez-Lechón

Journal:

Phytotherapy Research

Year:

2009

Language:

english

File:

PDF, 236 KB

english, 2009

3

Measurement of intracellular LDH activity in 96-well cultures: A rapid and automated assay for cytotoxicity studies

Xavier Ponsoda, Ramiro Jover, José Vicente Castell, María José Gómez-Lechón

Journal:

Methods in Cell Science

Year:

1991

Language:

english

File:

PDF, 409 KB

english, 1991

4

Influence of branched-chain amino acid composition of culture media on the synthesis of plasma proteins by serum-free cultured rat hepatocytes

Angel Montoya, Maria J. Gómez-Lechón, Jose V. Castell

Journal:

In Vitro Cellular & Developmental Biology - Plant

Year:

1989

Language:

english

File:

PDF, 630 KB

english, 1989

5

Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies

Castell, José V, Jover, Ramiro, Martínez-Jiménez, Celia P, Gómez-Lechón, María José

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2006

Language:

english

File:

PDF, 476 KB

english, 2006

6

Clinical Application of Pluripotent Stem Cells

Tolosa, Laia, Pareja, Eugenia, Gómez-Lechón, Maria José

Journal:

Transplantation Journal

Year:

2016

Language:

english

File:

PDF, 350 KB

english, 2016

7

Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Caron, Jérôme, Péne, Véronique, Tolosa, L., Villaret, M., Luce, E., Fourrier, Angélique, Sami, S., Bruckert, E., Gómez-Lechón, María José, Nguyen, T.H., Rosenberg, A.R., Weber, A., Dubart-Kupperschmit

Journal:

Journal of Hepatology

Year:

2018

Language:

english

File:

PDF, 52 KB

english, 2018

8

Cytotoxic and Apoptotic Effects on Hepatocytes of Secondary Metabolites Obtained from Lichens

Correché, Estela Raquel, Enriz, Ricardo Daniel, Piovano, Marisa, Garbarino, Juan, Gómez-Lechón, María José

Journal:

Alternatives to laboratory animals : ATLA

Year:

2004

Language:

english

File:

PDF, 112 KB

english, 2004

9

Human Hepatic Cell Cultures: In Vitro and In Vivo Drug Metabolism

Gómez-Lechón, María José, Donato, Teresa, Ponsoda, Xavier, Castell, José V.

Journal:

Alternatives to laboratory animals : ATLA

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

10

Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix

Maria José Gómez-Lechón, Ramiro Jover, Teresa Donato, Xavier Ponsoda, Cristina Rodriguez, Karsten G. Stenzel, Rainer Klocke, Dieter Paul, Isabel Guillén, Roque Bort, José V. Castell

Journal:

Journal of Cellular Physiology

Year:

1998

Language:

english

File:

PDF, 311 KB

english, 1998

11

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

José V. Castell, Maria José Gómez-lechón, Martina David, Ricardo Fabra, Ramón Trullenque, Prof. Dr. Peter C. Heinrich

Journal:

Year:

1990

Language:

english

File:

PDF, 881 KB

english, 1990

12

Effects of hepatocyte growth factor on the growth and metabolism of human hepatocytes in primary culture

María José Gómez-Lechón, José Castelli, Isabel Guillén, Enrique o'Connor, Toshikazu Nakamura, Ricardo Fabra, Ramón Trullenque

Journal:

Year:

1995

Language:

english

File:

PDF, 836 KB

english, 1995

13

Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs

Xavier Ponsoda, Ramiro Jover, María José Gómez-Lechón, Ricardo Fabra, Ramón Trullenque, JoséV. Castell

Journal:

Year:

1991

Language:

english

File:

PDF, 594 KB

english, 1991

14

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2

María J. Gómez-Lechón, Teresa Donato, Ramiro Jover, Cristina Rodriguez, Xavier Ponsoda, Denize Glaise, José V. Castell, Christiane Guguen-Guillouzo

Journal:

Year:

2001

Language:

english

File:

PDF, 1.32 MB

english, 2001

15

A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations

Agustín Lahoz, Maria Teresa Donato, Sandra Montero, José V. Castell, Maria José Gómez-Lechón

Journal:

Rapid Communications in Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 144 KB

english, 2008

16

Effect of dexamethasone on the isozyme pattern of adult rat liver parenchymal cells in primary cultures

Juan Emilio Felíu, Julio Coloma, María-José Gómez-Lechón, María Dolores García, José Báguena

Journal:

Molecular and Cellular Biochemistry

Year:

1982

Language:

english

File:

PDF, 780 KB

english, 1982

17

Characteristics of arachidonic acid metabolism of human endothelial cells in culture

Vincenta Martinez-Sales, Maria José Gomez-Lechón, Juan Gilabert

Journal:

Year:

1990

Language:

english

File:

PDF, 1.04 MB

english, 1990

18

Diclofenac sodium and cyclosporin A inhibit human lens epithelial cell proliferation in culture

Pedro Cortina, Maria José Gómez-Lechón, Amparo Navea, José Luis Menezo, Maria Carmen Terencio, Manuel Diaz-Llopis

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

1997

Language:

english

File:

PDF, 613 KB

english, 1997

19

Photobinding of Tiaprofenic Acid and Suprofen to Proteins and Cells: A Combined Study Using Radiolabeling, Antibodies and Laser Flash Photolysis of Model Bichromophores

José V. Castell, Daniel Hernández, María José Gómez-Lechón, Agustín Lahoz, Miguel A. Miranda, Isabel M. Morera, Julia Perez-Prieto, Zaideth Sarabia

Journal:

Photochemistry and Photobiology

Year:

1998

Language:

english

File:

PDF, 918 KB

english, 1998

20

Chronic Ethanol Consumption Enhances Interleukin-1-Mediated Signal Transduction in Rat Liver and in Cultured Hepatocytes

Soraya L. Valles, Ana M. Blanco, Inmaculada Azorin, Rosa Guasch, María Pascual, María Jose Gomez-Lechon, Jaime Renau-Piqueras, Consuelo Guerri

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2003

Language:

english

File:

PDF, 2.32 MB

english, 2003

21

Diagnosis of malignant ascites

Martín Prieto, María José Gómez-Lechón, Melchor Hoyos, Jose V. Castell, Domingo Carrasco, Joaquín Berenguer

Journal:

Digestive Diseases and Sciences

Year:

1988

Language:

english

File:

PDF, 483 KB

english, 1988

22

A human hepatocellular in vitro model to investigate steatosis

María José Gómez-Lechón, María Teresa Donato, Alicia Martínez-Romero, Nuria Jiménez, José Vicente Castell, José-Enrique O’Connor

Journal:

Chemico-Biological Interactions

Year:

2007

Language:

english

File:

PDF, 595 KB

english, 2007

23

Hepatocytes—the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo

María José Gómez-Lechón, José Vicente Castell, María Teresa Donato

Journal:

Chemico-Biological Interactions

Year:

2007

Language:

english

File:

PDF, 1.17 MB

english, 2007

24

Activities of Spanish network for alternatives (REMA) in promoting animal alternatives

Argelia Castaño, Jose V. Castell, María J. Gomez-Lechon, Francisco Ferrandiz, Adela Lopez de Cerain, Eduardo De la Peña, Pilar Prieto, Guillermo Repetto, Joan A. Vericat, Eugenio Vilanova

Journal:

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Year:

2009

Language:

english

File:

PDF, 69 KB

english, 2009

25

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach

José V. Castell, M. Teresa Donato, María José Gómez-Lechón

Journal:

Experimental and Toxicologic Pathology

Year:

2005

Language:

english

File:

PDF, 343 KB

english, 2005

26

Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction

Albert P. Li, Patrick Maurel, Maria Jose Gomez-Lechon, Larry C. Cheng, Malle Jurima-Romet

Journal:

Chemico-Biological Interactions

Year:

1997

Language:

english

File:

PDF, 913 KB

english, 1997

27

INVOLVEMENT OF DRUG-DERIVED PEROXIDES IN THE PHOTOTOXICITY OF NAPROXEN and TIAPROFENIC ACID

Jose V. Castell, Maria J. Gomez-Lechon, Carmina Grassa, Luis A. Martinez, Miguel A. Miranda, Pilar Tarrega

Journal:

Photochemistry and Photobiology

Year:

1993

Language:

english

File:

PDF, 666 KB

english, 1993

28

PHOTODYNAMIC LIPID PEROXIDATION BY THE PHOTOSENSITIZING NONSTEROIDAL ANTIINFLAMMATORY DRUGS SUPROFEN AND TIAPROFENIC ACID

Jose V. Castell, Maria J. Gomez-Lechon, Carmina Grassa, Luis A. Martinez, Miguel A. Miranda, Pilar Tarrega

Journal:

Photochemistry and Photobiology

Year:

1994

Language:

english

File:

PDF, 509 KB

english, 1994

29

MOLECULAR BASIS OF DRUG PHOTOTOXICITY: PHOTOSENSITIZED CELL DAMAGE BY THE MAJOR PHOTOPRODUCT OF TIAPROFENIC ACID

Jose V. Castell, Maria J. Gomez-Lechon, Daniel Hernandez, Luis A. Martinez, Miguel A. Miranda

Journal:

Photochemistry and Photobiology

Year:

1994

Language:

english

File:

PDF, 464 KB

english, 1994

30

Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

Cristina Rodrı&amp, #x0301, guez-Antona, Ramiro Jover, Maria-José Gómez-Lechón, José V. Castell

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 287 KB

english, 2000

31

Cytochrome P-450 mRNA Expression in Human Liver and Its Relationship with Enzyme Activity

Cristina Rodrı&amp, #x0301, guez-Antona, M.Teresa Donato, Eugenia Pareja, Maria-José Gómez-Lechón, José V. Castell

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 110 KB

english, 2001

32

Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

José V. Castell, Maria J. Gómez-Lechón, Martina David, Toshio Hirano, Tadamitsu Kishimoto, Peter C. Heinrich

Journal:

Year:

1988

Language:

english

File:

PDF, 705 KB

english, 1988

33

Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

José V. Castell, Maria J. Gómez-Lechón, Martina David, Tilo Andus, Thomas Geiger, Ramón Trullenque, Ricardo Fabra, Peter C. Heinrich

Journal:

Year:

1989

Language:

english

File:

PDF, 315 KB

english, 1989

34

Overexpression of SND p102, a rat homologue of p100 coactivator, promotes the secretion of lipoprotein phospholipids in primary hepatocytes

Lourdes Palacios, Begoña Ochoa, María José Gómez-Lechón, José Vicente Castell, Olatz Fresnedo

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2006

Language:

english

File:

PDF, 417 KB

english, 2006

35

Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2

Csaba Somlai, Estela Correche, Monica Olivella, Laia Tolosa, Maria José Gomez Lechon, György Dombi, Gábor K. Tóth, Botond Penke, Ricardo D. Enriz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 729 KB

english, 2012

36

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project

María José Gómez-Lechón, Laia Tolosa, José V. Castell, María Teresa Donato

Journal:

Toxicology in Vitro

Year:

2010

Language:

english

File:

PDF, 284 KB

english, 2010

37

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

Fred Schaper, Elmar Siewert, Maria José Gómez-Lechón, Petros Gatsios, Martin Sachs, Walter Birchmeier, Peter C Heinrich, José Castell

Journal:

Year:

1997

Language:

english

File:

PDF, 543 KB

english, 1997

38

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

Gabriela Pérez, Beatriz Tabares, Ramiro Jover, Maria-José Gómez-Lechón, José V. Castell

Journal:

Toxicology in Vitro

Year:

2003

Language:

english

File:

PDF, 350 KB

english, 2003

39

Modulation of biotransformation and elimination systems by BM-21, an aqueous ethanolic extract from Thalassia testudinum, and thalassiolin B on human hepatocytes

Idania Rodeiro, Maria José Gómez-Lechón, Laia Tolosa, Gabriela Perez, Ivones Hernandez, Roberto Menendez, Erick Luis Regalado, José Vicente Castell, Maria Teresa Donato

Journal:

Journal of Functional Foods

Year:

2012

Language:

english

File:

PDF, 431 KB

english, 2012

40

Optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity: Progress of the “A-Cute-Tox” project

Agnieszka Kinsner-Ovaskainen, Cecilia Clemedson, Thomas Cole, Richard Clothier, Sandra Coecke, José-Enrique O’Connor, Bas Blaauboer, Maria-José Gómez-Lechón, Joan-Albert Vericat, Anna Forsby, Michael

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 70 KB

english, 2007

41

Células madre del tejido adiposo: plasticidad hepática

Ana Bonora-Centelles, José Vicente Castell, María José Gómez-Lechón

Journal:

Gastroenterología y Hepatología

Year:

2008

File:

PDF, 173 KB

2008

42

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

Hewitt, Nicola J., Gómez Lechón, María José, Houston, J. Brian, Hallifax, David, Brown, Hayley S., Maurel, Patrick, Kenna, J. Gerald, Gustavsson, Lena, Lohmann, Christina, Skonberg, Christian, Guillou

Journal:

Drug Metabolism Reviews

Year:

2007

Language:

english

File:

PDF, 1.35 MB

english, 2007

43

In Vitro Methods in Pharmaceutical Research || Isolation, Culture and Use of Human Hepatocytes in Drug Research

Gómez-Lechón, María José

Year:

1996

Language:

english

File:

PDF, 3.20 MB

english, 1996

44

RENAL TUBERCULOSIS.

Cortina, Pedro, Jose Gomez-Lechon, Maria, Navea, Amparo, Menezo, Jose Luis

Journal:

Year:

1926

Language:

english

File:

PDF, 357 KB

english, 1926

45

In Vitro Test of Intraocular Lens Biocompatibility

Cortina, Pedro, Jose Gomez-Lechon, Maria, Navea, Amparo, Menezo, Jose Luis

Journal:

Journal of Cataract & Refractive Surgery

Year:

1995

Language:

english

File:

PDF, 270 KB

english, 1995

46

Influence of Branched-Chain Amino Acid Composition of Culture Media on the Synthesis of Plasma Proteins by Serum-Free Cultured Rat Hepatocytes

Angel Montoya, Maria J. Gómez-Lechón and Jose V. Castell

Journal:

In Vitro Cellular & Developmental Biology

Year:

1989

Language:

english

File:

PDF, 1.27 MB

english, 1989

47

Drug-Photosensitized Protein Modification: Identification of the Reactive Sites and Elucidation of the Reaction Mechanisms with Tiaprofenic Acid/Albumin as Model System †

Miranda, Miguel A., Castell, José V., Hernández, Daniel, Gómez-Lechón, María J., Bosca, Francisco, Morera, Isabel M., Sarabia, Zaideth

Journal:

Chemical Research in Toxicology

Year:

1998

Language:

english

File:

PDF, 119 KB

english, 1998

48

An update on metabolism studies using human hepatocytes in primary culture

Gómez-Lechón, María José, Castell, José V, Donato, María Teresa

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2008

Language:

english

File:

PDF, 440 KB

english, 2008

49

Effect of Glucocorticoids on the Expression of γ-Glutamyltransferase and Tyrosine Aminotransferase in Serum-Free-Cultured Hepatocytes

GÓMEZ-LECHÓN, María José, GARCÍA, María Dolores, CASTELL, José Vicente

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1983

Language:

english

File:

PDF, 907 KB

english, 1983

50

Measurement of Fibronectin in Human Body Fluids

Gómez-Lechón, Maria José, Castell, J. V.

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

1986

Language:

english

File:

PDF, 2.03 MB

english, 1986

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