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51

Multifunctional neuroprotective–neurorescue drugs for Parkinson’s disease

Van der Schyf, Cornelis J, Geldenhuys, Werner J, Youdim, Moussa BH

Journal:

Future Neurology

Year:

2007

Language:

english

File:

PDF, 1.76 MB

english, 2007

52

Identification of small molecules that bind to the mitochondrial protein mitoNEET

Geldenhuys, Werner J., Younutas, Heather, Morris, Daniel L., Sullivan, Patrick, Darvesh, Altaf S., Leeper, Thomas C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

53

Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury

Yonutas, Heather M., Hubbard, W. Brad, Pandya, Jignesh D., Vekaria, Hemendra J., Geldenhuys, Werner J., Sullivan, Patrick G.

Journal:

Experimental Neurology

Year:

2020

File:

PDF, 930 KB

2020

54

Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases

Van der Schyf, Cornelis J, Gal, Shunit, Geldenhuys, Werner J, Youdim, Moussa BH

Journal:

Expert Opinion on Investigational Drugs

Year:

2006

Language:

english

File:

PDF, 259 KB

english, 2006

55

Binding of thiazolidinediones to the endoplasmic reticulum protein nutrient-deprivation autophagy factor-1

Geldenhuys, Werner J., Skolik, Robert, Konkle, Mary E., Menze, Michael A., Long, Timothy E., Robart, Aaron R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 1.90 MB

english, 2019

56

Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells

Russell, Ashley E., Jun, Sujung, Sarkar, Saumyendra, Geldenhuys, Werner J., Lewis, Sara E., Rellick, Stephanie L., Simpkins, James W.

Journal:

Frontiers in Cellular Neuroscience

Year:

2019

Language:

english

File:

PDF, 4.35 MB

english, 2019

57

Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells

Julie A. Gaasch, Paul R. Lockman, Werner J. Geldenhuys, David D. Allen, Cornelis J. Van der Schyf

Journal:

Neurochemical Research

Year:

2007

Language:

english

File:

PDF, 319 KB

english, 2007

58

The emergence of designed multiple ligands for neurodegenerative disorders

Werner J. Geldenhuys, Moussa B.H. Youdim, Richard T. Carroll, Cornelis J. Van der Schyf

Journal:

Progress in Neurobiology

Year:

2011

Language:

english

File:

PDF, 1.14 MB

english, 2011

59

Triquinane scaffolds: Shape and geometry as a function of saturation and bridgehead groups

Young, Lois-May, Zeller, Matthias, Geldenhuys, Werner J., Malan, Sarel F., Van der Schyf, Cornelis J.

Journal:

Journal of Molecular Structure

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

60

A quantitative LC–MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies

Pedada, Kiran K., Zhou, Xiang, Jogiraju, Harini, Carroll, Richard T., Geldenhuys, Werner J., Lin, Li, Anderson, David J.

Journal:

Journal of Chromatography B

Year:

2014

Language:

english

File:

PDF, 536 KB

english, 2014

61

Evolution of a Natural Products and Nutraceuticals Course in the Pharmacy Curriculum

Geldenhuys, Werner J., Cudnik, Michelle L., Krinsky, Daniel L., Darvesh, Altaf S.

Journal:

American Journal of Pharmaceutical Education

Year:

2015

Language:

english

File:

PDF, 444 KB

english, 2015

62

Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion

Werner J. Geldenhuys, Altaf S. Darvesh, Dean E. Dluzen

Journal:

Neurochemistry International

Year:

2012

Language:

english

File:

PDF, 191 KB

english, 2012

63

In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery

Darvesh, Altaf S, Carroll, Richard T, Geldenhuys, Werner J, Gudelsky, Gary A, Klein, Jochen, Meshul, Charles K, Van der Schyf, Cornelis J

Journal:

Expert Opinion on Drug Discovery

Year:

2011

Language:

english

File:

PDF, 740 KB

english, 2011

64

Natural Products of Dietary Origin as Lead Compounds in Virtual Screening and Drug Design

J. Geldenhuys, Werner, Bishayee, Anupam, S. Darvesh, Altaf, T. Carroll, Richard

Journal:

Current Pharmaceutical Biotechnology

Year:

2012

Language:

english

File:

PDF, 327 KB

english, 2012

65

Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening

Werner J. Geldenhuys, Altaf S. Darvesh, Max O. Funk, Cornelis J. Van der Schyf, Richard T. Carroll

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

66

Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions

Daniel Wehrung, Werner J. Geldenhuys, Moses O. Oyewumi

Journal:

Colloids and Surfaces B: Biointerfaces

Year:

2012

Language:

english

File:

PDF, 710 KB

english, 2012

67

Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer

Venishetty, Vinay K., Geldenhuys, Werner J., Terell-Hall, Tori B., Griffith, Jessica I.G., Sondag, Gregory R., Safadi, Fayez F., Lockman, Paul R.

Journal:

Current Cancer Drug Targets

Year:

2017

Language:

english

File:

PDF, 3.19 MB

english, 2017

68

Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 a strategy for treatment of multiple myeloma

Hayes, Karen, Batsomboon, Paratchata, Chen, Wei-Chih, Becker, Andreas, Escherich, Steven, Yang, Yan, Robart, Aaron R., Dudley, Gregory, Geldenhuys, Werner J., Hazlehurst, Lori A

Journal:

Bioorganic & Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.49 MB

english, 2019

69

Structure–activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B

Richard T. Carroll, Dean E. Dluzen, Hilary Stinnett, Prabha S. Awale, Max O. Funk, Werner J. Geldenhuys

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

70

Neuroprotection in mice by NGP1-01 after transient focal brain ischemia

Jiukuan Hao, Alexander Mdzinarishvili, Thomas J. Abbruscato, Jochen Klein, Werner J. Geldenhuys, Cornelis J. Van der Schyf, Ulrich Bickel

Journal:

Year:

2008

Language:

english

File:

PDF, 654 KB

english, 2008

71

Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue

Werner J. Geldenhuys, Lois-May Bezuidenhout, Dean E. Dluzen

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 346 KB

english, 2009

72

Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors

Geldenhuys, Werner J., Ko, Kristin S., Stinnett, Hilary, Van der Schyf, Cornelis J., Lim, Mi Hee

Journal:

Year:

2011

Language:

english

File:

PDF, 198 KB

english, 2011

73

Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers

Geldenhuys, Werner, Wehrung, Daniel, Groshev, Anastasia, Hirani, Anjali, Sutariya, Vijaykumar

Journal:

Pharmaceutical Development and Technology

Year:

2015

Language:

english

File:

PDF, 832 KB

english, 2015

74

Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling

Sondag, Gregory R, Mbimba, Thomas S, Moussa, Fouad M, Novak, Kimberly, Yu, Bing, Jaber, Fatima A, Abdelmagid, Samir M, Geldenhuys, Werner J, Safadi, Fayez F

Journal:

Experimental and Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 3.77 MB

english, 2016

75

Pharmacology and Structure—Activity Relationships of Bioactive Polycyclic Cage Compounds: A Focus on Pentacycloundecane Derivatives

Werner J. Geldenhuys, Sarel F. Malan, Jeffrey R. Bloomquist, Alan P. Marchand, Cornelis J. Van der Schyf

Journal:

Year:

2005

File:

PDF, 8 KB

2005

76

A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET

Werner J. Geldenhuys, Max O. Funk, Prabha S. Awale, Li Lin, Richard T. Carroll

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 757 KB

english, 2011

77

Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening

Werner J. Geldenhuys, Phani K. Talasila, Prabodh Sadana

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

78

Screening for anticancer properties of thiazolidinedione compounds in a galactose media metastatic breast cancer cell model

Saralkar, Pushkar, Geldenhuys, Werner J.

Journal:

Medicinal Chemistry Research

Year:

2019

Language:

english

File:

PDF, 904 KB

english, 2019

79

Predictive screening model for potential vector-mediated transport of cationic substrates at the blood–brain barrier choline transporter

Werner J. Geldenhuys, Vamshi K. Manda, Rajendar K. Mittapalli, Cornelis J. Van der Schyf, Peter A. Crooks, Linda P. Dwoskin, David D. Allen, Paul R. Lockman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.78 MB

english, 2010

80

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

Cornelis J. Van der Schyf, Werner J. Geldenhuys, Moussa B. H. Youdim

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 562 KB

english, 2006

81

Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity

A. Blake Buletko, Dean E. Dluzen, Janet L. McDermott, Altaf S. Darvesh, Werner J. Geldenhuys

Journal:

Neurotoxicology and Teratology

Year:

2012

Language:

english

File:

PDF, 427 KB

english, 2012

82

Triquinane-based compounds as possible serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer’s disease

Werner J. Geldenhuys, Cornelis J. Van der Schyf

Journal:

Medical Hypotheses

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

83

Complexes of the Outer Mitochondrial Membrane Protein MitoNEET with Resveratrol-3-Sulfate

Arif, Waqar, Xu, Shu, Isailovic, Dragan, Geldenhuys, Werner J., Carroll, Richard T., Funk, Max O.

Journal:

Year:

2011

Language:

english

File:

PDF, 786 KB

english, 2011

84

mitoNEET as a novel drug target for mitochondrial dysfunction

Geldenhuys, Werner J., Leeper, Thomas C., Carroll, Richard T.

Journal:

Drug Discovery Today

Year:

2014

Language:

english

File:

PDF, 675 KB

english, 2014

85

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

Loskutov, Yuriy V., Griffin, Caryn L., Marinak, Kristina M., Bobko, Andrey, Margaryan, Naira V., Geldenhuys, Werner J., Sarkaria, Jann N., Pugacheva, Elena N.

Journal:

Year:

2018

Language:

english

File:

PDF, 3.53 MB

english, 2018

86

Identification of a Class of Novel Tubulin Inhibitors

Geldenhuys, Werner J., Feng, Ye, Pink, John J., Dowlati, Afshin, Xu, Yan, Zhou, Aimin, Su, Bin, Yi, Xin, Zhong, Bo, Smith, Kerri M.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 4.07 MB

english, 2012

87

Exploiting nutrient transporters at the blood–brain barrier to improve brain distribution of small molecules

Mittapalli, Rajendar K, Manda, Vamshi K, Adkins, Chris E, Geldenhuys, Werner J, Lockman, Paul R

Journal:

Therapeutic Delivery

Year:

2010

Language:

english

File:

PDF, 3.21 MB

english, 2010

88

Pioglitazone treatment following spinal cord injury maintains acute mitochondrial integrity and increases chronic tissue sparing and functional recovery

Patel, Samir P., Cox, David H., Gollihue, Jenna L., Bailey, William M., Geldenhuys, Werner J., Gensel, John C., Sullivan, Patrick G., Rabchevsky, Alexander G.

Journal:

Experimental Neurology

Year:

2017

Language:

english

File:

PDF, 1.68 MB

english, 2017

89

MitoNEET (CISD1) knockout mice show signs of striatal mitochondrial dysfunction and a Parkinson’s disease phenotype

Geldenhuys, Werner J., Benkovic, Stanley A, Lin, Li, Yonutas, Heather M, Crish, Samuel D, Sullivan, Patrick G, Darvesh, Altaf S, Brown, Candice M, Richardson, Jason

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.17 MB

english, 2017

90

Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells

Russell, Ashley E., Jun, Sujung, Sarkar, Saumyendra, Geldenhuys, Werner J., Lewis, Sara E., Rellick, Stephanie L., Simpkins, James W.

Journal:

Frontiers in Cellular Neuroscience

Year:

2019

File:

PDF, 4.35 MB

2019

91

Synthesis, biological evaluation, and molecular modeling of novel thioacridone derivatives related to the anticancer alkaloid acronycine

James P. Dheyongera, Werner J. Geldenhuys, Theodor G. Dekker, Cornelis J. Van der Schyf

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 427 KB

english, 2005

92

Molecular modeling studies on the active binding site of the blood–brain barrier choline transporter

Werner J. Geldenhuys, Paul R. Lockman, James H. McAfee, Kevin T. Fitzpatrick, Cornelis J. Van der Schyf, David D. Allen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 443 KB

english, 2004

93

Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders

Carroll, Richard T., Bhatia, Deepak, Geldenhuys, Werner, Bhatia, Ruchi, Miladore, Nicholas, Bishayee, Anupam, Sutariya, Vijaykumar

Journal:

Journal of Drug Targeting

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

94

Novel models for assessing blood–brain barrier drug permeation

Geldenhuys, Werner J, Allen, David D, Bloomquist, Jeffrey R

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2012

Language:

english

File:

PDF, 311 KB

english, 2012

95

Screening of novel pentacyclo-undecylamines for neuroprotective activity

Werner J Geldenhuys, Gisella Terre'Blanche, Cornelis J Van der Schyf, Sarel F Malan

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

96

The serotonin 5-HT 6 receptor: a viable drug target for treating cognitive deficits in Alzheimer’s disease

Geldenhuys, Werner J, Van der Schyf, Cornelis J

Journal:

Expert Review of Neurotherapeutics

Year:

2009

Language:

english

File:

PDF, 556 KB

english, 2009

97

Role of Serotonin in Alzheimer’s Disease

Geldenhuys, Werner J., Van der Schyf, Cornelis J.

Journal:

Year:

2011

Language:

english

File:

PDF, 776 KB

english, 2011

98

Synthesis and Anticancer Mechanism Investigation of Dual Hsp27 and Tubulin Inhibitors

Zhong, Bo, Chennamaneni, Snigdha, Lama, Rati, Yi, Xin, Geldenhuys, Werner J., Pink, John J., Dowlati, Afshin, Xu, Yan, Zhou, Aimin, Su, Bin

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.66 MB

english, 2013

99

Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers

Geldenhuys, Werner, Mbimba, Thomas, Bui, Thong, Harrison, Kimberly, Sutariya, Vijaykumar

Journal:

Journal of Drug Targeting

Year:

2011

Language:

english

File:

PDF, 945 KB

english, 2011

100

Novel Multifunctional Anti-Alzheimer Drugs with Various CNS Neurotransmitter Targets and Neuroprotective Moieties

Van der Schyf, Cornelis, Mandel, Silvia, Geldenhuys, Werner, Amit, Tamar, Avramovich, Yael, Zheng, Hailin, Fridkin, Mati, Gal, Shunit, Weinreb, Orly, Am, Orit, Sagi, Yotam, Youdim, Moussa

Journal:

Current Alzheimer Research

Year:

2007

Language:

english

File:

PDF, 420 KB

english, 2007

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