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51

Structural and functional studies of titin’s fn3 modules reveal conserved surface patterns and binding to myosin S1 - a possible role in the frank-starling mechanism of the heart

Claudia Muhle-Goll, Michael Habeck, Olivier Cazorla, Michael Nilges, Siegfried Labeit, Henk Granzier

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 1.05 MB

english, 2001

52

Changes in Titin and Collagen Underlie Diastolic Stiffness Diversity of Cardiac Muscle

Yiming Wu, Olivier Cazorla, Dietmar Labeit, Siegfried Labeit, Henk Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2000

Language:

english

File:

PDF, 271 KB

english, 2000

53

Complete Unfolding of the Titin Molecule under External Force

Miklós S.Z. Kellermayer, Steven B. Smith, Carlos Bustamante, Henk L. Granzier

Journal:

Journal of Structural Biology

Year:

1998

Language:

english

File:

PDF, 238 KB

english, 1998

54

PEVK Extension of Human Soleus Muscle Titin Revealed by Immunolabeling with the Anti-titin Antibody 9D10

K. Trombitás, M. Greaser, G. French, H. Granzier

Journal:

Journal of Structural Biology

Year:

1998

Language:

english

File:

PDF, 995 KB

english, 1998

55

Different Molecular Mechanics Displayed by Titin's Constitutively and Differentially Expressed Tandem Ig Segments

Kaori Watanabe, Claudia Muhle-Goll, Miklós S.Z. Kellermayer, Siegfried Labeit, Henk Granzier

Journal:

Journal of Structural Biology

Year:

2002

Language:

english

File:

PDF, 528 KB

english, 2002

56

Calcium-dependent inhibition of in vitro thin-filament motility by native titin

Miklós S.Z. Kellermayer, Henk L. Granzier

Journal:

Year:

1996

Language:

english

File:

PDF, 649 KB

english, 1996

57

Effect of diastolic pressure on MLC2v phosphorylation in the rat left ventricle

Carlos Hidalgo, Yiming Wu, Jun Peng, William F. Siems, Kenneth B. Campbell, Henk Granzier

Journal:

Archives of Biochemistry and Biophysics

Year:

2006

Language:

english

File:

PDF, 256 KB

english, 2006

58

Cardiac titin: Structure, functions and role in disease

Martin M. LeWinter, Yiming Wu, Siegfried Labeit, Henk Granzier

Journal:

Clinica Chimica Acta

Year:

2007

Language:

english

File:

PDF, 1.27 MB

english, 2007

59

Heart failure decreases passive tension generation of rat diaphragm fibers

H.W.H. van Hees, C.A.C. Ottenheijm, H.L. Granzier, P.N.R. Dekhuijzen, L.M.A. Heunks

Journal:

International Journal of Cardiology

Year:

2010

Language:

english

File:

PDF, 1.93 MB

english, 2010

60

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules

Melanie K. Miller, Marie-Louise Bang, Christian C. Witt, Dietmar Labeit, Charles Trombitas, Kaori Watanabe, Henk Granzier, Abigail S. McElhinny, Carol C. Gregorio, Siegfried Labeit

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 4.10 MB

english, 2003

61

Induction and Myofibrillar Targeting of CARP, and Suppression of the Nkx2.5 Pathway in the MDM Mouse with Impaired Titin-based Signaling

Christian C. Witt, Yasuko Ono, Eva Puschmann, Mark McNabb, Yiming Wu, Michael Gotthardt, Stephanie H. Witt, Markus Haak, Dietmar Labeit, Carol C. Gregorio, Hiroyuki Sorimachi, Henk Granzier, Siegfried

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 2.02 MB

english, 2004

62

MURF-1 and MURF-2 Target a Specific Subset of Myofibrillar Proteins Redundantly: Towards Understanding MURF-dependent Muscle Ubiquitination

Stephanie H. Witt, Henk Granzier, Christian C. Witt, Siegfried Labeit

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 495 KB

english, 2005

63

Expression of Distinct Classes of Titin Isoforms in Striated and Smooth Muscles by Alternative Splicing, and Their Conserved Interaction with Filamins

Siegfried Labeit, Sunshine Lahmers, Christoph Burkart, Chi Fong, Mark McNabb, Stephanie Witt, Christian Witt, Dietmar Labeit, Henk Granzier

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 3.66 MB

english, 2006

64

Altered Contractility of Skeletal Muscle in Mice Deficient in Titin’s M-Band Region

Coen A.C. Ottenheijm, Carlos Hidalgo, Katharina Rost, Michael Gotthardt, Henk Granzier

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.64 MB

english, 2009

65

Non-Proteolytic Functions of Calpain-3 in Sarcoplasmic Reticulum in Skeletal Muscles

Koichi Ojima, Yasuko Ono, Coen Ottenheijm, Shoji Hata, Hidenori Suzuki, Henk Granzier, Hiroyuki Sorimachi

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

66

The effects of PKCα phosphorylation on the extensibility of titin’s PEVK element

Brian R. Anderson, Julius Bogomolovas, Siegfried Labeit, Henk Granzier

Journal:

Journal of Structural Biology

Year:

2010

Language:

english

File:

PDF, 491 KB

english, 2010

67

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance

Anselmo S. Moriscot, Igor L. Baptista, Julius Bogomolovas, Christian Witt, Stephanie Hirner, Henk Granzier, Siegfried Labeit

Journal:

Journal of Structural Biology

Year:

2010

Language:

english

File:

PDF, 1.63 MB

english, 2010

68

Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2)

Coen A.C. Ottenheijm, Pleuni Hooijman, Elizabeth T. DeChene, Ger J. Stienen, Alan H. Beggs, Henk Granzier

Journal:

Journal of Structural Biology

Year:

2010

Language:

english

File:

PDF, 923 KB

english, 2010

69

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development

Danielle Buck, Bryan D. Hudson, Coen A.C. Ottenheijm, Siegfried Labeit, Henk Granzier

Journal:

Journal of Structural Biology

Year:

2010

Language:

english

File:

PDF, 915 KB

english, 2010

70

O.5 Skeletal muscle-specific calpain, p94/calpain 3, dynamically distributes in skeletal muscle cells to adapt to physical stress, defects of which cause muscular dystrophy

K. Ojima, Y. Ono, N. Doi, F. Kitamura, S. Hata, Y. Kawabata, K. Suzuki, T. Maeda, K. Abe, H. Nakao, A. Aiba, K. Nakao, H. Suzuki, H. Kawahara, C. Witt, S. Labeit, C. Ottenheijm, H. Granzier, N. Toyama

Journal:

Neuromuscular Disorders

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

71

Cellular and molecular mechanisms of systolic and diastolic dysfunction in an avian model of dilated cardiomyopathy

Yiming Wu, Anthony H Tobias, Kenneth Bell, William Barry, Michiel Helmes, Karoly Trombitas, Russell Tucker, Kenneth B Campbell, Henk L Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2004

Language:

english

File:

PDF, 402 KB

english, 2004

72

Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance

Yiming Wu, Jun Peng, Kenneth B Campbell, Siegfried Labeit, Henk Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 1.20 MB

english, 2007

73

Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease

Michael Gramlich, Beate Michely, Christian Krohne, Arnd Heuser, Bettina Erdmann, Sabine Klaassen, Bryan Hudson, Manuela Magarin, Florian Kirchner, Mihail Todiras, Henk Granzier, Siegfried Labeit, Ludw

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2009

Language:

english

File:

PDF, 577 KB

english, 2009

74

Excision of titin's cardiac PEVK spring element abolishes PKCα-induced increases in myocardial stiffness

Bryan D. Hudson, Carlos G. Hidalgo, Michael Gotthardt, Henk L. Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 792 KB

english, 2010

75

Calcium sensitivity and the Frank–Starling mechanism of the heart are increased in titin N2B region-deficient mice

Eun-Jeong Lee, Jun Peng, Michael Radke, Michael Gotthardt, Henk L Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

76

Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle

Charles S. Chung, Henk L. Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2011

Language:

english

File:

PDF, 929 KB

english, 2011

77

Titin based viscosity in ventricular physiology: An integrative investigation of PEVK–actin interactions

Charles S. Chung, Methajit Methawasin, O. Lynne Nelson, Michael H. Radke, Carlos G. Hidalgo, Michael Gotthardt, Henk L. Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2011

Language:

english

File:

PDF, 910 KB

english, 2011

78

Mechanics and structure of titin oligomers explored with atomic force microscopy

Miklós S.Z. Kellermayer, Carlos Bustamante, Henk L. Granzier

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2003

Language:

english

File:

PDF, 1.31 MB

english, 2003

79

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

Yiming Wu, Elizabeth D. Luczak, Eun-Jeong Lee, Carlos Hidalgo, Jinying Yang, Zhan Gao, Jingdong Li, Xander H.T. Wehrens, Henk Granzier, Mark E. Anderson

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2012

Language:

english

File:

PDF, 932 KB

english, 2012

80

The multifunctional Ca2 +/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements

Carlos G. Hidalgo, Charles S. Chung, Chandra Saripalli, Mei Methawasin, Kirk R. Hutchinson, George Tsaprailis, Siegfried Labeit, Alicia Mattiazzi, Henk L. Granzier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2013

Language:

english

File:

PDF, 977 KB

english, 2013

81

Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness

Cazorla, O., Freiburg, A., Helmes, M., Centner, T., McNabb, M., Wu, Y., Trombitas, K., Labeit, S., Granzier, H.

Journal:

Circulation Research

Year:

2000

Language:

english

File:

PDF, 914 KB

english, 2000

82

Extensibility of Isoforms of Cardiac Titin: Variation in Contour Length of Molecular Subsegments Provides a Basis for Cellular Passive Stiffness Diversity

Trombitás, Karoly, Redkar, Alka, Centner, Thomas, Wu, Yiming, Labeit, Siegfried, Granzier, Henk

Journal:

Biophysical Journal

Year:

2000

Language:

english

File:

PDF, 763 KB

english, 2000

83

Titin–Actin Interaction in Mouse Myocardium: Passive Tension Modulation and Its Regulation by Calcium/S100A1

Yamasaki, R., Berri, M., Wu, Y., Trombitás, K., McNabb, M., Kellermayer, M.S.Z., Witt, C., Labeit, D., Labeit, S., Greaser, M., Granzier, H.

Journal:

Biophysical Journal

Year:

2001

Language:

english

File:

PDF, 732 KB

english, 2001

84

Mechanical Fatigue in Repetitively Stretched Single Molecules of Titin

Kellermayer, Miklós S.Z., Smith, Steven B., Bustamante, Carlos, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2001

Language:

english

File:

PDF, 788 KB

english, 2001

85

Molecular Basis of Passive Stress Relaxation in Human Soleus Fibers: Assessment of the Role of Immunoglobulin-Like Domain Unfolding

Trombitás, K., Wu, Y., McNabb, M., Greaser, M., Kellermayer, M.S.Z., Labeit, S., Granzier, H.

Journal:

Biophysical Journal

Year:

2003

Language:

english

File:

PDF, 636 KB

english, 2003

86

Tuning Passive Mechanics through Differential Splicing of Titin during Skeletal Muscle Development

Ottenheijm, Coen A.C., Knottnerus, Anna M., Buck, Danielle, Luo, Xiuju, Greer, Kevin, Hoying, Adam, Labeit, Siegfried, Granzier, Henk

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 976 KB

english, 2009

87

Mouse Intact and Skinned Cardiac Myocyte Mechanics: Crossbridge and Titin-Based Stress in Unactivated Cells

Methawasin, Methajit, King, Nicholas M.P., Nedrud, Joshua, Chung, Charles S., Helmes, Michiel, Granzier, Henk L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 41 KB

english, 2011

88

Thick-Filament Strain and Interfilament Spacing in Passive Muscle: Effect of Titin-Based Passive Tension

Irving, Thomas, Wu, Yiming, Bekyarova, Tanya, Farman, Gerrie P., Fukuda, Norio, Granzier, Henk

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 635 KB

english, 2011

89

Mechanics on Myocardium Deficient in the N2B Region of Titin: The Cardiac-Unique Spring Element Improves Efficiency of the Cardiac Cycle

Nedrud, Joshua, Labeit, Siegfried, Gotthardt, Michael, Granzier, Henk

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 1.14 MB

english, 2011

90

G.P.108 Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

Lassche, S., Stienen, G.J.M., Irving, T.C., van der Maarel, S.M., Padberg, G.W., Granzier, H., Ottenheijm, C.A.C., van Engelen, B.G.M.

Journal:

Neuromuscular Disorders

Year:

2012

Language:

english

File:

PDF, 59 KB

english, 2012

91

Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations

Brian R. Anderson, Henk L. Granzier

Journal:

Progress in Biophysics and Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

92

Sarcomere length dependence of the force-velocity relation in single frog muscle fibers

Granzier, H.L., Burns, D.H., Pollack, G.H.

Journal:

Biophysical Journal

Year:

1989

Language:

english

File:

PDF, 1.02 MB

english, 1989

93

Passive tension and stiffness of vertebrate skeletal and insect flight muscles: the contribution of weak cross-bridges and elastic filaments

Granzier, H.L., Wang, K.

Journal:

Biophysical Journal

Year:

1993

Language:

english

File:

PDF, 2.36 MB

english, 1993

94

The effect of genetically expressed cardiac titin fragments on in vitro actin motility

Li, Q., Jin, J.P., Granzier, H.L.

Journal:

Biophysical Journal

Year:

1995

Language:

english

File:

PDF, 1.34 MB

english, 1995

95

Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics

Granzier, H., Helmes, M., Trombitás, K.

Journal:

Biophysical Journal

Year:

1996

Language:

english

File:

PDF, 2.14 MB

english, 1996

96

Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction

Granzier, H., Kellermayer, M., Helmes, M., Trombitás, K.

Journal:

Biophysical Journal

Year:

1997

Language:

english

File:

PDF, 1.88 MB

english, 1997

97

A Spring Tale: New Facts on Titin Elasticity

Linke, Wolfgang A., Granzier, Henk

Journal:

Biophysical Journal

Year:

1998

Language:

english

File:

PDF, 56 KB

english, 1998

98

Molecular Dissection of N2B Cardiac Titin’s Extensibility

Trombitás, Karoly, Freiburg, Alexandra, Centner, Thomas, Labeit, Siegfried, Granzier, Henk

Journal:

Biophysical Journal

Year:

1999

Language:

english

File:

PDF, 667 KB

english, 1999

99

Titin: An endosarcomeric protein that modulates myocardial stiffness in DCM

Yiming Wu, Siegfried LaBeit, Martin M. LeWinter, Henk Granzier

Journal:

Journal of Cardiac Failure

Year:

2002

Language:

english

File:

PDF, 425 KB

english, 2002

100

Hierarchical Extensibility in the PEVK Domain of Skeletal-Muscle Titin

Nagy, A., Grama, L., Huber, T., Bianco, P., Trombitás, K., Granzier, H.L., Kellermayer, M.S.Z.

Journal:

Biophysical Journal

Year:

2005

Language:

english

File:

PDF, 290 KB

english, 2005