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51

Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells

Fan, Keqiang, Zhang, Xia, Liu, Hongchun, Han, Hui, Luo, Yuanming, Wang, Qian, Geng, Meiyu, Yang, Keqian

Journal:

The Journal of Antibiotics

Year:

2012

Language:

english

File:

PDF, 277 KB

english, 2012

52

Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors

Zhang, Dengyou, Zhang, Xiaowei, Ai, Jing, Zhai, Yun, Liang, Zhongjie, Wang, Ying, Chen, Yi, Li, Chunpu, Zhao, Fei, Jiang, Hualiang, Geng, Meiyu, Luo, Cheng, Liu, Hong

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.96 MB

english, 2013

53

Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors

Zhang, Dengyou, Ai, Jing, Liang, Zhongjie, Zhu, Wei, Peng, Xia, Chen, Xianjie, Ji, YinChun, Jiang, Hualiang, Luo, Cheng, Geng, Meiyu, Liu, Hong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.62 MB

english, 2013

54

A novel long non-coding RNA-ARA: Adriamycin Resistance Associated

Jiang, Min, Huang, Ou, Xie, Zuoquan, Wu, Shuchao, Zhang, Xi, Shen, Aijun, Liu, Hongchun, Chen, Xiaosong, Wu, Jiayi, Lou, Ying, Mao, Yan, Sun, Kan, Hu, Shudong, Geng, Meiyu, Shen, Kunwei

Journal:

Biochemical Pharmacology

Year:

2014

Language:

english

File:

PDF, 3.68 MB

english, 2014

55

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

Ren, Jing, Li, Jian, Wang, Yueqin, Chen, Wuyan, Shen, Aijun, Liu, Hongchun, Chen, Danqi, Cao, Danyan, Li, Yanlian, Zhang, Naixia, Xu, Yechun, Geng, Meiyu, He, Jianhua, Xiong, Bing, Shen, Jingkang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.38 MB

english, 2014

56

Discovery of novel type II c-Met inhibitors based on BMS-777607

Zhang, Wei, Ai, Jing, Shi, Dakuo, Peng, Xia, Ji, Yinchun, Liu, Jian, Geng, Meiyu, Li, Yingxia

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

57

Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor

Peng, Jixing, Gao, Huquan, Li, Jing, Ai, Jing, Geng, Meiyu, Zhang, Guojian, Zhu, Tianjiao, Gu, Qianqun, Li, Dehai

Journal:

Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

58

Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity

Zhan, Zhengsheng, Ai, Jing, Liu, Qiufeng, Ji, Yinchun, Chen, Tiantian, Xu, Yechun, Geng, Meiyu, Duan, Wenhu

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

59

Design and synthesis of 3,3′-biscoumarin-based c-Met inhibitors

Xu, Jimin, Ai, Jing, Liu, Sheng, Peng, Xia, Yu, Linqian, Geng, Meiyu, Nan, Fajun

Journal:

Organic & Biomolecular Chemistry

Year:

2014

Language:

english

File:

PDF, 589 KB

english, 2014

60

Further SAR studies on 3,5-diamino-7-trifluoromethylquinolines as highly potent tyrosine kinase c-Met inhibitors: efforts to correct hERG inhibition

Wang, Yuanxiang, Ai, Jing, Yue, Jinfeng, Peng, Xia, Ji, Yinchun, Zhao, Ailing, Gao, Xin, Wang, Ying, Chen, Yi, Liu, Gang, Gao, Zhaobing, Geng, Meiyu, Zhang, Ao

Journal:

Year:

2012

Language:

english

File:

PDF, 271 KB

english, 2012

61

Design, synthesis, and structure–activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists

Ma, Haikuo, Lu, Wenfeng, Sun, Zhijian, Luo, Lusong, Geng, Delong, Yang, Zhaohui, Li, Enqin, Zheng, Jiyue, Wang, Meiyu, Zhang, Hongjian, Yang, Shilin, Zhang, Xiaohu

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

62

Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90

Meng, Tao, Zhang, Dadong, Xie, Zuoquan, Yu, Ting, Wu, Shuchao, Wyder, Lorenza, Regenass, Urs, Hilpert, Kurt, Huang, Min, Geng, Meiyu, Shen, Jingkang

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.90 MB

english, 2014

63

Discovery and SAR study of c-Met kinase inhibitors bearing an 3-amino-benzo[d]isoxazole or 3-aminoindazole scaffold

Jiang, Xiaolong, Liu, Hongyan, Song, Zilan, Peng, Xia, Ji, Yinchun, Yao, Qizheng, Geng, Meiyu, Ai, Jing, Zhang, Ao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 676 KB

english, 2015

64

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke–Blackburn–Bienaymé reaction and their Hsp90 inhibitory activity

Ren, Jing, Yang, Min, Liu, Hongchun, Cao, Danyan, Chen, Danqi, Li, Jian, Tang, Le, He, Jianhua, Chen, Yue-Lei, Geng, Meiyu, Xiong, Bing, Shen, Jingkang

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

65

Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization

An, Xiao-De, Liu, Hongyan, Xu, Zhong-Liang, Jin, Yi, Peng, Xia, Yao, Ying-Ming, Geng, Meiyu, Long, Ya-Qiu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.77 MB

english, 2015

66

Correction to Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway

Liang, Zhongjie, Ai, Jing, Ding, Xiao, Peng, Xia, Zhang, Dengyou, Zhang, Ruihan, Wang, Ying, Liu, Fang, Zheng, Mingyue, Jiang, Hualiang, Liu, Hong, Geng, Meiyu, Luo, Cheng

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 134 KB

english, 2015

67

Design and Optimization of a Series of 1-Sulfonylpyrazolo[4,3- b ]pyridines as Selective c-Met Inhibitors

Ma, Yuchi, Sun, Guangqiang, Chen, Danqi, Peng, Xia, Chen, Yue-Lei, Su, Yi, Ji, Yinchun, Liang, Jin, Wang, Xin, Chen, Lin, Ding, Jian, Xiong, Bing, Ai, Jing, Geng, Meiyu, Shen, Jingkang

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.74 MB

english, 2015

68

Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

Zhou, Zhenfang, Wang, Xin, Zhang, Hui, Sun, Jingya, Zheng, Linghui, Liu, Hongchun, Wang, Jidong, Shen, Aijun, Geng, Meiyu, Guo, Yuewei

Journal:

Acta Pharmaceutica Sinica B

Year:

2015

Language:

english

File:

PDF, 596 KB

english, 2015

69

Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3 + 2] Cycloaddition from Carpesium abrotanoides

Wu, Jiewei, Tang, Chunping, Chen, Lan, Qiao, Yan, Geng, Meiyu, Ye, Yang

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 295 KB

english, 2015

70

A new marine-derived sulfated polysaccharide from brown alga suppresses tumor metastasis both in vitro and in vivo

Tang, Xuelian, Li, Jing, Xin, Xianliang, Geng, Meiyu

Journal:

Cancer Biology & Therapy

Year:

2006

Language:

english

File:

PDF, 851 KB

english, 2006

71

Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis

Xing, Weiqiang, Ai, Jing, Jin, Shiyu, Shi, Zhangxing, Peng, Xia, Wang, Lang, Ji, Yinchun, Lu, Dong, Liu, Yang, Geng, Meiyu, Hu, Youhong

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

72

C-5 Substituted Pyrido[2,3-d]pyrimidin-7-ones as Highly Specific Kinase Inhibitors Targeting Clinical Resistance related EGFRT790M Mutant

Ding, Ke, Ding, Jian, Xie, Hua, Geng, Meiyu, Tong, Linjiang, Peng, Ting, Huang, zhaoyu, Xu, Tianfeng, Ren, xiaomei, Tu, Zhengchao, Zhang, Lianwen, zhang, zhang, lu, xiaoyun, Yu, Lei, Luo, Jinfeng

Journal:

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

73

Pyridazinone Derivatives Displaying Highly Potent and Selective Inhibitory Activities against c-Met Tyrosine Kinase

Liu, Yang, Jin, Shiyu, Peng, Xia, Lu, Dong, Zeng, Limin, Sun, Yiming, Ai, Jing, Geng, Meiyu, Hu, Youhong

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 766 KB

english, 2015

74

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

Chen, Danqi, Shen, Aijun, Fang, Guanghua, Liu, Hongchun, Zhang, Minmin, Tang, Shuai, Xiong, Bing, Ma, Lanping, Geng, Meiyu, Shen, Jingkang

Journal:

Acta Pharmaceutica Sinica B

Year:

2016

Language:

english

File:

PDF, 1.00 MB

english, 2016

75

Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site

Miao, Benchun, Chen, Yi, Li, Jing, Xin, Xianliang, Gan, Li, Fu, Xueyan, Geng, Meiyu

Journal:

Cancer Biology & Therapy

Year:

2010

Language:

english

File:

PDF, 5.10 MB

english, 2010

76

Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors

Lu, Dong, Shen, Aijun, Liu, Yang, Peng, Xia, Xing, Weiqiang, Ai, Jing, Geng, Meiyu, Hu, Youhong

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 905 KB

english, 2016

77

Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a Highly Potent and Selective c-Met Inhibitor

Zhan, Zhengsheng, Peng, Xia, Liu, Qiufeng, Chen, Fang, Ji, Yinchun, Yao, Shanyan, Xi, Yong, Lin, Yipeng, Chen, Tiantian, Xu, Yechun, Ai, Jing, Geng, Meiyu, Duan, Wenhu

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.69 MB

english, 2016

78

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors

Fan, Jun, Dai, Yang, Shao, Jingwei, Peng, Xia, Wang, Chen, Cao, Sufen, Zhao, Bin, Ai, Jing, Geng, Meiyu, Duan, Wenhu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 672 KB

english, 2016

79

Discovery and Structure Activity Relationship Study of Novel Indazole Amide Inhibitors for Extracellular Signal-Regulated Kinase1/2 (ERK1/2)

Li, Lei, Liu, Feifei, Jin, Nan, Tang, Shuai, Chen, Zhuxi, Yang, Xiaotong, Ding, Jian, Geng, Meiyu, Jiang, Lei, Huang, Min, Cao, Jianhua

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 529 KB

english, 2016

80

An orally available tyrosine kinase ALK and RET dual inhibitor bearing the tetracyclic benzo[b]carbazolone core

Song, Zilan, Xia, Zongjun, Ji, Yinchun, Xing, Li, Gao, Yinglei, Ai, Jing, Geng, Meiyu, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 969 KB

english, 2016

81

ChemInform Abstract: Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor.

Peng, Jixing, Gao, Huquan, Li, Jing, Ai, Jing, Geng, Meiyu, Zhang, Guojian, Zhu, Tianjiao, Gu, Qianqun, Li, Dehai

Journal:

Year:

2015

File:

PDF, 18 KB

2015

82

ChemInform Abstract: Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3 + 2] Cycloaddition from Carpesium abrotanoides.

Wu, Jiewei, Tang, Chunping, Chen, Lan, Qiao, Yan, Geng, Meiyu, Ye, Yang

Journal:

Year:

2015

File:

PDF, 15 KB

2015

83

Design, Synthesis and Biological Evaluation of c-Met kinase inhibitors bearing 2-oxo-1, 2-dihydroquinoline Scaffold

Cui, Hong, Peng, Xia, Liu, Jian, Ma, Chunhua, Ji, Yinchun, Zhang, Wei, Geng, Meiyu, Li, Yingxia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 548 KB

english, 2016

84

Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer

Zeng, Hanlin, Qu, Jia, Jin, Nan, Xu, Jun, Lin, Chenchu, Chen, Yi, Yang, Xinying, He, Xiang, Tang, Shuai, Lan, Xiaojing, Yang, Xiaotong, Chen, Ziqi, Huang, Min, Ding, Jian, Geng, Meiyu

Journal:

Year:

2016

Language:

english

File:

PDF, 4.39 MB

english, 2016

85

Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

Zhang, Chi, Wang, Xin, Liu, Hongchun, Zhang, Minmin, Geng, Meiyu, Sun, Liping, Shen, Aijun, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

86

Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors

Liu, Dr Yang, Peng, Xia, Guan, Xiaocong, Lu, Dong, Xi, Yong, Jin, Shiyu, Chen, Hui, Zeng, Limin, Ai, Jing, Geng, Meiyu, Hu, Youhong

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

87

Discovery of 4-chloro-3-(5-(pyridin-3-yl)-1,2,4-oxadiazole-3-yl)benzamides as novel RET kinase inhibitors

Han, Mei, Li, Shan, Ai, Jing, Sheng, Rong, Hu, Yongzhou, Hu, Youhong, Geng, Meiyu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 888 KB

english, 2016

88

Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core

Han, Mei, Wang, Chengyan, Ji, Yinchun, Song, Zilan, Xing, Li, Su, Yi, Wang, Xisheng, Zhang, Ao, Ai, Jing, Geng, Meiyu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 832 KB

english, 2016

89

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

Lu, Junyan, Zeng, Hanlin, Liang, Zhongjie, Chen, Limin, Zhang, Liyi, Zhang, Hao, Liu, Hong, Jiang, Hualiang, Shen, Bairong, Huang, Ming, Geng, Meiyu, Spiegel, Sarah, Luo, Cheng

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

90

Immunogenic Comparison of Two Coupling Methods of Marine Polysaccharide to Bovine Serum Albumin

Gan, Li, Xin, Xianliang, Geng, Meiyu, Ding, Jian

Journal:

Biological & Pharmaceutical Bulletin

Year:

2004

Language:

english

File:

PDF, 121 KB

english, 2004

91

Determination of the Accessibility of Acidic Oligosaccharide Sugar Chain to Blood-Brain Barrier Using Surface Plasmon Resonance

Guo, XiuLi, Xin, XianLiang, Gan, Li, Nie, Qin, Geng, MeiYu

Journal:

Biological & Pharmaceutical Bulletin

Year:

2006

Language:

english

File:

PDF, 156 KB

english, 2006

92

Studies of Marine Sulfated Polymannuroguluronate on Endothelial Cell Proliferation and Endothelial Immunity and Related Mechanisms

Wang, Lichun, Geng, Meiyu, Li, Jing, Guan, Huashi, Ding, Jian

Journal:

Journal of Pharmacological Sciences

Year:

2003

Language:

english

File:

PDF, 398 KB

english, 2003

93

Acidic Oligosaccharide Sugar Chain, a Marine-Derived Acidic Oligosaccharide, Inhibits the Cytotoxicity and Aggregation of Amyloid Beta Protein

Hu, Jinfeng, Geng, Meiyu, Li, Jing, Xin, Xianliang, Wang, Jia, Tang, Minke, Zhang, Juntian, Zhang, Xiao, Ding, Jian

Journal:

Journal of Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 451 KB

english, 2004

94

Potentiation of T Cell Function by a Marine Algae-Derived Sulfated Polymannuroguluronate: In Vitro Analysis of Novel Mechanisms

Xia, Wei, Li, Jing, Geng, Meiyu, Xin, Xianliang, Ding, Jian

Journal:

Journal of Pharmacological Sciences

Year:

2005

Language:

english

File:

PDF, 679 KB

english, 2005

95

Exploiting histone deacetylases for cancer therapy: from hematological malignancies to solid tumors

Huang, Min, Geng, Meiyu

Journal:

SCIENCE CHINA Life Sciences

Year:

2017

Language:

english

File:

PDF, 678 KB

english, 2017

96

Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold

Zhang, Wei, Ai, Jing, Shi, Dakuo, Peng, Xia, Ji, Yinchun, Liu, Jian, Geng, Meiyu, Li, Yingxia

Journal:

Year:

2014

Language:

english

File:

PDF, 528 KB

english, 2014

97

Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells

Qu, Jia, Sun, Wenyi, Zhong, Jie, Lv, Hao, Zhu, Mingrui, Xu, Jun, Jin, Nan, Xie, Zuoquan, Tan, Minjia, Lin, Shu-Hai, Geng, Meiyu, Ding, Jian, Huang, Min

Journal:

The Journal of Cell Biology

Year:

2017

Language:

english

File:

PDF, 3.54 MB

english, 2017

98

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors

Liu, Yifu, Xie, Zuoquan, Zhao, Dan, Zhu, Jin, Mao, Fei, Tang, Shuai, Xu, Hui, Luo, Cheng, Geng, Meiyu, Huang, Min, Li, Jian

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.94 MB

english, 2017

99

Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation

Lian, Qiaoshi, Xu, Jun, Yan, Shanshan, Huang, Min, Ding, Honghua, Sun, Xiaoyu, Bi, Aiwei, Ding, Jian, Sun, Bing, Geng, Meiyu

Journal:

Year:

2017

Language:

english

File:

PDF, 8.68 MB

english, 2017

100

Targeting sphingosine-1-phosphate signaling for cancer therapy

Xie, Zuoquan, Liu, Hong, Geng, Meiyu

Journal:

SCIENCE CHINA Life Sciences

Year:

2017

Language:

english

File:

PDF, 966 KB

english, 2017