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51

Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential

Tigyi, Gabor Jozsef, Johnson, Leonard R., Lee, Sue Chin, Norman, Derek D., Szabo, Erzsebet, Balogh, Andrea, Thompson, Karin, Boler, Alyssa L., McCool, Shannon W.

Journal:

The Journal of Lipid Research

Year:

2019

File:

PDF, 3.58 MB

2019

52

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

Euijung Jo, M. Germana Sanna, Pedro J. Gonzalez-Cabrera, Shobha Thangada, Gabor Tigyi, Daniel A. Osborne, Timothy Hla, Abby L. Parrill, Hugh Rosen

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 746 KB

english, 2005

53

Synthesis and antitumor properties of a plasmalogen methyl ether analogue

Robert Bittman, Donghui Qin, De-An Wong, Gabor Tigyi, Pranati Samadder, Gilbert Arthur

Journal:

Year:

2001

Language:

english

File:

PDF, 235 KB

english, 2001

54

Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors

Tabchy, Adel, Tigyi, Gabor, Mills, Gordon B

Journal:

Nature Structural and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 837 KB

english, 2011

55

The functional PDGFβ receptor–S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor

Jaclyn S. Long, Viswanathan Natarajan, Gabor Tigyi, Susan Pyne, Nigel J. Pyne

Journal:

Prostaglandins and Other Lipid Mediators

Year:

2006

Language:

english

File:

PDF, 406 KB

english, 2006

56

New trends in lysophospholipid research

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2013

Language:

english

File:

PDF, 122 KB

english, 2013

57

Optical Control of Lysophosphatidic Acid Signaling

Morstein, Johannes, Dacheux, MÃ©lanie A., Norman, Derek D., Shemet, Andrej, Donthamsetti, Prashant C., Citir, Mevlut, Frank, James, Schultz, Carsten, Isacoff, Ehud Y., Parrill, Abby L, Tigyi, Gabor J.

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 1.22 MB

2020

58

T cell recognition of the posttranslationally cleaved intersubunit region of influenza virus hemagglutinin

Éva Rajnavölgyi, Zoltán Nagy, István Kurucz, Péter Gogolák, Gábor K. Tóth, Györgyi Váradi, Botond Penke, Zoltán Tigyi, Miklós Hollósi, János Gergely

Journal:

Molecular Immunology

Year:

1994

Language:

english

File:

PDF, 1.33 MB

english, 1994

59

Molecular Cloning of a High-Affinity Receptor for the Growth Factor-Like Lipid Mediator Lysophosphatidic Acid from Xenopus Oocytes

Zhong Guo, Karoly Liliom, David J. Fischer, Ian C. Bathurst, L. David Tomei, Michael C. Kiefer and Gabor Tigyi

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.59 MB

english, 1996

60

Tu1377 Rapid Disruption of Colonic Epithelial Tight Junctions by Ionizing Radiation in Mice In Vivo: Protection by N-Acetyl L-Cysteine

Shukla, Pradeep K., Gangwar, Ruchika, Manda, Bhargavi, Yadav, Nikki, Szabo, Erzsebet, Balogh, Andrea, Tigyi, Gabor, Rao, Radhakrishna (RK)

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 75 KB

english, 2015

61

Corrigendum to ‘Opposing regulation of megakaryopoiesis by LPA receptor 2 and 3 in K562 human erythroleukemia cells’ [Biochim. Biophys. Acta 1851/2, (2015) 172–183]

Ho, Ya-Hsuan, Yao, Chao-Ling, Lin, Kuan-Hung, Hou, Fen-Han, Chen, Wei-min, Chiang, Chi-Ling, Lin, Yu-Nung, Li, Meng-Wei, Lin, Shi-Hung, Yang, Ya-Jan, Lin, Chu-Cheng, Lu, Jenher, Tigyi, Gabor, Lee, Hsi

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2015

Language:

english

File:

PDF, 123 KB

english, 2015

62

Lysophospholipids and their G protein-coupled receptors in biology and diseases

Edward J. Goetzl, Gabor Tigyi

Journal:

Journal of Cellular Biochemistry

Year:

2004

Language:

english

File:

PDF, 32 KB

english, 2004

63

Thrombogenic and atherogenic activities of lysophosphatidic acid

Wolfgang Siess, Gabor Tigyi

Journal:

Journal of Cellular Biochemistry

Year:

2004

Language:

english

File:

PDF, 99 KB

english, 2004

64

Identification of non-lipid LPA3 antagonists by virtual screening

James I. Fells, Ryoko Tsukahara, Yuko Fujiwara, Jianxiong Liu, Donna H. Perygin, Daniel A. Osborne, Gabor Tigyi, Abby L. Parrill

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 762 KB

english, 2008

65

Sphingosylphosphorylcholine Is a Bona Fide Mediator Regulating Heart Rate

KÁROLY LILIOM, MORITZ BÜNEMANN, GUOPING SUN, DUANE MILLER, DOMINIC M. DESIDERIO, BODO BRANDTS, KIRSTEN BENDER, LUTZ POTT, NÓRA NUSSER, GÁBOR TIGYI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 389 KB

english, 2000

66

Molecular mechanisms of lysophosphatidic acid action

Gabor Tigyi, Abby L. Parrill

Journal:

Progress in Lipid Research

Year:

2003

Language:

english

File:

PDF, 474 KB

english, 2003

67

LPA 1 receptor–mediated thromboxane A 2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction

Dancs, Péter Tibor, Ruisanchez, Éva, Balogh, Andrea, Panta, Cecília Rita, Miklós, Zsuzsanna, Nüsing, Rolf M., Aoki, Junken, Chun, Jerold, Offermanns, Stefan, Tigyi, Gábor, Benyó, Zoltán

Journal:

The FASEB Journal

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

68

Monoclonal antibodies to the hydrogenase ofThiocapsa roseopersicina

Gábor J. Tigyi, Kornél L. Kovács

Journal:

Current Microbiology

Year:

1984

Language:

english

File:

PDF, 703 KB

english, 1984

69

Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: Inhibition of LPA GPCR and activation of PPARs

Karoly Liliom, Tamotsu Tsukahara, Ryoko Tsukahara, Monika Zelman-Femiak, Ewa Swiezewska, Gabor Tigyi

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2006

Language:

english

File:

PDF, 802 KB

english, 2006

70

Microinjection into Xenopus oocytes: a precise semi-automatic instrument and optimal parameters for injection of mRNAs

Gabor Tigyi, Ian Parker

Journal:

Journal of Biochemical and Biophysical Methods

Year:

1991

Language:

english

File:

PDF, 1.33 MB

english, 1991

71

In honor of Robert Bittman 1942–2014

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2014

Language:

english

File:

PDF, 105 KB

english, 2014

72

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells

Banerjee, Souvik, Norman, Derek D., Lee, Sue Chin, Parrill, Abby L., Pham, Truc Chi T., Baker, Daniel L., Tigyi, Gabor J., Miller, Duane D.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.21 MB

english, 2017

73

Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells

Noreen A. Moughal, Catherine M. Waters, William J. Valentine, Michelle Connell, Jill C. Richardson, Gabor Tigyi, Susan Pyne, Nigel J. Pyne

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 764 KB

english, 2006

74

Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells

Susanne Vidot, James Witham, Roshan Agarwal, Sebastian Greenhough, Harnoor S. Bamrah, Gabor J. Tigyi, Stanley B. Kaye, Alan Richardson

Journal:

Cellular Signalling

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

75

Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality

Yaoqian Pan, Louisa Balazs, Gabor Tigyi, Junming Yue

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

76

Cdc42/N-WASP and Rac1/WAVE2 Required for LPA-induced Migration of Rat Ascites Hepatoma Cells

Uchiyama, Ayako, Tigyi, Gabor, Murakami-Murofushi, Kimiko

Journal:

Year:

2010

Language:

english

File:

PDF, 1.79 MB

english, 2010

77

Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100

Thompson, Karin E, Ray, Ramesh M, Alli, Shanta, Ge, Wenbo, Boler, Alyssa, Shannon McCool, W, Meena, Avtar S, Shukla, Pradeep K, Rao, Radakrishna, Johnson, Leonard R, Miller, Mark A, Tigyi, Gabor J

Journal:

Experimental Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 964 KB

english, 2018

78

α-Substituted Phosphonate Analogues of Lysophosphatidic Acid (LPA) Selectively Inhibit Production and Action of LPA

Guowei Jiang, Yong Xu, Yuko Fujiwara, Tamotsu Tsukahara, Ryoko Tsukahara, Joanna Gajewiak, Gabor Tigyi, Glenn D. Prestwich

Journal:

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

79

A Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA), and Its Biological Functions

KIMIRO MURAKAMI-MUROFUSHI, MUTSUKO MUKAI, SUSUMU KOBAYASHI, TETSUYUKI KOBAYASHI, GABOR TIGYI, HIROMU MUROFUSHI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 1.05 MB

english, 2000

80

Lysophospholipid signaling: Beyond the EDGs

William J. Valentine, Yuko Fujiwara, Ryoko Tsukahara, Gabor Tigyi

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2008

Language:

english

File:

PDF, 921 KB

english, 2008

81

Synthesis, Pharmacology, and Cell Biology of sn -2-Aminooxy Analogues of Lysophosphatidic Acid

Gajewiak, Joanna, Tsukahara, Ryoko, Fujiwara, Yuko, Tigyi, Gabor, Prestwich, Glenn D.

Journal:

Organic Letters

Year:

2008

Language:

english

File:

PDF, 137 KB

english, 2008

82

Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition

Ragle, Lauren E., Palanisamy, Dilip J., Joe, Margaux J., Stein, Rachel S., Norman, Derek D., Tigyi, Gabor, Baker, Daniel L., Parrill, Abby L.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

83

Phospholipid Growth Factors and Corneal Wound Healing

MITCHELL A. WATSKY, MAY GRIFFITH, DE-AN WANG, GABOR J. TIGYI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 12.26 MB

english, 2000

84

Isolation of the human myelin basic protein by immunoaffinity chromatography with a monoclonal antibody

Gábor J. Tigyi, Louisa Balázs, Éva Monostori, István Andó

Journal:

Molecular Immunology

Year:

1984

Language:

english

File:

PDF, 694 KB

english, 1984

85

Synthesis of Cyclic Phosphonate Analogues of (Lyso)phosphatidic Acid Using a Ring-Closing Metathesis Reaction

Zhang, Honglu, Tsukuhara, Ryoko, Tigyi, Gabor, Prestwich, Glenn D.

Journal:

Journal of Organic Chemistry

Year:

2006

Language:

english

File:

PDF, 92 KB

english, 2006

86

Synthesis of Photoactivatable Analogues of Lysophosphatidic Acid and Covalent Labeling of Plasma Proteins

Li, Zaiguo, Baker, Daniel L., Tigyi, Gabor, Bittman, Robert

Journal:

Journal of Organic Chemistry

Year:

2006

Language:

english

File:

PDF, 224 KB

english, 2006

87

Reference Module in Biomedical Sciences || Lysophospholipid Receptors

Tigyi, Gabor J.

Year:

2018

Language:

english

File:

PDF, 88 KB

english, 2018

88

Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors

Veeresa Gududuru, Kui Zeng, Ryoko Tsukahara, Natalia Makarova, Yuko Fujiwara, Kathryn R. Pigg, Daniel L. Baker, Gabor Tigyi, Duane D. Miller

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 147 KB

english, 2006

89

MULTIPLE FUNCTIONS OF THE SPHINGOSINE 1-PHOSPHATE RECEPTOR S1P1 IN ENDOTHELIAL CELLS

Vera Krump-Konvalinkova, Tina Rubic, Claudia Vosseler, Wolfgang Erl, Satoshi Yasuda, Gabor Tigyi, Charles James Kirkpatrick, Wolfgang Siess

Journal:

Cardiovascular Pathology

Year:

2004

Language:

english

File:

PDF, 38 KB

english, 2004

90

Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors

Dagmar Meyer zu Heringdorf, Karoly Liliom, Michael Schaefer, Kerstin Danneberg, Jonathan H. Jaggar, Gabor Tigyi, Karl H. Jakobs

Journal:

Year:

2003

Language:

english

File:

PDF, 1.05 MB

english, 2003

91

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration

Long, Jaclyn S., Yokoyama, Kazuaki, Tigyi, Gabor, Pyne, Nigel J., Pyne, Susan

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 607 KB

english, 2006

92

Structural Features of EDG1 Receptor-Ligand Complexes Revealed by Computational Modeling and Mutagenesis

ABBY L. PARRILL, DANIEL L. BAKER, DE-AN WANG, DAVID J. FISCHER, DEBRA L. BAUTISTA, JAMES VAN BROCKLYN, SARAH SPIEGEL, GABOR TIGYI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 4.33 MB

english, 2000

93

Proteolytic resistance and its utilization in purification of hydrogenase from Thiocapsa roseopersicina

Kornel L. Kovacs, Csaba Bagyinka, Gabor Tigyi

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1988

Language:

english

File:

PDF, 508 KB

english, 1988

94

Doxycycline Inducible Kruppel-Like Factor 4 Lentiviral Vector Mediates Mesenchymal to Epithelial Transition in Ovarian Cancer Cells

Chen, Zixuan, Wang, Yinan, Liu, Wen, Zhao, Guannan, Lee, Suechin, Balogh, Andrea, Zou, Yanan, Guo, Yuqi, Zhang, Zhan, Gu, Weiwang, Li, Chengyao, Tigyi, Gabor, Yue, Junming, Liu, Chunming

Journal:

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

95

Role of autotaxin in cancer stem cells

Lee, Dongjun, Suh, Dong-Soo, Lee, Sue Chin, Tigyi, Gabor J., Kim, Jae Ho

Journal:

Cancer and Metastasis Reviews

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

96

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

Yatomi, Yutaka, Ohmori, Tsukasa, Rile, Ge, Kazama, Fuminori, Okamoto, Hirotaka, Sano, Takamitsu, Satoh, Kaneo, Kume, Shoji, Tigyi, Gabor, Igarashi, Yasuyuki, Ozaki, Yukio

Journal:

Year:

2000

File:

PDF, 309 KB

2000

97

Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors

Banerjee, Souvik, Norman, Derek D., Deng, Shanshan, Fakayode, Sayo O., Lee, Sue Chin, Parrill, Abby L., Li, Wei, Miller, Duane D., Tigyi, Gabor J.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.08 MB

2020

98

Alkoxymethylenephosphonate Analogues of (Lyso)phosphatidic Acid Stimulate Signaling Networks Coupled to the LPA2 Receptor

Joanna Gajewiak, Ryoko Tsukahara, Tamotsu Tsukahara, Yuko Fujiwara, Shuanxing Yu, Yiling Lu, Mandi Murph, Gordon B. Mills, Gabor Tigyi, Glenn D. Prestwich

Journal:

Year:

2008

File:

PDF, 58 KB

2008

99

Development of an LC–MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecyl thiophosphate (OTP) in monkeys

Hari Kosanam, Fei Ma, Hui He, Suma Ramagiri, Veeresa Gududuru, Gabor J. Tigyi, Koen Van Rompay, Duane D. Miller, Charles R. Yates

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 187 KB

english, 2010

100

Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate

Markus Fueller, De An Wang, Gabor Tigyi, Wolfgang Siess

Journal:

Cellular Signalling

Year:

2003

Language:

english

File:

PDF, 347 KB

english, 2003

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