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51

Diverse fibrillar peptides directly bind the Alzheimer’s amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

Anthony R White, Fran Maher, Marcus W Brazier, Michael F Jobling, James Thyer, Leanne R Stewart, Andrew Thompson, Riki Gibson, Colin L Masters, Gerd Multhaup, Konrad Beyreuther, Colin J Barrow, Steven

Journal:

Year:

2003

Language:

english

File:

PDF, 1009 KB

english, 2003

52

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

Anthony R White, Rosario Reyes, Julian F.B Mercer, James Camakaris, Hui Zheng, Ashley I Bush, Gerd Multhaup, Konrad Beyreuther, Colin L Masters, Roberto Cappai

Journal:

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

53

Possible mechanisms of APP-mediated oxidative stress in Alzheimer’s disease

Gerd Multhaup, Stefan Scheuermann, Andrea Schlicksupp, Andreas Simons, Markus Strauss, André Kemmling, Christian Oehler, Roberto Cappai, Rüdiger Pipkorn, Thomas A Bayer

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 170 KB

english, 2002

54

Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie

James HOPE, Gerd MULTHAUP, Laura J. D. REEKIE, Richard H. KIMBERLIN, Konrad BEYREUTHER

Journal:

Year:

1988

Language:

english

File:

PDF, 1.07 MB

english, 1988

55

Human Amyloid Precursor-Like Protein 1 : cDNA Cloning, Ectopic Expression in COS-7 Cells and Identification of Soluble Forms in the Cerebrospinal Fluid

Krzysztof Paliga, Gisela Peraus, Sylvia Kreger, Ulrike Dürrwang, Lars Hesse, Gerd Multhaup, Colin L. Masters, Konrad Beyreuther, Andreas Weidemann

Journal:

Year:

1997

Language:

english

File:

PDF, 3.30 MB

english, 1997

56

Suppression of Amyloid A11 Antibody Immunoreactivity by Vitamin C: POSSIBLE ROLE OF HEPARAN SULFATE OLIGOSACCHARIDES DERIVED FROM GLYPICAN-1 BY ASCORBATE-INDUCED, NITRIC OXIDE (NO)-CATALYZED DEGRADATION

Cheng, F., Cappai, R., Ciccotosto, G. D., Svensson, G., Multhaup, G., Fransson, L.-A., Mani, K.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 5.45 MB

english, 2011

57

The Metalloprotease Meprin Generates Amino Terminal-truncated Amyloid Peptide Species

Bien, J., Jefferson, T., Causevic, M., Jumpertz, T., Munter, L., Multhaup, G., Weggen, S., Becker-Pauly, C., Pietrzik, C. U.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

58

Interaction of the CopZ Copper Chaperone with the CopA Copper ATPase of Enterococcus hirae Assessed by Surface Plasmon Resonance

Gerd Multhaup, Daniel Strausak, Karl-Dimiter Bissig, Marc Solioz

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 83 KB

english, 2001

59

Chelation and Intercalation: Complementary Properties in a Compound for the Treatment of Alzheimer's Disease

Robert A. Cherny, Kevin J. Barnham, Toni Lynch, Irene Volitakis, Qiao-Xin Li, Catriona A. McLean, Gerd Multhaup, Konrad Beyreuther, Rudolph E. Tanzi, Colin L. Masters, Ashley I. Bush

Journal:

Journal of Structural Biology

Year:

2000

Language:

english

File:

PDF, 106 KB

english, 2000

60

Conservation of the acetylation pattern of histones and the transcriptional activity in Ehrlich ascites tumor cells by sodium butyrate

Irmgard Multhaup, Adam Csordas, Hans Grunicke, Rudolf Pfister, Bernd Puschendorf

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 576 KB

english, 1983

61

Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

Walter Schubert, Reinhard Prior, Andreas Weidemann, Heinrich Dircksen, Gerd Multhaup, Colin L. Masters, Konrad Beyreuther

Journal:

Year:

1991

Language:

english

File:

PDF, 1.38 MB

english, 1991

62

The βA4 amyloid precursor protein binding to copper

Lars Hesse, Dirk Beher, Colin L. Masters, Gerd Multhaup

Journal:

Year:

1994

Language:

english

File:

PDF, 743 KB

english, 1994

63

Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP)

Gerd Multhaup, Ashley I. Bush, Peter Pollwein, Colin L. Masters

Journal:

Year:

1994

Language:

english

File:

PDF, 325 KB

english, 1994

64

Detection of the 47-kilodalton membrane immunogen gene of Treponema pallidum in various tissue sources of patients with syphilis

Alexander Vasilevich Kouznetsov, Peter Weisenseel, Paul Trommler, Susanne Multhaup, Joerg Christoph Prinz

Journal:

Diagnostic Microbiology and Infectious Disease

Year:

2005

Language:

english

File:

PDF, 86 KB

english, 2005

65

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

Sven O. Dahms, Ina Könnig, Dirk Roeser, Karl-Heinz Gührs, Magnus C. Mayer, Daniela Kaden, Gerd Multhaup, Manuel E. Than

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 2.12 MB

english, 2012

66

Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

Christoph Schmitz, Bart P.F. Rutten, Andrea Pielen, Stephanie Schäfer, Oliver Wirths, Günter Tremp, Christian Czech, Veronique Blanchard, Gerd Multhaup, Payam Rezaie, Hubert Korr, Harry W.M. Steinbusc

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 1.46 MB

english, 2004

67

A novel substrate for analyzing Alzheimer’s disease γ-secretase

Stefan F. Lichtenthaler, Gerd Multhaup, Colin L. Masters, Konrad Beyreuther

Journal:

Year:

1999

Language:

english

File:

PDF, 187 KB

english, 1999

68

Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch

Christian Haass, Luka Kulic, Anja Capell, Harold Steiner, Gerd Multhaup, David Teplow, Helmut Romig

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 177 KB

english, 2000

69

The structure and function of the amyloid precursor protein N-terminal region

Roberto Cappai, Anthony R. White, Gerd Multhaup, Kevin Barnham, William J. McKinstry, Elise Needham, Denise Galatis, Jamie Rossjohn

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 205 KB

english, 2000

70

O3-04-06 Structural and functional analysis of the Alzheimer's disease amyloid precursor protein copper binding domain

Roberto Cappai, Geoffrey Kong, William McKinstry, Denise Galatis, Julian Adams, Shane Bellingham, James Camakaris, Cyril Curtain, Nicholas Williamson, Anthony White, Konrad Beyreuther, Gerd Multhaup,

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 164 KB

english, 2004

71

P1-211 Characterization of Aβ-dimerization in an in vivo transmembrane dimerization selection system

Lisa M. Munter, Eric Lindner, Dieter Langosch, Gerd Multhaup

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 167 KB

english, 2004

72

297 Molecular dissection of APP and βA4/Aβ pathology and neurodegeneration in Alzheimer's disease

K. Beyreuther, G. Multhaup, C.L. Masters

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 162 KB

english, 1996

73

483 Inverse Relationship Between BAPP and BAP Expression in the Pathogenesis of Neuritic Plaques

H.P. Schmitt, Y. Yang, I. Nobuo, G. Multhaup, K. Beyreuther

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 148 KB

english, 1996

74

619 Reduction of copper(II) to copper(I) by the Amyloid Precursor Protein (APP) of Alzheimer's disease

G. Multhaup, A. Schlicksupp, L. Hesse, D. Beher, T. Ruppert, C.L. Masters, K. Beyreuther

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 136 KB

english, 1996

75

789 Exon 15 of APP regulates βA4 production and polarized secretion of APP

Tobias Hartmann, Christian Bergsdorf, Sophie Bieger, Pentti J. Tienari, Nobuo Ida, Gerd Multhaup, Rupert Sandbrink, Andreas Weidemann, Colin L. Masters, Konrad Beyreuther

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 143 KB

english, 1996

76

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

Oliver Wirths, Gerd Multhaup, Christian Czech, Véronique Blanchard, Saliha Moussaoui, Günter Tremp, Laurent Pradier, Konrad Beyreuther, Thomas A Bayer

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 581 KB

english, 2001

77

Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic mice

Oliver Wirths, Gerd Multhaup, Christian Czech, Véronique Blanchard, Günter Tremp, Laurent Pradier, Konrad Beyreuther, Thomas A. Bayer

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 195 KB

english, 2001

78

Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases

Daniel Strausak, Julian F.B Mercer, Hermann H Dieter, Wolfgang Stremmel, Gerd Multhaup

Journal:

Brain Research Bulletin

Year:

2001

Language:

english

File:

PDF, 306 KB

english, 2001

79

Amyloid precursor protein, copper and Alzheimer's disease

Journal:

Biomedicine & Pharmacotherapy

Year:

1997

Language:

english

File:

PDF, 627 KB

english, 1997

80

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment

Bart P.F Rutten, Oliver Wirths, Wilma D.J Van de Berg, Stefan F Lichtenthaler, Jochen Vehoff, Harry W.M Steinbusch, Hubert Korr, Konrad Beyreuther, Gerd Multhaup, Thomas A Bayer, Christoph Schmitz

Journal:

Neurobiology of Disease

Year:

2003

Language:

english

File:

PDF, 608 KB

english, 2003

81

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability

Hua, Haiqing, Münter, Lisa, Harmeier, Anja, Georgiev, Oleg, Multhaup, Gerd, Schaffner, Walter

Journal:

Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 1.89 MB

english, 2011

82

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

Gabriele Grenningloh, Iris Pribilla, Peter Prior, Gerd Multhaup, Konrad Beyreuther, Omar Taleb, Heinrich Betz

Journal:

Year:

1990

Language:

english

File:

PDF, 1.64 MB

english, 1990

83

Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer †

Klopfleisch, Robert, Klose, Patricia, Weise, Christoph, Bondzio, Angelika, Multhaup, Gerd, Einspanier, Ralf, Gruber, Achim D.

Journal:

Journal of Proteome Research

Year:

2010

Language:

english

File:

PDF, 482 KB

english, 2010

84

The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid

Resenberger, U. K., Muller, V., Munter, L. M., Baier, M., Multhaup, G., Wilson, M. R., Winklhofer, K. F., Tatzelt, J.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

85

Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels

Stephanie Schäfer, Frank-Gerald Pajonk, Gerd Multhaup, Thomas A. Bayer

Journal:

Journal of Molecular Medicine

Year:

2007

Language:

english

File:

PDF, 43 KB

english, 2007

86

Depression of histone acetylation by alkylating antitumor agents: significance for antitumor activity and possible biological consequences

H. Grunicke, A. Csordas, W. Helliger, S. Hauptlorenz, A. Loidl, I. Multhaup, H. Zwierzina, B. Puschendorf

Journal:

Advances in Enzyme Regulation

Year:

1984

Language:

english

File:

PDF, 708 KB

english, 1984

87

O2-04-06: New lessons form the APP/PS1 transgenic mouse model with neuron loss: Metal biology, axonal degeneration and intraneuronal N-modified Aβ aggregation

Thomas A. Bayer, Oliver Wirths, Stephanie Schäfer, Henning Breyhan, Martina Muckenthaler, André Delacourte, Rakez Kayed, Takaomi Saido, Gerd Multhaup, Joachim Weis

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 68 KB

english, 2006

88

O1-02-05: Dimerization of the APP transmembrane sequence is critical for Aβ42 generation

Lisa M. Munter, Philipp Voigt, Eric Lindner, Michael Schaefer, Dieter Langosch, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

89

O4-06-02: Role of single amino acids of the Aβ sequence on cytotoxicity and inhibition of LTP

Anja Harmeier, Christian Wozny, Lisa Münter, Rüdiger Pipkorn, Dietmar Schmitz, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 62 KB

english, 2006

90

P1-042: Neuronal loss and changes in metal homeostasis in the APP751SLPS1ki mouse model of Alzheimer’s disease

Henning Breyhan, Stefanie Schäfer, Oliver Wirths, Martina Muckenthaler, Gerd Multhaup, Thomas A. Bayer

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

91

P1-375: Dietary copper recovers young APP transgenic mice from adverse effects of clioquinol

Stephanie Schaefer, Gerd Multhaup, Thomas A. Bayer

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

92

P2-056: Homo-and heterophilic interactions of APP-family-proteins

Daniela Kaden, Lisa M. Munter, Philipp Voigt, Michael Schaefer, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 71 KB

english, 2006

93

O1-03-04: Deleterious effects of familial Alzheimer's disease (FAD) mutations in APP are mediated through the GxxxG interaction motif

Lisa M. Munter, Anja Harmeier, Dieter Langosch, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

94

P1-122: Dissection of the individual domains of APP family members involved in homo- and heterotypic interactions

Daniela Kaden, Lisa-Marie Munter, Philipp Voigt, Michael Schaefer, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 417 KB

english, 2008

95

Reassessment of APP Familial Alzheimer's Disease (FAD) mutations

Lisa M. Munter, Anne Botev, Luise Richter, Chris Weise, Dieter Langosch, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 38 KB

english, 2009

96

APP and APLP2 are processed by different enzymes during induced conditions

Kristin T. Jacobsen, Linda Adlerz, Gerd Multhaup, Kerstin Iverfeldt

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 39 KB

english, 2010

97

Alzheimer‘s disease and gene regulation: A possible role of Aß in the nucleus

Christian Barucker, Anja Harmeier, Joerg Weiske, Kai Albring, Otmar Huber, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 68 KB

english, 2010

98

Differential interaction of beta-amyloid-42 and beta-amyloid-40 to plasma membrane lipids

Veit Althoff, Luise Richter, Lisa M. Munter, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

99

The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species

Jessica Bien, Tamara Jefferson, Mirsada Causevic, Thorsten Jumpertz, Lisa M. Munter, Gerd Multhaup, Sascha Weggen, Christoph Becker-Pauly, Claus Pietrzik

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

100

Effects of copper and zinc on amyloid precursor protein function and metabolism

Gerd Multhaup, Andrea Schlicksupp, Carsten Schmidt, Markus Strauss, Thilo Borchardt, James Camakaris, Colin L. Masters

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000