Gut, Philip: search on Z-Library

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51

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Pereira, Nuno A. L., Monteiro, Ângelo, Machado, Marta, Gut, Jiri, Molins, Elies, Perry, M. Jesus, Dourado, Jorge, Moreira, Rui, Rosenthal, Philip J., Prudêncio, Miguel, Santos, Maria M. M.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.65 MB

english, 2015

52

Synthesis and Evaluation of Isatins (V) and Thiosemicarbazone Derivatives (I) Against Cruzain, Falcipain-2 and Rhodesain.

Idan Chiyanzu, Elizabeth Hansell, Jiri Gut, Philip J. Rosenthal, James H. McKerrow, Kelly Chibale

Journal:

Year:

2004

File:

PDF, 87 KB

2004

53

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

João Lavrado, Alexandra Paulo, Jiri Gut, Philip J. Rosenthal, Rui Moreira

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 131 KB

english, 2008

54

Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands

Setshaba D. Khanye, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal, Gregory S. Smith, Kelly Chibale

Journal:

Journal of Organometallic Chemistry

Year:

2011

Language:

english

File:

PDF, 238 KB

english, 2011

55

Synthesis and Evaluation of New Antimalarial Phenylurenyl Chalcone Derivatives

Domínguez, José N., León, Caritza, Rodrigues, Juan, Gamboa de Domínguez, Neira, Gut, Jiri, Rosenthal, Philip J.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 134 KB

english, 2005

56

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Ressurreição, Ana S., Gonçalves, Daniel, Sitoe, Ana R., Albuquerque, Inês S., Gut, Jiri, Góis, Ana, Gonçalves, Lídia M., Bronze, Maria R., Hanscheid, Thomas, Biagini, Giancarlo A., Rosenthal, Philip J

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 880 KB

english, 2013

57

Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine-Resistant Plasmodium falciparum

Bianca Pérez, Dr. Cátia Teixeira, Jiri Gut, Prof. Philip J. Rosenthal, Dr. José R. B. Gomes, Prof. Paula Gomes

Journal:

Year:

2012

Language:

english

File:

PDF, 338 KB

english, 2012

58

Identification of Novel Parasitic Cysteine Protease Inhibitors Using Virtual Screening. 1. The ChemBridge Database

Desai, Prashant V., Patny, Akshay, Sabnis, Yogesh, Tekwani, Babu, Gut, Jiri, Rosenthal, Philip, Srivastava, Anuradha, Avery, Mitchell

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 225 KB

english, 2004

59

Novel anti-Plasmodialhits identified by virtual screening of the ZINC database

Mugumbate, Grace, Newton, Ana S., Rosenthal, Philip J., Gut, Jiri, Moreira, Rui, Chibale, Kelly, Guedes, Rita C.

Journal:

Journal of Computer-Aided Molecular Design

Year:

2013

Language:

english

File:

PDF, 778 KB

english, 2013

60

Imidazoquines as Antimalarial and Antipneumocystis Agents †

Vale, Nuno, Prudêncio, Miguel, Marques, Catarina A., Collins, Margaret S., Gut, Jiri, Nogueira, Fátima, Matos, Joana, Rosenthal, Philip J., Cushion, Melanie T., do Rosário, Virgílio E., Mota, Mari

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.16 MB

english, 2009

61

Open Notebook Science - Falcipain-2 Preliminary Results

Bradley, Jean-Claude, Rosenthal, Philip, Guha, Rajarshi, Mirza, Khalid, Gut, Jiri

Journal:

Bioentrepreneur

Year:

2008

Language:

english

File:

PDF, 3.43 MB

english, 2008

62

Novel thiolactone–isatin hybrids as potential antimalarial and antitubercular agents

Renate H. Hans, Ian J.F. Wiid, Paul D. van Helden, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

63

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

Nuno Vale, Margaret S. Collins, Jiri Gut, Ricardo Ferraz, Philip J. Rosenthal, Melanie T. Cushion, Rui Moreira, Paula Gomes

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 124 KB

english, 2008

64

Computer-Aided Drug Design of Falcipain Inhibitors: Virtual Screening, Structure–Activity Relationships, Hydration Site Thermodynamics, and Reactivity Analysis

Shah, Falgun, Gut, Jiri, Legac, Jennifer, Shivakumar, Devleena, Sherman, Woody, Rosenthal, Philip J., Avery, Mitchell A.

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

65

Identification of new antimalarial leads by use of virtual screening against cytochrome bc1

Tiago Rodrigues, Rui Moreira, Jiri Gut, Philip J. Rosenthal, Paul M. O′Neill, Giancarlo A. Biagini, Francisca Lopes, Daniel J.V.A. dos Santos, Rita C. Guedes

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 915 KB

english, 2011

66

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation

Dennis S.B. Ongarora, Jiri Gut, Philip J. Rosenthal, Collen M. Masimirembwa, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 540 KB

english, 2012

67

Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity

Setshaba D. Khanye, Jiri Gut, Philip J. Rosenthal, Kelly Chibale, Gregory S. Smith

Journal:

Journal of Organometallic Chemistry

Year:

2011

Language:

english

File:

PDF, 247 KB

english, 2011

68

The pedunculopontine tegmental nucleus-A functional hypothesis from the comparative literature

Gut, Nadine K., Winn, Philip

Journal:

Movement Disorders

Year:

2016

Language:

english

File:

PDF, 370 KB

english, 2016

69

Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents

Paulo M.C. Glória, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Rui Moreira, Maria M.M. Santos

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 620 KB

english, 2011

70

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

Naoaki Fujii, Jeremy P. Mallari, Elizabeth J. Hansell, Z. Mackey, Patricia Doyle, Y.M. Zhou, Jiri Gut, Philip J. Rosenthal, James H. McKerrow, R. Kiplin Guy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 253 KB

english, 2005

71

Dipeptide vinyl sultams: Synthesis via the Wittig–Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

Cláudia Valente, Rita C. Guedes, Rui Moreira, Jim Iley, Jiri Gut, Philip J. Rosenthal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 186 KB

english, 2006

72

Antimalarial activity of azadipeptide nitriles

Reik Löser, Jiri Gut, Philip J. Rosenthal, Maxim Frizler, Michael Gütschow, Katherine T. Andrews

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 471 KB

english, 2010

73

7-Chloroquinoline-isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation

Raj, Raghu, Biot, Christophe, Carrère-Kremer, Séverine, Kremer, Laurent, Guérardel, Yann, Gut, Jiri, Rosenthal, Philip J., Forge, Delphine, Kumar, Vipan

Journal:

Chemical Biology & Drug Design

Year:

2014

Language:

english

File:

PDF, 650 KB

english, 2014

74

Design, synthesis and biological evaluation of novel benzothiazole and triazole analogs as falcipain inhibitors

Shah, Falgun, Wu, Yunshan, Gut, Jiri, Pedduri, Yakambram, Legac, Jennifer, Rosenthal, Philip J., Avery, Mitchell A.

Journal:

Year:

2011

Language:

english

File:

PDF, 365 KB

english, 2011

75

Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

S. SIJWALI, Puran, R. SHENAI, Bhaskar, GUT, Jiri, SINGH, Ajay, J. ROSENTHAL, Philip

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 392 KB

english, 2001

76

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

Rita Capela, Rudi Oliveira, Lídia M. Gonçalves, Ana Domingos, Jiri Gut, Philip J. Rosenthal, Francisca Lopes, Rui Moreira

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 311 KB

english, 2009

77

Tetrazole-based deoxyamodiaquines: Synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents

Tukulula, Matshawandile, Njoroge, Mathew, Mugumbate, Grace C., Gut, Jiri, Rosenthal, Philip J., Barteau, Samuel, Streckfuss, Judith, Heudi, Olivier, Kameni-Tcheudji, Jacques, Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 749 KB

english, 2013

78

Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆

Bradford W Gutting, Farida Bouzahzah, Philip L Kong, Lawrence W Updyke, David E Amacher, Joe Craft

Journal:

Toxicology and Applied Pharmacology

Year:

2003

Language:

english

File:

PDF, 629 KB

english, 2003

79

Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials

Pérez, Bianca C., Teixeira, Cátia, Figueiras, Marta, Gut, Jiri, Rosenthal, Philip J., Gomes, José R.B., Gomes, Paula

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 815 KB

english, 2012

80

Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds

Tukulula, Matshawandile, Njoroge, Mathew, Abay, Efrem T., Mugumbate, Grace C., Wiesner, Lubbe, Taylor, Dale, Gibhard, Liezl, Norman, Jennifer, Swart, Kenneth J., Gut, Jiri, Rosenthal, Philip J., Barte

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

81

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Miranda, Daniela, Capela, Rita, Albuquerque, Inês S., Meireles, Patrícia, Paiva, Isa, Nogueira, Fátima, Amewu, Richard, Gut, Jiri, Rosenthal, Philip J., Oliveira, Rudi, Mota, Maria M., Moreira, Rui, M

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 299 KB

english, 2014

82

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain

Idan Chiyanzu, Elizabeth Hansell, Jiri Gut, Philip J. Rosenthal, James H. McKerrow, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

83

Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies

Guantai, Eric M., Ncokazi, Kanyile, Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Bhampidipati, Ravi, Kopinathan, Anitha, Smith, Peter J., Chibale, Kelly

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.02 MB

english, 2011

84

An image-based assay for high throughput screening of Giardia lamblia

Jiri Gut, Kenny K.H. Ang, Jennifer Legac, Michelle R. Arkin, Philip J. Rosenthal, James H. McKerrow

Journal:

Journal of Microbiological Methods

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

85

In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites

Pérez, Bianca, Teixeira, Cátia, Gomes, Ana S., Albuquerque, Inês S., Gut, Jiri, Rosenthal, Philip J., Prudêncio, Miguel, Gomes, Paula

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 359 KB

english, 2013

86

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

Ang, Kenny K. H., Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B., Skrzypczynska, Katarzyna M., Debnath, Anjan, Engel, Juan C., Rosenthal, Philip J., McKerrow, Jam

Journal:

PLoS Neglected Tropical Diseases

Year:

2011

Language:

english

File:

PDF, 1.61 MB

english, 2011

87

4-Aminoquinoline-chalcone/- N -acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation

Kumar, Sumit, Saini, Anu, Gut, Jiri, Rosenthal, Philip J., Raj, Raghu, Kumar, Vipan

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 931 KB

english, 2017

88

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Newman, John C., Covarrubias, Anthony J., Zhao, Minghao, Yu, Xinxing, Gut, Philip, Ng, Che-Ping, Huang, Yu, Haldar, Saptarsi, Verdin, Eric

Journal:

Cell Metabolism

Year:

2017

Language:

english

File:

PDF, 2.00 MB

english, 2017

89

Application of Multi-Component Reactions to Antimalarial Drug Discovery. Part 1. Parallel Synthesis and Antiplasmodial Activity of New 4-Aminoquinoline Ugi Adducts.

Chitalu C. Musonda, Dale Taylor, Julie Lehman, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Year:

2004

File:

PDF, 21 KB

2004

90

Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants

Fabrice Fekam Boyom, Vincent Ngouana, Paul Henri Amvam Zollo, Chantal Menut, Jean Marie Bessiere, Jiri Gut, Philip J Rosenthal

Journal:

Year:

2003

Language:

english

File:

PDF, 254 KB

english, 2003

91

Corrigendum: Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine-Resistant Plasmodium falciparum

Pérez, Bianca, Teixeira, Cátia, Gut, Jiri, Rosenthal, Philip J., Gomes, José R. B., Gomes, Paula

Journal:

Year:

2013

Language:

english

File:

PDF, 86 KB

english, 2013

92

Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents

Ribeiro, Carlos J.A., Kumar, S. Praveen, Gut, Jiri, Gonçalves, Lídia M., Rosenthal, Philip J., Moreira, Rui, Santos, Maria M.M.

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 377 KB

english, 2013

93

Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation

Singh, Pardeep, Raj, Raghu, Singh, Parvesh, Gut, Jiri, Rosenthal, Philip J., Kumar, Vipan

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 345 KB

english, 2014

94

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

Blank, Brian R., Gut, Jiri, Rosenthal, Philip J., Renslo, Adam R.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 638 KB

english, 2017

95

Open Notebook Science - Falcipain-2 Preliminary Results

Bradley, Jean-Claude, Rosenthal, Philip, Guha, Rajarshi, Mirza, Khalid, Gut, Jiri

Journal:

Bioentrepreneur

Year:

2008

File:

PDF, 3.43 MB

2008

96

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts

Chitalu C Musonda, Dale Taylor, Julie Lehman, Jiri Gut, Philip J Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

97

Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure−Antimalarial Activity Relationships and Mechanistic Studies

Lavrado, João, Cabal, Ghislain G., Prudêncio, Miguel, Mota, Maria M., Gut, Jiri, Rosenthal, Philip J., Díaz, Cecília, Guedes, Rita C., dos Santos, Daniel J. V. A., Bichenkova, Elena, Douglas, Kenn

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.43 MB

english, 2011

98

Comparison of the antiplasmodial and falcipain-2 inhibitory activity of β-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids

Renate H. Hans, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 299 KB

english, 2010

99

Phosphonium lipocations as antiparasitic agents

Timothy E. Long, Xiao Lu, Melina Galizzi, Roberto Docampo, Jiri Gut, Philip J. Rosenthal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 610 KB

english, 2012

100

N-Cinnamoylated Chloroquine Analogues as Dual-Stage Antimalarial Leads

Pérez, Bianca C., Teixeira, Cátia, Albuquerque, Inês S., Gut, Jiri, Rosenthal, Philip J., Gomes, José R. B., Prudêncio, Miguel, Gomes, Paula

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.14 MB

english, 2013

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