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51

Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels

Stephanie Schäfer, Frank-Gerald Pajonk, Gerd Multhaup, Thomas A. Bayer

Journal:

Journal of Molecular Medicine

Year:

2007

Language:

english

File:

PDF, 43 KB

english, 2007

52

O2-04-06: New lessons form the APP/PS1 transgenic mouse model with neuron loss: Metal biology, axonal degeneration and intraneuronal N-modified Aβ aggregation

Thomas A. Bayer, Oliver Wirths, Stephanie Schäfer, Henning Breyhan, Martina Muckenthaler, André Delacourte, Rakez Kayed, Takaomi Saido, Gerd Multhaup, Joachim Weis

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 68 KB

english, 2006

53

O1-02-05: Dimerization of the APP transmembrane sequence is critical for Aβ42 generation

Lisa M. Munter, Philipp Voigt, Eric Lindner, Michael Schaefer, Dieter Langosch, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

54

O4-06-02: Role of single amino acids of the Aβ sequence on cytotoxicity and inhibition of LTP

Anja Harmeier, Christian Wozny, Lisa Münter, Rüdiger Pipkorn, Dietmar Schmitz, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 62 KB

english, 2006

55

P1-042: Neuronal loss and changes in metal homeostasis in the APP751SLPS1ki mouse model of Alzheimer’s disease

Henning Breyhan, Stefanie Schäfer, Oliver Wirths, Martina Muckenthaler, Gerd Multhaup, Thomas A. Bayer

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

56

P1-375: Dietary copper recovers young APP transgenic mice from adverse effects of clioquinol

Stephanie Schaefer, Gerd Multhaup, Thomas A. Bayer

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

57

P2-056: Homo-and heterophilic interactions of APP-family-proteins

Daniela Kaden, Lisa M. Munter, Philipp Voigt, Michael Schaefer, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 71 KB

english, 2006

58

O1-03-04: Deleterious effects of familial Alzheimer's disease (FAD) mutations in APP are mediated through the GxxxG interaction motif

Lisa M. Munter, Anja Harmeier, Dieter Langosch, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

59

P1-122: Dissection of the individual domains of APP family members involved in homo- and heterotypic interactions

Daniela Kaden, Lisa-Marie Munter, Philipp Voigt, Michael Schaefer, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 417 KB

english, 2008

60

Reassessment of APP Familial Alzheimer's Disease (FAD) mutations

Lisa M. Munter, Anne Botev, Luise Richter, Chris Weise, Dieter Langosch, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 38 KB

english, 2009

61

APP and APLP2 are processed by different enzymes during induced conditions

Kristin T. Jacobsen, Linda Adlerz, Gerd Multhaup, Kerstin Iverfeldt

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 39 KB

english, 2010

62

Alzheimer‘s disease and gene regulation: A possible role of Aß in the nucleus

Christian Barucker, Anja Harmeier, Joerg Weiske, Kai Albring, Otmar Huber, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 68 KB

english, 2010

63

Differential interaction of beta-amyloid-42 and beta-amyloid-40 to plasma membrane lipids

Veit Althoff, Luise Richter, Lisa M. Munter, Gerd Multhaup

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

64

The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species

Jessica Bien, Tamara Jefferson, Mirsada Causevic, Thorsten Jumpertz, Lisa M. Munter, Gerd Multhaup, Sascha Weggen, Christoph Becker-Pauly, Claus Pietrzik

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

65

Effects of copper and zinc on amyloid precursor protein function and metabolism

Gerd Multhaup, Andrea Schlicksupp, Carsten Schmidt, Markus Strauss, Thilo Borchardt, James Camakaris, Colin L. Masters

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

66

Light-Controlled Toxicity of Engineered Amyloid β-Peptides

Hoppmann, Christian, Barucker, Christian, Lorenz, Dorothea, Multhaup, Gerd, Beyermann, Michael

Journal:

Year:

2012

Language:

english

File:

PDF, 521 KB

english, 2012

67

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

Simone Isbert, Katja Wagner, Simone Eggert, Andrea Schweitzer, Gerd Multhaup, Sascha Weggen, Stefan Kins, Claus U. Pietrzik

Journal:

Cellular and Molecular Life Sciences

Year:

2012

Language:

english

File:

PDF, 984 KB

english, 2012

68

Reactive oxygen species and Alzheimer's disease

Gerd Multhaup, Thomas Ruppert, Andrea Schlicksupp, Lars Hesse, Dirk Beher, Colin L. Masters, Konrad Beyreuther

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.01 MB

english, 1997

69

Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndrome

KONRAD BEYREUTHER, PETER POLLWEIN, GERD MULTHAUP, URSULA MÖNNING, GERHARD KÖNIG, THOMAS DYRKS, WALTER SCHUBERT, COLIN L. MASTERS

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 698 KB

english, 1993

70

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction †

Huang, Xudong, Atwood, Craig S., Hartshorn, Mariana A., Multhaup, Gerd, Goldstein, Lee E., Scarpa, Richard C., Cuajungco, Math P., Gray, Danielle N., Lim, James, Moir, Robert D., Tanzi, Rudolph E., Bu

Journal:

Year:

1999

Language:

english

File:

PDF, 97 KB

english, 1999

71

Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors

Holzhauser, Susanne, Freiwald, Anja, Weise, Christoph, Multhaup, Gerd, Han, Chung-Ting, Sauer, Sascha

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 726 KB

english, 2013

72

Is There a Malignant Progression Associated with a Linear Change in Protein Expression Levels from Normal Canine Mammary Gland to Metastatic Mammary Tumors?

Klose, Patricia, Weise, Christoph, Bondzio, Angelika, Multhaup, Gerd, Einspanier, Ralf, Gruber, Achim D., Klopfleisch, Robert

Journal:

Journal of Proteome Research

Year:

2011

Language:

english

File:

PDF, 4.43 MB

english, 2011

73

Membrane Protein Function and Transmembrane Helix Backbone Dynamics

Langosch, Dieter, Pester, Oxana, Scharnagl, Christina, Kirrbach, Jan, Ried, Christian, Sah, Rashmi, Langer, Marcella, Muenter, Lisa, Multhaup, Gerd

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 80 KB

english, 2012

74

P4-037 Important role of PRP in metal-ion homeostasis

Treiber, Carina, Simons, Andreas, Multhaup, Gerd

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

75

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

Kaden, Daniela, Harmeier, Anja, Weise, Christoph, Munter, Lisa M., Althoff, Veit, Rost, Benjamin, Hildebrand, Peter, Schmitz, Dietmar, Lurz, Rudi, Finckh, Ulrich, Multhaup, Gerd

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 159 KB

english, 2012

76

Zinc-dependent oligomerization of APP family proteins

Mayer, Magnus, Kaden, Daniela, Schaefer, Michael, Multhaup, Gerd

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

77

Nsaids modulate app dimerization

Richter, Luise, Munter, Lisa Marie, Fehse, Susanne, Unterreitmeier, Stephanie, Langosch, Dieter, Multhaup, Gerd

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 40 KB

english, 2009

78

Mapping the Backbone Dynamics of the Alzheimer's APP Transmembrane Domain

Pester, Oxana, Hornburg, Daniel, Duerrbaum, Milena, Hornburg, Philipp, Scharnagl, Christina, Multhaup, Gerd, Langosch, Dieter

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 68 KB

english, 2012

79

Mechanism of gamma-secretase-mediated APP processing and modulation

Lundkvist, Johan, Olsson, Fredrik, Schmidt, Staffan, Althoff, Veit, Jin, Shaobo, Lendahl, Urban, Multhaup, Gerd, Arvidsson, Per

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 86 KB

english, 2012

80

P1-427: The GxxxG motif of the Aβ sequence unlinks Aβ aggregation from toxicity

Harmeier, Anja, Munter, Lisa, Wozny, Christian, Rost, Benjamin, Zhuang, Wei, Gensler, Manuel, Beyermann, Michael, Lurz, Rudi, Rabe, Jürgen, Schmitz, Dietmar, Multhaup, Gerd

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

81

Structural dynamics of the transmembrane domain of the amyloid precursor protein (APP) determined by deuterium/hydrogen exchange

Pester, Oxana, Stelzer, Walter, Poschner, Bernard C., Münter, Lisa-Maria, Multhaup, Gerd, Langosch, Dieter

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 44 KB

english, 2009

82

Aggregation of Aß42 is strongly influenced by Gly33 of the GxxxG motif and an inhibitor peptide which mimics Gly33 substitutions

Harmeier, Anja, Gensler, Manuel, Barucker, Christian, Rost, Benjamin, Zhuang, W., Beyermann, Michael, Hildebrand, Peter W., Schmitz, Dietmar, Lurz, Rudi, Rabe, Jürgen P., Multhaup, Gerd

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 53 KB

english, 2011

83

Amyloid Plaque Core Protein in Alzheimer Disease and Down Syndrome

Colin L. Masters, Gail Simms, Nicola A. Weinman, Gerd Multhaup, Brian L. McDonald and Konrad Beyreuther

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.07 MB

english, 1985

84

Amyloid of Neurofibrillary Tangles of Guamanian Parkinsonism-Dementia and Alzheimer Disease Share Identical Amino Acid Sequence

Don C. Guiroy, Masayuki Miyazaki, Gerd Multhaup, Peter Fischer, Ralph M. Garruto, Konrad Beyreuther, Colin L. Masters, Gail Simms, Clarence J. Gibbs and D. Carleton Gajdusek

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 1.15 MB

english, 1987

85

Intracellular and Secreted Alzheimer β -Amyloid Species are Generated by Distinct Mechanisms in Cultured Hippocampal Neurons

Pentti J. Tienari, Nobuo Ida, Elina Ikonen, Mikael Simons, Andreas Weidemann, Gerd Multhaup, Colin L. Masters, Carlos G. Dotti and Konrad Beyreuther

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.88 MB

english, 1997

86

Proteolytic Processing of the Alzheimer Disease-Associated Presenilin-1 Generates an in vivo Substrate for Protein Kinase C

Jochen Walter, Jürgen Grünberg, Anja Capell, Brigitte Pesold, Alice Schindzielorz, Martin Citron, Klaus Mendla, Peter St George-Hyslop, Gerd Multhaup, Dennis J. Selkoe and Christian Haass

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.41 MB

english, 1997

87

Mutations in the Transmembrane Domain of APP Altering γ-Secretase Specificity †

Lichtenthaler, Stefan F., Ida, Nobuo, Multhaup, Gerd, Masters, Colin L., Beyreuther, Konrad

Journal:

Year:

1997

Language:

english

File:

PDF, 167 KB

english, 1997

88

Model Peptides Uncover the Role of the β-Secretase Transmembrane Sequence in Metal Ion Mediated Oligomerization

Munter, Lisa M., Sieg, Holger, Bethge, Tobias, Liebsch, Filip, Bierkandt, Frank S., Schleeger, Michael, Bittner, Heiko J., Heberle, Joachim, Jakubowski, Norbert, Hildebrand, Peter W., Multhaup, Gerd

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 3.61 MB

english, 2013

89

The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators

Botev, Anne, Munter, Lisa-Marie, Wenzel, Ringo, Richter, Luise, Althoff, Veit, Ismer, Jochen, Gerling, Ulla, Weise, Christoph, Koksch, Beate, Hildebrand, Peter W., Bittl, Robert, Multhaup, Gerd

Journal:

Year:

2011

Language:

english

File:

PDF, 2.68 MB

english, 2011

90

Effect of Copper and Manganese on the de Novo Generation of Protease-Resistant Prion Protein in Yeast Cells †

Treiber, Carina, Simons, Andreas, Multhaup, Gerd

Journal:

Year:

2006

Language:

english

File:

PDF, 302 KB

english, 2006

91

Copper-Binding Amyloid Precursor Protein Undergoes a Site-Specific Fragmentation in the Reduction of Hydrogen Peroxide †

Multhaup, Gerd, Ruppert, Thomas, Schlicksupp, Andrea, Hesse, Lars, Bill, Eckhard, Pipkorn, Rüdiger, Masters, Colin L., Beyreuther, Konrad

Journal:

Year:

1998

Language:

english

File:

PDF, 207 KB

english, 1998

92

Cellular Copper Import by Nanocarrier Systems, Intracellular Availability, and Effects on Amyloid β Peptide Secretion

Treiber, Carina, Quadir, Mohiuddin Abdul, Voigt, Philipp, Radowski, Michal, Xu, Shangjie, Munter, Lisa-Marie, Bayer, Thomas A., Schaefer, Michael, Haag, Rainer, Multhaup, Gerd

Journal:

Year:

2009

Language:

english

File:

PDF, 4.40 MB

english, 2009

93

Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes

Rupp, Ralph A.W., Kruse, Ulrich, Multhaup, Gerd, Göbel, Ulrike, Beyreuther, Konrad, Sippel, Albrecht E.

Journal:

Nucleic Acids Research

Year:

1990

Language:

english

File:

PDF, 2.44 MB

english, 1990

94

The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above-Average Backbone Dynamics

Pester, Oxana, Götz, Alexander, Multhaup, Gerd, Scharnagl, Christina, Langosch, Dieter

Journal:

Year:

2013

Language:

english

File:

PDF, 988 KB

english, 2013

95

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

Dahms, Sven O., Mayer, Magnus C., Roeser, Dirk, Multhaup, Gerd, Than, Manuel E.

Journal:

Acta Crystallographica Section D Biological Crystallography

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

96

Clioquinol Mediates Copper Uptake and Counteracts Copper Efflux Activities of the Amyloid Precursor Protein of Alzheimer's Disease

Treiber, Carina, Simons, Andreas, Strauss, Markus, Hafner, Mathias, Cappai, Roberto, Bayer, Thomas A., Multhaup, Gerd

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 716 KB

english, 2004

97

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

Rumble, Baden, Retallack, Robert, Hilbich, Caroline, Simms, Gail, Multhaup, Gerd, Martins, Ralph, Hockey, Athel, Montgomery, Philip, Beyreuther, Konrad, Masters, Colin L.

Journal:

Boston Medical and Surgical Journal

Year:

1989

Language:

english

File:

PDF, 4.55 MB

english, 1989

98

Structural mechanism of the interaction of Alzheimer's disease Aβ fibrils with the NSAID sulindac sulfide

Prade, Elke, Bittner, Heiko J., Sarkar, Riddhiman, Lopez del Amo, Juan-Miguel, Althoff-Ospelt, Gerhard, Multhaup, Gerd, Hildebrand, Peter W., Reif, Bernd

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.77 MB

english, 2015

99

Amyloid Precursor Protein and BACE Function as Oligomers

Journal:

Neurodegenerative Diseases

Year:

2006

Language:

english

File:

PDF, 114 KB

english, 2006

100

Lewy body variant of Alzheimerʼs disease

Wirths, Oliver, Weickert, Svenja, Majtenyi, Katalin, Havas, Laszlo, Kahle, Philipp J., Okochi, Masayasu, Haass, Christian, Multhaup, Gerd, Beyreuther, Konrad, Bayer, Thomas A.

Journal:

Year:

2000

Language:

english

File:

PDF, 983 KB

english, 2000

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