George F. Njoroge: search on Z-Library

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51

Erratum to “Enhanced FTase activity achieved via piperazine interaction with catalytic zinc” [Bioorg. Med. Chem. Lett. 16 (2006) 984–988]

F. George Njoroge, Bancha Vibulbhan, Patrick Pinto, Corey Strickland, W. Robert Bishop, Amin Nomeir, Vivyoor Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

File:

PDF, 61 KB

2006

52

P2–P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Ashok Arasappan, F. George Njoroge, Kevin X. Chen, Srikanth Venkatraman, Tejal N. Parekh, Haining Gu, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Vincent Madison, Viyyoor Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 197 KB

english, 2006

53

Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity

F.George Njoroge, Bancha Vibulbhan, W.Robert Bishop, Paul Kirschmeier, Mathew S. Bryant, Amin A. Nomeir, Ming Liu, Ronald J. Doll, Viyyoor M. Girijavallabhan, Ashit K. Ganguly

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 258 KB

english, 1999

54

Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors

Velázquez, Francisco, Venkatraman, Srikanth, Lesburg, Charles A., Duca, José, Rosenblum, Stuart B., Kozlowski, Joseph A., Njoroge, F. George

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 717 KB

english, 2012

55

Characterization of resistance mutations against HCV ketoamide protease inhibitors

Xiao Tong, Stephane Bogen, Robert Chase, V. Girijavallabhan, Zhuyan Guo, F. George Njoroge, Andrew Prongay, Anil Saksena, Angela Skelton, Ellen Xia, Robert Ralston

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 612 KB

english, 2008

56

Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors

Cheng Li, Latha Nair, Tongtong Liu, Fangbiao Li, John Pichardo, Sony Agrawal, Robert Chase, Xiao Tong, Annette S. Uss, Stephane Bogen, F. George Njoroge, Richard A. Morrison, K.-C. Cheng

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

57

Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans

Cheng Li, Tongtong Liu, Lisa Broske, Jean-Marc Brisson, Annette S. Uss, F. George Njoroge, Richard A. Morrison, K.-C. Cheng

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 559 KB

english, 2008

58

A notable conversion of a thiolacetate to its corresponding sulfonyl chloride

Yuhua Huang, Frank Bennett, Vishal Verma, F. George Njoroge, Malcolm MacCoss

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 478 KB

english, 2012

59

Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Njoroge, F. George, Chen, Kevin X., Shih, Neng-Yang, Piwinski, John J.

Journal:

Accounts of Chemical Research

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

60

Current drug discovery strategies for treatment of hepatitis C virus infection

K.-C. Cheng, Samir Gupta, Hongwu Wang, Annette S. Uss, George F. Njoroge, Eric Hughes

Journal:

Journal of Pharmacy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 345 KB

english, 2011

61

Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design

Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor M., Madison, Vincent S., Yao, Nanua H., Prongay, Andrew J., Butkiewicz, Nancy, Pichardo, John

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

62

Regiochemistry, stereochemistry, and mechanism of addition of trifluoroacetic acid to (Z)-cyclooctene

Nordlander, J. Eric, Kotian, Kirtivan D., Raff, Dwight E., Njoroge, George F., Winemiller, Jeffry J.

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 725 KB

english, 1984

63

A Convenient Synthesis of Cis and Trans 4- tert -Butoxycarbonyl-Substituted Cyclohexylglycine

Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor, McPhail, Andrew T.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 52 KB

english, 2002

64

Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

Chen, Kevin X., Njoroge, F. George, Pichardo, John, Prongay, Andrew, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

65

Coordination behavior and binding properties of (3,5-dimethyl- 1H -pyrazol-1-yl)ethanol with Cu(II), Zn(II), Cd(II), and Pb(II) metals

Njoroge, Martha W., Ojwach, Stephen O., Nyamato, George S., Omondi, Bernard, Darkwa, James

Journal:

Journal of Coordination Chemistry

Year:

2013

Language:

english

File:

PDF, 246 KB

english, 2013

66

A short synthesis of (S)-(+)-tylophorine

Nordlander, J. Eric, Njoroge, F. George

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 553 KB

english, 1987

67

Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors

Tong, Xiao, Guo, Zhuyan, Wright-Minogue, Jacquelyn, Xia, Ellen, Prongay, Andrew, Madison, Vincent, Qiu, Ping, Venkatraman, Srikanth, Velazquez, Francisco, Njoroge, F. George, Malcolm, Bruce A.

Journal:

Year:

2006

Language:

english

File:

PDF, 482 KB

english, 2006

68

Synthesis of C-11 Methyl-Substituted Benzocycloheptapyridine Inhibitors of Farnesyl Protein Transferase

Njoroge, F. George, Vibulbhan, Bancha, Wong, Jesse K., White, Steven K., Wong, Shing-Chun, Carruthers, Nicholas I., Kaminski, James J., Doll, Ronald J., Girijavallabhan, V., Ganguly, Ashit K.

Journal:

Organic Letters

Year:

1999

Language:

english

File:

PDF, 90 KB

english, 1999

69

Syntheses of Novel 4- tert -Alkyl Ether Proline-Based 16- and 17-Membered Macrocyclic Compounds

Chen, Kevin X., Njoroge, F. George, Vibulbhan, Bancha, Buevich, Alexei, Chan, Tze-Ming, Girijavallabhan, Viyyoor

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 76 KB

english, 2002

70

Computational Study of the Effects of Mutations A156T, D168V, and D168Q on the Binding of HCV Protease Inhibitors

Guo, Zhuyan, Prongay, Andrew, Tong, Xiao, Fischmann, Thierry, Bogen, Stephane, Velazquez, Francisco, Venkatraman, Srikanth, Njoroge, F. George, Madison, Vincent

Journal:

Journal of Chemical Theory and Computation

Year:

2006

Language:

english

File:

PDF, 223 KB

english, 2006

71

Enzymatic Kinetic Resolution of Piperidine Atropisomers: Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336

Morgan, Brian, Zaks, Aleksey, Dodds, David R., Liu, Jinchu, Jain, Rama, Megati, Sreeni, Njoroge, F. George, Girijavallabhan, Viyyoor M.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 206 KB

english, 2000

72

3-(D- Erythro -Trihydroxypropyl)-1-Neopentyl Pyrrole-2-Carboxaldehyde. A Novel Nonenzymatic Browning Product of Glucose

Njoroge, F. George, Fernandes, Albert A., Monnier, Vincent M.

Journal:

Journal of Carbohydrate Chemistry

Year:

1987

Language:

english

File:

PDF, 549 KB

english, 1987

73

Application of Ring-Closing Metathesis for the Synthesis of Macrocyclic Peptidomimetics as Inhibitors of HCV NS3 Protease

Velázquez, Francisco, Venkatraman, Srikanth, Wu, Wanli, Blackman, Melissa, Prongay, Andrew, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Njoroge, F. George

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 180 KB

english, 2007

74

Stereoselective Synthesis of β-Substituted β-Amino Sulfones and Sulfonamides via Addition of Sulfonyl Anions to Chiral N -Sulfinyl Imines

Velázquez, Francisco, Arasappan, Ashok, Chen, Kevin, Sannigrahi, Mousumi, Venkatraman, Srikanth, McPhail, Andrew T., Chan, Tze-Ming, Shih, Neng-Yang, Njoroge, F. George

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 79 KB

english, 2006

75

Application of Ruthenium-Induced Macrocyclization for the Construction of Macrocyclic Depsipeptides

Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor, McPhail, Andrew T.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

76

Regioselective Cobalt-Catalyzed Addition of Sulfides to Unactivated Alkenes

Girijavallabhan, Vinay, Alvarez, Carmen, Njoroge, F. George

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 985 KB

english, 2011

77

An efficient synthesis of 3,4-dihydropyridone via a tandem olefin isomerization–ring-closing metathesis reaction

Si, Chong, Fales, Kevin R., Boyer, Robert D., George Njoroge, F.

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 1.62 MB

english, 2014

78

Non-Peptidic Small-Molecule Inhibitors of the Single-Chain Hepatitis C Virus NS3 Protease/NS4A Cofactor Complex Discovered by Structure-Based NMR Screening

Wyss, Daniel F., Arasappan, Ashok, Senior, Mary M., Wang, Yu-Sen, Beyer, Brian M., Njoroge, F. George, McCoy, Mark A.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 712 KB

english, 2004

79

A short enantiospecific synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN)

Nordlander, J. Eric, Payne, Mark J., Njoroge, F. George, Vishwanath, Vasanth M., Han, Gi Rin, Laikos, George D., Balk, Michael A.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 623 KB

english, 1985

80

Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N -Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Bishop, W. Robert, Bryant, Mathew S., Nomeir, Amin A., Lin, C.-C., Liu, Ming, Doll, Ronald J., Girijavallabhan, V., Ganguly, Ashit K.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 132 KB

english, 1998

81

Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

Taveras, Arthur G., Deskus, Jeff, Chao, Jianping, Vaccaro, Cynthia J., Njoroge, F. George, Vibulbhan, Bancha, Pinto, Pat, Remiszewski, Stacy, del Rosario, Jocelyn, Doll, Ronald J., Alvarez, Carmen, La

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 371 KB

english, 1999

82

Highly Regioselective Nitration Reactions Provide a Versatile Method of Functionalizing Benzocycloheptapyridine Tricyclic Ring Systems: Application toward Preparation of Nanomolar Inhibitors of Farnesyl Protein Transferase

Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Chan, Tze-Ming, Osterman, Rebecca, Remiszewski, Stacy, Del Rosario, Jocelyn, Doll, Ronald, Girijavallabhan, V., Ganguly, Ashit K.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 175 KB

english, 1998

83

Novel Dipeptide Macrocycles from 4-Oxo, -Thio, and -Amino-Substituted Proline Derivatives

Arasappan, Ashok, Chen, Kevin X., Njoroge, F. George, Parekh, Tejal N., Girijavallabhan, Viyyoor

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 61 KB

english, 2002

84

Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles

Chen, Kevin X., Njoroge, F. George, Arasappan, Ashok, Venkatraman, Srikanth, Vibulbhan, Bancha, Yang, Weiying, Parekh, Tejal N., Pichardo, John, Prongay, Andrew, Cheng, Kuo-Chi, Butkiewicz, Nancy, Yao

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 289 KB

english, 2006

85

Design, Synthesis, and Biological Activity of m -Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

Chen, Kevin X., Njoroge, F. George, Pichardo, John, Prongay, Andrew, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 215 KB

english, 2005

86

Structural Interaction of Natural and Synthetic Inhibitors with the Venom Metalloproteinase, Atrolysin C (Form d)

Dachuan Zhang, Istvan Botos, Franz-Xaver Gomis-Rüth, Ronald Doll, Christine Blood, F. George Njoroge, Jay w. Fox, Wolfram Bode and Edgar F. Meyer

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.87 MB

english, 1994

87

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B

Chen, Guangming, Ren, Hongyu, Zhang, Nanjing, Lennox, William, Turpoff, Anthony, Paget, Steven, Li, Chunshi, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Colacino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 383 KB

english, 2015

88

Macrocyclic Inhibitors of HCV NS3-4A Protease: Design and Structure Activity Relationship

Srikanth Venkatraman, Bentham Science Publisher, F. George Njoroge, Bentham Science Publisher

Journal:

Current Topics in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 536 KB

english, 2007

89

Validation of Two Rapid Diagnostic Tests for Visceral Leishmaniasis in Kenya

Mbui, Jane, Wasunna, Monique, Balasegaram, Manica, Laussermayer, Adrian, Juma, Rashid, Njenga, Simon Njoroge, Kirigi, George, Riongoita, Mark, de la Tour, Roberto, van Peteghem, Joke, Omollo, Raymond,

Journal:

PLoS Neglected Tropical Diseases

Year:

2013

Language:

english

File:

PDF, 145 KB

english, 2013

90

Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva

Sitt, Tatjana, Poole, E. Jane, Ndambuki, Gideon, Mwaura, Stephen, Njoroge, Thomas, Omondi, George P., Mutinda, Matthew, Mathenge, Joseph, Prettejohn, Giles, Morrison, W. Ivan, Toye, Philip

Journal:

International Journal for Parasitology: Parasites and Wildlife

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

91

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B

Zhang, Nanjing, Turpoff, Anthony, Zhang, Xiaoyan, Huang, Song, Liu, Yalei, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Pichardo, John, Colacino, Joseph, Lahser,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.77 MB

english, 2015

92

For the EAC, Products are Visibility

Njoroge, George

Journal:

Africa Journal of Management

Year:

2015

Language:

english

File:

PDF, 319 KB

english, 2015

93

Enantioselective Synthesis of 3,3-Difluoropyrrolidin-4-ol, a Valuable Building Block in Medicinal Chemistry

Si, Chong, Fales, Kevin R., Torrado, Alicia, Frimpong, Kwame, Kaoudi, Talbi, Vandeveer, Harold George, Njoroge, F. George

Journal:

Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 576 KB

english, 2016

94

Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity

Yu, Wensheng, Coburn, Craig A., Yang, De-Yi, Meinke, Peter T., Wong, Michael, Rosenblum, Stuart B., Chen, Kevin X., Njoroge, George F., Chen, Lei, Dwyer, Michael P., Jiang, Yueheng, Nair, Anilkumar G.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.98 MB

english, 2016

95

ChemInform Abstract: An Efficient Synthesis of 3,4-Dihydropyridone via a Tandem Olefin Isomerization-Ring-Closing Metathesis Reaction.

Si, Chong, Fales, Kevin R., Boyer, Robert D., George Njoroge, F.

Journal:

Year:

2015

File:

PDF, 23 KB

2015

96

Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Non-Classical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.

Fales, Kevin R., Njoroge, F. George, Brooks, Harold B, Thibodeaux, Stefan, Torrado, Alicia, Si, Chong, Toth, James L, Mc Cowan, Jefferson R, Roth, Kenneth D., Thrasher, Kenneth Jeff, Frimpong, Kwame,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

97

Corrigendum to “Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva” [Int. J. Parasitol. Parasites Wildl. 4(2) (2015) 244–251]

Sitt, Tatjana, Poole, E. Jane, Ndambuki, Gideon, Mwaura, Stephen, Njoroge, Thomas, Omondi, George P., Mutinda, Matthew, Mathenge, Joseph, Prettejohn, Giles, Morrison, W. Ivan, Toye, Philip

Journal:

International Journal for Parasitology: Parasites and Wildlife

Year:

2017

Language:

english

File:

PDF, 127 KB

english, 2017

98

Who uses sustainable land management practices and what are the costs and benefits? Insights from Kenya

Dallimer, Martin, Stringer, Lindsay C., Orchard, Steven E., Osano, Philip, Njoroge, George, Wen, Cheng, Gicheru, Patrick

Journal:

Land Degradation & Development

Year:

2018

Language:

english

File:

PDF, 1.18 MB

english, 2018

99

“How I Wish This Thing Was Initiated 100 Years Ago!” Willingness to Take Daily Oral Pre-Exposure Prophylaxis among Men Who Have Sex with Men in Kenya

Karuga, Robinson Njoroge, Njenga, Serah Nduta, Mulwa, Rueben, Kilonzo, Nduku, Bahati, Prince, O’reilley, Kevin, Gelmon, Lawrence, Mbaabu, Stephen, Wachihi, Charles, Githuka, George, Kiragu, Michael, K

Journal:

Year:

2016

Language:

english

File:

PDF, 208 KB

english, 2016

100

Preoperative Fasting among Adult Patients for Elective Surgery in a Kenyan Referral Hospital

Njoroge, George, Kivuti-Bitok, Lucy, Kimani, Samuel

Journal:

International Scholarly Research Notices

Year:

2017

Language:

english

File:

PDF, 1.46 MB

english, 2017