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51

152 Characterization of Mutants of the Soluble GP130 Protein in Terms of their Binding Affinity Against the IL6/SIL6R Complex

Stephanie Tenhumberg, Georg H. Waetzig, Dirk Seegert, Jürgen Scheller, Joachim Grötzinger, Stefan Rose-John

Journal:

Year:

2007

Language:

english

File:

PDF, 50 KB

english, 2007

52

227 Design of high affinity interleukin-6 and gp130 variants: Implications for cytokine-receptor assembly

Nina Adam, Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris, Björn Rabe, Jan Suthaus, Dirk Seegert, Jürgen Scheller, Stefan Rose-John, Joachim Grötzinger

Journal:

Year:

2008

Language:

english

File:

PDF, 45 KB

english, 2008

53

Unraveling viral interleukin-6 binding to gp130 and activation of stat-signaling pathways independent of interleukin-6

Nina Adam, Björn Rabe, Joachim Grötzinger, Stefan Rose-John, Jürgen Scheller

Journal:

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

54

Hexamer, tetramer or both: The IL6-IL-6R-gp130 complex

Inken Lorenzen, Markus Perbandt, Georg Wätzig, Stefan Rose-John, Rolf Hilgenfeld, Joachim Grötzinger

Journal:

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

55

CS11-5. Inhibition of Interleukin 6 classic signaling is a novel function of soluble gp130 which is controlled by the ratio of Interleukin 6 and soluble Interleukin 6 receptor

Christoph Garbers, Wolfgang Thaiss, Georg H. Waetzig, Gareth W. Jones, Doreen M. Floss, Inken Lorenzen, Joachim Grötzinger, Simon A. Jones, Stefan Rose-John, Jürgen Scheller

Journal:

Year:

2011

Language:

english

File:

PDF, 140 KB

english, 2011

56

Plasticity and cross-talk of Interleukin 6-type cytokines

Christoph Garbers, Heike M. Hermanns, Fred Schaper, Gerhard Müller-Newen, Joachim Grötzinger, Stefan Rose-John, Jürgen Scheller

Journal:

Cytokine & Growth Factor Reviews

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

57

The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes

Matthias Michalek, Christoph Gelhaus, Oliver Hecht, Rainer Podschun, Jens Michael Schröder, Matthias Leippe, Joachim Grötzinger

Journal:

Developmental & Comparative Immunology

Year:

2009

Language:

english

File:

PDF, 602 KB

english, 2009

58

Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity

Thomas Roeder, Mareike Stanisak, Christoph Gelhaus, Iris Bruchhaus, Joachim Grötzinger, Matthias Leippe

Journal:

Developmental & Comparative Immunology

Year:

2010

Language:

english

File:

PDF, 385 KB

english, 2010

59

Caenopore-5: The three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans

Justyna Mysliwy, Andrew J. Dingley, Mareike Stanisak, Sascha Jung, Inken Lorenzen, Thomas Roeder, Matthias Leippe, Joachim Grötzinger

Journal:

Developmental & Comparative Immunology

Year:

2010

Language:

english

File:

PDF, 1.05 MB

english, 2010

60

Structural characterization and binding properties of the hemopexin-like domain of the matrixmetalloproteinase-19

Justyna Mysliwy, Andrew J. Dingley, Radislav Sedlacek, Joachim Grötzinger

Journal:

Protein Expression and Purification

Year:

2006

Language:

english

File:

PDF, 403 KB

english, 2006

61

Cell-free synthesis and combinatorial selective 15N-labeling of the cytotoxic protein amoebapore A from Entamoeba histolytica

Yang Xun, Pierre Tremouilhac, Colm Carraher, Christoph Gelhaus, Kiyoshi Ozawa, Gottfried Otting, Nicholas E. Dixon, Matthias Leippe, Joachim Grötzinger, Andrew J. Dingley, Andrew V. Kralicek

Journal:

Protein Expression and Purification

Year:

2009

Language:

english

File:

PDF, 580 KB

english, 2009

62

An equine α-defensin: Gene transcription, recombinant expression and characterization of the structure and function

Oliver Bruhn, Petra Regenhard, Matthias Michalek, Sven Paul, Christoph Gelhaus, Sascha Jung, Georg Thaller, Rainer Podschun, Matthias Leippe, Joachim Grötzinger, Ernst Kalm

Journal:

Veterinary Immunology and Immunopathology

Year:

2009

Language:

english

File:

PDF, 87 KB

english, 2009

63

Unusual function of the activation loop in the protein kinase DYRK1A

Stephan Wiechmann, Hanna Czajkowska, Katrin de Graaf, Joachim Grötzinger, Hans-Georg Joost, Walter Becker

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

64

Different epitopes are required for gp130 activation by interleukin-6, oncostatin M and leukemia inhibitory factor

Andreas Timmermann, Stefan Pflanz, Joachim Grötzinger, Andrea Küster, Ingo Kurth, Vincent Pitard, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

2000

Language:

english

File:

PDF, 396 KB

english, 2000

65

A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130

Stefan Pflanz, Ingrid Tacken, Joachim Grötzinger, Yannick Jacques, Heike Dahmen, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

1999

Language:

english

File:

PDF, 338 KB

english, 1999

66

Erratum to: A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130 (FEBS 21942): [FEBS Letters 450 (1999) 117–122]

Stefan Pflanz, Ingrid Tacken, Joachim Grötzinger, Yannick Jacques, Stéphane Minvielle, Heike Dahmen, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

1999

Language:

english

File:

PDF, 24 KB

english, 1999

67

Inactive conformation of an insulin despite its wild-type sequence

Gunther Kurapkat, Elke De Wolf, Joachim Grotzinger, Axel Wollmer

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 5.29 MB

english, 1997

68

Self-assembly of the isolated KCNQ2 subunit interaction domain

Christina Wehling, Christian Beimgraben, Christoph Gelhaus, Thomas Friedrich, Paul Saftig, Joachim Grötzinger, Michael Schwake

Journal:

Year:

2007

Language:

english

File:

PDF, 351 KB

english, 2007

69

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis

Jan Sodenkamp, Georg H. Waetzig, Jürgen Scheller, Dirk Seegert, Joachim Grötzinger, Stefan Rose-John, Stefan Ehlers, Christoph Hölscher

Journal:

Year:

2012

Language:

english

File:

PDF, 2.80 MB

english, 2012

70

O-59 Quality of life with single agent oral topotecan vs intravenous topotecan in patients with chemosensitive small cell lung cancer (SCLC). An international phase III study

Graila, Richard J., Eckardt, John, von Pawel, Joachim, Grotzinger, Kelly M., Ross, Graham A.

Journal:

Year:

2003

Language:

english

File:

PDF, 169 KB

english, 2003

71

Identification of the domain in the human interleukin-11 receptor that mediates ligand binding

Karin Schleinkofer, Andrew Dingley, Ingrid Tacken, Matthias Federwisch, Gerhard Müller-Newen, Peter C Heinrich, Patricia Vusio, Yannick Jacques, Joachim Grötzinger

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 338 KB

english, 2001

72

Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human β-defensins 2 and 3

Björn Spudy, Frank D. Sönnichsen, Georg H. Waetzig, Joachim Grötzinger, Sascha Jung

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 450 KB

english, 2012

73

Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane

Andreas Schroers, Oliver Hecht, Karl-Josef Kallen, Michael Pachta, Stefan Rose-John, Joachim Grötzinger

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 169 KB

english, 2005

74

The Soluble Interleukin-6 Receptor

STEFAN ROSE-JOHN, MARC EHLERS, JOACHIM GRÖTZINGER, JÜRGEN MÜLLBERG

Journal:

Annals of the New York Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

75

Residues 77-95 of the Human Interleuken-6 Protein are Responsible for Receptor Binding and Residues 41-56 for Signal Transduction

MARC EHLERS, JOACHIM GRÖTZINGER, FLORIS D. De HON, JÜRGEN MÜLLBERG, JUST P. J. BRAKENHOFF, AXEL WOLLMER, STEFAN ROSE-JOHN

Journal:

Annals of the New York Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 120 KB

english, 1995

76

Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes

Andrä, Jörg, Hammer, Malte U., Grötzinger, Joachim, Jakovkin, Igor, Lindner, Buko, Vollmer, Ekkehard, Fedders, Henning, Leippe, Matthias, Gutsmann, Thomas

Journal:

Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 363 KB

english, 2009

77

Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations

Menabò, Soara, Polat, Seher, Baldazzi, Lilia, Kulle, Alexandra E, Holterhus, Paul-Martin, Grötzinger, Joachim, Fanelli, Flaminia, Balsamo, Antonio, Riepe, Felix G

Journal:

European Journal of Human Genetics

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

78

Determination of disulfide linkages in antimicrobial peptides of the macin family by combination of top-down and bottom-up proteomics

Hung, Chien-Wen, Jung, Sascha, Grötzinger, Joachim, Gelhaus, Christoph, Leippe, Matthias, Tholey, Andreas

Journal:

Journal of Proteomics

Year:

2014

Language:

english

File:

PDF, 2.17 MB

english, 2014

79

Differential aggregation properties of alpha-synuclein isoforms

Bungeroth, May, Appenzeller, Silke, Regulin, Annika, Völker, Wolfgang, Lorenzen, Inken, Grötzinger, Joachim, Pendziwiat, Manuela, Kuhlenbäumer, Gregor

Journal:

Neurobiology of Aging

Year:

2014

Language:

english

File:

PDF, 2.00 MB

english, 2014

80

Upd3 – An ancestor of the four-helix bundle cytokines

Oldefest, Mirja, Nowinski, Jana, Hung, Chien-Wen, Neelsen, Denis, Trad, Ahmad, Tholey, Andreas, Grötzinger, Joachim, Lorenzen, Inken

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

81

Analysis of the Leukemia Inhibitory Factor Receptor Functional Domains by Chimeric Receptors and Cytokines †

Aasland, Dorthe, Schuster, Björn, Grötzinger, Joachim, Rose-John, Stefan, Kallen, Karl-Josef

Journal:

Year:

2003

Language:

english

File:

PDF, 275 KB

english, 2003

82

The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor

Hecht, Oliver, Dingley, Andrew J., Schwanter, Andreas, Özbek, Suat, Rose-John, Stefan, Grötzinger, Joachim

Journal:

Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

83

Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase

Düsterhöft, Stefan, Jung, Sascha, Hung, Chien-Wen, Tholey, Andreas, Sönnichsen, Frank D., Grötzinger, Joachim, Lorenzen, Inken

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

84

Four Novel Missense Mutations in the CYP21A2 Gene Detected in Russian Patients Suffering from the Classical Form of Congenital Adrenal Hyperplasia: Identification, Functional Characterization, and Structural Analysis

Grischuk, Yulia, Rubtsov, Petr, Riepe, Felix G., Grötzinger, Joachim, Beljelarskaia, Svetlana, Prassolov, Vladimir, Kalintchenko, Natalya, Semitcheva, Tatyana, Peterkova, Valentina, Tiulpakov, Anatoly

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2006

Language:

english

File:

PDF, 703 KB

english, 2006

85

Structure and mode of action of the antimicrobial peptide arenicin

Andrä, Jörg, Jakovkin, Igor, Grötzinger, Joachim, Hecht, Oliver, Krasnosdembskaya, Anna D., Goldmann, Torsten, Gutsmann, Thomas, Leippe, Matthias

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 725 KB

english, 2008

86

Identification of Single Amino Acid Residues of Human IL-6 Involved in Receptor Binding and Signal Initiation

EHLERS, MARC, GRÖTZINGER, JOACHIM, FISCHER, MARTINA, BOS, HANNY KLAASSE, BRAKENHOFF, JUST P.J., ROSE-JOHN, STEFAN

Journal:

Journal of Interferon & Cytokine Research

Year:

1996

Language:

english

File:

PDF, 3.77 MB

english, 1996

87

Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6

Bobby, Romel, Robustelli, Paul, Kralicek, Andrew V., Mobli, Mehdi, King, Glenn F., Grötzinger, Joachim, Dingley, Andrew J.

Journal:

Year:

2014

Language:

english

File:

PDF, 6.26 MB

english, 2014

88

In vitro effectiveness of the antimicrobial peptide eCATH1 against antibiotic-resistant bacterial pathogens of horses

Schlusselhuber, Margot, Guldbech, Kristen, Sevin, Corinne, Leippe, Matthias, Petry, Sandrine, Grötzinger, Joachim, Giguère, Steeve, Cauchard, Julien

Journal:

FEMS Microbiology Letters

Year:

2014

Language:

english

File:

PDF, 76 KB

english, 2014

89

d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers

Magbanua, Eileen, Zivkovic, Tijana, Hansen, Björn, Beschorner, Niklas, Meyer, Cindy, Lorenzen, Inken, Grötzinger, Joachim, Hauber, Joachim, Torda, Andrew E., Mayer, Günter, Rose-John, Stefan, Hahn, Ul

Journal:

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

90

Non-Canonical Interleukin 23 Receptor Complex Assembly

Schröder, Jutta, Moll, Jens M., Baran, Paul, Grötzinger, Joachim, Scheller, Jürgen, Floss, Doreen M.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.62 MB

english, 2015

91

Stabilized Interleukin-6 receptor binding RNA aptamers

Meyer, Cindy, Berg, Katharina, Eydeler-Haeder, Katja, Lorenzen, Inken, Grötzinger, Joachim, Rose-John, Stefan, Hahn, Ulrich

Journal:

Year:

2014

Language:

english

File:

PDF, 359 KB

english, 2014

92

A Novel Entity of Clinically Isolated Adrenal Insufficiency Caused by a Partially Inactivating Mutation of the Gene Encoding for P450 Side Chain Cleavage Enzyme (CYP11A1)

Parajes, Silvia, Kamrath, Clemens, Rose, Ian T., Taylor, Angela E., Mooij, Christiaan F., Dhir, Vivek, Grötzinger, Joachim, Arlt, Wiebke, Krone, Nils

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2011

Language:

english

File:

PDF, 1.13 MB

english, 2011

93

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

Yamamoto, Kosuke, Trad, Ahmad, Baumgart, Anja, Hüske, Linda, Lorenzen, Inken, Chalaris, Athena, Grötzinger, Joachim, Dechow, Tobias, Scheller, Jürgen, Rose‑John, Stefan

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.30 MB

english, 2012

94

Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding

Gill, Raj, Wallach, Brenda, Verma, Chandra, Ursø, Birgitte, De Wolf, Elke, Grötzinger, Joachim, Murray-Rust, Judith, Pitts, Jim, Wollmer, Axel, De Meyts, Pierre, Wood, Steve

Journal:

Protein Engineering Design and Selection

Year:

1996

Language:

english

File:

PDF, 8.45 MB

english, 1996

95

Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1

Michalek, Matthias, Jung, Sascha, Shomali, Mohammad R., Cauchard, Severine, Sönnichsen, Frank D., Grötzinger, Joachim

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

96

Elucidating the Underlying Molecular Pathogenesis of NR3C2 Mutants Causing Autosomal Dominant Pseudohypoaldosteronism Type 1

Riepe, Felix G., Finkeldei, Johannes, de Sanctis, Luisa, Einaudi, Silvia, Testa, Alberto, Karges, Beate, Peter, Michael, Viemann, Matthias, Grötzinger, Joachim, Sippell, Wolfgang G., Fejes-Toth, Geza,

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2006

Language:

english

File:

PDF, 697 KB

english, 2006

97

17a-Hydroxylase Deficiency Diagnosed in Early Infancy Caused by a Novel Mutation of the CYP17A1 Gene

Petri, Christina, Wudy, Stefan A., Riepe, Felix G., Holterhus, Paul-Martin, Siegel, Jens, Hartmann, Michaela F., Kulle, Alexandra E., Welzel, Maik, Grötzinger, Joachim, Schild, Ralf L., Heger, Sabine

Journal:

Hormone Research in Paediatrics

Year:

2014

Language:

english

File:

PDF, 506 KB

english, 2014

98

Steroid 17α-Hydroxylase Deficiency: Functional Characterization of Four Mutations (A174E, V178D, R440C, L465P) in the CYP17A1 Gene

Dhir, Vivek, Reisch, Nicole, Bleicken, Caroline M., Lebl, Jan, Kamrath, Clemens, Schwarz, Hans-Peter, Grötzinger, Joachim, Sippell, Wolfgang G., Riepe, Felix G., Arlt, Wiebke, Krone, Nils

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 214 KB

english, 2009

99

The Novel Mutation p.Trp147Arg of the Steroidogenic Acute Regulatory Protein Causes Classic Lipoid Congenital Adrenal Hyperplasia with Adrenal Insufficiency and 46,XY Disorder of Sex Development

Yüksel, Bilgin, Kulle, Alexandra E., Gürbüz, Fatih, Welzel, Maik, Kotan, Damla, Mengen, Eda, Holterhus, Paul-Martin, Topaloglu, Ali Kemal, Grötzinger, Joachim, Riepe, Felix G.

Journal:

Hormone Research in Paediatrics

Year:

2013

Language:

english

File:

PDF, 293 KB

english, 2013

100

gp130 activation is regulated by D2–D3 interdomain connectivity

Schütt, Antje, Zacharias, Martin, Schneider, Nico, Horn, Silke, Grötzinger, Joachim, Rose‑John, Stefan, Schmidt‑Arras, Dirk

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013