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51

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes

von Geldern, Thomas W., Tu, Noah, Kym, Philip R., Link, James T., Jae, Hwan-Soo, Lai, Chunqiu, Apelqvist, Theresa, Rhonnstad, Patrik, Hagberg, Lars, Koehler, Konrad, Grynfarb, Marlena, Goos-Nilsson, A

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 551 KB

english, 2004

52

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Thomas W. von Geldern, Chunqiu Lai, Rebecca J. Gum, Melissa Daly, Chaohong Sun, Elizabeth H. Fry, Celerino Abad-Zapatero

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 261 KB

english, 2006

53

Synthesis and Biological Evaluation of Novel, Selective, Nonsteroidal Glucocorticoid Receptor Antagonists.

Irini Akritopoulou-Zanze, Jyoti R. Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K. Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W. von Geldern, Philip R. Kym

Journal:

Year:

2004

File:

PDF, 131 KB

2004

54

Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists

Bradley J. Backes, Gregory L. Hamilton, Phong Nguyen, Denise Wilcox, Steven Fung, Jiahong Wang, Marlena Grynfarb, Annika Goos-Nilsson, Peer B. Jacobson, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 217 KB

english, 2007

55

An Evaluation of a C-Glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist

Bryan K. Sorensen, J.T. Link, Thomas von Geldern, Maurice Emery, Jiahong Wang, Bach Hickman, Marlena Grynfarb, Annika Goos-Nilsson, Sherry Carroll

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

56

Expression of atrial natriuretic peptide receptor-A antagonizes the mitogen-activated protein kinases (Erk2 and P38MAPK) in cultured human vascular smooth muscle cells

Guru Dutt Sharma, Huong T. Nguyen, Alexander S. Antonov, Ross G. Gerrity, Thomas von Geldern, Kailash N. Pandey

Journal:

Molecular and Cellular Biochemistry

Year:

2002

Language:

english

File:

PDF, 158 KB

english, 2002

57

Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W., Longenecker, Kenton, Pireh, Daisy, Stewart, Kent D., Backes, Bradley J., Lai, Chunqiu, Lubben, Thomas H., Ballaron, Stephen J., Beno, David W. A.,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 155 KB

english, 2007

58

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

Hübner, Marc P., Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W., Marsh, Kennan, Turner,

Journal:

PLoS Neglected Tropical Diseases

Year:

2019

Language:

english

File:

PDF, 4.89 MB

english, 2019

59

Synthetic studies on arene-olefin cycloadditions. 10. A concise, stereocontrolled total synthesis of (.+-.)-laurenene

Wender, Paul A., Von Geldern, Thomas W., Levine, Barry H.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 409 KB

english, 1988

60

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ETA receptor selectivity

Steven A Boyd, Robert A Mantei, Andrew S Tasker, Gang Liu, Bryan K Sorensen, Kenneth J Henry Jr, Thomas W von Geldern, Martin Winn, Jinshyun R Wu-Wong, William J Chiou, Douglas B Dixon, Charles W Hutc

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 234 KB

english, 1999

61

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity

von Geldern, Thomas W., Tasker, Andrew S., Sorensen, Bryan K., Winn, Martin, Szczepankiewicz, Bruce G., Dixon, Douglas B., Chiou, William J., Wang, Liming, Wessale, Jerry L., Adler, Andy

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 260 KB

english, 1999

62

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors.

Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W., Wiedeman, Paul E., Lubben, Thomas H., Zinker, Bradley A., Stewart, Kent, Ballaron, Stephen J., Stashko, Michael A., Mika, Aman

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 6 KB

english, 2006

63

Discovery of 2-[4-{{2-(2 S ,5 R )-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

Madar, David J., Kopecka, Hana, Pireh, Daisy, Yong, Hong, Pei, Zhonghua, Li, Xiaofeng, Wiedeman, Paul E., Djuric, Stevan W., Von Geldern, Thomas W., Fickes, Michael G., Bhagavatula, Lakshmi, McDermott

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 216 KB

english, 2006

64

The Synthesis and Characterization of a Novel Insulin Sensitizing Agent.

Thomas W. von Geldern, Regina P. Brun, Masha Kalmanovich, Denise Wilcox, Peer B. Jacobson

Journal:

Year:

2004

File:

PDF, 16 KB

2004

65

Total Synthesis of (±)-Norsecurinine

H. Heathcock, Clayton, W. von Geldern, Thomas

Journal:

Year:

1987

Language:

english

File:

PDF, 100 KB

english, 1987

66

Small atrial natriuretic peptide analogs: design, synthesis, and structural requirements for guanylate cyclase activation

Von Geldern, Thomas W., Rockway, Todd W., Davidsen, Steven K., Budzik, Gerald P., Bush, Eugene N., Chu-Moyer, Margaret Y., Devine, Edward M., Holleman, William H., Johnson, Marty C.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.86 MB

english, 1992

67

Truncated atrial natriuretic factor analogs retain full agonist activity

Holleman, W. H., Budzik, G. P., Devine, E. M., Pollock, D. M., Opgenorth, T. J., Thomas, A. M., Geldern, T. W. von, Rockway, T. W.

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.49 MB

english, 1991

68

Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists

Steven J. Richards, Thomas W. von Geldern, Peer Jacobson, Denise Wilcox, Phong Nguyen, Lars Öhman, Marie Österlund, Birgitta Gelius, Marlena Grynfarb, Annika Goos-Nilsson, Jiahong Wang, Steven Fung, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 173 KB

english, 2006

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