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1

Dose-finding designs in pediatric phase I clinical trials: Comparison by simulations in a realistic timeline framework

A. Doussau, B. Asselain, M.C. Le Deley, B. Geoerger, F. Doz, G. Vassal, X. Paoletti

Journal:

Contemporary Clinical Trials

Year:

2012

Language:

english

File:

PDF, 514 KB

english, 2012

2

Implementation of mechanism of action biology-driven early drug development for children with cancer

Pearson, Andrew D.J., Herold, Ralf, Rousseau, Raphaël, Copland, Chris, Bradley-Garelik, Brigid, Binner, Debbie, Capdeville, Renaud, Caron, Hubert, Carleer, Jacqueline, Chesler, Louis, Geoerger, Birgit

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 409 KB

english, 2016

3

Early phase clinical trials of anticancer agents in children and adolescents — an ITCC perspective

Moreno, Lucas, Pearson, Andrew D. J., Paoletti, Xavier, Jimenez, Irene, Geoerger, Birgit, Kearns, Pamela R., Zwaan, C. Michel, Doz, Francois, Baruchel, Andre, Vormoor, Josef, Casanova, Michela, Pfiste

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

Language:

english

File:

PDF, 429 KB

english, 2017

4

From class waivers to precision medicine in paediatric oncology

Pearson, Andrew D J, Pfister, Stefan M, Baruchel, Andre, Bourquin, Jean-Pierre, Casanova, Michela, Chesler, Louis, Doz, François, Eggert, Angelika, Geoerger, Birgit, Jones, David T W, Kearns, Pamela R

Journal:

The Lancet Oncology

Year:

2017

Language:

english

File:

PDF, 138 KB

english, 2017

5

Integrated analysis of long-term growth and bone development in pediatric and adolescent patients receiving bevacizumab

Müller, Hermann L., Merks, Johannes H.M., Geoerger, Birgit, Grill, Jacques, Hargrave, Darren, Glade Bender, Julia, Gururangan, Sridharan, Navid, Fariba, Johnston, Michael, Bachir, Jeanette, Elze, Mark

Journal:

Pediatric Blood & Cancer

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

6

Sequential or combined designs for Phase I/II clinical trials? A simulation study

Rossoni, Caroline, Bardet, Aurélie, Geoerger, Birgit, Paoletti, Xavier

Journal:

Clinical Trials

Year:

2019

Language:

english

File:

PDF, 889 KB

english, 2019

7

Biological stability of RNA isolated from RNAlater-treated brain tumor and neuroblastoma xenografts

Grotzer, Michael A., Patti, Ratnakar, Geoerger, Birgit, Eggert, Angelika, Chou, Thomas T., Phillips, Peter C.

Journal:

Medical and Pediatric Oncology

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

8

Prognostic significance of Ki-67 (MIB-1) proliferation index in childhood primitive neuroectodermal tumors of the central nervous system

Michael A. Grotzer, Birgit Geoerger, Anna J. Janss, Huaqing Zhao, Lucy B. Rorke, Peter C. Phillips

Journal:

Pediatric Blood & Cancer

Year:

2001

Language:

english

File:

PDF, 226 KB

english, 2001

9

Metabolic activity and clinical features of primary ganglioneuromas

Birgit Geoerger, Barbara Hero, Dieter Harms, Jochen Grebe, Klemens Scheidhauer, Frank Berthold

Journal:

Year:

2001

Language:

english

File:

PDF, 251 KB

english, 2001

10

EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts

Birgit Geoerger, Nathalie Gaspar, Paule Opolon, Jackie Morizet, Pauline Devanz, Yann Lecluse, Alexander Valent, Ludovic Lacroix, Jacques Grill, Gilles Vassal

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 806 KB

english, 2008

11

The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts

Jochen Rössler, Yann Monnet, Francoise Farace, Paule Opolon, Estelle Daudigeos-Dubus, Abderrahmane Bourredjem, Gilles Vassal, Birgit Geoerger

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 533 KB

english, 2011

12

Expression of p53, or targeting towards EGFR, enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma

Birgit Geoerger, Victor W. van Beusechem, Paule Opolon, Jackie Morizet, Lysiane Laudani, Yann Lecluse, Michel Barrois, Sander Idema, Jacques Grill, Winald R. Gerritsen, Gilles Vassal

Journal:

The Journal of Gene Medicine

Year:

2005

Language:

english

File:

PDF, 426 KB

english, 2005

13

p53 pathway dysfunction in primary childhood ependymomas

Nathalie Gaspar, Jacques Grill, Birgit Geoerger, Arielle Lellouch-Tubiana, Mariana Bohns Michalowski, Gilles Vassal

Journal:

Pediatric Blood & Cancer

Year:

2006

Language:

english

File:

PDF, 411 KB

english, 2006

14

Do medulloblastoma tumors meet the food and drug administration criteria for anti-erbB2 therapy with trastuzumab?

Natacha Entz-Werle, Valérie Velasco, Agnès Neuville, Birgit Geoerger, Marie-Christine Mathieu, Eric Guerin, Pierre Kehrli, Marie-Pierre Gaub, Gilles Vassal, Jacques Grill

Journal:

Pediatric Blood & Cancer

Year:

2008

Language:

english

File:

PDF, 246 KB

english, 2008

15

Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies

Geoerger, B, Vassal, G, Doz, F, O'Quigley, J, Wartelle, M, Watson, A J, Raquin, M-A, Frappaz, D, Chastagner, P, Gentet, J-C

Journal:

British Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 147 KB

english, 2005

16

Pleiotrophin, a candidate gene for poor tumor vasculature and in vivo neuroblastoma sensitivity to irinotecan

Calvet, L, Geoerger, B, Regairaz, M, Opolon, P, Machet, L, Morizet, J, Joseph, J-M, Elie, N, Vassal, G

Journal:

Year:

2006

Language:

english

File:

PDF, 267 KB

english, 2006

17

Thérapies ciblées en oncologie pédiatrique : nouvelle approche thérapeutique

C. Jubert, B. Geoerger, J. Grill, O. Hartmann, G. Vassal

Journal:

Archives de Pédiatrie

Year:

2006

Language:

french

File:

PDF, 203 KB

french, 2006

18

Neuroblastome : intérêt des traitements anti-angiogéniques

M. Taylor, B. Geoerger, J. Lagodny, F. Farace, G. Vassal, J. Rössler

Journal:

Archives de Pédiatrie

Year:

2009

Language:

english

File:

PDF, 473 KB

english, 2009

19

The role of the ‘innovative therapies for children with cancer’ (ITCC) European consortium

C. Michel Zwaan, Pamela Kearns, Huib Caron, Arnauld Verschuur, Riccardo Riccardi, Joachim Boos, Francois Doz, Birgit Geoerger, Bruce Morland, Gilles Vassal

Journal:

Cancer Treatment Reviews

Year:

2010

Language:

english

File:

PDF, 344 KB

english, 2010

20

Angiogenesis as a target in neuroblastoma

Jochen Rössler, Melissa Taylor, Birgit Geoerger, Francoise Farace, Jeanette Lagodny, Regine Peschka-Süss, Charlotte M. Niemeyer, Gilles Vassal

Journal:

European Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 838 KB

english, 2008

21

A phase II study of irinotecan in children with relapsed or refractory neuroblastoma: A European cooperation of the Société Française d’Oncologie Pédiatrique (SFOP) and the United Kingdom Children Cancer Study Group (UKCCSG)

Gilles Vassal, Francesco Giammarile, Mariel Brooks, Birgit Geoerger, Dominique Couanet, Jean Michon, Elizabeth Stockdale, Matthias Schell, Anne Geoffray, Jean-Claude Gentet, Fabienne Pichon, Hervé Rub

Journal:

European Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 141 KB

english, 2008

22

Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium

Birgit Geoerger, Bruce Morland, Anna Ndiaye, Francois Doz, Gabriel Kalifa, Anne Geoffray, Fabienne Pichon, Didier Frappaz, Etienne Chatelut, Paule Opolon, Sharon Hain, Francoise Boderet, Jacques Bosq,

Journal:

European Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 261 KB

english, 2009

23

Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours

Hervé Rubie, Birgit Geoerger, Didier Frappaz, Antonin Schmitt, Pierre Leblond, Anna Ndiaye, Isabelle Aerts, Marie-Cécile Le Deley, Jean-Claude Gentet, Angelo Paci, Pascal Chastagner, Nathalie Dias, La

Journal:

European Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 224 KB

english, 2010

24

Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

Birgit Geoerger, Jean-François Brasme, Estelle Daudigeos-Dubus, Paule Opolon, Corinne Venot, Laurent Debussche, Patricia Vrignaud, Gilles Vassal

Journal:

European Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 921 KB

english, 2010

25

Phase II study of gemcitabine combined with oxaliplatin in relapsed or refractory paediatric solid malignancies: An innovative therapy for children with Cancer European Consortium Study

Birgit Geoerger, Julia Chisholm, Marie-Cecile Le Deley, Jean-Claude Gentet, Christian Michel Zwaan, Nathalie Dias, Timothy Jaspan, Kieran Mc Hugh, Dominique Couanet, Sharon Hain, Annick Devos, Riccard

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 454 KB

english, 2011

26

Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma

Birgit Geoerger, Mark W. Kieran, Stephan Grupp, Danuta Perek, Jill Clancy, Mizue Krygowski, Revathi Ananthakrishnan, Joseph P. Boni, Anna Berkenblit, Sheri L. Spunt

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 292 KB

english, 2012

27

A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: An Innovative Therapies for Children with Cancer (ITCC) study

Birgit Geoerger, Edward J. Estlin, Isabelle Aerts, Pamela Kearns, Brenda Gibson, Nadège Corradini, François Doz, Pilar Lardelli, Bernardo De Miguel, Arturo Soto, Raquel Prados, Gilles Vassal

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 268 KB

english, 2012

28

277 INVITED IGF1R Targeting in Non-sarcoma Pediatric Malignancies

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

29

246 INVITED Imatinib mesylate in recurrent solid tumours expressing KIT or PDGFR (phase II)

B.J. Morland, B. Geoerger, M.-C. Le Deley, F. Doz, F. Pichon, D. Frappaz, J.-C. Gentet, J. Landman-Parker, P. Berthaud, G. Vassal

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 54 KB

english, 2006

30

248/249 INVITED Clinical phase I-II and pharmacokinetic study of plitidepsin in children with malignant tumors

B. Geoerger, F. Doz, E. Estlin, P. Kearns, S. Bezares, C. Pico, G. Vassal

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

31

9 INVITED Targeted therapies for paediatric brain tumours

Journal:

European Journal of Cancer Supplements

Year:

2007

Language:

english

File:

PDF, 57 KB

english, 2007

32

248 ORAL Notch pathway: a potential new target for the treatment of paediatric ependymomas

C. Dantas-Barbosa, B. Geoerger, S. Puget, L. Lacroix, F. Andreiuolo, A. Valent, P. Varlet, C. Sainte-Rose, G. Vassal, J. Grill

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 78 KB

english, 2008

33

181 POSTER Evaluation of the marine compound PM02734 against a pediatric tumor cell line panel by ITCC preclinical drug evaluation program

B. Geoerger, C. Lanvers, A. Verschuu, P. Aviles, C. Cuevas, J. Boos, G. Vassal, H. Caron

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

34

193 POSTER Preclinical evaluation of the marine compound PM00104 within the ITCC pediatric tumor cell line panel in vitro and in vivo

A. Verschuur, C. Lanvers, B. Geoerger, P. Aviles, P. Rodier, C. Cuevas, J. Boos, G. Vassal, H. Caron

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 121 KB

english, 2008

35

562 POSTER The anti-insulin-like growth factor I receptor antibody EM164 (murine AVE1642) enhances anti-tumor activity of temozolomide against neuroblastoma cell lines and xenografts

B. Geoerger, J.F. Brasme, E. Daudigeos, F. Bladt, C. Venot, L. Debussche, P. Vrignaud, G. Vassal

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

36

596 POSTER The topoisomerase I inhibitor gimatecan exhibits synergistic activity with temozolomide and tyrosine kinase inhibitors in malignant glioma xenografts

B. Geoerger, N. Hamelin, P. Rodier, P. Opolon, R. Versace, G. Vassal

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 81 KB

english, 2008

37

A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study

Darren Hargrave, Birgit Geoerger, Didier Frappaz…

Journal:

Journal of Neuro-Oncology

Year:

2013

Language:

english

File:

PDF, 197 KB

english, 2013

38

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

Grill, J., Geoerger, B., Gesner, L., Perek, D., Leblond, P., Canete, A., Aerts, I., Madero, L., de Toledo Codina, J. S., Verlooy, J., Estlin, E., Cisar, L., Breazna, A., Dorman, A., Bailey, S., Nicoli

Journal:

Year:

2013

Language:

english

File:

PDF, 113 KB

english, 2013

39

253 Anti-tumor Activity of the PLK Inhibitor Volasertib (BI 6727) and the Aurora Kinase Inhibitor BI 811283 in Pediatric Malignancies

Lanvers-Kaminsky, C., Abbou, S., Daudigeos-Dubus, E., Molenaar, J., Verschuur, A., Caron, H., Vassal, G., Geoerger, B.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

40

A comparative analysis of paediatric dose-finding trials of molecularly targeted agent with adults’ trials

Paoletti, Xavier, Geoerger, Birgit, Doz, François, Baruchel, André, Lokiec, François, Le Tourneau, Christophe

Journal:

European Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 840 KB

english, 2013

41

Everolimus for astrocytomas in tuberous sclerosis complex

Geoerger, Birgit, Blockus, Heike

Journal:

Year:

2013

Language:

english

File:

PDF, 66 KB

english, 2013

42

205 Development of Metastasis Following Inhibition of VEGFR Pathway in an Orthotopic Neuroblastoma Model

Daudigeos-Dubus, E., Le Dret, L., Philippe, C., Andreiuolo, F., Bawa, O., Pata-Merci, N., Munier, F., Vassal, G., Geoerger, B.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 64 KB

english, 2012

43

347 Efficacy of Dasatinib in Targeting Diffuse Intrinsic Pontine Glioma (DIPG) Specific Pathway Activation in Vitro

Truffaux, N., Puget, S., Vassal, G., Geoerger, B., Grill, J.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 62 KB

english, 2012

44

Une nouvelle approche pour intégrer les données de toxicité de l’ensemble des cycles de traitement et leur grade, dans l’analyse des essais de phase I de recherche de dose en oncologie

Dousseau, A., Thiebaut, R., Geoerger, B., Le Deley, M.-C., Schöffski, P., Fumoleau, P., Mathoulin-Pélissier, S., Rizzo, E., Le Tourneau, C., Paoletti, X.

Journal:

Revue d'Épidémiologie et de Santé Publique

Year:

2014

Language:

french

File:

PDF, 278 KB

french, 2014

45

New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future

Taylor, Melissa, Rössler, Jochen, Geoerger, Birgit, Vassal, Gilles, Farace, Françoise

Journal:

Expert Opinion on Investigational Drugs

Year:

2010

Language:

english

File:

PDF, 475 KB

english, 2010

46

A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma

Shou, Y., Robinson, D. M., Amakye, D. D., Rose, K. L., Cho, Y.-J., Ligon, K. L., Sharp, T., Haider, A. S., Bandaru, R., Ando, Y., Geoerger, B., Doz, F., Ashley, D. M., Hargrave, D. R., Casanova, M., T

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 2.52 MB

english, 2015

47

Vemurafenib in pediatric patients with BRAFV 600E mutated high-grade gliomas

Bautista, Francisco, Paci, Angelo, Minard-Colin, Veronique, Dufour, Christelle, Grill, Jacques, Lacroix, Ludovic, Varlet, Pascale, Valteau-Couanet, Dominique, Geoerger, Birgit

Journal:

Pediatric Blood & Cancer

Year:

2014

Language:

english

File:

PDF, 683 KB

english, 2014

48

Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts

Geoerger, B, Grill, J, Opolon, P, Morizet, J, Aubert, G, Lecluse, Y, van Beusechem, V W, Gerritsen, W R, Kirn, D H, Vassal, G

Journal:

British Journal of Cancer

Year:

2003

Language:

english

File:

PDF, 360 KB

english, 2003

49

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma

Truffaux, N., Philippe, C., Paulsson, J., Andreiuolo, F., Guerrini-Rousseau, L., Cornilleau, G., Le Dret, L., Richon, C., Lacroix, L., Puget, S., Geoerger, B., Vassal, G., Ostman, A., Grill, J.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

50

Phase II Trial of Irinotecan in Children With Relapsed or Refractory Rhabdomyosarcoma: A Joint Study of the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group

Vassal, G., Couanet, D., Stockdale, E., Geoffray, A., Geoerger, B., Orbach, D., Pichon, F., Gentet, J. C., Picton, S., Bergeron, C., Cisar, L., Assadourian, S., Morland, B.

Journal:

Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 88 KB

english, 2007